Pub Date : 2026-03-01Epub Date: 2025-12-19DOI: 10.1016/j.urology.2025.12.012
Stephen Kisty , Sarah A. Korth , Blaise W. Abramovitz , Oluwasanmi Adenaiye , Paul Rusilko , Brad E. Dicianno
Objective
To determine if serum cystatin C, which does not depend on muscle mass, is a potential alternative measure of kidney function in individuals with Spina Bifida and lower urinary tract dysfunction. Assessment using serum creatinine to estimate glomerular filtration rate is often compromised in this population because of decreased muscle mass from paralysis, which varies over spinal lesion levels and sub-phenotypes. We hypothesized creatinine-based formulas overestimate glomerular filtration rate at higher lesion levels relative to cystatin C-based formulas, and cystatin C-based equations provide stable estimates.
Methods
We retrospectively analyzed data from 155 adults with Spina Bifida. Estimated glomerular filtration rates from 5 equations (Cr-eGFR-2009, Cr-eGFR-2021, CysC-eGFR-2012, Zappitelli-CysC-eGFR, and CrCysC-eGFR-2021) were compared across 5 lesion levels and 2 Spina Bifida sub-phenotypes (myelomeningocele vs non-myelomeningocele).
Results
Creatinine-based estimated glomerular filtration rate increased with higher lesion levels (both P <.001), overestimating kidney function by a median of 12 mL/min/1.73 m² in thoracic-level myelomeningocele compared with cystatin C estimates. All 3 cystatin C-based formulas were stable across lesion levels (P >.39) and highly correlated (ρ = 0.84-0.94); P30 exceeded 90% for every pair. We identified biases up to ±7.8 mL/min/1.73 m² and limits of agreement wider than ±40 mL/min/1.73 m².
Conclusion
Significant discrepancies were observed among creatinine-based equations, which consistently estimated kidney function to be higher at higher lesion levels (relative to cystatin C) and in myelomeningocele. Cystatin C-based estimates were stable regardless of lesion level. However, clinicians should be cautious about the interchangeability of cystatin C-based estimates.
{"title":"Variability in Cystatin C- and Creatinine-estimated Glomerular Filtration Rate in Adults With Spina Bifida","authors":"Stephen Kisty , Sarah A. Korth , Blaise W. Abramovitz , Oluwasanmi Adenaiye , Paul Rusilko , Brad E. Dicianno","doi":"10.1016/j.urology.2025.12.012","DOIUrl":"10.1016/j.urology.2025.12.012","url":null,"abstract":"<div><h3>Objective</h3><div>To determine if serum cystatin C, which does not depend on muscle mass, is a potential alternative measure of kidney function in individuals with Spina Bifida and lower urinary tract dysfunction. Assessment using serum creatinine to estimate glomerular filtration rate is often compromised in this population because of decreased muscle mass from paralysis, which varies over spinal lesion levels and sub-phenotypes. We hypothesized creatinine-based formulas overestimate glomerular filtration rate at higher lesion levels relative to cystatin C-based formulas, and cystatin C-based equations provide stable estimates.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed data from 155 adults with Spina Bifida. Estimated glomerular filtration rates from 5 equations (Cr-eGFR-2009, Cr-eGFR-2021, CysC-eGFR-2012, Zappitelli-CysC-eGFR, and CrCysC-eGFR-2021) were compared across 5 lesion levels and 2 Spina Bifida sub-phenotypes (myelomeningocele vs non-myelomeningocele).</div></div><div><h3>Results</h3><div>Creatinine-based estimated glomerular filtration rate increased with higher lesion levels (both <em>P</em> <.001), overestimating kidney function by a median of 12 mL/min/1.73 m² in thoracic-level myelomeningocele compared with cystatin C estimates. All 3 cystatin C-based formulas were stable across lesion levels (<em>P</em> >.39) and highly correlated (ρ = 0.84-0.94); P30 exceeded 90% for every pair. We identified biases up to ±7.8 mL/min/1.73 m² and limits of agreement wider than ±40 mL/min/1.73 m².