Pub Date : 2021-06-01DOI: 10.1177/03008916211012333
S. Abdelhamid, H. El-mesallamy, Hm AbdelAziz, A. Zekri
Introduction: Clinical findings regarding the impact of BRCA1/2 mutational status on the prognosis of breast cancer patients are still controversial. We aimed to investigate the prognostic relevance of BRCA1/2 mutations on recurrence and long-term survival, for the first time, in Egyptian female breast cancer patients. Patients and Methods: The study cohort comprised 103 Egyptian female breast cancer patients previously tested for BRCA1/2 mutations using HRM analysis and direct sequencing. Clinicopathological and long-term clinical follow-up data including date and site of disease progression, were retrieved from medical records until death or loss to follow-up. Outcome measures including overall survival (OS), disease-free survival (DFS), recurrence-free survival, and metastasis-free survival (MFS) were compared in all BRCA1/2 mutation carriers versus non-carriers at 2, 5, 10, and 15 years after diagnosis. Results: The profile of the detected variants was previously reported. The American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) guidelines were used to re-classify the variants. The median follow-up time was 6.9 years (range, 4.2-24.4 years). BRCA carriers had significantly worse DFS than non-carriers, at 2 years 86.7% vs 88.2%; at 5 years 38.1% vs 57.8%; and at 10 years 21.6% vs 34.1% (P=0.024). Negative estrogen receptor (ER) status (HR=2.44, 95%CI=1.33-4.47) and large tumor size (HR=2.19, HR=1.21-3.98) were also significant factors for worse DFS. Recurrence-free survival was significantly worse in BRCA carriers compared to non-carriers, at 5 years: 95.2%vs 98.2%; at 10 years: 54.4% vs 79.8%; and at 15 years 34.6% vs 61.7% (P=0.005). BRCA carriers showed poorer OS and MFS, though not statistically significant [OS in BRCA carriers and non-carriers at 5 years: 81.6% vs 89.3%; at 10 years: 59.2% vs 60.6%; and at 15 years: 36.3 vs 59.2% (P=0.42); and MFS at 2 years 86.7% vs 88.1%; at 5 years 44.5% vs 61.1% ; and at 10 years: 25.3% vs 38.2% (P=0.41)]. Conclusion: To our knowledge, this is the first study in the Middle East to investigate long-term survival outcome of BRCA1/2 related breast cancer. We, herein, underline the necessity of implementing BRCA screening strategies and intensive surveillance in the mainstream oncology practice in Egypt.
简介:BRCA1/2突变状态对乳腺癌患者预后影响的临床研究结果仍存在争议。我们的目的是首次在埃及女性乳腺癌患者中研究BRCA1/2突变与复发和长期生存的预后相关性。患者和方法:该研究队列包括103名埃及女性乳腺癌患者，此前使用HRM分析和直接测序进行了BRCA1/2突变检测。临床病理和长期临床随访数据，包括疾病进展的日期和部位，从医疗记录中检索，直到死亡或失去随访。在诊断后2年、5年、10年和15年，比较所有BRCA1/2突变携带者与非携带者的预后指标，包括总生存期(OS)、无病生存期(DFS)、无复发生存期和无转移生存期(MFS)。结果:检测到的变异的概况以前报道过。使用美国医学遗传学和基因组学学院和分子病理学协会(ACMG/AMP)指南对变异进行重新分类。中位随访时间为6.9年(4.2-24.4年)。BRCA携带者的DFS明显差于非携带者，2年86.7% vs 88.2%;5年38.1% vs 57.8%;10年21.6% vs 34.1% (P=0.024)。雌激素受体(ER)阴性(HR=2.44, 95%CI=1.33-4.47)和肿瘤大小较大(HR=2.19, HR=1.21-3.98)也是导致DFS恶化的重要因素。BRCA携带者的无复发生存率显著低于非携带者，为5年:95.2%vs 98.2%;10年:54.4% vs 79.8%;15岁时34.6% vs 61.7% (P=0.005)。BRCA携带者的OS和MFS较差，但没有统计学意义[5年BRCA携带者和非携带者的OS: 81.6% vs 89.3%;10年:59.2% vs 60.6%;15岁时:36.3% vs 59.2% (P=0.42);MFS为2年86.7% vs 88.1%;5年44.5% vs 61.1%;10年:25.3% vs 38.2% (P=0.41)]。结论:据我们所知，这是中东地区第一个研究BRCA1/2相关乳腺癌长期生存结局的研究。在此，我们强调在埃及主流肿瘤学实践中实施BRCA筛查策略和强化监测的必要性。
{"title":"BRCA1/2 Mutations and Long-Term Clinical Outcomes in Egyptian Breast Cancer Patients","authors":"S. Abdelhamid, H. El-mesallamy, Hm AbdelAziz, A. Zekri","doi":"10.1177/03008916211012333","DOIUrl":"https://doi.org/10.1177/03008916211012333","url":null,"abstract":"Introduction: Clinical findings regarding the impact of BRCA1/2 mutational status on the prognosis of breast cancer patients are still controversial. We aimed to investigate the prognostic relevance of BRCA1/2 mutations on recurrence and long-term survival, for the first time, in Egyptian female breast cancer patients. Patients