Pub Date : 2025-12-03DOI: 10.1016/j.tem.2025.11.002
Leah D’Silva, Chloe Cheng, Joeva J. Barrow
{"title":"Unlocking thermogenic silencers for the treatment of metabolic disease","authors":"Leah D’Silva, Chloe Cheng, Joeva J. Barrow","doi":"10.1016/j.tem.2025.11.002","DOIUrl":"https://doi.org/10.1016/j.tem.2025.11.002","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.tem.2025.10.006
Alexandra E. Schneider, Colin C. Conine
{"title":"Run for your sons: paternal exercise boosts offspring fitness","authors":"Alexandra E. Schneider, Colin C. Conine","doi":"10.1016/j.tem.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.tem.2025.10.006","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"184 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/s1043-2760(25)00229-2
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1043-2760(25)00229-2","DOIUrl":"https://doi.org/10.1016/s1043-2760(25)00229-2","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145434407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/s1043-2760(25)00232-2
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1043-2760(25)00232-2","DOIUrl":"https://doi.org/10.1016/s1043-2760(25)00232-2","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145434406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tem.2025.10.005
Beatriz Rodriguez-Cortes, Ricardo Gomez-Martínez, Rachel Spenle, Markus Schwaninger, Ruben Nogueiras, Sowmyalakshmi Rasika, Vincent Prevot
{"title":"Tanycytes: bloodhounds of the metabolic brain","authors":"Beatriz Rodriguez-Cortes, Ricardo Gomez-Martínez, Rachel Spenle, Markus Schwaninger, Ruben Nogueiras, Sowmyalakshmi Rasika, Vincent Prevot","doi":"10.1016/j.tem.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.tem.2025.10.005","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145411969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1016/j.tem.2025.10.001
Marica Esposito, Ida Rimauro, Vittoria Frattolillo, Gianmario Forcina, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Anna Di Sessa
{"title":"MASLD in childhood as a multisystem health challenge beyond the liver","authors":"Marica Esposito, Ida Rimauro, Vittoria Frattolillo, Gianmario Forcina, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Anna Di Sessa","doi":"10.1016/j.tem.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.tem.2025.10.001","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"205 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145382739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.1016/j.tem.2025.10.004
Tobias Carling
Adrenal tumors driving hormone excess, like primary aldosteronism, Cushing syndrome, and pheochromocytoma, claim thousands of lives yearly; yet, adrenalectomy remains underused despite its lifesaving potential. Ideal surgical rates in the USA, UK, and Sweden could prevent tens of thousands of deaths, rivaling cancer operations' impact. Urgent screening reforms are needed.
{"title":"Adrenalectomy is underused: a call to reduce mortality.","authors":"Tobias Carling","doi":"10.1016/j.tem.2025.10.004","DOIUrl":"https://doi.org/10.1016/j.tem.2025.10.004","url":null,"abstract":"Adrenal tumors driving hormone excess, like primary aldosteronism, Cushing syndrome, and pheochromocytoma, claim thousands of lives yearly; yet, adrenalectomy remains underused despite its lifesaving potential. Ideal surgical rates in the USA, UK, and Sweden could prevent tens of thousands of deaths, rivaling cancer operations' impact. Urgent screening reforms are needed.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145381149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-25DOI: 10.1016/j.tem.2025.09.011
Daan A Jiskoot,Jeroen L A Pennings,Willie J G M Peijnenburg,Gerard J P van Westen,Willem Jespers,Pim N H Wassenaar
Endocrine-disrupting chemicals (EDCs) pose health risks; yet, conventional in vitro and in vivo testing remains slow, costly, and animal-intensive. Enhanced use of in silico approaches can contribute to earlier and increased detection of potential EDCs. This review evaluates advances in computational toxicology for early identification and prioritization of EDCs, with a focus on estrogen, androgen, thyroid, and steroidogenesis pathways. We discuss various implementations of ligand- and structure-based approaches, covering machine learning, deep learning, docking, molecular dynamics, and free energy methods, as well as their application in a regulatory setting. Moreover, we outline the future prospects necessary to advance the field and improve the in silico identification of potential EDCs.
{"title":"In silico prediction of endocrine activity.","authors":"Daan A Jiskoot,Jeroen L A Pennings,Willie J G M Peijnenburg,Gerard J P van Westen,Willem Jespers,Pim N H Wassenaar","doi":"10.1016/j.tem.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.tem.2025.09.011","url":null,"abstract":"Endocrine-disrupting chemicals (EDCs) pose health risks; yet, conventional in vitro and in vivo testing remains slow, costly, and animal-intensive. Enhanced use of in silico approaches can contribute to earlier and increased detection of potential EDCs. This review evaluates advances in computational toxicology for early identification and prioritization of EDCs, with a focus on estrogen, androgen, thyroid, and steroidogenesis pathways. We discuss various implementations of ligand- and structure-based approaches, covering machine learning, deep learning, docking, molecular dynamics, and free energy methods, as well as their application in a regulatory setting. Moreover, we outline the future prospects necessary to advance the field and improve the in silico identification of potential EDCs.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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