Urology最新文献

英文中文

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.08.056

Tiago Aparecido Silva, Luciana Saboya Dal Col, Pedro Rodrigues Beal, Diego Pucharelli Resuto, Vitor Bonadia Buonfiglio

引用次数: 0

Natural History of Artificial Urinary Sphincter Erosion: Long-term Lower Urinary Tract Outcomes and Incontinence Management 人工尿道括约肌侵蚀的自然史：人工尿道括约肌侵蚀的自然史：下尿路的长期疗效和尿失禁处理。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.06.054

Bridget L. Findlay, Anthony Fadel, Sierra T. Pence, Cameron J. Britton, Brian J. Linder, Daniel S. Elliott

Objective

To describe long-term lower urinary tract outcomes and incontinence management after AUS erosion, including risk factors associated with each outcome.

Methods

We retrospectively reviewed our prospectively maintained AUS database for men undergoing device explantation for urethral erosion from January 1, 1986 to October 10, 2023. Outcomes included development of urethral stricture and management of post-explant incontinence (eg, pads/clamp, catheter, salvage AUS, supravesical diversion). Risk factors were tested for association with stricture formation and repeat AUS erosion using logistic regression.

Results

Around 1943 unique patients underwent AUS implantation during the study period, and 217 (11%) had a device explantation for urethral erosion. Of these, 194 had complete records available and were included for analysis. Median follow-up from implantation was 7.5 years (IQR 2.7-13.7) and median time to erosion was 2 yrs (IQR 0-6). Ninety-six patients (49%) underwent salvage AUS placement. Of those, 38/96 (40%) were explanted for subsequent erosion. On multivariable analysis, no factors were significantly associated with risk of salvage AUS erosion. On multivariable model, pelvic radiation (OR 2.7; 95% CI 1.0-7.4) and urethral reapproximation during explant for erosion (OR 4.2; 95% CI 1.5-11.2) were significantly associated with increased risk of urethral stricture (P <.05). At the time of last follow-up, 69/194 (36%) patients had a functioning salvage AUS, including both initial and subsequent salvage implants.

Conclusion

Following AUS erosion, radiation history and urethral reapproximation at explantation were risk factors for development of urethral stricture. Salvage AUS replacement can be performed, but has a higher rate of repeat urethral erosion.

目的描述 AUS 侵蚀后的长期下尿路结果和尿失禁处理情况，包括与每种结果相关的风险因素：我们对前瞻性维护的 AUS 数据库进行了回顾性分析，该数据库收录了自 1986 年 1 月 1 日至 2023 年 10 月 31 日期间因尿道侵蚀而接受器械剥离术的男性患者。结果包括尿道狭窄的发生和器械剥离后尿失禁的处理（如尿垫/夹钳、导尿管、抢救性 AUS、膀胱上分流）。使用逻辑回归法检测了风险因素与狭窄形成和重复 AUS 侵蚀的相关性：在研究期间，共有 1943 名患者接受了 AUS 植入手术，其中 217 人（11%）因尿道侵蚀而进行了装置拆卸。其中 194 人有完整的病历资料，并纳入分析。植入后的中位随访时间为 7.5 年（IQR 2.7-13.7），发生侵蚀的中位时间为 2 年（IQR 0-6）。96名患者（49%）接受了修复性AUS置入术。其中，38/96（40%）的患者因后续侵蚀而被切除。在多变量分析中，没有任何因素与 AUS 再次侵蚀的风险显著相关。在多变量模型中，盆腔辐射（OR 2.7；95% CI 1.0-7.4）和因侵蚀而切除尿道时的尿道再切除（OR 4.2；95% CI 1.5-11.2）与尿道狭窄风险的增加有显著相关性（P结论：AUS被侵蚀后，辐射史和切开时尿道再逼近是发生尿道狭窄的风险因素。可以进行抢救性AUS置换，但尿道再次侵蚀的发生率较高。

