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Bayesian genomic prediction of junctional epidermolysis bullosa in sheep 绵羊大疱性结缔组织表皮松解症的贝叶斯基因组预测
Pub Date : 2021-01-01 DOI: 10.3906/vet-2106-83
Bayesian genomic prediction of junctional epidermolysis bullosa in sheep 1 Abstract: Junctional epidermolysis bullosa (JEP) is a heritable skin and mucosa disorders 2 condition in association with mendelian mutations in sheep. The purpose of this investigation 3 is to explore the relationship between different priors, linkage disequilibrium and single 4 nucleotide polymorphisms (SNPs) selection methods to accuracy of Bayesian GP of JEP in 5 sheep. 92 Spanish Churra sheep breed genotyped by 40668 SNP markers. Bayes Cπ shown to 6 have slightly higher predicted accuracy [0.724 (0.113)] by unselected data. Prediction 7 performance of the Bayesian GP models was found to be similar after correction for LD. There 8 was a significant difference between predicted accuracies due to the SNPs selection by ranked 9 p values of whole and training only dataset using linear model. The relevance of genetic 10 architecture in conjugate to the prior distributions clearly supported by the unselected data. The 11 most obvious finding emerge from this study is that preselection of SNPs referring to genetic 12 architecture of the phenotype may lower the needs of computational load. 13
摘要:大疱性结缔组织表皮松解症(JEP)是绵羊的一种遗传性皮肤和粘膜疾病,与孟德尔基因突变有关。本研究的目的是探讨不同的先验、连锁不平衡和单核苷酸多态性(snp)选择方法与5只绵羊JEP贝叶斯GP准确性的关系。用40668个SNP标记对92个西班牙丘拉羊品种进行基因分型。未选择数据时,Bayes cp = 6的预测精度略高[0.724(0.113)]。在对LD进行校正后,发现贝叶斯GP模型的预测性能相似。由于使用线性模型的全数据集和仅训练数据集的9个p值进行snp选择,预测精度之间存在显着差异。遗传结构的相关性共轭到先验分布清楚地由未选择的数据支持。本研究最明显的发现是,参考表型遗传结构的snp预选可能会降低计算负荷的需求。13
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引用次数: 0
The effects of dietary fish protein hydrolysate-based supplementation on sensory properties and meat quality of broiler chicken 饲粮中添加鱼水解蛋白对肉鸡感官性能和肉品质的影响
Pub Date : 2021-01-01 DOI: 10.3906/vet-2104-80
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引用次数: 3
Effects of partial replacement of conventional limestone with dietary micro-calcium carbonate on performance, egg quality, hematology, and calcium metabolism in laying hens during peak production 饲粮微碳酸钙部分替代常规石灰石对生产高峰期蛋鸡生产性能、蛋品质、血液学和钙代谢的影响
Pub Date : 2021-01-01 DOI: 10.3906/vet-2104-25
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引用次数: 0
Ruminal kinetics of carbohydrates, gas production and bromatology of sugarcane silage with high levels of sodium benzoate 高苯甲酸钠水平下甘蔗青贮碳水化合物、产气和肉质学的瘤胃动力学
Pub Date : 2021-01-01 DOI: 10.3906/vet-2005-59
C. Heinzen, Odimari Pricila Prado Calixto, E. H. Horst, Leonardo Trolegi, Fernando Luiz Massaro, I. Y. Mizubuti, M. Neumann, V. Bumbieris
: The objective of this study was to evaluate the chemical composition, ruminal kinetics, gas production and aerobic stability of sugarcane silage added with increasing levels of sodium benzoate up to 1% of the natural matter. After harvesting, the sugarcane was chopped and placed in experimental polyethylene silos for storage for 30 days. An increasing concentration of sodium benzoate in the silage promoted a linear decrease in the crude protein content, varying from 2.79% to 2.51%. The addition of sodium benzoate reduced the fiber concentration of the silage (P = 0.0015) and increased gas production of the fibrous and nonfibrous carbohydrates (R 2 = 0.83 and 0.65, respectively). The volume and rate of degradation of nonfibrous carbohydrates ( V cnf and Kd cnf, respectively) were significantly affected (P < 0.05) by the inclusion of sodium benzoate, with the largest volume of gas produced by fermentation of nonfibrous carbohydrates with a dose 0.25% of sodium benzoate and, not coincidentally, it was the treatment that presented the lowest Kd (5.52 g DM -1 ). The aerobic stability was higher in the silage with the highest additive content than in the other silages. The high levels of sodium benzoate used in this work, above what is commonly studied, have been shown to improve sugarcane silage with dry matter contents that are normally difficult to control.
