{"title":"Evaluating the Knowledge, Attitude and Experience of Anesthesiologist About Nasotracheal Intubation: A Questionnaire Study","authors":"Sibel Çatalca, G. Kulturoglu, R. Polat","doi":"10.5505/vtd.2022.32043","DOIUrl":"https://doi.org/10.5505/vtd.2022.32043","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"188 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72643474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Sakız, M. Çalapkulu, M. Sencar, Seyit Murat Bayram, I. Ozturk Unsal, M. Kizilgul, B. Uçan, M. Özbek, E. Çakal
Introduction: Although GLP-1 agonists have been shown to reduce cardiovascular events, their effect on the progression of subclinical atherosclerosis is not clear. In this respect, it was planned to evaluate cardiovascular risk markers in obese and diabetic patients receiving exenatide therapy. Materials and Methods: This retrospective study included 56 patients with Type 2 Diabetes Mellitus (DM) with a body mass index (BMI) >35. Demographic, anthropometric and clinic characteristics before and after six-month treatment with exenatide were screened. Cardiovascular risk marker Atherogenic Index of Plasma (AIP), uric acid, carotis intima media thickness (CIMT), HbA1c, fasting blood glucose (FBS) and postprandial blood glucose (TCG) levels were evaluated. Results: Eleven of the fifty-six patients had discontinued exenatide due to side effects, etc. 45 patients (35 females, 10 males; age 50 ± 9.5 years) completed the study. AIP, HbA1c, uric acid, fasting plasma glucose, postprandial glucose, waist circumference, hip circumference, body mass index (BMI), total cholesterol, and triglyceride levels were improved with exenatide treatment. However, no change was detected in CIMT, blood pressure, spot urine albumin/creatinine ratio, LDL, and HDL levels. Conclusion: Glycemic parameters, AIP and uric acid levels, which are biochemical predictors of subclinical atherosclerosis, were improved with GLP-1 agonist exetide treatment. However, no change was observed in CIMT measurements. These findings can be interpreted as exenatide therapy, can slow down the progression of subclinical atherosclerosis, but has no effect on existing atherosclerotic plaque.
{"title":"The Effect of GLP-1 Agonist Treatment On Subclinical Atherosclerosis","authors":"D. Sakız, M. Çalapkulu, M. Sencar, Seyit Murat Bayram, I. Ozturk Unsal, M. Kizilgul, B. Uçan, M. Özbek, E. Çakal","doi":"10.5505/vtd.2022.09815","DOIUrl":"https://doi.org/10.5505/vtd.2022.09815","url":null,"abstract":"Introduction: Although GLP-1 agonists have been shown to reduce cardiovascular events, their effect on the progression of subclinical atherosclerosis is not clear. In this respect, it was planned to evaluate cardiovascular risk markers in obese and diabetic patients receiving exenatide therapy. Materials and Methods: This retrospective study included 56 patients with Type 2 Diabetes Mellitus (DM) with a body mass index (BMI) >35. Demographic, anthropometric and clinic characteristics before and after six-month treatment with exenatide were screened. Cardiovascular risk marker Atherogenic Index of Plasma (AIP), uric acid, carotis intima media thickness (CIMT), HbA1c, fasting blood glucose (FBS) and postprandial blood glucose (TCG) levels were evaluated. Results: Eleven of the fifty-six patients had discontinued exenatide due to side effects, etc. 45 patients (35 females, 10 males; age 50 ± 9.5 years) completed the study. AIP, HbA1c, uric acid, fasting plasma glucose, postprandial glucose, waist circumference, hip circumference, body mass index (BMI), total cholesterol, and triglyceride levels were improved with exenatide treatment. However, no change was detected in CIMT, blood pressure, spot urine albumin/creatinine ratio, LDL, and HDL levels. Conclusion: Glycemic parameters, AIP and uric acid levels, which are biochemical predictors of subclinical atherosclerosis, were improved with GLP-1 agonist exetide treatment. However, no change was observed in CIMT measurements. These findings can be interpreted as exenatide therapy, can slow down the progression of subclinical atherosclerosis, but has no effect on existing atherosclerotic plaque.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81896980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abbas Tokyay, S. Özkan, N. Güven, Tülin Türközü, Bayram Ersidar
{"title":"The Effect of Computed Tomography on Planning the Type of Operation in Hip Intertochanteric Fractures","authors":"Abbas Tokyay, S. Özkan, N. Güven, Tülin Türközü, Bayram Ersidar","doi":"10.5505/vtd.2022.92331","DOIUrl":"https://doi.org/10.5505/vtd.2022.92331","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"35 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91455405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"G6PD Deficiency in Neonatal Jaundice","authors":"Altay Babacan, F. F. Şenol, I. Bahceci","doi":"10.5505/vtd.2022.96237","DOIUrl":"https://doi.org/10.5505/vtd.2022.96237","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"192 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91443319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glutamate is an essential excitatory neurotransmitter in the brain, neuronal cell loss by overactivation in high concentrations. Epigenetic mechanisms, such as histone modifications, alter gene expression for maintaining cellular balance and are activated during sustained neuroinflammation and oxidative stress. Suberoylanilide hydroxamic acid (SAHA) is a well-known histone deacetylase inhibitor for its antitumor and anti-inflammatory properties. Therefore, in this study, we aimed to investigate the neuroprotective effect of SAHA against glutamate-induced oxidative stress in HT-22 hippocampal cells. Materials and Methods: The HT-22 hippocampal neuronal cells were cultured in DMEM medium with 10% FBS and 1% penicillin/streptomycin and incubated at 37°C in a humidified atmosphere containing 5% CO 2 . Cell viability was determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay after administration of glutamate and SAHA to HT-22 cells, and then the absorbance levels were measured at 550 nm using a microplate reader. The neuroprotective effect of SAHA was evaluated by measuring the oxidative stress parameters like reduced glutathione (GSH) level, and antioxidant enzyme activities of glutathione reductase (GR) and glutathione peroxide (GPx) by Enzyme-like immunosorbent assay (ELISA). Results: SAHA has reduced glutamate-induced neuron death in HT-22 cells. Moreover, SAHA alleviated glutamate-induced oxidative stress by increasing GSH levels, and the activities of the antioxidant enzymes GR and GPx. Conclusion: These results demonstrated that SAHA has antioxidant activity, reduces glutamate-induced oxidative stress, and confers protection against glutamate-induced neuronal death.