{"title":"Natural History of Artificial Urinary Sphincter Erosion: Long-term Lower Urinary Tract Outcomes and Incontinence Management","authors":"Bridget L. Findlay, Anthony Fadel, Sierra T. Pence, Cameron J. Britton, Brian J. Linder, Daniel S. Elliott","doi":"10.1016/j.urology.2024.06.054","DOIUrl":"10.1016/j.urology.2024.06.054","url":null,"abstract":"<div><h3>Objective</h3><div>To describe long-term lower urinary tract<span> outcomes and incontinence management after AUS erosion, including risk factors associated with each outcome.</span></div></div><div><h3>Methods</h3><div><span>We retrospectively reviewed our prospectively maintained AUS database for men undergoing device explantation for urethral erosion from January 1, 1986 to October 10, 2023. Outcomes included development of urethral stricture and management of post-explant incontinence (eg, pads/clamp, catheter, salvage AUS, supravesical diversion). Risk factors were tested for association with stricture formation and repeat AUS erosion using </span>logistic regression.</div></div><div><h3>Results</h3><div>Around 1943 unique patients underwent AUS implantation during the study period, and 217 (11%) had a device explantation for urethral erosion. Of these, 194 had complete records available and were included for analysis. Median follow-up from implantation was 7.5 years (IQR 2.7-13.7) and median time to erosion was 2 yrs (IQR 0-6). Ninety-six patients (49%) underwent salvage AUS placement. Of those, 38/96 (40%) were explanted for subsequent erosion. On multivariable analysis, no factors were significantly associated with risk of salvage AUS erosion. On multivariable model, pelvic radiation (OR 2.7; 95% CI 1.0-7.4) and urethral reapproximation during explant for erosion (OR 4.2; 95% CI 1.5-11.2) were significantly associated with increased risk of urethral stricture (<em>P</em> <.05). At the time of last follow-up, 69/194 (36%) patients had a functioning salvage AUS, including both initial and subsequent salvage implants.</div></div><div><h3>Conclusion</h3><div>Following AUS erosion, radiation history and urethral reapproximation at explantation were risk factors for development of urethral stricture. Salvage AUS replacement can be performed, but has a higher rate of repeat urethral erosion.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 204-210"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery of Social Continence and Sexual Function in Men With High-risk Prostate Cancer After Radical Prostatectomy: Results From a Statewide Collaborative 根治性前列腺切除术后高危前列腺癌男性的社交能力和性功能恢复情况：全州合作研究的结果。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.06.018

Daniel Triner , Kyle Johnson , Sabir Meah , Stephanie Daignault-Newton , Neil Vaishampayan , Apoorv Dhir , Corinne Labardee , Stephanie Ferrante , Kevin B. Ginsburg , Brian R. Lane , Arvin K. George , Alice Semerjian , Michigan Urological Surgery Improvement Collaborative

Objectives

To examine post-operative urinary and sexual functional outcomes for men with high-risk prostate cancer (HRPCa) who underwent radical prostatectomy (RP) within the Michigan Urological Surgery Improvement Collaborative (MUSIC).

Methods

We identified patients who underwent RP for HRPCa in MUSIC between 2014 and 2023. HRPCa was defined according to American Urological Association criteria. Patients completed Expanded Prostate Cancer Index Composite (EPIC-26) pre-RP and 3-, 6-, 12-, and 24-months postoperatively. Primary outcomes included social continence, defined as 0-1 pads used daily; and recovery of sexual function, defined as the ability to achieve erections firm enough for intercourse. Multivariable and bivariate analyses were performed to identify factors associated with recovery of social continence and sexual function.

Results

Around 1323 patients were included in the post-RP urinary continence analysis and 422 men in the sexual function analysis. Fifty-eight percent and 86% of patients achieved social continence at 3- and 12-months post-RP, respectively. Continence recovery was associated with higher baseline EPIC-26 urinary continence scores (OR 1.10, per 5 points, 95% CI 1.06-1.15, P <.001), and negatively associated with increasing age (OR 0.78 per 5-year increase, 95% CI 0.71-0.85 P <.001). Fifteen percent of patients had recovery of sexual function at 12-month post-RP. On bivariate analysis, recovery of sexual function was associated with nerve-sparing at time of RP, lower pre-operative PSA, and not receiving post-RP ADT/RT.

Conclusion

RP for HRPCa has acceptable rates of postoperative social continence. However, post-RP recovery of sexual function remains a challenge. This information has important implications for pre-operative counseling and post-operative follow-up for patients with HRPCa.