and Methods: The study cohort comprised 103 Egyptian female breast cancer patients previously tested for BRCA1/2 mutations using HRM analysis and direct sequencing. Clinicopathological and long-term clinical follow-up data including date and site of disease progression, were retrieved from medical records until death or loss to follow-up. Outcome measures including overall survival (OS), disease-free survival (DFS), recurrence-free survival, and metastasis-free survival (MFS) were compared in all BRCA1/2 mutation carriers versus non-carriers at 2, 5, 10, and 15 years after diagnosis. Results: The profile of the detected variants was previously reported. The American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) guidelines were used to re-classify the variants. The median follow-up time was 6.9 years (range, 4.2-24.4 years). BRCA carriers had significantly worse DFS than non-carriers, at 2 years 86.7% vs 88.2%; at 5 years 38.1% vs 57.8%; and at 10 years 21.6% vs 34.1% (P=0.024). Negative estrogen receptor (ER) status (HR=2.44, 95%CI=1.33-4.47) and large tumor size (HR=2.19, HR=1.21-3.98) were also significant factors for worse DFS. Recurrence-free survival was significantly worse in BRCA carriers compared to non-carriers, at 5 years: 95.2%vs 98.2%; at 10 years: 54.4% vs 79.8%; and at 15 years 34.6% vs 61.7% (P=0.005). BRCA carriers showed poorer OS and MFS, though not statistically significant [OS in BRCA carriers and non-carriers at 5 years: 81.6% vs 89.3%; at 10 years: 59.2% vs 60.6%; and at 15 years: 36.3 vs 59.2% (P=0.42); and MFS at 2 years 86.7% vs 88.1%; at 5 years 44.5% vs 61.1% ; and at 10 years: 25.3% vs 38.2% (P=0.41)]. Conclusion: To our knowledge, this is the first study in the Middle East to investigate long-term survival outcome of BRCA1/2 related breast cancer. We, herein, underline the necessity of implementing BRCA screening strategies and intensive surveillance in the mainstream oncology practice in Egypt.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"51 1","pages":"4 - 4"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84859619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.1177/03008916211016800
I. Ramadan, Shaaban El-Assal, M. Farouk, Sherif El-zawawy, Hany el-Deeb
Background: Whole brain radiotherapy is the treatment of choice for patients with brain metastases. However, neurocognitive functions decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT might provide meaningful neurocognitive functions preservation. Our study aims to demonstrate the impact of delivering HA‑WBRT on NCF changes in patients receiving WBRT. Methods: fifty patients who were referred for cranial irradiation were enrolled in the study. Before the HA‑WBRT course and randomly assigned to two equal groups, the first group will receive conventional whole brain palliative radiotherapy and the second group will receive hippocampal sparing whole brain radiotherapy, assigned to 30 Gy over 10 fractions over two weeks, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed,the primary endpoint was delayed recall, as determined by the change/decline in Hopkins Verbal Learning Test (HVLT-R) and The One Card Learning Test (OCLT) from the baseline assessment to 4 months after the start of HA‑WBRT. Results: Regarding neurocognitive outcomes, no statistically significant differences were found between various NCF scores obtained at baseline and at post‑radiotherapy intervals, in immediate verbal memory and non‑verbal memory, except for delayed recall memory on HVLT-R Hopkins Verbal Learning Test -Revised for delayed recall Learning, p =0.008. Conclusions: Functional preservation by hippocampal sparing during WBRT could largely be achieved in this study, which also suggests that HA‑WBRT should be a feasible technique preserving neurocognitive functions while maintaining intracranial control.