{"title":"Suberoylanilide Hydroxamic Acid (SAHA) Reduces Glutamate-Induced Oxidative Stress in Hippocampal Cells","authors":"Caner Günayd, Z. B. Çelik","doi":"10.5505/vtd.2022.01979","DOIUrl":"https://doi.org/10.5505/vtd.2022.01979","url":null,"abstract":"Glutamate is an essential excitatory neurotransmitter in the brain, neuronal cell loss by overactivation in high concentrations. Epigenetic mechanisms, such as histone modifications, alter gene expression for maintaining cellular balance and are activated during sustained neuroinflammation and oxidative stress. Suberoylanilide hydroxamic acid (SAHA) is a well-known histone deacetylase inhibitor for its antitumor and anti-inflammatory properties. Therefore, in this study, we aimed to investigate the neuroprotective effect of SAHA against glutamate-induced oxidative stress in HT-22 hippocampal cells. Materials and Methods: The HT-22 hippocampal neuronal cells were cultured in DMEM medium with 10% FBS and 1% penicillin/streptomycin and incubated at 37°C in a humidified atmosphere containing 5% CO 2 . Cell viability was determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay after administration of glutamate and SAHA to HT-22 cells, and then the absorbance levels were measured at 550 nm using a microplate reader. The neuroprotective effect of SAHA was evaluated by measuring the oxidative stress parameters like reduced glutathione (GSH) level, and antioxidant enzyme activities of glutathione reductase (GR) and glutathione peroxide (GPx) by Enzyme-like immunosorbent assay (ELISA). Results: SAHA has reduced glutamate-induced neuron death in HT-22 cells. Moreover, SAHA alleviated glutamate-induced oxidative stress by increasing GSH levels, and the activities of the antioxidant enzymes GR and GPx. Conclusion: These results demonstrated that SAHA has antioxidant activity, reduces glutamate-induced oxidative stress, and confers protection against glutamate-induced neuronal death.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81997393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Coronovirus 2019 (COVID-19) infection has spread rapidly, causing a worldwide pandemic. Although a good clinical course ranging from asymptomatic carriage to a simple flu infection is encountered in most patients, pneumonia and even multi-organ failure and mortality can be seen in some patients. In studies on which patients are more associated with a worse prognosis, it has been associated with increased mortality in patients with lung disease. In this study, it was aimed to show the mortality rate and possible prognostic factors associated with COVID-19 in patients with interstitial lung disease due to connective tissue disease (CTD-ILD). Materials and Methods: In a tertiary referral centre, patients with previously diagnosed CTD-ILD were retrospectively reviewed. Between 1st April 2020 to 1st April 2021 patient data related to ILD disease, COVID-19 infection and mortality were obtained from electronic records retrospectively. The primary outcome was death on day 30 of COVID-19 infection Results: There were 271patients diagnosed with CTD-ILD. 74 patients had COVID-19 infection, which was confirmed by polymerase chain reaction. 29 patients were dead during the followed-up period of whom 13 patients had COVID-19 infection-related mortality (17.5% vs 8.1%, p:0.045). COVID infection related to mortality was more frequently seen in patients with decreased forced vital capacity , smoking history, extended disease and rheumatoid arthritis. On multivariate regression analysis, only decreased forced vital capacity were related to poor outcomes. Conclusion : COVID-19 infection is related to increased risk of mortality in CTD-ILD patients. Decreased forced vital capacity is a poor prognostic risk factor
