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Ciprofloxacin Resistance: A Review of Patients in East London Undergoing Prostate Biopsy. 环丙沙星耐药性:东伦敦接受前列腺活检的患者回顾。
Pub Date : 2016-07-01
Bruce Turner, Jhumur Pati, Vinod Nargund, Alleyna Claxton, Victoria Longstaff, Somita Sarkar, James Green

Transrectal ultrasound guided biopsy of the prostate remains the gold standardinvestigation to diagnose prostate cancer. Although post-biopsy complicationsare relatively rare, the risk of sepsis associated with the procedure means thatprophylactic antibiotics are paramount. The most widely used antibiotic regimenincludes a quinolone, such as ciprofloxacin. Resistance to quinolone antibioticsis rising. In this small pilot study, the incidence of quinolone resistance was 18%in our population of patients attending the prostate biopsy clinic.

经直肠超声引导下的前列腺活检仍然是诊断前列腺癌的金标准。虽然活检后并发症相对较少,但与手术相关的败血症风险意味着预防性抗生素是至关重要的。最广泛使用的抗生素方案包括喹诺酮类药物,如环丙沙星。喹诺酮类抗生素耐药性上升。在这个小规模的初步研究中,在我们的前列腺活检门诊患者中,喹诺酮类药物耐药性的发生率为18%。
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引用次数: 0
Hazardous Drugs in the Urology Workplace: Focus on Intravesical Medications. 泌尿外科工作场所的危险药物:重点是膀胱内用药。
Pub Date : 2016-07-01
Debbie Hensley

The Society of Urologic Nurses and Associates (SUNA) and the AmericanUrological Association (AUA) collaborated to develop a standard operating procedurein 2015 for instillation of intravesical cytotoxic, immunotherapeutic, and/ortherapeutic drugs for patients with urothelial carcinoma of the bladder and interstitialcystitis. This is a synthesis of the standard operating procedure in the contextof hazardous drug administration, including indications for administration,guidelines, and principles of hazardous drugs in the clinical setting, peri-treatmentconcerns, and patient and staff education.

泌尿外科护士协会(SUNA)和美国泌尿外科协会(AUA)于2015年合作制定了膀胱内滴注细胞毒性、免疫治疗和/或治疗药物的标准操作程序,用于膀胱尿路上皮癌和间质性膀胱炎患者。这是危险药物管理方面的标准操作程序的综合,包括给药指征、临床环境中危险药物的指南和原则、治疗前后的问题以及患者和工作人员的教育。
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引用次数: 0
Cycling Versus Continuous Mode In Neuromodulator Programming: A Crossover, Randomized, Controlled Trial. 神经调节器编程中的循环模式与连续模式:交叉、随机、对照试验。
Pub Date : 2016-05-01
Gwendolyn M Beer, Margaret M Gurule, Yuko M Komesu, Clifford R Qualls, Rebecca G Rogers

This is a randomized, controlled, blind, crossover trial comparing cycling versus continuous programming of a sacral neuromodulator in women diagnosed with overactive bladder (OAB). At 6 months, treatment order significantly affected Overactive Bladder Questionnaire - Short Form (OABq-SF) symptom scores. The cycling followed by continuous stimulation group had superior OABq-SF scores (p > 0.02).

这是一项随机、对照、盲法、交叉试验,比较了骶神经调节器在确诊为膀胱过度活动症(OAB)的女性患者中循环使用与持续使用的区别。6 个月后,治疗顺序对膀胱过度活动症问卷-简表(OABq-SF)症状评分有明显影响。先循环后持续刺激组的 OABq-SF 评分更高(P > 0.02)。
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引用次数: 0
Osteonecrosis of the Jaw in Patients Receiving Bone-Targeted Therapies: An Overview--Part I. 接受骨靶向治疗的颌骨骨坏死患者:综述-第一部分。
Pub Date : 2016-05-01
Bruce Turner, Lawrence Drudge-Coates, Sacha Ali, Jhumur Pati, Vinod Nargund, Enamul Ali, Leo Cheng, Paula Wells

