Pub Date : 2026-01-03DOI: 10.1007/s00240-025-01928-5
Junkun Hou, Pan Liu, Sida Wang, Benhong Li, Jiawei Guan, Junfeng Yang
This case-control study investigated the association between calcium-sensing receptor (CaSR) gene polymorphisms and calcium-containing kidney stone susceptibility in 100 patients and 100 matched healthy controls from the Kunming Han Chinese population. Genotyping of three CaSR loci (rs1042636, rs1801725, and rs1801726) was performed using SNaPshot technology. The rs1801725 GT genotype significantly increased stone formation risk (odds ratio = 1.50, 95% confidence interval: 1.10-2.00, P = 0.042) and was associated with elevated 24-hour urinary calcium excretion compared with controls (10.683 ± 2.535 vs. 7.436 ± 1.742 mmol/24 h, P = 0.002), suggesting impaired renal tubular calcium reabsorption as the underlying mechanism. No significant association was found for rs1042636, while rs1801726 exhibited complete monomorphism (100% CC genotype) across all samples. This study provides the first evidence that the CaSR rs1801725 GT genotype serves as an independent genetic risk marker for urinary calcium stones in the Kunming Han Chinese population. Future research should integrate additional calcium transport pathway genes to develop polygenic risk prediction models and elucidate gene-environment interactions in stone pathogenesis.
本病例对照研究调查了来自昆明汉族人群的100例患者和100例匹配的健康对照者的钙敏感受体（CaSR）基因多态性与含钙肾结石易感性之间的关系。采用SNaPshot技术对三个CaSR位点（rs1042636、rs1801725和rs1801726）进行基因分型。rs1801725 GT基因型显著增加结石形成风险（优势比= 1.50,95%可信区间：1.10-2.00,P = 0.042），与对照组相比，24小时尿钙排泄量升高（10.683±2.535 vs. 7.436±1.742 mmol/24 h, P = 0.002），提示肾小管钙重吸收障碍是其潜在机制。rs1042636未发现显著相关性，而rs1801726在所有样本中表现为完全单态（100% CC基因型）。本研究首次证明CaSR rs1801725 GT基因型是昆明汉族人群尿钙结石的独立遗传风险标记。未来的研究应整合更多的钙转运途径基因，以建立多基因风险预测模型，并阐明结石发病机制中基因与环境的相互作用。
{"title":"Association between calcium-Sensing receptor gene polymorphisms and urinary calcium stone formation in the Han Chinese population from a High-Altitude region (Kunming) in China.","authors":"Junkun Hou, Pan Liu, Sida Wang, Benhong Li, Jiawei Guan, Junfeng Yang","doi":"10.1007/s00240-025-01928-5","DOIUrl":"10.1007/s00240-025-01928-5","url":null,"abstract":"<p><p>This case-control study investigated the association between calcium-sensing receptor (CaSR) gene polymorphisms and calcium-containing kidney stone susceptibility in 100 patients and 100 matched healthy controls from the Kunming Han Chinese population. Genotyping of three CaSR loci (rs1042636, rs1801725, and rs1801726) was performed using SNaPshot technology. The rs1801725 GT genotype significantly increased stone formation risk (odds ratio = 1.50, 95% confidence interval: 1.10-2.00, P = 0.042) and was associated with elevated 24-hour urinary calcium excretion compared with controls (10.683 ± 2.535 vs. 7.436 ± 1.742 mmol/24 h, P = 0.002), suggesting impaired renal tubular calcium reabsorption as the underlying mechanism. No significant association was found for rs1042636, while rs1801726 exhibited complete monomorphism (100% CC genotype) across all samples. This study provides the first evidence that the CaSR rs1801725 GT genotype serves as an independent genetic risk marker for urinary calcium stones in the Kunming Han Chinese population. Future research should integrate additional calcium transport pathway genes to develop polygenic risk prediction models and elucidate gene-environment interactions in stone pathogenesis.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"28"},"PeriodicalIF":2.2,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Learning curves after position switch in PCNL: prone- vs. supine-trained surgeons.","authors":"Mucahit Gelmis, Ali Ayten, Oguzhan Yildiz, Hakan Ceylan, Kanan Maharramov, Enver Ozdemir","doi":"10.1007/s00240-025-01924-9","DOIUrl":"https://doi.org/10.1007/s00240-025-01924-9","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"24"},"PeriodicalIF":2.2,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-29DOI: 10.1007/s00240-025-01915-w
Muhammad Usman, Zhouhang Li, Qingyou Zheng, Yang Cui, Changlong Cai, Wang He, Kewei Xu
{"title":"Efficacy and safety of super-pulse thulium fiber laser compared to holmium: YAG laser for ureteral and renal stones: a multicenter retrospective study.","authors":"Muhammad Usman, Zhouhang Li, Qingyou Zheng, Yang Cui, Changlong Cai, Wang He, Kewei Xu","doi":"10.1007/s00240-025-01915-w","DOIUrl":"10.1007/s00240-025-01915-w","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"23"},"PeriodicalIF":2.2,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12748295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-29DOI: 10.1007/s00240-025-01926-7
İbrahim Altundağ
{"title":"Letter to the editor: The association between frailty index and all-cause mortality in US individuals with kidney stones.","authors":"İbrahim Altundağ","doi":"10.1007/s00240-025-01926-7","DOIUrl":"https://doi.org/10.1007/s00240-025-01926-7","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"22"},"PeriodicalIF":2.2,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1007/s00240-025-01922-x
Bin Wang, Yingying Zhou, Jiaxin Cai