{"title":"Comparative Study Evaluating Cognitive Functions in Patients Receiving Conventional Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy","authors":"I. Ramadan, Shaaban El-Assal, M. Farouk, Sherif El-zawawy, Hany el-Deeb","doi":"10.1177/03008916211016800","DOIUrl":"https://doi.org/10.1177/03008916211016800","url":null,"abstract":"Background: Whole brain radiotherapy is the treatment of choice for patients with brain metastases. However, neurocognitive functions decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT might provide meaningful neurocognitive functions preservation. Our study aims to demonstrate the impact of delivering HA‑WBRT on NCF changes in patients receiving WBRT. Methods: fifty patients who were referred for cranial irradiation were enrolled in the study. Before the HA‑WBRT course and randomly assigned to two equal groups, the first group will receive conventional whole brain palliative radiotherapy and the second group will receive hippocampal sparing whole brain radiotherapy, assigned to 30 Gy over 10 fractions over two weeks, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed,the primary endpoint was delayed recall, as determined by the change/decline in Hopkins Verbal Learning Test (HVLT-R) and The One Card Learning Test (OCLT) from the baseline assessment to 4 months after the start of HA‑WBRT. Results: Regarding neurocognitive outcomes, no statistically significant differences were found between various NCF scores obtained at baseline and at post‑radiotherapy intervals, in immediate verbal memory and non‑verbal memory, except for delayed recall memory on HVLT-R Hopkins Verbal Learning Test -Revised for delayed recall Learning, p =0.008. Conclusions: Functional preservation by hippocampal sparing during WBRT could largely be achieved in this study, which also suggests that HA‑WBRT should be a feasible technique preserving neurocognitive functions while maintaining intracranial control.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"15 1","pages":"16 - 16"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82223323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.1177/03008916211012341
D. Aissaoui, M. Bohli, R. Ben amor, J. Yahyaoui, A. Hamdoun, R. Moujahed, L. Kochbati
Introduction: Inflammatory Breast Cancer (IBC) is a rare and very aggressive breast cancer with poor prognosis. The prevalence is different from a country to another. In Tunisia, it is about 5 to 7% of breast cancer. The aim of this study is to describe the epidemiological and histopathological features of patients with inflammatory breast cancer and to evaluate the treatment response according to the molecular subtypes. Methods: This retrospective review identified 31 patients with no metastatic IBC treated in our radiotherapy department between December 2019 and November 2020. IBC was confirmed using the clinical criteria. Baseline clinic-pathological and treatment information was retrieved from medical records. Statistical analysis was performed with IBM SPSS V.20. Results: Median age was 51.3 years [27-68]. 48% of tumors were grade 3. The average tumor size was 36mm [10-90]. The histological type was ductal carcinoma in 97%. Vascular invasion was noted in 24 patients (77%). Thirty patients were classified as stage IIIB and one patient was IIIC. 74% were hormone receptor positive and 45% were HER2 positive. Luminal B was the predominant subtype (52%) followed by Her2 positive (32%), Luminal A (23%), and triple negative (3%) All patients had chemotherapy: neoadjuvant for 26 patients (84%) and adjuvant for 5 patients (16%). Nine patients (29%) had tumor pathological complete response (pCR). Partial response was observed in 18 patients (58%). Lymph node pCR was noted in 16% of cases (n=5). Endocrine therapy and trastuzumab were given to 76% and 45% of patients, respectively. The influence of the molecular subtype was not statistically significant on the response to neoadjuvant treatment. The highest rate of pCR were 43% for Her2positive, then 27%, 21% and 9% for Luminal B, Luminal A and Triple negative, respectively (p=0.2). Conclusion: Our study showed a high percentage of hormone receptor and Her2+ (74% and 45% respectively) in IBC. Luminal B was the most frequent subtype. Anthracycline-based chemotherapy and trastuzumab improved the pCR rate: 44% for Her2positive. Triple negative showed poorer pCR than other breast cancer subtype without a significant difference. A larger study is warranted to confirm our findings.
{"title":"Inflammatory Breast Cancer: Clinical Characteristics and Influence of Molecular Subtypes on Treatment Response","authors":"D. Aissaoui, M. Bohli, R. Ben amor, J. Yahyaoui, A. Hamdoun, R. Moujahed, L. Kochbati","doi":"10.1177/03008916211012341","DOIUrl":"https://doi.org/10.1177/03008916211012341","url":null,"abstract":"Introduction: Inflammatory Breast Cancer (IBC) is a rare and very aggressive breast cancer with poor prognosis. The prevalence is different from a country to another. In Tunisia, it is about 5 to 7% of breast cancer. The aim of this study is to describe the epidemiological and histopathological features of patients with inflammatory breast cancer and to evaluate the treatment response according to the molecular subtypes. Methods: This retrospective review identified 31 patients with no metastatic IBC treated in our radiotherapy department between December 2019 and November 2020. IBC was confirmed using the clinical criteria. Baseline clinic-pathological and treatment information was retrieved from medical records. Statistical analysis was performed with IBM SPSS V.20. Results: Median age was 51.3 years [27-68]. 