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Tumor Biology最新文献

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Erratum to: SMAD4 and its role in pancreatic cancer. SMAD4及其在胰腺癌中的作用。
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2022-01-01 DOI: 10.3233/TUB-229004
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引用次数: 0
Unfavorable prognosis and clinical consequences of APOBEC3B expression in breast and other cancers: A systematic review and meta-analysis. APOBEC3B在乳腺癌和其他癌症中的不良预后和临床后果:一项系统综述和荟萃分析。
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2022-01-01 DOI: 10.3233/TUB-211577
Sima Jafarpour, Maryam Yazdi, Reza Nedaeinia, Sepideh Ghobakhloo, Rasoul Salehi

Introduction: Controversy exists regarding the association of apolipoprotein B mRNA editing enzyme catalytic subunit 3B APOBEC3B, (A3B) overexpression and poor prognosis, metastasis, and chemotherapy drug resistance in cancers. Here we conducted a systematic review and meta-analysis to determine its prognostic value and clinicopathological features in breast cancer and some other malignancies.

Materials and methods: PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE were searched up to Feb 2022 for the association of A3B with breast, ovarian, gastrointestinal and lung cancers. The pooled hazard ratios with 95% confidence interval (CI) were evaluated to assess disease-free survival (DFS), overall survival (OS), and recurrence-free survival (RFS) in cancers under study.

Results: Over 3700 patients were included in this meta-survey. Elevated levels of A3B were significantly related to low OS (pooled HR = 1.30; 95% CI:1.09-1.55, P < 0.01), poor DFS (pooled HR = 1.66; 95% CI:1.17-2.35, P < 0.01) and poor RFS (HR = 1.51, 95% CI:1.11-2.04, P = 0.01). Subgroup analysis revealed that high A3B expression was associated with poor OS in lung (HR = 1.85, 95% CI: 1.40-2.45), and breast cancers (HR = 1.38, 95% CI: 1.00-1.89). High expression of A3B did not display any significant association with clinicopathologic features.

Conclusion: APOBEC3B overexpression is related to poor OS, DFS and RFS only in some cancer types and no generalized role could be predicted for all cancers.