</div></div><div><h3>Conclusion</h3><div>Significant discrepancies were observed among creatinine-based equations, which consistently estimated kidney function to be higher at higher lesion levels (relative to cystatin C) and in myelomeningocele. Cystatin C-based estimates were stable regardless of lesion level. However, clinicians should be cautious about the interchangeability of cystatin C-based estimates.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"209 ","pages":"Pages 1-7"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-08DOI: 10.1016/j.urology.2025.12.043
Jennifer A. Kane, Joseph Y. Clark
{"title":"Editorial Comment on “Management of Accidentally Contaminated Buccal Mucosa Grafts”","authors":"Jennifer A. Kane, Joseph Y. Clark","doi":"10.1016/j.urology.2025.12.043","DOIUrl":"10.1016/j.urology.2025.12.043","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"209 ","pages":"Pages 125-126"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-13DOI: 10.1016/j.urology.2026.01.012
Mei Tuong
{"title":"Editorial Comment on “Time Dependent Material Fatigue of the Artificial Urinary Sphincter Pressure-regulating Balloon: A Mechanical and Microscopic Analysis”","authors":"Mei Tuong","doi":"10.1016/j.urology.2026.01.012","DOIUrl":"10.1016/j.urology.2026.01.012","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"209 ","pages":"Pages 134-135"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-13DOI: 10.1016/j.urology.2026.01.014
Aurora J. Grutman , Mohammad Elmojtaba Gumma , Nicole Page , Andrew T. Gabrielson , Marisa Clifton , Heather DiCarlo
{"title":"Reply to Letter to the Editor on “Cannabis Use is Associated With Lower Urinary Tract Symptoms in Pediatric Patients – A Large Claims Database Study”","authors":"Aurora J. Grutman , Mohammad Elmojtaba Gumma , Nicole Page , Andrew T. Gabrielson , Marisa Clifton , Heather DiCarlo","doi":"10.1016/j.urology.2026.01.014","DOIUrl":"10.1016/j.urology.2026.01.014","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":"209 ","pages":"Pages 168-169"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-21DOI: 10.1016/j.urology.2025.11.237
Makenna E. Romanelli , Bryan D. Naelitz , Raevti Bole , Neel V. Parekh , Daniel A. Shoskes , Scott D. Lundy , Sarah C. Vij
Objective
To characterize the effect of microscopic spermatic cord denervation (mSCD) on chronic scrotal content pain (CSCP) after inguinal hernia repair (IHR) and identify factors associated with pain resolution.
Methods
We conducted a retrospective chart review of patients who underwent mSCD for CSCP following IHR from January 2018 to June 2024 at a single academic medical center. Patient demographics, medical history, IHR surgical parameters, and postoperative self-reported pain assessments were collected. Patients were categorized as having complete, partial, or no resolution of pain. Univariate regression analysis was performed to identify predictors of pain resolution.
Results
Forty-two patients with CSCP following IHR who underwent mSCD were included. Five patients underwent bilateral mSCD, resulting in 47 cases for analysis. Pain resolved completely in 43% (n = 20/47) and improved in 87% (n = 41/47) of cases as assessed at a median follow-up time of 7 weeks (IQR: 6-14 weeks). No patient factors or IHR operative parameters were associated with complete pain resolution on univariate analysis. Patients who reported no improvement in pain (14%, n = 6/42) were younger (33 vs 58 years, P = .03) and more likely to have a history of levator tenderness/spasm (50 vs 7%, P = .02).
Conclusion
mSCD results in palliation of CSCP in most patients with prior IHR. mSCD may be less likely to benefit younger patients and those with a history of levator tenderness/spasm. General surgeons should consider urologic referral for mSCD in this patient population.