目的研究密歇根州泌尿外科手术改进合作组织（MUSIC）中接受根治性前列腺切除术（RP）的高危前列腺癌（HRPCa）男性患者的术后排尿和性功能结果：我们确定了 2014-2023 年间在 MUSIC 接受前列腺癌根治术的患者。HRPCa根据美国泌尿外科协会标准定义。患者在RP术前和术后3个月、6个月、12个月和24个月完成了前列腺癌指数扩展综合指数（EPIC-26）。主要结果包括：社交障碍，定义为每天使用 0-1 片尿布；性功能恢复，定义为勃起硬度足以进行性交。研究人员进行了多变量和双变量分析，以确定与社交失禁和性功能恢复相关的因素：1323名患者参与了RP术后尿失禁分析，422名男性参与了性功能分析。在手术后 3 个月和 12 个月，分别有 58% 和 86% 的患者实现了社交性尿失禁。尿失禁恢复与较高的基线EPIC-26尿失禁评分有关（OR 1.10，每5分，95% CI 1.06-1.15，p结论：RP治疗HRPCa的术后排尿通畅率是可以接受的。然而，RP术后性功能的恢复仍是一个挑战。这些信息对 HRPCa 患者的术前咨询和术后随访具有重要意义。

{"title":"Recovery of Social Continence and Sexual Function in Men With High-risk Prostate Cancer After Radical Prostatectomy: Results From a Statewide Collaborative","authors":"Daniel Triner , Kyle Johnson , Sabir Meah , Stephanie Daignault-Newton , Neil Vaishampayan , Apoorv Dhir , Corinne Labardee , Stephanie Ferrante , Kevin B. Ginsburg , Brian R. Lane , Arvin K. George , Alice Semerjian , Michigan Urological Surgery Improvement Collaborative","doi":"10.1016/j.urology.2024.06.018","DOIUrl":"10.1016/j.urology.2024.06.018","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine post-operative urinary<span><span> and sexual functional outcomes for men with high-risk prostate cancer<span> (HRPCa) who underwent radical prostatectomy (RP) within the Michigan </span></span>Urological Surgery Improvement Collaborative (MUSIC).</span></div></div><div><h3>Methods</h3><div>We identified patients who underwent RP for HRPCa in MUSIC between 2014 and 2023. HRPCa was defined according to American Urological Association criteria. Patients completed Expanded Prostate Cancer Index Composite (EPIC-26) pre-RP and 3-, 6-, 12-, and 24-months postoperatively. Primary outcomes included social continence<span>, defined as 0-1 pads used daily; and recovery of sexual function, defined as the ability to achieve erections firm enough for intercourse. Multivariable and bivariate analyses were performed to identify factors associated with recovery of social continence and sexual function.</span></div></div><div><h3>Results</h3><div>Around 1323 patients were included in the post-RP urinary continence analysis and 422 men in the sexual function analysis. Fifty-eight percent and 86% of patients achieved social continence at 3- and 12-months post-RP, respectively. Continence recovery was associated with higher baseline EPIC-26 urinary continence scores (OR 1.10, per 5 points, 95% CI 1.06-1.15, <em>P</em> <.001), and negatively associated with increasing age (OR 0.78 per 5-year increase, 95% CI 0.71-0.85 <em>P</em><span> <.001). Fifteen percent of patients had recovery of sexual function at 12-month post-RP. On bivariate analysis, recovery of sexual function was associated with nerve-sparing at time of RP, lower pre-operative PSA, and not receiving post-RP ADT/RT.</span></div></div><div><h3>Conclusion</h3><div>RP for HRPCa has acceptable rates of postoperative social continence. However, post-RP recovery of sexual function remains a challenge. This information has important implications for pre-operative counseling and post-operative follow-up for patients with HRPCa.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 125-132"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bladder Embryonal Rhabdomyosarcoma Presenting in the Perinatal Period: Report of Two Consecutive Cases 围产期出现的膀胱胚胎性横纹肌肉瘤：两个连续病例的报告。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.06.070

Catalina Sánchez B. , Mandy Rickard , Avram Denburg , Adree Khondker , Furqan Shaikh , Rodrigo Romao , Michael E. Chua , Joana Dos Santos , Armando J. Lorenzo

Bladder embryonal rhabdomyosarcomas (ERMS) are malignant soft tissue tumors that rarely present in the perinatal period. Herein, we report 2 cases that were diagnosed in the newborn period (one with concomitant posterior urethral valves [PUV]), managed with chemotherapy and surgical resection to minimize the need for radiation.

