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Volume 5,Issue 1,2019最新文献

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Effect of Costus igneus Leaf Juice on Antidiabetic Activity of Glimepiride in Rats – A Suggestive Study 火木叶汁对大鼠格列美脲抗糖尿病作用的初步研究
Pub Date : 2019-05-06 DOI: 10.30799/JNPR.075.19050103
K. Akhil, B. .
Article history: Received 30 March 2019 Accepted 20 April 2019 Available online 06 May 2019 Due to therapeutic efficacy, Costus igneus Nak. (CI), (popularly known as insulin plant) is one medicinal plant in the limelight of having cure for diabetes. An oral diabetic agent Glimepiride was selected to evaluate the activity in per se and in combination with Costus igneus. The study drugs (glimepiride or Costus igneus leaf juice) were administered orally and blood glucose levels were determined using Glucometer at stipulated time intervals. It perhaps works in pathophysiologic/metabolic deranged conditions as observed by its per se effect in streptozotocin-induced diabetic rats’ contrast to its effect in normal rats. The results of our study confirm that, the combined action of glimepiride and Costus igneus leaf juice has greater antidiabetic effects than their individual effects (per se).
文章历史:2019年3月30日收稿2019年4月20日收稿2019年5月6日上线(CI)(俗称胰岛素植物)是一种因治疗糖尿病而备受关注的药用植物。选择一种口服糖尿病药物格列美脲来评估其单独使用和与火火木联合使用的活性。口服研究药物(格列美脲或火木叶汁),并在规定的时间间隔用血糖仪测定血糖水平。它可能在病理生理/代谢紊乱的情况下起作用,因为它对链脲佐菌素诱导的糖尿病大鼠的作用与对正常大鼠的作用形成了对比。我们的研究结果证实,格列美脲和火木叶汁的联合作用比单独作用具有更大的降糖作用。
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引用次数: 0
Evaluation of Antimicrobial and Antifungal Activity of Chemical Constituents Isolated from Vernonia guineensis Roots (Asteraceae) 豚鼠Vernonia guineensis根(Asteraceae)化学成分抑菌活性评价
Pub Date : 2019-05-06 DOI: 10.30799/JNPR.076.19050102
.. Y.O.NgansoDitchou, A. K. Doutsing, .. M.T.G.MalaOpono, .. B.Nyasse
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引用次数: 1
Probing Subsistence of Host Guest Inclusion Complexes of Oligosaccharides with Allopurinol for Regulatory Release with the Manifestation of Solvation Consequences 别嘌呤醇寡糖主客体包合物调控释放的存在及其溶剂化效应的表现
Pub Date : 2019-05-06 DOI: 10.30799/jacs.205.19050105
J. Mondal, Ashutosh Dutta, K. Das, D. Das, P. Karmakar, S. Sengupta, A. Bhattacharya, R. Das, M. Roy
Article history: Received 09 February 2019 Accepted 01 March 2019 Available online 05 May 2019 The inspection of molecular interaction widespread in allopurinol and in aqueous solutions of α-, and HP-β-cyclodextrin have been probed by thermophysical properties. The established complexes obtained with 1:1 stoichiometry. Role of solvent (aqueous solution of α-CD, -CD, HP-β-CD) and contribution of solute–solute and solute–solvent interactions to solution complexes, have also been analyzed via stability constant-NMR, UV, steady state fluorescence, FTIR, HRMS, SEM, PXRD, cytotoxicity, hydrophobic effect, hydrogen-bonding, structural effects in creation of inclusion complexes.
文章历史:通过热物理性质研究了别嘌呤醇和α-、和HP-β-环糊精水溶液中广泛存在的分子相互作用。以1:1的化学计量得到已建立的配合物。通过稳定常数nmr、UV、稳态荧光、FTIR、HRMS、SEM、PXRD、细胞毒性、疏水效应、氢键、结构效应等方法分析了溶剂(α-CD水溶液、-CD、HP-β-CD)和溶质-溶质、溶质-溶剂相互作用对溶液配合物的作用。
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引用次数: 0
Effects on the Phagocytosis Modulation of Stems Extract and Triterpenes from Gouania longipetala (Hemsl.), A Plant of The Cameroonian Pharmacopeia 喀麦隆药典植物长瓣石楠茎提取物和三萜对吞噬调节作用的影响
Pub Date : 2019-04-17 DOI: 10.30799/JNPR.073.19050101
S. B. Tamo, S. R. Essama, O. N. Eteme, T.J.L. Mundene, J. Ze, E. T. Ngalani, D. K. Setchaba, B. Nyassé, F. Etoa
Article history: Received 23 December 2018 Accepted 07 March 2019 Available online 17 April 2019 Immunomodulatory therapy is now being recognized as an alternative to conventional chemotherapy for a variety of disease conditions, involving the impaired immune response of the host. The goal of this study is to valorize Gouania longipetala (Hemsl.) like potential source of drugs against immune system dysfunction. This medicinal plant is commonly used in the Cameroonian pharmacopeia to cure a lot of diseases including inflammatory diseases. In this work, we evaluated the immunomodulation properties of infused stems extract (GLE) and triterpenes from G. longipetala (Hemsl.), with respect to the phagocytosis. GLE was obtained by infusion of dry bark powder in water and the triterpenes were isolated after fractionation of GLE in solvent systems following by column chromatography. The structure elucidation of isolated compounds was based on analysis of spectroscopic data including 1Dand 2D-NMR. The immunomodulation activity was evaluated by two methods. Firstly, the capacity of GLE and triterpenes to modulate phagocytic activity of polymorphonuclear (PMNs) cells was assessed in vitro against Candida albicans. Secondly, the ability of GLE to modulate reticuloendothelial system was investigated in vivo on wistar rats by carbon clearance test. Two triterpenes were isolated, alphitolic and epigouanic acids. The stimulation percentage of PMNs by plant extracts was ranged between 4.25 and 42.55% with GLE and between 14.89 and 46.80% with alphitolic acid. Epigouanic acid show biphasic activity profile, with stimulation of phagocytic activity of PMNs cells at lower concentrations and suppression effects at higher concentrations. In vivo test showed that GLE liberates the glutathione particles from animal’s liver and enhance the phagocytic activity by stimulating the reticuloendothelial system. The phagocytic index obtained was ranged between 0.020 ± 0.004 and 0.074 ± 0.006. The results obtained from this study show that extract from G. longipetala (Hemsl.) modulate phagocytic activity and would be therefore the potential sources of drugs against immunological disorders.
