Kübra Çeleğen, Esra Özgül, Zeynep Yeşi̇ldağ, Erdem Yusuf Çamirci, M. Çeleğen, Ayşegül Bükülmez
{"title":"Risk factors of congenital nomalies of the kidney and urinary tract (CAKUT): Exposureto mobile phones during pregnancy","authors":"Kübra Çeleğen, Esra Özgül, Zeynep Yeşi̇ldağ, Erdem Yusuf Çamirci, M. Çeleğen, Ayşegül Bükülmez","doi":"10.55730/1300-0144.5790","DOIUrl":"https://doi.org/10.55730/1300-0144.5790","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Funda Akansel, Umur Sakallıoğlu, M. Lütfioğlu, Feyza O Özden, Adil Karadağ
{"title":"Adjunctive use of laser biostimulation with nonsurgical periodontal therapy: a split mouth, randomized, case-control study in diabetic and nondiabetic periodontitispatients","authors":"Funda Akansel, Umur Sakallıoğlu, M. Lütfioğlu, Feyza O Özden, Adil Karadağ","doi":"10.55730/1300-0144.5797","DOIUrl":"https://doi.org/10.55730/1300-0144.5797","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Şule Büyük Yaytokgil, K. Demir, Özge Yılmaz Topal, A. P. Metbulut, I. K. Celik, M. Toyran, E. Civelek, E. Mısırlıoğlu
{"title":"Evaluation of accompanying allergic disease in children with proven drug allergies","authors":"Şule Büyük Yaytokgil, K. Demir, Özge Yılmaz Topal, A. P. Metbulut, I. K. Celik, M. Toyran, E. Civelek, E. Mısırlıoğlu","doi":"10.55730/1300-0144.5793","DOIUrl":"https://doi.org/10.55730/1300-0144.5793","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140517226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. O. Sahin, Emine Karataş, Mikail Demir, Busra Tan, Huseyin Per, Yusuf Özkul, M. Dündar
CAPN3
CAPN3
{"title":"A retrospective study on the clinical and molecular outcomes of calpainopathy in a Turkish patient cohort","authors":"I. O. Sahin, Emine Karataş, Mikail Demir, Busra Tan, Huseyin Per, Yusuf Özkul, M. Dündar","doi":"10.55730/1300-0144.5769","DOIUrl":"https://doi.org/10.55730/1300-0144.5769","url":null,"abstract":"CAPN3","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-18eCollection Date: 2024-01-01DOI: 10.55730/1300-0144.5858
Ramadhea Laila Afifa An-Nur Willya Saputri, Nur Arfian, Junaedy Yunus, Fauziyatul Munawaroh, Sagita Mega Sekar Kencana, Dwi Cahyani Ratna Sari
Background/aim: Diabetes mellitus, characterized by hyperglycemia, causes various complications, one of which is memory dysfunction. The frontal lobe is known to be responsible for impaired memory function due to hyperglycemia and is associated with oxidative stress-mediated neuronal cell apoptosis. Chlorogenic acid (CGA) is reported to have neuroprotective effects. However, its effect on the frontal lobe in diabetes mellitus (DM) rats is not widely known. This research aimed to elucidate the effect of CGA on the mRNA expressions of SOD1, SOD2, p53, and Bcl-2 in the frontal lobe of DM rats.
Materials and methods: Thirty male Wistar rats (2-month-old, 150-200 gBW) were randomly divided into six groups: C (control), DM1.5 (1.5-month DM), DM2 (2-month DM), CGA12.5, CGA25 and CGA50 (DM+CGA 12.5, 25, and 50 mg/kgBW, respectively). A single dose of streptozotocin (60 mg/kgBW) was intraperitoneally injected. Intraperitoneal CGA injection was administered daily for DM1.5 rats for 14 days. Path length was measured in the Morris water maze (MWM) probe test. After termination, the frontal lobes were carefully harvested for RNA extraction. Reverse transcriptase PCR was performed to examine the mRNA expression of SOD1, SOD2, p53, and Bcl-2.
Results: The DM2 group demonstrated significant shorter path length on the MWM probe test and significantly lower mRNA expression of SOD1 and Bcl-2, compared to the C group. After CGA administration, the CGA25 group showed a significantly shorter path length than the C group. The CGA12.5 and CGA25 groups had significantly higher mRNA expression of SOD1 than the DM1.5 group. Compared to the DM1.5 and DM2 groups, SOD2 mRNA expression of the administration of all three CGA doses increased markedly. Furthermore, Bcl-2 mRNA expression was significantly increased in the CGA12.5 and CGA50 groups, compared with the DM2 group.
Conclusion: Chlorogenic acid might improve memory function through upregulation of frontal lobes' SOD1, SOD2, and Bcl-2 mRNA expression in DM rats.