{"title":"Microscopic Spermatic Cord Denervation for Chronic Scrotal Content Pain Following Inguinal Hernia Repair: Outcomes and Predictors of Success","authors":"Makenna E. Romanelli , Bryan D. Naelitz , Raevti Bole , Neel V. Parekh , Daniel A. Shoskes , Scott D. Lundy , Sarah C. Vij","doi":"10.1016/j.urology.2025.11.237","DOIUrl":"10.1016/j.urology.2025.11.237","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the effect of microscopic spermatic cord denervation (mSCD) on chronic scrotal content pain (CSCP) after inguinal hernia repair (IHR) and identify factors associated with pain resolution.</div></div><div><h3>Methods</h3><div>We conducted a retrospective chart review of patients who underwent mSCD for CSCP following IHR from January 2018 to June 2024 at a single academic medical center. Patient demographics, medical history, IHR surgical parameters, and postoperative self-reported pain assessments were collected. Patients were categorized as having complete, partial, or no resolution of pain. Univariate regression analysis was performed to identify predictors of pain resolution.</div></div><div><h3>Results</h3><div>Forty-two patients with CSCP following IHR who underwent mSCD were included. Five patients underwent bilateral mSCD, resulting in 47 cases for analysis. Pain resolved completely in 43% (n = 20/47) and improved in 87% (n = 41/47) of cases as assessed at a median follow-up time of 7 weeks (IQR: 6-14 weeks). No patient factors or IHR operative parameters were associated with complete pain resolution on univariate analysis. Patients who reported no improvement in pain (14%, n = 6/42) were younger (33 vs 58 years, <em>P</em> = .03) and more likely to have a history of levator tenderness/spasm (50 vs 7%, <em>P</em> = .02).</div></div><div><h3>Conclusion</h3><div>mSCD results in palliation of CSCP in most patients with prior IHR. mSCD may be less likely to benefit younger patients and those with a history of levator tenderness/spasm. General surgeons should consider urologic referral for mSCD in this patient population.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"209 ","pages":"Pages 151-155"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-19DOI: 10.1016/j.urology.2026.01.008
Nishan Sohoni , Nimit S. Sohoni , Ryan A. Sutherland , Vinaik M. Sundaresan , Shayan Smani , Prasanna Ananth , John A. Onofrey , Sanjay Aneja , Marcin Miszczyk , Ho-Joon Lee , Julia E. Olivieri , Michael S. Leapman
Objective
To examine the performance of large language models (LLMs) for the analysis of adverse events (AEs) associated with a perirectal hydrogel spacer (SpaceOAR) prior to prostate radiation.
Methods
We queried the Food and Drug Administration’s (FDA’s) Manufacturer and User Facility Device Experience (MAUDE) database to extract reports related to “SpaceOAR”. Ninety-seven reports were initially manually abstracted to classify the problems associated with each event, subsequent modifications in radiation timing, and severity using the Common Terminology Criteria for Adverse Events (CTCAE) score. We compared the accuracy of 3 families of LLMs when compared to human abstraction. The highest-performing LLM was then used to classify AEs based on all available MAUDE data for spaceOAR (n = 1455) from January 2015 to December 2024.
Results
The ability of LLMs to correctly identify the AE outcomes was aggregated into an overall score. The highest-performing model was GPT-4o, with an overall score of 4.96 (σ = 0.00526) compared to the human reviewers who had an overall score of 4.99 (σ =.216). When run on all 1455 reports, GPT-4o revealed that the most common primary problems were malpositioned gel (58.7%), infection/inflammation/abscess (10.4%), fistula (7.1%), and rectal ulcer (4.7%). ICU level care and death were reported 0.1% and 0.3% of the time, respectively.
Conclusion
These findings highlight the potential for LLMs to automate the time-consuming process of tabulating device-related AEs. Reported serious AEs associated with spaceOAR underscore potential safety concerns, warranting dynamic ongoing surveillance and careful consideration when opting to implement hydrogel spacers.