48% of tumors were grade 3. The average tumor size was 36mm [10-90]. The histological type was ductal carcinoma in 97%. Vascular invasion was noted in 24 patients (77%). Thirty patients were classified as stage IIIB and one patient was IIIC. 74% were hormone receptor positive and 45% were HER2 positive. Luminal B was the predominant subtype (52%) followed by Her2 positive (32%), Luminal A (23%), and triple negative (3%) All patients had chemotherapy: neoadjuvant for 26 patients (84%) and adjuvant for 5 patients (16%). Nine patients (29%) had tumor pathological complete response (pCR). Partial response was observed in 18 patients (58%). Lymph node pCR was noted in 16% of cases (n=5). Endocrine therapy and trastuzumab were given to 76% and 45% of patients, respectively. The influence of the molecular subtype was not statistically significant on the response to neoadjuvant treatment. The highest rate of pCR were 43% for Her2positive, then 27%, 21% and 9% for Luminal B, Luminal A and Triple negative, respectively (p=0.2). Conclusion: Our study showed a high percentage of hormone receptor and Her2+ (74% and 45% respectively) in IBC. Luminal B was the most frequent subtype. Anthracycline-based chemotherapy and trastuzumab improved the pCR rate: 44% for Her2positive. Triple negative showed poorer pCR than other breast cancer subtype without a significant difference. A larger study is warranted to confirm our findings.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"20 1","pages":"12 - 12"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87724735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.1177/03008916211012343
A. Elkholy, A. Awadeen
Introduction: Radical mastectomy shall be a lifesaving procedure for patients with breast cancer. However, it is associated with considerable alteration of patients’ self-esteem and body image. Currently, 40% of women are subjected to breast reconstruction subsequent to radical mastectomy, ranking such surgery the most common reconstruction approach. Two-stage tissue expander-to-implant is the preferable technique that accomplished the desired aesthetic outcomes. The current study was executed to assess the safety and efficacy of Carbon-dioxide based tissue expansion, in contrast to saline-based tissue expansion. Materials and Methods: Comprehensive literature review up to 1 December 2020 was carried out throughout the following databases; PubMed, Google Scholar, Web of Science, Scopus, WHO Global Health Library, Clinical trials, Cochrane, SIGLE, NYAM, mRCT, and ICTRP to identify all clinical studies compared carbon-dioxide based and saline-based tissue expansion. Data analysis was done using Review Manager version 5.3 (RevMan5.3). The significant difference was established at P < 0.05. Results: This meta-analysis included four articles which comprised 619 reconstructed breasts. Of them, 374 breasts were reconstructed using carbon-dioxide based tissue expander, whereby 245 breasts were reconstructed using saline-based tissue expander. Carbon-dioxide based tissue expander accomplished statistically significant shorter duration to accomplish complete expansion (MD-36.28;95%CI-44.09,-28.47;P<0.001) and shorter duration to achieve complete reconstruction (MD-41.91;95%CI-54.24,-29.58;P<0.001). There was no statistically significant difference between carbon-dioxide and saline-based tissue expanders regarding the success rate (RR 1;95%CI 0.96, 1.06;P=0.85), device malfunction (RR 0.94;95%CI 0.11, 8.06;P=0.96), and implant extrusion (RR 0.71;95%CI 0.14, 3.62;P=0.68). There was no statistically significant difference between both methods regarding total; complications (RR 0.93;95%CI 0.64, 1.37;P=0.72). This includes wound infection (RR 0.46;95%CI 0.08, 2.72;P=0.39), wound dehiscence (RR 0.47;95%CI 0.10, 2.25;P=0.34), seroma (RR 1.01;95%CI 0.40, 2.57;P=0.99), and hematoma (RR 0.28;95%CI 0.06, 1.29;P=0.1). Conclusions: Carbon-dioxide based tissue expander is a safe, effective, and promising approach with considerable advancement relative to saline-based tissue expander, principally regarding the time to accomplish complete implant expansion and the time to achieve complete breast reconstruction.
{"title":"Carbon Dioxide based versus Saline Tissue Expansion for Breast Reconstruction; A Meta-Analysis","authors":"A. Elkholy, A. Awadeen","doi":"10.1177/03008916211012343","DOIUrl":"https://doi.org/10.1177/03008916211012343","url":null,"abstract":"Introduction: Radical mastectomy shall be a lifesaving procedure for patients with breast cancer. However, it is associated with considerable alteration of patients’ self-esteem and body image. Currently, 40% of women are subjected to breast reconstruction subsequent to radical mastectomy, ranking such surgery the most common reconstruction approach. Two-stage tissue expander-to-implant is the preferable technique that accomplished the desired aesthetic outcomes. The current study was executed to assess the safety and efficacy of Carbon-dioxide based tissue expansion, in contrast to saline-based tissue expansion. Materials and Methods: Comprehensive literature review up to 1 December 2020 was carried out throughout the following databases; PubMed, Google Scholar, Web of Science, Scopus, WHO Global Health Library, Clinical trials, Cochrane, SIGLE, NYAM, mRCT, and ICTRP to identify all clinical studies compared carbon-dioxide based and saline-based tissue expansion. Data analysis was done using Review Manager version 5.3 (RevMan5.3). The significant difference was established at P < 0.05. Results: This meta-analysis included four articles which comprised 619 reconstructed breasts. Of them, 374 breasts were reconstructed using carbon-dioxide based tissue expander, whereby 245 breasts were reconstructed using saline-based tissue expander. Carbon-dioxide based tissue expander accomplished statistically significant shorter duration to accomplish complete expansion (MD-36.28;95%CI-44.09,-28.47;P<0.001) and shorter duration to achieve complete reconstruction (MD-41.91;95%CI-54.24,-29.58;P<0.001). There was no statistically significant difference between carbon-dioxide and saline-based tissue expanders regarding the success rate (RR 1;95%CI 0.96, 1.06;P=0.85), device malfunction (RR 0.94;95%CI 0.11, 8.06;P=0.96), and implant extrusion (RR 0.71;95%CI 0.14, 3.62;P=0.68). There was no statistically significant difference between both methods regarding total; complications (RR 0.93;95%CI 0.64, 1.37;P=0.72). This includes wound infection (RR 0.46;95%CI 0.08, 2.72;P=0.39), wound dehiscence (RR 0.47;95%CI 0.10, 2.25;P=0.34), seroma (RR 1.01;95%CI 0.40, 2.57;P=0.99), and hematoma (RR 0.28;95%CI 0.06, 1.29;P=0.1). Conclusions: Carbon-dioxide based tissue expander is a safe, effective, and promising approach with considerable advancement relative to saline-based tissue expander, principally regarding the time to accomplish complete implant expansion and the time to achieve complete breast reconstruction.