{"title":"Chlorogenic acid ameliorates memory dysfunction via attenuating frontal lobe oxidative stress and apoptosis in diabetic rat model.","authors":"Ramadhea Laila Afifa An-Nur Willya Saputri, Nur Arfian, Junaedy Yunus, Fauziyatul Munawaroh, Sagita Mega Sekar Kencana, Dwi Cahyani Ratna Sari","doi":"10.55730/1300-0144.5858","DOIUrl":"https://doi.org/10.55730/1300-0144.5858","url":null,"abstract":"<p><strong>Background/aim: </strong>Diabetes mellitus, characterized by hyperglycemia, causes various complications, one of which is memory dysfunction. The frontal lobe is known to be responsible for impaired memory function due to hyperglycemia and is associated with oxidative stress-mediated neuronal cell apoptosis. Chlorogenic acid (CGA) is reported to have neuroprotective effects. However, its effect on the frontal lobe in diabetes mellitus (DM) rats is not widely known. This research aimed to elucidate the effect of CGA on the mRNA expressions of SOD1, SOD2, p53, and Bcl-2 in the frontal lobe of DM rats.</p><p><strong>Materials and methods: </strong>Thirty male Wistar rats (2-month-old, 150-200 gBW) were randomly divided into six groups: C (control), DM1.5 (1.5-month DM), DM2 (2-month DM), CGA12.5, CGA25 and CGA50 (DM+CGA 12.5, 25, and 50 mg/kgBW, respectively). A single dose of streptozotocin (60 mg/kgBW) was intraperitoneally injected. Intraperitoneal CGA injection was administered daily for DM1.5 rats for 14 days. Path length was measured in the Morris water maze (MWM) probe test. After termination, the frontal lobes were carefully harvested for RNA extraction. Reverse transcriptase PCR was performed to examine the mRNA expression of SOD1, SOD2, p53, and Bcl-2.</p><p><strong>Results: </strong>The DM2 group demonstrated significant shorter path length on the MWM probe test and significantly lower mRNA expression of SOD1 and Bcl-2, compared to the C group. After CGA administration, the CGA25 group showed a significantly shorter path length than the C group. The CGA12.5 and CGA25 groups had significantly higher mRNA expression of SOD1 than the DM1.5 group. Compared to the DM1.5 and DM2 groups, SOD2 mRNA expression of the administration of all three CGA doses increased markedly. Furthermore, Bcl-2 mRNA expression was significantly increased in the CGA12.5 and CGA50 groups, compared with the DM2 group.</p><p><strong>Conclusion: </strong>Chlorogenic acid might improve memory function through upregulation of frontal lobes' SOD1, SOD2, and Bcl-2 mRNA expression in DM rats.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CSRP1 expression is associated with a mesenchymal, stroma-rich tumor profile and poor prognosis in colon cancer","authors":"Secil Demirkol Canli","doi":"10.55730/1300-0144.5736","DOIUrl":"https://doi.org/10.55730/1300-0144.5736","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Çetinkaya, Deniz Elcik, Ş. Keleşoğlu, B. Cesur, M. Yasan, Ugur Karabiyik, Bi̇lge Bi̇ngöl, N. Kalay, Ramazan Topsakal, Aydin Tuncay, Ali̇ Doğan, M. T. İnanç
{"title":"Is electrophysiological study a novel predictor for permanent pacemaker implantation after transcatheter aortic valve implantation?","authors":"Z. Çetinkaya, Deniz Elcik, Ş. Keleşoğlu, B. Cesur, M. Yasan, Ugur Karabiyik, Bi̇lge Bi̇ngöl, N. Kalay, Ramazan Topsakal, Aydin Tuncay, Ali̇ Doğan, M. T. İnanç","doi":"10.55730/1300-0144.5750","DOIUrl":"https://doi.org/10.55730/1300-0144.5750","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esra Güzel Tanoğlu, Seyfure Adigüzel, A. Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
{"title":"Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets","authors":"Esra Güzel Tanoğlu, Seyfure Adigüzel, A. Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç","doi":"10.55730/1300-0144.5724","DOIUrl":"https://doi.org/10.55730/1300-0144.5724","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Yalçınkaya, Şafak Sağol, A. Azizova, E. Bilgin, Kader Karli Oğuz, U. Kalyoncu
{"title":"Craniocervical junction involvement in inflammatory arthritis: a single-center radiologic study","authors":"F. Yalçınkaya, Şafak Sağol, A. Azizova, E. Bilgin, Kader Karli Oğuz, U. Kalyoncu","doi":"10.55730/1300-0144.5740","DOIUrl":"https://doi.org/10.55730/1300-0144.5740","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of sestrin 2 and tribbles homolog 3 levels in obese and nonobese women with polycystic ovary syndrome","authors":"Ayşegül Çatal, E. Kovalak","doi":"10.55730/1300-0144.5738","DOIUrl":"https://doi.org/10.55730/1300-0144.5738","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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