膀胱胚胎性横纹肌肉瘤（ERMS）是一种恶性软组织肿瘤，很少出现在围产期。在此，我们报告了两例在新生儿期确诊的膀胱胚胎性横纹肌肉瘤（其中一例同时伴有后尿道瓣膜 [PUV]），通过化疗和手术切除治疗，最大限度地减少了放射治疗的需要。

引用次数: 0

Predictors of Contralateral Disease in Men With Unilateral Lesions on Multiparametric Magnetic Resonance Imaging 多参数磁共振成像中单侧病变男性对侧疾病的预测因素。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.07.009

Vyom Sawhney, Richard Huang, William C. Huang, Herbert Lepor, Samir S. Taneja, James Wysock

Objective

To evaluate predictors of contralateral clinically significant prostate cancer (csPCa) in men with biopsy-proven unilateral lesions on magnetic resonance imaging (MRI).

Methods

We retrospectively identified men with no prior diagnosis of PCa with unilateral biopsy-confirmed csPCa within PI-RADS 2-5 lesions within our institutional biopsy database. Multivariate logistic regression was used to identify clinical predictors of contralateral disease.

Results

Four hundred ninety men met study inclusion criteria, of which 385 men (78.6%) had no contralateral csPCa and 105 men (21.4%) had contralateral csPCa (Fig. 1).

Prior negative biopsy (OR 0.34 [0.14, 0.75], P = .012), prostate-specific antigen density (OR 18.8 [2.77, 249], P = .017), and tumor location in the transverse plane (“Posterior”: OR 1.93 [1.02, 3.87], P = .048; “Throughout Transverse Plane”: OR 6.56 [2.26, 19.6], P < .001) were significantly associated with contralateral csPCa in multivariate logistic regression models. However, there appear to be no attributes within the MRI-targeted tumor that reliably predict contralateral csPCa (Table 2).

Conclusion

Approximately 20% of men with unilateral MRI findings and csPCa on targeted biopsy were found to have contralateral csPCa on systematic biopsy (SB). Prior negative biopsy was associated with a decreased odds of contralateral csPCa. Prostate-specific antigen density and tumor in the posterior aspect of or throughout the transverse plane were associated with increased odds of contralateral csPCA. Consideration of these clinical factors may afford an opportunity to only use SB in cases in which the odds of contralateral csPCa are high.

目的评估磁共振成像（MRI）中活检证实有单侧病变的男性患对侧有临床意义的前列腺癌（csPCa）的预测因素：我们在本机构的活检数据库中回顾性地识别了既往未确诊 PCa 且单侧活检证实为 csPCa PI-RADS 2-5 病变的男性。采用多变量逻辑回归确定对侧疾病的临床预测因素：共有 490 名男性符合研究纳入标准，其中 385 名男性（78.6%）无对侧 csPCa，105 名男性（21.4%）有对侧 csPCa。(图 1）。既往活检阴性（OR 0.34 [0.14，0.75]，p = 0.012）、PSA 密度（OR 18.8 [2.77，249]，p = 0.017）和肿瘤位置在横向平面（"后方"，OR 1.93 [1.02]）：OR：1.93 [1.02，3.87]，p =0.048；"整个横向平面"：OR：6.56 [2.26，19.6]，P 结论：在单侧 MRI 结果和靶向活检发现 csPCa 的男性中，约有 20% 发现对侧有 csPCa。之前的阴性活组织检查与对侧 csPCa 的几率降低有关。PSA密度和肿瘤位于横切面后方或整个横切面与对侧csPCA几率增加有关。考虑到这些临床因素，只有在对侧 csPCa 发生几率较高的病例中才有机会使用 SB。

