Objective: This study aimed to evaluate the usefulness of YouTube videos on epiretinal membrane surgery in the retina. Methods: When ‘epiretinal membrane surgery’ was searched on the YouTube search engine, the first 100 videos on this topic were evaluated. These videos were then analyzed and scored using DISCERN, Journal of the American Medical Association (JAMA), and Global Quality (GQ) scoring systems. Results: The evaluated videos had a DISCERN score of 30.0 ± 7.8, a JAMA score of 1.5 ± 0.6, and a GQ score of 1.8 ± 0.6. When the results of epiretinal membrane surgery were evaluated according to the quality scoring of these three scoring systems, the DISCERN score was evaluated as poor, the JAMA score as low quality, and the GQ scored as poor quality. Conclusion: Although there are many videos about epiretinal membrane surgery on Youtube, the usefulness of these videos as a resource is low and the quality is poor.
{"title":"Epiretinal Membrane Surgery on Youtube","authors":"M. Songur, M. Çıtırık","doi":"10.5505/vtd.2022.67503","DOIUrl":"https://doi.org/10.5505/vtd.2022.67503","url":null,"abstract":"Objective: This study aimed to evaluate the usefulness of YouTube videos on epiretinal membrane surgery in the retina. Methods: When ‘epiretinal membrane surgery’ was searched on the YouTube search engine, the first 100 videos on this topic were evaluated. These videos were then analyzed and scored using DISCERN, Journal of the American Medical Association (JAMA), and Global Quality (GQ) scoring systems. Results: The evaluated videos had a DISCERN score of 30.0 ± 7.8, a JAMA score of 1.5 ± 0.6, and a GQ score of 1.8 ± 0.6. When the results of epiretinal membrane surgery were evaluated according to the quality scoring of these three scoring systems, the DISCERN score was evaluated as poor, the JAMA score as low quality, and the GQ scored as poor quality. Conclusion: Although there are many videos about epiretinal membrane surgery on Youtube, the usefulness of these videos as a resource is low and the quality is poor.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86545739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to determine the importance and reliability of interleukin-6 (IL-6), IL8, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels in terms of diagnosis and prognosis in neonatal sepsis. Methods: Thirty newborns who were followed up and treated in the neonatal intensive care unit with a pre-diagnosis of neonatal sepsis and 20 healthy newborns who were born without any problem from mothers without any disease were included in the study.Gender, gestational age, postnatal age, place and mode of delivery, birth weight, IL-6, IL-8, TNF-α, and CRP levels were recorded. Results: Of the 30 cases diagnosed with sepsis, 16 (53.3%) were male and 14 (46.7%) were female. In the control group of 20 cases, 11 (55%) were male, and 9 (45%) were female. Of the cases diagnosed with sepsis, 8 were considered early-onset (26.6%) and 22 were considered late-onset (73.4%) neonatal sepsis. The mortality rate in early-onset sepsis was 25%, while this rate was 36.3% in late-onset sepsis cases. The levels of CRP, IL-6, and IL-8 were significantly higher in the sepsis group than in the control group. The difference between the groups in terms of TNF-α levels was not statistically significant. IL-6 (P = 0.001) and IL-8 (P = 0.007) levels were found to be statistically significantly higher in the deceased cases than in the healing cases. Conclusion: CRP, IL-6,and IL-8 levels were found to be useful parameters in the diagnosis of neonatal sepsis, while TNF-α was not found to have diagnostic value.IL-6 and IL-8 levels were found to be significant in the prognosis of neonatal sepsis.
{"title":"IL-6, IL-8, TNF-α and C-Reactive Protein Levels in the Diagnosis and Prognosis of Neonatal Sepsis","authors":"Ruken Yıldırım, Mehmet Celal Devecioğlu","doi":"10.5505/vtd.2022.89166","DOIUrl":"https://doi.org/10.5505/vtd.2022.89166","url":null,"abstract":"Objective: This study aimed to determine the importance and reliability of interleukin-6 (IL-6), IL8, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels in terms of diagnosis and prognosis in neonatal sepsis. Methods: Thirty newborns who were followed up and treated in the neonatal intensive care unit with a pre-diagnosis of neonatal sepsis and 20 healthy newborns who were born without any problem from mothers without any disease were included in the study.Gender, gestational age, postnatal age, place and mode of delivery, birth weight, IL-6, IL-8, TNF-α, and CRP levels were recorded. Results: Of the 30 cases diagnosed with sepsis, 16 (53.3%) were male and 14 (46.7%) were female. In the control group of 20 cases, 11 (55%) were male, and 9 (45%) were female. Of the cases diagnosed with sepsis, 8 were considered early-onset (26.6%) and 22 were considered late-onset (73.4%) neonatal sepsis. The mortality rate in early-onset sepsis was 25%, while this rate was 36.3% in late-onset sepsis cases. The levels of CRP, IL-6, and IL-8 were significantly higher in the sepsis group than in the control group. The difference between the groups in terms of TNF-α levels was not statistically significant. IL-6 (P = 0.001) and IL-8 (P = 0.007) levels were found to be statistically significantly higher in the deceased cases than in the healing cases. Conclusion: CRP, IL-6,and IL-8 levels were found to be useful parameters in the diagnosis of neonatal sepsis, while TNF-α was not found to have diagnostic value.IL-6 and IL-8 levels were found to be significant in the prognosis of neonatal sepsis.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79772442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to explain the benefits and possible protective mechanisms of sinapic acid (SA) against cisplatin-induced oxido-inflammatory damage in HT-22 rat hippocampal cells by biochemical and molecular methods. Materials and methods: Sinapic acid (SA) was applied at different concentrations (100, 400, and 800 μM) before cisplatin treatment on HT-22 cells under in vitro conditions to elicit neuroprotective activity. Half an hour after SA treatment, 5.5 μM cisplatin was added to all wells except the control group and incubated for 24 hours. Cell viability was determined by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cytotoxicity was determined by lactate dehydrogenase (LDH) assays. Oxidative stress was evaluated by total antioxidant capacity (TAC), catalase (CAT), glutathione reductase (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) assays. In addition, the effect of SA on Caspase-3 gene regulation in HT-22 cells was investigated by real-time PCR. Results: Cisplatin decreased cell viability by approximately 40% and increased LDH level in HT-22 cells. In SA-treated groups, cell viability increased and LDH level decreased dose-independently. SA showed neuroprotective activity by inhibiting the cytotoxic activity of cisplatin and increasing the antioxidant activity in cells. Similarly, Caspase-3, which was up-regulated by cisplatin, approached the control value upon SA administration. SA eliminated the neurotoxicity of cisplatin and significantly reduced cell death and oxidative stress. Conclusion: The results of this study indicate that SA protects HT-22 cells against cisplatin by inhibiting both the formation of oxidative stress and induction of cell apoptosis.