Urologic patients receiving bone-targeted therapies are at risk of developing osteonecrosis of the jaw (ONJ). ONJ has historically been associated with bisphosphonate therapy. More recently, RANK-Ligand inhibitors (denosumab) have also been used to reduce the risk of skeletal-related events in patients who have advanced cancers with bone metastases. More than 65% of men with metastatic prostate cancer and nearly 75% of women with metastatic breast cancer are affected by bone metastases. The literature has described ONJ associated with bisphosphonate therapy as bisphosphonate-related osteonecrosis of the jaw (BRONJ). However, with evidence also linking the use of RANK-Ligand inhibitors with osteonecrosis of the jaw, we advocate use of the term "anti-bone resorption therapy-related osteonecrosis of the jaw" (ABRT-ONJ). The term "medication-related osteonecrosis of the jaw" (MRONJ) is now becoming more widespread. There is not a universally accepted definition of ABRT-ONJ, which may have hindered recognition and reporting of the condition. In Part I of this article, a review of current knowledge around the etiology of ABRT-ONJ and incidence data are provided. In Part II, we provide an audit of ONJ in a nurse consultant-led bone support clinic. In the article, we refer to zoledronic acid because this is the bisphosphonate of choice for use in men with prostate cancer in the United Kingdom.

接受骨靶向治疗的泌尿系统患者有发生颌骨骨坏死(ONJ)的风险。ONJ历来与双膦酸盐治疗有关。最近,rank -配体抑制剂(denosumab)也被用于降低伴有骨转移的晚期癌症患者骨骼相关事件的风险。超过65%的男性转移性前列腺癌患者和近75%的女性转移性乳腺癌患者受到骨转移的影响。文献将ONJ与双膦酸盐治疗相关描述为双膦酸盐相关性颌骨骨坏死(BRONJ)。然而,也有证据表明rank -配体抑制剂的使用与颌骨骨坏死有关,我们提倡使用“抗骨吸收治疗相关颌骨骨坏死”(ABRT-ONJ)这一术语。“药物相关性颌骨骨坏死”(MRONJ)这个术语现在变得越来越普遍。ABRT-ONJ并没有一个被普遍接受的定义,这可能阻碍了对该疾病的识别和报告。在本文的第一部分中,综述了目前关于ABRT-ONJ病因学和发病率数据的知识。在第二部分,我们提供了一个审计ONJ在护士顾问领导的骨支持诊所。在这篇文章中,我们提到了唑来膦酸,因为在英国,这是治疗前列腺癌的首选双膦酸盐。
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引用次数: 0
Application to the Evidence Base: Decision-Making in Prostate Cancer: Active Surveillance over Other Treatment Options. 在证据基础上的应用:前列腺癌的决策:对其他治疗方案的主动监测。
Pub Date : 2016-05-01
Cynthia M Sublett
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引用次数: 0
Sleepless in America: Burning the Candle at Both Ends? At What Cost? 《美国失眠夜》:两头烧蜡烛?代价是什么?
Pub Date : 2016-05-01
Kaye K Gaines
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引用次数: 0
Retrospective Audit: Does Prior Assessment by Oral and Maxillofacial Surgeons Reduce the Risk of Osteonecrosis of The Jaw in Patients Receiving Bone-Targeted Therapies for Metastatic Cancers to the Skeleton?--Part II. 回顾性审计:口腔颌面外科医生的事先评估是否能降低接受骨靶向治疗的骨转移癌患者颌骨骨坏死的风险?——第二部分。
Pub Date : 2016-05-01
Bruce Turner, Sacha Ali, Jhumur Pati, Vinod Nargund, Enamul Ali, Leo Cheng, Paula Wells

Men who receive bone-targeted therapy for metastatic prostate cancer are at increased risk of osteonecrosis of the jaw (ONJ). Development of ONJ has been associated with the administration of bone-targeted therapies in association with other risk factors. ONJ can be distressing for a patient because it can cause pain, risk of jaw fracture, body image disturbance, difficultly eating, and difficulty maintaining good oral hygiene. The aim of this article is to report results of an audit of prior assessment by oral and maxillofacial surgeons (OMFS) before initiation of bone-targeted therapies and whether it may reduce the risk of ONJ in patients receiving bone-targeted therapies for advanced cancers.