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"72 1","pages":"14 - 14"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84104325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Uncertainty still surrounds the nature and origin of the ongoing coronavirus disease 2019 (COVID-19) pandemic outbreak, especially concerning the most probable date of spill over and worldwide propagation.Methods: An electronic search was carried out on Google Trends, with the Italian search terms “febbre” (fever), “tosse” (cough) and “raffreddore” (cold), which are among the most commonly reported COVID-19 symptoms in Italy. The search period was comprised between June 2019 and February 2020, and was limited to the area of the Lombardia region. The number of national influenza cases was also concomitantly retrieved from the Italian Network of Influenza Surveillance.Results: The trend of Google searches for “febbre” (fever), “tosse” (cough) and “raffreddore” (cold) seemed to mirror that of influenza cases, but only after the second week of November 2020. An unexpected peak of Google searches for these symptoms could be noted between the first week of September and the last week of October. This anomalous volume of Google searches could not be directly attributed to influenza spread. This increase was significantly higher compared to the same period of the previous year 2018 (20.4±15.0%;p=0.020). The volumes of Google searches for the three symptoms were also significantly inter-correlated (correlation coefficients between 0.66-0.83;all p<0.001).Conclusions: The results of our analysis seem to confirm that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have started to circulate in Italy, and more specifically in the region of Lombardia, earlier before the overt pandemic period, probably already at the beginning of September 2019.
{"title":"Unexpected volume of Google searches for COVID-19 symptoms in the prepandemic period in Lombardia, Italy","authors":"G. Lippi, C. Mattiuzzi","doi":"10.2139/ssrn.3732725","DOIUrl":"https://doi.org/10.2139/ssrn.3732725","url":null,"abstract":"Background: Uncertainty still surrounds the nature and origin of the ongoing coronavirus disease 2019 (COVID-19) pandemic outbreak, especially concerning the most probable date of spill over and worldwide propagation.Methods: An electronic search was carried out on Google Trends, with the Italian search terms “febbre” (fever), “tosse” (cough) and “raffreddore” (cold), which are among the most commonly reported COVID-19 symptoms in Italy. The search period was comprised between June 2019 and February 2020, and was limited to the area of the Lombardia region. The number of national influenza cases was also concomitantly retrieved from the Italian Network of Influenza Surveillance.Results: The trend of Google searches for “febbre” (fever), “tosse” (cough) and “raffreddore” (cold) seemed to mirror that of influenza cases, but only after the second week of November 2020. An unexpected peak of Google searches for these symptoms could be noted between the first week of September and the last week of October. This anomalous volume of Google searches could not be directly attributed to influenza spread. This increase was significantly higher compared to the same period of the previous year 2018 (20.4±15.0%;p=0.020). The volumes of Google searches for the three symptoms were also significantly inter-correlated (correlation coefficients between 0.66-0.83;all p<0.001).Conclusions: The results of our analysis seem to confirm that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have started to circulate in Italy, and more specifically in the region of Lombardia, earlier before the overt pandemic period, probably already at the beginning of September 2019.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"10 1","pages":"468 - 469"},"PeriodicalIF":0.0,"publicationDate":"2020-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78463501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-01DOI: 10.1177/0300891619882504
D. Facchinelli, A. Parisi, M. Krampera, D. Veneri
Purpose: We assessed the frequency of triple-positive serology (viral capsid antigen [VCA]–immunoglobulin G [IgG], VCA–immunoglobulin M, Epstein-Barr nuclear antigen–IgG) for Epstein-Barr virus (EBV) in a small number of patients with angioimmunoblastic T-cell lymphoma (AITL) at disease onset. Methods: Nine patients with newly diagnosed AITL were retrospectively enrolled in the present study. For all of them, EBV serology data were available. Results: Of 9 patients, 7 (77.7%) had a triple-positive serology (VCA-IgG, VCA-IgM, EBNA-IgG ) for EBV. These patients were characterized by bone marrow involvement, high incidence of thrombocytopenia, and poor prognosis according to Revised International Prognostic Index and Prognostic Index for Angioimmunoblastic T-cell Lymphoma scores. Conclusion: Assessment of both viremia and serology for EBV could be useful in patients with clinical and laboratory data suggesting lymphoma diagnosis; furthermore, although our data need to be validated in a larger cohort of patients, triple positivity for EBV serology might help to direct the diagnosis toward AITL.