{"title":"Recognizing uric acid type of urinary stones by deep learning.","authors":"Bin Wang, Yingying Zhou, Jiaxin Cai","doi":"10.1007/s00240-025-01922-x","DOIUrl":"https://doi.org/10.1007/s00240-025-01922-x","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"21"},"PeriodicalIF":2.2,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1007/s00240-025-01913-y
Mohammed Zain Ulabedin Adhoni, Vineet Gauhar, Oliver Traxer, Thomas Herrmann, Daniele Castellani, Steffi Kar Kei Yuen, Bhaskar Somani
{"title":"When should we stop operating? Multicenter analysis of operative time, outcomes, and complications in ureteroscopy with flexible navigable suction access sheath (FANS) by EAU Endourology.","authors":"Mohammed Zain Ulabedin Adhoni, Vineet Gauhar, Oliver Traxer, Thomas Herrmann, Daniele Castellani, Steffi Kar Kei Yuen, Bhaskar Somani","doi":"10.1007/s00240-025-01913-y","DOIUrl":"https://doi.org/10.1007/s00240-025-01913-y","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"19"},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dietary inflammatory index and phenotypic age mediate the association between the dietary index for gut microbiota and kidney stone disease among U.S. overweight/obese adults.","authors":"Wanting Gao, Nan Luo, Yusen Ou, Junjie Lu, Chao Tian, Suquan Zhong","doi":"10.1007/s00240-025-01921-y","DOIUrl":"https://doi.org/10.1007/s00240-025-01921-y","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"18"},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the outflow of the sheath of pediatric nephroscope with access sheath of various sizes in the boundaries of a standardized in vivo experimental set-up. Two female porcines of 10 kg each were used in this experiment. The experiment was performed with the use of a 7.5Fr Pediatric Nephroscope and two different access sheaths; 8.5/9.5Fr and 11/12Fr. The measurements of outflow were performed with the use of gravity irrigation and manual pump irrigation. Additionally, the presence of accessory instruments in the working channel was evaluated. Using the 8.5/9.5Fr access sheath, the outflow with gravity irrigation was estimated at 12.3±1.3 ml/min, while under manual pump irrigation conditions, the outflow was calculated at 13.9±1.6 ml/min. The presence of Laser Fiber in the working channel diminished the outflow to 10.05±1.85 ml/min and 12.4±1.9 ml/min with the use of gravity and manual pump irrigation, respectively. Moreover, the outflow was estimated at 5.05±1.5 ml/min and 5.8±1.4 ml/min with the utilization of gravity and manual pump irrigation, respectively, when the basket was inserted into the working channel. The outcomes were ameliorated with the use of 11/12Fr access sheath. Both access sheaths used in this experimental study presented adequate outflow, even when the working channel was used for the introduction of instruments. Although no monitoring of IRP and temperature was performed in our experiment the outflow values we recorded probably correspond to safe changes in IRP and temperature.
{"title":"In vivo evaluation of the outflow pattern of pediatric nephroscope with various access sheaths.","authors":"Vasileios Tatanis, Angelis Peteinaris, Theodoros Spinos, Paraskevi Katsakiori, Solon Faitatziadis, Nikos Mourmouras, Theofanis Vrettos, Evangelos Liatsikos, Panagiotis Kallidonis","doi":"10.1007/s00240-025-01908-9","DOIUrl":"10.1007/s00240-025-01908-9","url":null,"abstract":"<p><p>To evaluate the outflow of the sheath of pediatric nephroscope with access sheath of various sizes in the boundaries of a standardized in vivo experimental set-up. Two female porcines of 10 kg each were used in this experiment. The experiment was performed with the use of a 7.5Fr Pediatric Nephroscope and two different access sheaths; 8.5/9.5Fr and 11/12Fr. The measurements of outflow were performed with the use of gravity irrigation and manual pump irrigation. Additionally, the presence of accessory instruments in the working channel was evaluated. Using the 8.5/9.5Fr access sheath, the outflow with gravity irrigation was estimated at 12.3±1.3 ml/min, while under manual pump irrigation conditions, the outflow was calculated at 13.9±1.6 ml/min. The presence of Laser Fiber in the working channel diminished the outflow to 10.05±1.85 ml/min and 12.4±1.9 ml/min with the use of gravity and manual pump irrigation, respectively. Moreover, the outflow was estimated at 5.05±1.5 ml/min and 5.8±1.4 ml/min with the utilization of gravity and manual pump irrigation, respectively, when the basket was inserted into the working channel. The outcomes were ameliorated with the use of 11/12Fr access sheath. Both access sheaths used in this experimental study presented adequate outflow, even when the working channel was used for the introduction of instruments. Although no monitoring of IRP and temperature was performed in our experiment the outflow values we recorded probably correspond to safe changes in IRP and temperature.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":"11"},"PeriodicalIF":2.2,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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