接受骨靶向治疗转移性前列腺癌的男性患颌骨骨坏死(ONJ)的风险增加。ONJ的发展与骨靶向治疗的实施以及其他危险因素有关。ONJ会让患者感到痛苦,因为它会导致疼痛、下颌骨折的风险、身体形象障碍、进食困难和难以保持良好的口腔卫生。本文的目的是报告口腔颌面外科医生(OMFS)在开始骨靶向治疗前的事先评估审计结果,以及是否可以降低接受骨靶向治疗的晚期癌症患者发生ONJ的风险。
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引用次数: 0
Preoperative Nutritional Status and The Impact on Radical Cystectomy Recovery: An International Comparative Study. 术前营养状况及对根治性膀胱切除术恢复的影响:一项国际比较研究。
Pub Date : 2016-05-01
Bente Thoft Jensen, Guido Dalbagni, Michael Borre, Nora Love-Retinger

In radical cystectomy, under-nutrition is common and has detrimental physiological and clinical effects, which can lead to increased complications and prolonged recovery. This article compares measurements and outcomes across continents in this patient population with advanced bladder cancer. The association of preoperative nutritional risk, nutritional status, and length of stay is equal across continents, and the results promote increased clinical awareness that women at severe risk should be identified preoperatively.

在根治性膀胱切除术中,营养不良是常见的,具有有害的生理和临床影响,可导致并发症增加和恢复时间延长。这篇文章比较了各大洲晚期膀胱癌患者的测量和结果。术前营养风险、营养状况和住院时间的关联在各大洲都是相同的,结果促进了临床意识的提高,即术前应识别有严重风险的妇女。
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引用次数: 0
Decision-Making in Prostate Cancer: Active Surveillance Over Other Treatment Options. 前列腺癌的决策:主动监测优于其他治疗方案。
Pub Date : 2016-05-01
David Bayliss, Jed Duff, Phil Stricker, Kim Walker

A qualitative-descriptive study of four patients with prostate cancer used the Cognitive-Social Health Information Processing framework to understand how and why men diagnosed with prostate cancer choose active surveillance over other treatment options. In accordance with the literature, it was found that the surgeon or general practitioner's recommendation was the most influential factor when patients are making a treatment decision.

一项对四名前列腺癌患者的定性描述性研究使用了认知社会健康信息处理框架来理解前列腺癌患者如何以及为什么选择主动监测而不是其他治疗方案。根据文献,我们发现外科医生或全科医生的建议是患者做出治疗决定时最具影响力的因素。
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引用次数: 0
Effect of an Education Presentation On the Knowledge and Awareness of Urinary Tract Infection among Non-Licensed and Licensed Health Care Workers in Long-Term Care Facilities. 一次教育对长期护理机构非执业和执业医护人员尿路感染知识和意识的影响。
Pub Date : 2016-03-01
Jennifer H Freeman-Jobson, Jamie L Rogers, Peggy Ward-Smith

This article presents the findings of a pre-test, post-test quality improvement project that describes the change in knowledge from prior to and following an evidence-based education presentation. The presentation addressed the clinical symptoms, diagnostic processes, interventions, and responsibilities of licensed and unlicensed health care workers employed in long-term care facilities related to prevention and detection of non-catheter-related urinary tract infections. Results indicate that the education presentation improved knowledge in specific.

本文介绍了一个测试前、测试后质量改进项目的发现,该项目描述了在基于证据的教育演示之前和之后知识的变化。介绍了长期护理机构雇用的持证和无证卫生保健工作者在预防和检测非导尿管相关性尿路感染方面的临床症状、诊断过程、干预措施和责任。结果表明,教育呈现提高了具体知识。
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引用次数: 0
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Urologic nursing
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