导语:2019冠状病毒(COVID-19)感染已迅速蔓延，导致全球大流行。虽然大多数患者的临床病程良好，从无症状携带到简单的流感感染，但在一些患者中可以看到肺炎，甚至多器官衰竭和死亡。在与患者预后更差相关的研究中，它与肺部疾病患者死亡率增加有关。本研究旨在揭示结缔组织病(CTD-ILD)间质性肺疾病患者的死亡率及与COVID-19相关的可能预后因素。材料和方法:在三级转诊中心，回顾性分析了先前诊断为CTD-ILD的患者。从电子记录中回顾性获取2020年4月1日至2021年4月1日期间与ILD疾病、COVID-19感染和死亡率相关的患者数据。主要终点为COVID-19感染第30天死亡。结果:271例患者被诊断为CTD-ILD。经聚合酶链反应确诊新冠肺炎感染74例。随访期间死亡29例，其中COVID-19感染相关死亡率13例(17.5% vs 8.1%， p:0.045)。与死亡率相关的COVID感染更常见于强迫肺活量下降、吸烟史、病程延长和类风湿性关节炎患者。在多变量回归分析中，只有用力肺活量下降与预后不良有关。结论:COVID-19感染与CTD-ILD患者死亡风险增加有关。肺活量下降是一个不良的预后危险因素
{"title":"Covid-19 Course in Connective Tissue Disease-Related Interstitial Lung Disease Patients","authors":"H. Satış, Y. Ünsal, A. Tufan","doi":"10.5505/vtd.2022.67790","DOIUrl":"https://doi.org/10.5505/vtd.2022.67790","url":null,"abstract":"Introduction: Coronovirus 2019 (COVID-19) infection has spread rapidly, causing a worldwide pandemic. Although a good clinical course ranging from asymptomatic carriage to a simple flu infection is encountered in most patients, pneumonia and even multi-organ failure and mortality can be seen in some patients. In studies on which patients are more associated with a worse prognosis, it has been associated with increased mortality in patients with lung disease. In this study, it was aimed to show the mortality rate and possible prognostic factors associated with COVID-19 in patients with interstitial lung disease due to connective tissue disease (CTD-ILD). Materials and Methods: In a tertiary referral centre, patients with previously diagnosed CTD-ILD were retrospectively reviewed. Between 1st April 2020 to 1st April 2021 patient data related to ILD disease, COVID-19 infection and mortality were obtained from electronic records retrospectively. The primary outcome was death on day 30 of COVID-19 infection Results: There were 271patients diagnosed with CTD-ILD. 74 patients had COVID-19 infection, which was confirmed by polymerase chain reaction. 29 patients were dead during the followed-up period of whom 13 patients had COVID-19 infection-related mortality (17.5% vs 8.1%, p:0.045). COVID infection related to mortality was more frequently seen in patients with decreased forced vital capacity , smoking history, extended disease and rheumatoid arthritis. On multivariate regression analysis, only decreased forced vital capacity were related to poor outcomes. Conclusion : COVID-19 infection is related to increased risk of mortality in CTD-ILD patients. Decreased forced vital capacity is a poor prognostic risk factor","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"77 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89519431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Oztermeli, B. Yılmaz, G. Ozdemir, E. Şirin, I. Arslan, B. Komur, A. I. Demir
{"title":"Recurrence is Unavoidable in Hand and Wrist Ganglion Cyst Surgery","authors":"A. Oztermeli, B. Yılmaz, G. Ozdemir, E. Şirin, I. Arslan, B. Komur, A. I. Demir","doi":"10.5505/vtd.2022.54037","DOIUrl":"https://doi.org/10.5505/vtd.2022.54037","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74205134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dilek Cebeci, E. Gurkas, Z. Öztürk, A. GÜven, Z. S. Karalok, A. Değerliyurt, Nefise Arıbaş Öz, İ. Öncel, Serkan Özmen, Ş. Yılmaz, Tulin Hakan Demirkan
{"title":"Clinical Characteristics and Visual Outcomes of Pediatric Optic Neuritis: A Single Center Experience","authors":"Dilek Cebeci, E. Gurkas, Z. Öztürk, A. GÜven, Z. S. Karalok, A. Değerliyurt, Nefise Arıbaş Öz, İ. Öncel, Serkan Özmen, Ş. Yılmaz, Tulin Hakan Demirkan","doi":"10.5505/vtd.2022.92604","DOIUrl":"https://doi.org/10.5505/vtd.2022.92604","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83980992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yi̇ği̇t, A. Gezer, M. Yayla, Erdem Toktay, Pinar Aksu Kilicle, S. Bingol, Çiğdem Eda BALKAN BOZLAK
{"title":"Protective Effects of Berberis Vulgaris Plant Extract on Paracetamol-induced Liver Toxicity in Rats","authors":"S. Yi̇ği̇t, A. Gezer, M. Yayla, Erdem Toktay, Pinar Aksu Kilicle, S. Bingol, Çiğdem Eda BALKAN BOZLAK","doi":"10.5505/vtd.2022.36675","DOIUrl":"https://doi.org/10.5505/vtd.2022.36675","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90523214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：