{"title":"Is triple-positive serology for Epstein-Barr virus (VCA-IgG, VCA-IgM, EBNA-IgG) a specific feature of angioimmunoblastic T-cell lymphoma?","authors":"D. Facchinelli, A. Parisi, M. Krampera, D. Veneri","doi":"10.1177/0300891619882504","DOIUrl":"https://doi.org/10.1177/0300891619882504","url":null,"abstract":"Purpose: We assessed the frequency of triple-positive serology (viral capsid antigen [VCA]–immunoglobulin G [IgG], VCA–immunoglobulin M, Epstein-Barr nuclear antigen–IgG) for Epstein-Barr virus (EBV) in a small number of patients with angioimmunoblastic T-cell lymphoma (AITL) at disease onset. Methods: Nine patients with newly diagnosed AITL were retrospectively enrolled in the present study. For all of them, EBV serology data were available. Results: Of 9 patients, 7 (77.7%) had a triple-positive serology (VCA-IgG, VCA-IgM, EBNA-IgG ) for EBV. These patients were characterized by bone marrow involvement, high incidence of thrombocytopenia, and poor prognosis according to Revised International Prognostic Index and Prognostic Index for Angioimmunoblastic T-cell Lymphoma scores. Conclusion: Assessment of both viremia and serology for EBV could be useful in patients with clinical and laboratory data suggesting lymphoma diagnosis; furthermore, although our data need to be validated in a larger cohort of patients, triple positivity for EBV serology might help to direct the diagnosis toward AITL.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"211 1","pages":"424 - 426"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77757042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-01DOI: 10.1177/0300891620953388
Anonymous
The proceedings contain 385 papers The topics discussed include: developing a structured guidance and education program for patients (PTS) with cancer during SARS CoVID-2 pandemia in a North East Piedmont Hospital;phone follow-up (PFU) for breast cancer survivors (CS) during COVID-19 pandemic: a single breast unit experience;on-line psychological treatment with oncology patients during COVID-19 emergency;incidence of influenza-like illness (ILI) in cancer patients during COVID-19: the ONCOVID prospective observational study;training and information during COVID19 pandemic: the masterpiece in young oncologists;the relevance of pre-triage and triage sequence for cancer patients access to the in-patient and outpatient oncology units at the AOU Mater Domini of Catanzaro to prevent COVID-19 in hospital outbreak;and the appropriateness of invasive ventilation in COVID-19 positive cancer patients: the hardest decision for oncologists
会议记录包含385篇论文，讨论的主题包括:东北皮埃蒙特医院在SARS -2大流行期间为癌症患者(PTS)制定结构化指导和教育计划;COVID-19大流行期间乳腺癌幸存者(CS)的电话随访(PFU):单乳房单位体验;COVID-19急诊期间肿瘤患者的在线心理治疗;COVID-19期间癌症患者的流感样疾病(ILI)发病率;2019冠状病毒病(COVID-19)大流行期间的培训和信息:年轻肿瘤学家的经典;癌症患者进入卡坦萨罗州AOU Mater Domini的住院和门诊肿瘤科时，分诊前和分诊顺序与预防医院爆发COVID-19的相关性;对COVID-19阳性癌症患者进行有创通气的适宜性:肿瘤学家最难做出的决定
{"title":"AIOM abstracts","authors":"Anonymous","doi":"10.1177/0300891620953388","DOIUrl":"https://doi.org/10.1177/0300891620953388","url":null,"abstract":"The proceedings contain 385 papers The topics discussed include: developing a structured guidance and education program for patients (PTS) with cancer during SARS CoVID-2 pandemia in a North East Piedmont Hospital;phone follow-up (PFU) for breast cancer survivors (CS) during COVID-19 pandemic: a single breast unit experience;on-line psychological treatment with oncology patients during COVID-19 emergency;incidence of influenza-like illness (ILI) in cancer patients during COVID-19: the ONCOVID prospective observational study;training and information during COVID19 pandemic: the masterpiece in young oncologists;the relevance of pre-triage and triage sequence for cancer patients access to the in-patient and outpatient oncology units at the AOU Mater Domini of Catanzaro to prevent COVID-19 in hospital outbreak;and the appropriateness of invasive ventilation in COVID-19 positive cancer patients: the hardest decision for oncologists","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"53 1","pages":"1 - 215"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74227363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1177/0300891620914144
SM Abd Elsalam, A. Said, M. Sarah
Introduction: Breast cancer is the most invasive malignant tumour in females worldwide and is the second leading cause of cancer death in females after lung cancer. In Egypt, cancer breast is the first common site of tumours among females (32%) and the second common tumour site in both sexes. The aim of this study was to evaluate and compare the diagnostic performance of quantitative parameters derived from diffusion-weighted imaging (DWI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and magnetic resonance spectroscopy (MRS) with ultrasound +/- conventional mammography in differentiating suspicious breast masses (BI-RADS III and IV) and to suggest the most accurate imaging combination for early diagnosis and treatment of cancer breast. Materials and Methods: The study included 40 patients with suspicious breast lesions detected by clinical examination, ultrasound+/- mammography . Dynamic MRI study was performed using 1.5T MRI. Lesions were analyzed regarding their morphology, kinetic curve pattern, ADC value and tCho peak measurement. The results of each MRI parameter were correlated to histo-pathology. Results: In this study sensitivity of sono-mammography was 70% and its specificity was 66.6%. According to using MRI sensitivity was 90% and specificity was 80% by using morphological and curve patterns. As regarding MRS sensitivity was 50% and specificity was 86.7%. Regarding sensitivity of ADC was 90%while its specificity was 93%. The cut off ADC value was 0.95 x 10−3 mm2/s. By using MRI with additive modalities (ADC and MRS) sensitivity was 100% and specificity was 93%. Conclusion: In comparison with MRI, sonomammography alone lack both sensitivity and specificity in detection of breast lesions in suspicious cases. MRI with additive modalities (ADC and MRS) is the best imaging modality in detection of malignant cases and exclusion of benign cases.