{"title":"Automated Classification of Adverse Events After Hydrogel Perirectal Spacer Insertion for Prostate Cancer Using Large Language Models","authors":"Nishan Sohoni , Nimit S. Sohoni , Ryan A. Sutherland , Vinaik M. Sundaresan , Shayan Smani , Prasanna Ananth , John A. Onofrey , Sanjay Aneja , Marcin Miszczyk , Ho-Joon Lee , Julia E. Olivieri , Michael S. Leapman","doi":"10.1016/j.urology.2026.01.008","DOIUrl":"10.1016/j.urology.2026.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the performance of large language models (LLMs) for the analysis of adverse events (AEs) associated with a perirectal hydrogel spacer (SpaceOAR) prior to prostate radiation.</div></div><div><h3>Methods</h3><div>We queried the Food and Drug Administration’s (FDA’s) Manufacturer and User Facility Device Experience (MAUDE) database to extract reports related to “SpaceOAR”. Ninety-seven reports were initially manually abstracted to classify the problems associated with each event, subsequent modifications in radiation timing, and severity using the Common Terminology Criteria for Adverse Events (CTCAE) score. We compared the accuracy of 3 families of LLMs when compared to human abstraction. The highest-performing LLM was then used to classify AEs based on all available MAUDE data for spaceOAR (n = 1455) from January 2015 to December 2024.</div></div><div><h3>Results</h3><div>The ability of LLMs to correctly identify the AE outcomes was aggregated into an overall score. The highest-performing model was GPT-4o, with an overall score of 4.96 (σ = 0.00526) compared to the human reviewers who had an overall score of 4.99 (σ =.216). When run on all 1455 reports, GPT-4o revealed that the most common primary problems were malpositioned gel (58.7%), infection/inflammation/abscess (10.4%), fistula (7.1%), and rectal ulcer (4.7%). ICU level care and death were reported 0.1% and 0.3% of the time, respectively.</div></div><div><h3>Conclusion</h3><div>These findings highlight the potential for LLMs to automate the time-consuming process of tabulating device-related AEs. Reported serious AEs associated with spaceOAR underscore potential safety concerns, warranting dynamic ongoing surveillance and careful consideration when opting to implement hydrogel spacers.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"209 ","pages":"Pages 18-24"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-25DOI: 10.1016/j.urology.2026.02.030
Pedro Z Padovani, Lucas B Vergamini, Bristol B Whiles, Maxton Thoman, Wilson R Molina
{"title":"Editorial Comment on \"Silent Satisfaction and Improved Laser Ergonomics With Thulium Fiber Laser: A Prospective Randomized Controlled Trial Comparing SuperPulse Thulium Fiber Laser vs High-power Holmium:Yttrium-Aluminum-Garnet With Moses for flexible ureteroscopy\".","authors":"Pedro Z Padovani, Lucas B Vergamini, Bristol B Whiles, Maxton Thoman, Wilson R Molina","doi":"10.1016/j.urology.2026.02.030","DOIUrl":"10.1016/j.urology.2026.02.030","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-21DOI: 10.1016/j.urology.2026.02.029
Yee Jia Heng, Pooi Pooi Leong, Waye Hann Kang
{"title":"Stem Leydig Cell Transplantation: Advanced Innovation to Treat Testosterone Deficiency Within the Global Male Fertility Crisis.","authors":"Yee Jia Heng, Pooi Pooi Leong, Waye Hann Kang","doi":"10.1016/j.urology.2026.02.029","DOIUrl":"10.1016/j.urology.2026.02.029","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1016/j.urology.2026.02.027
Joshua Wang, Jersey-Kate Castillo, Matthew Buell, John Shin, Antoin Douglawi, Martin Hofmann, Brian Hu, Herbert Ruckle, Muhannad Alsyouf
Objective: To evaluate the mental health outcomes of patients with testicular cancer (TC) and identify the relative risk of mental health diagnoses following TC diagnosis compared to a control population without TC.
Materials and methods: The TriNetX Diamond network database was queried for men between 15 and 45 years undergoing radical orchiectomy for TC and compared to an age-matched control group of men who underwent an orchiectomy for testicular torsion. Patients with history of mental health disorders, with nodal/metastatic disease, and patients who underwent chemotherapy, radiotherapy, or RPLND were excluded. A 1:1 propensity score matching was performed to compare the prevalence of newly diagnosed anxiety disorders, sleep disorders, and depressive episodes anytime following orchiectomy.
Results: A total of 9264 males underwent an orchiectomy. After matching for age, race, and use of antidepressants/antipsychotics, 2178 men were included (1089 radical and 1089 simple orchiectomies). After propensity score matching, patients with TC had significantly higher rates of newly diagnosed depression (8.4% vs 3.1%; P <.01), anxiety (17.6% vs 7.1%; P <.01), and sleep disorders (9.0% vs 3.6%; P <.01) compared to patients undergoing simple orchiectomy. Patients diagnosed with TC had a 2.7-fold higher relative risk of developing depression, 2.5-fold higher risk of anxiety, and 2.5-fold higher risk of sleep disorders compared to the control population.