{"title":"Does Sinapic Acid Provide Neuroprotection Against Cisplatin-Induced Toxicity in HT-22 Cells","authors":"B. Çiçek, Sidika Genc","doi":"10.5505/vtd.2023.98411","DOIUrl":"https://doi.org/10.5505/vtd.2023.98411","url":null,"abstract":"Objective: The aim of this study was to explain the benefits and possible protective mechanisms of sinapic acid (SA) against cisplatin-induced oxido-inflammatory damage in HT-22 rat hippocampal cells by biochemical and molecular methods. Materials and methods: Sinapic acid (SA) was applied at different concentrations (100, 400, and 800 μM) before cisplatin treatment on HT-22 cells under in vitro conditions to elicit neuroprotective activity. Half an hour after SA treatment, 5.5 μM cisplatin was added to all wells except the control group and incubated for 24 hours. Cell viability was determined by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cytotoxicity was determined by lactate dehydrogenase (LDH) assays. Oxidative stress was evaluated by total antioxidant capacity (TAC), catalase (CAT), glutathione reductase (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) assays. In addition, the effect of SA on Caspase-3 gene regulation in HT-22 cells was investigated by real-time PCR. Results: Cisplatin decreased cell viability by approximately 40% and increased LDH level in HT-22 cells. In SA-treated groups, cell viability increased and LDH level decreased dose-independently. SA showed neuroprotective activity by inhibiting the cytotoxic activity of cisplatin and increasing the antioxidant activity in cells. Similarly, Caspase-3, which was up-regulated by cisplatin, approached the control value upon SA administration. SA eliminated the neurotoxicity of cisplatin and significantly reduced cell death and oxidative stress. Conclusion: The results of this study indicate that SA protects HT-22 cells against cisplatin by inhibiting both the formation of oxidative stress and induction of cell apoptosis.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83574344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Femoral Pseudoaneurysm Compression Theraphy With Usg Guidance","authors":"Ensar Türko, Muhammed Bilal Akıncı","doi":"10.5505/vtd.2023.76094","DOIUrl":"https://doi.org/10.5505/vtd.2023.76094","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79852231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation Between the Modified and the Classical Methods in Carpal Tunnel Syndrome Diagnosis","authors":"H. Şahin","doi":"10.5505/vtd.2023.29863","DOIUrl":"https://doi.org/10.5505/vtd.2023.29863","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"93 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87754704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Earthquake: What is Post Traumatic Normal? Where Does the Psychopathology Begin?","authors":"Yavuz Selim Atan, Pınar Guzel Ozdemir","doi":"10.5505/vtd.2023.30075","DOIUrl":"https://doi.org/10.5505/vtd.2023.30075","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73776362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nesrin Sakarya, Ayşe Büyüktaş Manay, H. Demirbakan, Deniz Gazel
{"title":"Comparison of Two Different Methods for Determination of hVISA Rates in Methicilline-Resistant Staphylococcus aureus","authors":"Nesrin Sakarya, Ayşe Büyüktaş Manay, H. Demirbakan, Deniz Gazel","doi":"10.5505/vtd.2023.47639","DOIUrl":"https://doi.org/10.5505/vtd.2023.47639","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85557648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Matrix Metalloproteinase-3 (MMP-3) Gene Methylation Status with the Risk of Developing Achilles Tendonitis: A Preliminary Study","authors":"Ercan Tural, Z. B. Çelik, Esra Tekcan, S. Tural","doi":"10.5505/vtd.2023.88864","DOIUrl":"https://doi.org/10.5505/vtd.2023.88864","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86050672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Yaşa, Gonul Karatas Durusoy, G. Demir, U. Tunç, Z. Alkın
{"title":"Dexamethasone Implant as an Adjunct Therapy in Refractory Diabetic Macular Edema: Real-World Experience in a Turkish Population.","authors":"D. Yaşa, Gonul Karatas Durusoy, G. Demir, U. Tunç, Z. Alkın","doi":"10.5505/vtd.2023.26504","DOIUrl":"https://doi.org/10.5505/vtd.2023.26504","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"36 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90656287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of MicroRNAs in Monitoring Post Renal Transplantation Graft Functions","authors":"M. Anapali, E. Balkan","doi":"10.5505/vtd.2023.98705","DOIUrl":"https://doi.org/10.5505/vtd.2023.98705","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79521519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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