{"title":"Predictors of Contralateral Disease in Men With Unilateral Lesions on Multiparametric Magnetic Resonance Imaging","authors":"Vyom Sawhney, Richard Huang, William C. Huang, Herbert Lepor, Samir S. Taneja, James Wysock","doi":"10.1016/j.urology.2024.07.009","DOIUrl":"10.1016/j.urology.2024.07.009","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate predictors of contralateral clinically significant prostate cancer (csPCa) in men with biopsy-proven unilateral lesions on magnetic resonance imaging (MRI).</div></div><div><h3>Methods</h3><div>We retrospectively identified men with no prior diagnosis of PCa with unilateral biopsy-confirmed csPCa within PI-RADS 2-5 lesions within our institutional biopsy database. Multivariate logistic regression was used to identify clinical predictors of contralateral disease.</div></div><div><h3>Results</h3><div>Four hundred ninety men met study inclusion criteria, of which 385 men (78.6%) had no contralateral csPCa and 105 men (21.4%) had contralateral csPCa (Fig. 1).</div><div>Prior negative biopsy (OR 0.34 [0.14, 0.75], <em>P</em> = .012), prostate-specific antigen density (OR 18.8 [2.77, 249], <em>P</em> = .017), and tumor location in the transverse plane (“Posterior”: OR 1.93 [1.02, 3.87], <em>P</em> = .048; “Throughout Transverse Plane”: OR 6.56 [2.26, 19.6], <em>P</em> < .001) were significantly associated with contralateral csPCa in multivariate logistic regression models. However, there appear to be no attributes within the MRI-targeted tumor that reliably predict contralateral csPCa (Table 2).</div></div><div><h3>Conclusion</h3><div>Approximately 20% of men with unilateral MRI findings and csPCa on targeted biopsy were found to have contralateral csPCa on systematic biopsy (SB). Prior negative biopsy was associated with a decreased odds of contralateral csPCa. Prostate-specific antigen density and tumor in the posterior aspect of or throughout the transverse plane were associated with increased odds of contralateral csPCA. Consideration of these clinical factors may afford an opportunity to only use SB in cases in which the odds of contralateral csPCa are high.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 147-152"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial Antimicrobial Testing of a Novel Reusable Intermittent Urinary Catheter System and Catheter Reprocessing Device 新型可重复使用间歇性导尿管系统和导尿管再处理装置的初步抗菌测试。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.07.015

Alyssa A. La Bella , Alex Molesan , Daniel A. Wollin , Souvik Paul , Ana L. Flores-Mireles

Objective

To evaluate the efficacy of the Aurie System, a preclinical prototype allowing for standardized intermittent catheter (IC) reuse of novel reusable no-touch ICs. Individuals with neurogenic bladder often require single-use ICs to urinate, but urinary tract infection (UTI) is a common cause of morbidity for IC users. Safer no-touch catheters are not easily affordable, and the Aurie System attempts to provide no-touch catheters at a fraction of the price by allowing for standardized and safe IC reuse.

Methods

Standard ICs were inoculated with Escherichia coli and Pseudomonas aeruginosa and incubated for 48 hours to assess microbial burden and biofilm formation (the latter using infrared fluorescence imaging). This procedure was repeated with Aurie ICs, focusing on evaluating catheter microbial burden after inoculation and reprocessing with the prototype washer-disinfector. This was repeated with up to 100 cycles to evaluate repetitive use.

Results

Standard ICs showed bacterial attachment and biofilm development peaking at 24 hours of incubation. The Aurie catheters produced a similar outcome but, after reprocessing, microbial burden was reduced below the level of detection. Repeat cycles showed pathogen clearance to similar levels. One catheter reached 100 cycles and there was no viable pathogen load after reprocessing.

Conclusion

Intermittent urinary catheters, when cleaned inappropriately, can harbor viable bacteria and biofilm. The Aurie System, when used to disinfect novel reusable ICs within a prototype reprocessing device, can reduce microbial burden below level of detection even after 100 cycles. This suggests the Aurie System may be a feasible technology for safe IC reuse.

目的：评估 Aurie 系统的功效：评估 Aurie 系统的疗效，该系统是一种临床前原型，可实现新型可重复使用免接触间歇导尿管 (IC) 的标准化重复使用。神经源性膀胱患者通常需要一次性使用的间歇性导尿管来排尿，但尿路感染（UTI）是间歇性导尿管使用者常见的发病原因。更安全的免接触导尿管并不容易买得起，Aurie 系统试图通过标准化和安全的 IC 重复使用，以极低的价格提供免接触导尿管：方法：在标准 IC 上接种大肠杆菌和铜绿假单胞菌，培养 48 小时，以评估微生物负荷和生物膜的形成（后者使用红外荧光成像）。对 Aurie IC 重复这一过程，重点评估接种后的导管微生物负荷以及原型清洗消毒器的再处理情况。这一过程最多重复 100 次，以评估重复使用情况：结果：标准 IC 显示，细菌附着和生物膜的形成在培养 24 小时后达到高峰。Aurie 导管也产生了类似的结果，但在重新处理后，微生物负荷降低到了检测水平以下。重复周期显示病原体清除率达到类似水平。一根导尿管使用了 100 个周期，重新处理后没有存活的病原体：结论：间歇性导尿管清洗不当会滋生细菌和生物膜。使用 Aurie 系统对原型后处理设备中的新型可重复使用集成电路进行消毒时，即使在 100 次循环后也能将微生物负荷降至检测水平以下。这表明 Aurie 系统可能是安全重复使用集成电路的可行技术。