导读:载脂蛋白B mRNA编辑酶催化亚基3B APOBEC3B、(A3B)过表达与癌症预后不良、转移及化疗耐药的关系存在争议。在此，我们进行了一项系统回顾和荟萃分析，以确定其在乳腺癌和其他一些恶性肿瘤中的预后价值和临床病理特征。材料和方法:截至2022年2月，检索PubMed、Scopus、Cochrane Library、Web of Science和EMBASE，查找A3B与乳腺癌、卵巢癌、胃肠道和肺癌的关联。评估具有95%置信区间(CI)的合并风险比，以评估研究中癌症的无病生存(DFS)、总生存(OS)和无复发生存(RFS)。结果:超过3700名患者纳入了这项荟萃调查。A3B水平升高与低OS显著相关(合并HR = 1.30;结论:APOBEC3B过表达仅在某些类型的癌症中与不良的OS、DFS和RFS相关，不能预测其在所有癌症中的普遍作用。
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引用次数: 1
Erratum to: Galectin-3: A factotum in carcinogenesis bestowing an archery for prevention 勘误表：半乳糖凝集素-3：致癌作用中的一位杂役授予预防箭术
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-11-09 DOI: 10.3233/tub-219009
T. Ram
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引用次数: 1
Abstract 2992: Proteogenomic characterization of triple-negative breast cancer patient-derived xenografts reveals molecular correlates of differential chemotherapy response and potential therapeutic targets to overcome resistance 摘要2992:三阴性乳腺癌患者来源的异种移植物的蛋白质基因组学特征揭示了差异化疗反应的分子相关性和克服耐药性的潜在治疗靶点
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2992
Jonathan T. Lei, Chen Huang, R. R. Srinivasan, S. Vasaikar, L. Dobrolecki, Alaina N. Lewis, Christina Sallas, S. Hilsenbeck, C. Osborne, M. Rimawi, M. Ellis, V. Petrosyan, Alexander B. Saltzman, A. Malovannaya, G. Wulf, D. Kraushaar, Tao Wang, G. Echeverria, Bing Zhang, M. Lewis
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引用次数: 0
Abstract 3145: TRIPODD: a novel fluorescence imaging platform for in situ quantification of drug distribution and therapeutic response TRIPODD:一种用于原位定量药物分布和治疗反应的新型荧光成像平台
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-3145
Nathan P. McMahon, Allison Solanki, Jocelyn A. Jones, Lei G. Wang, K. Tichauer, K. Samkoe, Summer L. Gibbs
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引用次数: 0
Abstract 2755: Single-cell RNA sequencing reveals priming professional antigen-presenting macrophages and chemokine expressing T cells in tumor microenvironment by AXL inhibitor, SKI-G-801 摘要2755:单细胞RNA测序揭示了AXL抑制剂SKI-G-801在肿瘤微环境中启动专业抗原呈递巨噬细胞和表达趋化因子的T细胞
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2755
Kyung-Ho Pyo, H. K. Lee, H. Jo, Wongeun Lee, S. Heo, S. Lim, Dong Kwon Kim, Chun-Bong Synn, Y. Byeon, Young Seob Kim, B. Ahn, M. Hong, S. Lim, H. Kim, B. Cho
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引用次数: 0
Abstract 2995: Zebrafish tumor-derived xenografts established from breast cancer pdx models predict treatment outcome and dissemination risk with superior sensitivity and specificity 摘要2995：从癌症pdx模型建立的斑马鱼肿瘤衍生异种移植物以优异的敏感性和特异性预测治疗结果和扩散风险
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2995
Gabriela Vazquez Rodriguez, Z. Ali, Anna Erkstam, J. Schueler, A. Fahlgren, Lasse D. Jensen
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引用次数: 0
Abstract 2936: Ago2 induces Kras signaling and promotes tumor progression in mouse models of lung adenocarcinoma 2936: Ago2诱导Kras信号通路，促进肺腺癌小鼠模型的肿瘤进展
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2936
J. Tien, Seema Chugh, Andrew Goodrum, Yun-Chien Cheng, Lisha Wang, R. Mannan, Xiaoming Wang, Vijaya L. Dommeti, Yuping Zhang, A. Xu, Fengyun Su, Xuhong Cao, Sunita Shankar, A. Chinnaiyan
{"title":"Abstract 2936: Ago2 induces Kras signaling and promotes tumor progression in mouse models of lung adenocarcinoma","authors":"J. Tien, Seema Chugh, Andrew Goodrum, Yun-Chien Cheng, Lisha Wang, R. Mannan, Xiaoming Wang, Vijaya L. Dommeti, Yuping Zhang, A. Xu, Fengyun Su, Xuhong Cao, Sunita Shankar, A. Chinnaiyan","doi":"10.1158/1538-7445.AM2021-2936","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2936","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45205911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2830: Effect of tobacco and alcohol intake on the future development of liver metastasis 2830:烟酒摄入对肝转移未来发展的影响
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2830
M. Tobi, F. Antaki, MaryAnn Rambus, E. Levi, H. Talwar, M. Lawson, B. McVicker
{"title":"Abstract 2830: Effect of tobacco and alcohol intake on the future development of liver metastasis","authors":"M. Tobi, F. Antaki, MaryAnn Rambus, E. Levi, H. Talwar, M. Lawson, B. McVicker","doi":"10.1158/1538-7445.AM2021-2830","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2830","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49062030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2771: Comprehensive analysis of immuno oncology markers in the tumor microenvironment of solid tumor samples using GeoMxTMdigital spatial profiler (DSP) and MultiOmyxTMhyperplexed immunofluorescence (IF) 2771:利用GeoMxTMdigital spatial profiler (DSP)和MultiOmyxTMhyperplexed immunofluorescence (IF)综合分析实体瘤样本肿瘤微环境中的免疫肿瘤标志物
Q3 Biochemistry, Genetics and Molecular Biology
Tumor Biology
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2771
Lakshmi Chandramohan, Q. Au, M. Nagy, E. Parnell, T. Peters
{"title":"Abstract 2771: Comprehensive analysis of immuno oncology markers in the tumor microenvironment of solid tumor samples using GeoMxTMdigital spatial profiler (DSP) and MultiOmyxTMhyperplexed immunofluorescence (IF)","authors":"Lakshmi Chandramohan, Q. Au, M. Nagy, E. Parnell, T. Peters","doi":"10.1158/1538-7445.AM2021-2771","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2771","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49252112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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