本研究的目的是评价甘蔗青贮饲料中添加苯甲酸钠至1%时的化学组成、瘤胃动力学、产气量和有氧稳定性。收获后,甘蔗被切碎,放入实验聚乙烯筒仓中储存30天。随着青贮饲料中苯甲酸钠浓度的增加,粗蛋白质含量呈线性下降,下降幅度在2.79% ~ 2.51%之间。添加苯甲酸钠降低了青贮饲料的纤维含量(P = 0.0015),提高了纤维性和非纤维性碳水化合物的产气量(r2分别为0.83和0.65)。苯甲酸钠的加入对非纤维性碳水化合物的体积和降解率(V cnf和Kd cnf)有显著影响(P < 0.05),其中0.25%苯甲酸钠浓度的非纤维性碳水化合物发酵产气量最大,且Kd最低(5.52 g DM -1)。添加剂含量最高的青贮,其有氧稳定性高于其他青贮。在这项工作中使用的高水平苯甲酸钠,高于通常研究的水平,已被证明可以改善甘蔗青贮,其干物质含量通常难以控制。
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引用次数: 0
Novel heat index models for subtropical region based on daily milk production in crossbred Holstein cows 基于杂交荷斯坦奶牛日产奶量的亚热带地区热指数模型
Pub Date : 2021-01-01 DOI: 10.3906/vet-2003-118
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引用次数: 0
Chemical castration using intratesticular injection of mannitol: A preliminary study in a rat model 大鼠睾丸内注射甘露醇化学去势的初步研究
Pub Date : 2021-01-01 DOI: 10.3906/vet-2010-111
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引用次数: 1
Effects of honeybee (apis mellifera) venom on redox balance, biochemical and hematological profile in diabetic rats: A preliminary study 蜜蜂毒液对糖尿病大鼠氧化还原平衡、生化和血液学影响的初步研究
Pub Date : 2021-01-01 DOI: 10.3906/vet-2006-139
B. Denk, Abdurrahman Fatih
: The treatment of diseases with honeybee venom (apitoxin) is a branch of apitherapy, which has yet to find substantial scientific support. In this present study, we used apitoxin to investigate its effects on diabetes mellitus (DM) in rats. The use of apitoxin injection on single-dose streptozotocin (STZ)-treated rat model was selected, and the study took 28 days. Fasting blood glucose (FBG) was measured weekly. Biochemical and hematological parameters, oxidative stress markers, and insulin levels were measured from the blood samples provided on the last day of the study, and the DNA damage marker (8-OHdG) was measured from urine samples. We found that apitoxin increased malondialdehyde (MDA) and carbonylated protein (PCO), and decreased glutathione (GSH) levels significantly. Additionally, apitoxin increased nitric oxide (NOx) levels significantly in diabetic rats. The findings suggest that apitoxin increases oxidative stress to some extent. Apitoxin had no significant effect on plasma insulin levels. Apitoxin apparently caused small decreases in FBG levels. Apitoxin appears to cause an increase in aspartate aminotransferase (AST), and an increase in the number of platelets (PLT) and granulocytes (GRAN) in diabetic rats. Consequently, the possible antidiabetic effect of apitoxin on DM could only be supported at the preliminary level and presented with speculation in this state of the study. honeybee venom, plasma insulin concentration, redox system, streptozotocin-induced diabetes mellitus
用蜂毒(蜂毒素)治疗疾病是蜂疗的一个分支,尚未得到充分的科学支持。在本研究中,我们用蜂毒研究其对大鼠糖尿病(DM)的影响。选择单剂量链脲佐菌素(STZ)处理大鼠模型,采用蜂毒注射液,研究时间28 d。每周测量空腹血糖(FBG)。在研究最后一天提供的血液样本中测量生化和血液学参数、氧化应激标志物和胰岛素水平,并从尿液样本中测量DNA损伤标志物(8-OHdG)。我们发现蜂毒增加丙二醛(MDA)和羰基化蛋白(PCO),并显著降低谷胱甘肽(GSH)水平。此外,蜂毒显著增加了糖尿病大鼠的一氧化氮(NOx)水平。研究结果表明,蜂毒在一定程度上增加了氧化应激。蜂毒对血浆胰岛素水平无显著影响。蜂毒明显引起FBG水平的小幅度下降。蜂毒似乎引起糖尿病大鼠天冬氨酸转氨酶(AST)的增加,血小板(PLT)和粒细胞(GRAN)的增加。因此,蜂毒素对糖尿病的可能的降糖作用只能在初步水平上得到支持,在目前的研究状态下只能进行推测。蜂毒,血浆胰岛素浓度,氧化还原系统,链脲佐菌素引起的糖尿病
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引用次数: 1
Elastography acoustic radiation force impulse (ARFI): an investigation of ocular elasticity in dogs with chronic secondary glaucoma 弹性成像声辐射力脉冲(ARFI):慢性继发性青光眼犬眼弹性的研究
Pub Date : 2021-01-01 DOI: 10.3906/vet-2005-86
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引用次数: 0
Investigation of the non-typical Pasteurella multocida strains obtained from multiple sources, regions, and times: An unexpected increase was detected 从多个来源、地区和时间获得的非典型多杀性巴氏杆菌菌株的调查:发现意外增加
Pub Date : 2021-01-01 DOI: 10.3906/vet-2009-71
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引用次数: 1
Determination of plant-specific retrotransposons in chicken 鸡植物特异性反转录转座子的测定
Pub Date : 2021-01-01 DOI: 10.3906/vet-2102-56
Levent Mercan, Cihat Erdem Bulbul, Fatih Bilgi, S. Marakli
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引用次数: 2
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