{"title":"Initial Antimicrobial Testing of a Novel Reusable Intermittent Urinary Catheter System and Catheter Reprocessing Device","authors":"Alyssa A. La Bella , Alex Molesan , Daniel A. Wollin , Souvik Paul , Ana L. Flores-Mireles","doi":"10.1016/j.urology.2024.07.015","DOIUrl":"10.1016/j.urology.2024.07.015","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of the Aurie System, a preclinical prototype allowing for standardized intermittent catheter (IC) reuse of novel reusable no-touch ICs. Individuals with neurogenic bladder often require single-use ICs to urinate, but urinary tract infection (UTI) is a common cause of morbidity for IC users. Safer no-touch catheters are not easily affordable, and the Aurie System attempts to provide no-touch catheters at a fraction of the price by allowing for standardized and safe IC reuse.</div></div><div><h3>Methods</h3><div>Standard ICs were inoculated with <em>Escherichia coli</em> and <em>Pseudomonas aeruginosa</em> and incubated for 48 hours to assess microbial burden and biofilm formation (the latter using infrared fluorescence imaging). This procedure was repeated with Aurie ICs, focusing on evaluating catheter microbial burden after inoculation and reprocessing with the prototype washer-disinfector. This was repeated with up to 100 cycles to evaluate repetitive use.</div></div><div><h3>Results</h3><div>Standard ICs showed bacterial attachment and biofilm development peaking at 24 hours of incubation. The Aurie catheters produced a similar outcome but, after reprocessing, microbial burden was reduced below the level of detection. Repeat cycles showed pathogen clearance to similar levels. One catheter reached 100 cycles and there was no viable pathogen load after reprocessing.</div></div><div><h3>Conclusion</h3><div>Intermittent urinary catheters, when cleaned inappropriately, can harbor viable bacteria and biofilm. The Aurie System, when used to disinfect novel reusable ICs within a prototype reprocessing device, can reduce microbial burden below level of detection even after 100 cycles. This suggests the Aurie System may be a feasible technology for safe IC reuse.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"193 ","pages":"Pages 8-15"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Editorial Comment on “A Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial” 对 "单次注射富血小板血浆以治疗女性压力性尿失禁：随机安慰剂对照试验"。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.07.030

Leah Ashton , Hannah Nakatsuka , Colin M. Johnson , Kimberly Kenne , Karl J. Kreder , Ryan Kruse , Linder Wendt , Elizabeth B. Takacs , Annah J. Vollstedt

引用次数: 0

Editorial Comment on “The Current Application and Future Potential of Artificial Intelligence in Renal Cancer” 关于 "人工智能在肾癌中的应用现状及未来潜力 "的编辑评论。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.08.021

Betty Wang, Nicholas Heller, Christopher J. Weight

引用次数: 0

Fluoroscopic and CT Cystography Following Robotic Suprapubic Prostatectomy 机器人耻骨上前列腺切除术后的透视和 CT 膀胱造影。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.08.039

Jordan Kassab , Megan Ngai , Parth Joshi , Eric J. Moskowitz

引用次数: 0

Letter to the Editor on “Long-term Outcomes of Augmentation Cystoplasty in Genitourinary Tuberculosis in Adults: A 12-Year Follow-up Experience at a Tertiary Care Center” 对 "成人泌尿生殖系统结核膀胱成形术的长期疗效：一家三级医疗中心的 12 年随访经验 "发表评论。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology

Pub Date : 2024-11-01 DOI: 10.1016/j.urology.2024.08.044

Giovanni Drocchi , Guglielmo Mantica , Carlo Terrone , André Van der Merwe

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Urology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