{"title":"Multiparametric Approach with Dynamic Contrast-Enhanced Mri, Diffusion-Weighted Imaging and Mrs of The Breast in Assessment of Suspicious Breast Lesions","authors":"SM Abd Elsalam, A. Said, M. Sarah","doi":"10.1177/0300891620914144","DOIUrl":"https://doi.org/10.1177/0300891620914144","url":null,"abstract":"Introduction: Breast cancer is the most invasive malignant tumour in females worldwide and is the second leading cause of cancer death in females after lung cancer. In Egypt, cancer breast is the first common site of tumours among females (32%) and the second common tumour site in both sexes. The aim of this study was to evaluate and compare the diagnostic performance of quantitative parameters derived from diffusion-weighted imaging (DWI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and magnetic resonance spectroscopy (MRS) with ultrasound +/- conventional mammography in differentiating suspicious breast masses (BI-RADS III and IV) and to suggest the most accurate imaging combination for early diagnosis and treatment of cancer breast. Materials and Methods: The study included 40 patients with suspicious breast lesions detected by clinical examination, ultrasound+/- mammography . Dynamic MRI study was performed using 1.5T MRI. Lesions were analyzed regarding their morphology, kinetic curve pattern, ADC value and tCho peak measurement. The results of each MRI parameter were correlated to histo-pathology. Results: In this study sensitivity of sono-mammography was 70% and its specificity was 66.6%. According to using MRI sensitivity was 90% and specificity was 80% by using morphological and curve patterns. As regarding MRS sensitivity was 50% and specificity was 86.7%. Regarding sensitivity of ADC was 90%while its specificity was 93%. The cut off ADC value was 0.95 x 10−3 mm2/s. By using MRI with additive modalities (ADC and MRS) sensitivity was 100% and specificity was 93%. Conclusion: In comparison with MRI, sonomammography alone lack both sensitivity and specificity in detection of breast lesions in suspicious cases. MRI with additive modalities (ADC and MRS) is the best imaging modality in detection of malignant cases and exclusion of benign cases.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"20 1","pages":"16 - 16"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81900924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1177/0300891620914163
Lamiss Mohamed Abd el Aziz, Dareen Mohamed Abd El Aziz, A. Elkady, Noha ElAnwar
The chemoresistance of epithelial ovarian cancer (EOC) is a major problem Thus, the search for novel biomarkers associated with cisplatin sensitivity is overwhelming. Previous studies have shown that chemokine receptor (CXCR4) is associated with tumor growth, angiogenesis and distant metastases and replication regulatory timing factor (RIF1) is responsible for repair of double strand DNA breaks. This study, thus, aimed to identify the correlation between CXCR4 and RIF1 overexpression and cisplatin sensitivity in EOC. Patients and methods: Fifty five EOC patients were recruited to assess chemosensitivity of EOC to cisplatin based chemotherapy in Oncology Department, Tanta University Hospitals. Results: The results showed that patients with a higher CXCR4 and RIF1 expression exhibited a significantly lower chemosensitivity, worse overall survival and a poorer progression-free survival. The only prognostic associated with overall survival was CXCR4.