Conclusion: Receiving a TC diagnosis was associated with greater prevalence of newly diagnosed anxiety, sleep disorders, and depression. These findings indicate that the cancer diagnosis itself, rather than the orchiectomy, is likely a driver of mental health disorders in this young patient group.
目的：评价睾丸癌（TC）患者的心理健康结局，并与未患TC的对照组相比，确定TC诊断后心理健康诊断的相对风险。材料和方法：在TriNetX Diamond网络数据库中查询了15-45岁因TC接受根治性睾丸切除术的男性，并与年龄匹配的因睾丸扭转接受睾丸切除术的男性对照组进行了比较。排除有精神病史、淋巴结/转移性疾病以及接受化疗、放疗或RPLND的患者。采用1:1的倾向评分匹配来比较睾丸切除术后任何时间新诊断的焦虑症、睡眠障碍和抑郁发作的患病率。结果：共有9264名男性接受了睾丸切除术。在匹配了年龄、种族和抗抑郁药/抗精神病药的使用后，2178名男性被纳入研究（1089名根治性和1089名单纯性睾丸切除术）。在倾向评分匹配后，TC患者的新诊断抑郁率明显更高（8.4% vs 3.1%）。结论：接受TC诊断与新诊断的焦虑、睡眠障碍和抑郁的患病率更高相关。这些发现表明，癌症诊断本身，而不是睾丸切除术，可能是这一年轻患者群体精神健康障碍的驱动因素。
{"title":"Mental Health Burden of a Testicular Cancer Diagnosis: Insights From a Large Claims Database.","authors":"Joshua Wang, Jersey-Kate Castillo, Matthew Buell, John Shin, Antoin Douglawi, Martin Hofmann, Brian Hu, Herbert Ruckle, Muhannad Alsyouf","doi":"10.1016/j.urology.2026.02.027","DOIUrl":"10.1016/j.urology.2026.02.027","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the mental health outcomes of patients with testicular cancer (TC) and identify the relative risk of mental health diagnoses following TC diagnosis compared to a control population without TC.</p><p><strong>Materials and methods: </strong>The TriNetX Diamond network database was queried for men between 15 and 45 years undergoing radical orchiectomy for TC and compared to an age-matched control group of men who underwent an orchiectomy for testicular torsion. Patients with history of mental health disorders, with nodal/metastatic disease, and patients who underwent chemotherapy, radiotherapy, or RPLND were excluded. A 1:1 propensity score matching was performed to compare the prevalence of newly diagnosed anxiety disorders, sleep disorders, and depressive episodes anytime following orchiectomy.</p><p><strong>Results: </strong>A total of 9264 males underwent an orchiectomy. After matching for age, race, and use of antidepressants/antipsychotics, 2178 men were included (1089 radical and 1089 simple orchiectomies). After propensity score matching, patients with TC had significantly higher rates of newly diagnosed depression (8.4% vs 3.1%; P <.01), anxiety (17.6% vs 7.1%; P <.01), and sleep disorders (9.0% vs 3.6%; P <.01) compared to patients undergoing simple orchiectomy. Patients diagnosed with TC had a 2.7-fold higher relative risk of developing depression, 2.5-fold higher risk of anxiety, and 2.5-fold higher risk of sleep disorders compared to the control population.</p><p><strong>Conclusion: </strong>Receiving a TC diagnosis was associated with greater prevalence of newly diagnosed anxiety, sleep disorders, and depression. These findings indicate that the cancer diagnosis itself, rather than the orchiectomy, is likely a driver of mental health disorders in this young patient group.</p>","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1016/j.urology.2026.02.022
Brett Friedman, Kevin J Campbell
{"title":"Editorial Comment on \"In Vitro Fertilization Utilization Rates and Outcomes in States With and Without Insurance Coverage Mandates for Male Infertility Care\".","authors":"Brett Friedman, Kevin J Campbell","doi":"10.1016/j.urology.2026.02.022","DOIUrl":"10.1016/j.urology.2026.02.022","url":null,"abstract":"","PeriodicalId":23415,"journal":{"name":"Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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