{"title":"CXCR4 and RIF1 Overexpression Induces Resistance of Epithelial Ovarian Cancer to Cisplatin","authors":"Lamiss Mohamed Abd el Aziz, Dareen Mohamed Abd El Aziz, A. Elkady, Noha ElAnwar","doi":"10.1177/0300891620914163","DOIUrl":"https://doi.org/10.1177/0300891620914163","url":null,"abstract":"The chemoresistance of epithelial ovarian cancer (EOC) is a major problem Thus, the search for novel biomarkers associated with cisplatin sensitivity is overwhelming. Previous studies have shown that chemokine receptor (CXCR4) is associated with tumor growth, angiogenesis and distant metastases and replication regulatory timing factor (RIF1) is responsible for repair of double strand DNA breaks. This study, thus, aimed to identify the correlation between CXCR4 and RIF1 overexpression and cisplatin sensitivity in EOC. Patients and methods: Fifty five EOC patients were recruited to assess chemosensitivity of EOC to cisplatin based chemotherapy in Oncology Department, Tanta University Hospitals. Results: The results showed that patients with a higher CXCR4 and RIF1 expression exhibited a significantly lower chemosensitivity, worse overall survival and a poorer progression-free survival. The only prognostic associated with overall survival was CXCR4.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"87 1","pages":"31 - 31"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84251442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1177/0300891620914145
D. Maksimov, A. V. Aseev, E. Evstifeeva, S. Filippchenkova, L. Murashova, O. O. Suleymanova
Introduction: Breast cancer (BC) is the leading pathology in the mortality structure of the female population in the world, reduces the quality of life (QOL), affecting all aspects of life. Objective: To study the features of the QOL associated with health, the level of reflexivity and existence women with BC. Materials and Methods: On the basis of TSMU a study of patients with BC who are being treated in the Tver Regional Clinical Oncology Center. The sample included 138 patients aged 30 to 80 years old with a confirmed diagnosis of BC of stages IA – IIIC, who underwent complex treatment. The volume of surgical treatment was not considered. We used the methods of SF-36, existential scaling A. Lange and K. Orgler, reflexivity questionnaires A. Karpov. The reliability of the results is provided by SPSS Statistics 22. Results and Discussion: The QOL associated with health patients with BC is formed by indicators of physical functioning (63.3 ± 23.0), role functioning (26.9 ± 36.9) and pain intensity (20, 4 ± 22.2), general health (60.9 ± 14.0), vitality (60 ± 13.1), social functioning (50.5 ± 26.5), emotional functioning (43.4 ± 39, 9) and self-esteem of mental health (56.5 ± 14.4). A study of the level of reflexivity showed that 25% have low rates and average - 75%. Patients with a high level were not identified. The study of existence showed that self-distance (33.5 ± 7.9) has a high degree of severity in 38%, low - in 17%. Self-transcendence (65.1 ± 13.1) in a high degree of severity in 53%, low - in 6%. Freedom (39.1 ± 6.9) has a high level in 8%, low - in 15%. Responsibility (53.6 ± 14.7) in a high level was recorded in 26%, low - in 7%. Conclusions: Patients with BC rate their own overall health, vitality, social functioning, and psychological health quite low. Such QOL indicators as physical, role and emotional functioning have an average level of ratings. Respondents highly rate their own experience of pain. Patients suffer physical and mental health components, which significantly increases the risk of complications in the postoperative period.
{"title":"Quality of Life in Breast Cancer Patients","authors":"D. Maksimov, A. V. Aseev, E. Evstifeeva, S. Filippchenkova, L. Murashova, O. O. Suleymanova","doi":"10.1177/0300891620914145","DOIUrl":"https://doi.org/10.1177/0300891620914145","url":null,"abstract":"Introduction: Breast cancer (BC) is the leading pathology in the mortality structure of the female population in the world, reduces the quality of life (QOL), affecting all aspects of life. Objective: To study the features of the QOL associated with health, the level of reflexivity and existence women with BC. Materials and Methods: On the basis of TSMU a study of patients with BC who are being treated in the Tver Regional Clinical Oncology Center. The sample included 138 patients aged 30 to 80 years old with a confirmed diagnosis of BC of stages IA – IIIC, who underwent complex treatment. The volume of surgical treatment was not considered. We used the methods of SF-36, existential scaling A. Lange and K. Orgler, reflexivity questionnaires A. Karpov. The reliability of the results is provided by SPSS Statistics 22. Results and Discussion: The QOL associated with health patients with BC is formed by indicators of physical functioning (63.3 ± 23.0), role functioning (26.9 ± 36.9) and pain intensity (20, 4 ± 22.2), general health (60.9 ± 14.0), vitality (60 ± 13.1), social functioning (50.5 ± 26.5), emotional functioning (43.4 ± 39, 9) and self-esteem of mental health (56.5 ± 14.4). A study of the level of reflexivity showed that 25% have low rates and average - 75%. Patients with a high level were not identified. The study of existence showed that self-distance (33.5 ± 7.9) has a high degree of severity in 38%, low - in 17%. Self-transcendence (65.1 ± 13.1) in a high degree of severity in 53%, low - in 6%. Freedom (39.1 ± 6.9) has a high level in 8%, low - in 15%. Responsibility (53.6 ± 14.7) in a high level was recorded in 26%, low - in 7%. Conclusions: Patients with BC rate their own overall health, vitality, social functioning, and psychological health quite low. Such QOL indicators as physical, role and emotional functioning have an average level of ratings. Respondents highly rate their own experience of pain. Patients suffer physical and mental health components, which significantly increases the risk of complications in the postoperative period.","PeriodicalId":23450,"journal":{"name":"Tumori Journal","volume":"13 1","pages":"17 - 17"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84365804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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