文章历史:2018年12月23日接收2019年3月7日接受2019年4月17日在线提供2019年4月17日免疫调节疗法现在被认为是多种疾病的常规化疗的替代方案,涉及宿主免疫反应受损。本研究的目的是为龙茅属植物(Hemsl.)开发抗免疫功能障碍的潜在药物来源。这种药用植物在喀麦隆药典中常用来治疗包括炎症性疾病在内的许多疾病。在这项工作中,我们评估了注入的茎提取物(GLE)和三萜从吞噬作用方面的免疫调节特性。将干树皮粉末浸泡在水中得到GLE,在溶剂体系中对GLE进行分离,然后用柱层析法分离出其中的三萜。分离化合物的结构解析是基于光谱数据的分析,包括1d和2D-NMR。采用两种方法评价其免疫调节活性。首先,在体外研究了GLE和三萜对多形核细胞(PMNs)抗白色念珠菌吞噬活性的调节作用。其次,通过碳清除试验,在wistar大鼠体内研究GLE对网状内皮系统的调节能力。分离出两种三萜:α -酚酸和表果酸。植物提取物对PMNs的刺激率分别为4.25 ~ 42.55%和14.89 ~ 46.80%。表酒甘酸呈双相活性,低浓度时对PMNs细胞的吞噬活性有刺激作用,高浓度时对PMNs细胞有抑制作用。体内实验表明,GLE通过刺激网状内皮系统,使谷胱甘肽颗粒从动物肝脏中释放出来,增强其吞噬活性。所得吞噬指数范围为0.020±0.004 ~ 0.074±0.006。本研究结果表明,长蹄草提取物具有调节机体吞噬活性的作用,有望成为抗免疫疾病药物的潜在来源。
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引用次数: 1
Determination of Physicochemical Properties and Toxic Heavy Metals Levels in Honey Samples from West of Libya 利比亚西部蜂蜜样品理化性质及有毒重金属含量测定
Pub Date : 2019-04-16 DOI: 10.30799/JACS.207.19050104
A. Salama, A. Etorki, M. Awad
Article history: Received 23 February 2019 Accepted 21 March 2019 Available online 16 April 2019 This study was done to investigate the physicochemical properties of bee honey samples collected from different locations in west of Libya. The concentration of essential elements (Na, K, and Ca), and toxic heavy metals (Pb, Cd, Hg, and As) in honey samples were determined by flame photometer, and atomic absorption spectrometer. The results showed significant variation among the honey samples may be attributed to the plants floral types, which indicate that the mean values of moisture ranged from 20.6 to 25.1% was a slight higher than the Codex limit 20%, pH mean values 4.12 to 4.74, free acid equivalent 20 to 27 m eq./kg, total dissolved substance 646 to 994 ppm, and specific conductivity 638.5 to 1004 μS/cm. The mean values of minerals concentration in (mg/kg) such as potassium were ranged from 1120.1 to 1980.6, sodium 506.8 to 804.6, calcium 923.92 to 1117.5, lead 2.42 to 10.98, cadmium 0.125 to 0.150, mercury 0.021 to 0.10, and arsenic 0.006 to 0.018. The results revealed that the concentration of Hg and As in honey samples confine with the Codex range, on the other hand the study indicated that the concentration of Pb and Cd in honey confine with some international specifications and different with some others. The honey study may be useful for assessing the presence of environmental contaminants.
文章历史:收到2019年2月23日接受2019年3月21日在线提供2019年4月16日这项研究是为了调查从利比亚西部不同地点采集的蜜蜂蜂蜜样本的物理化学性质。采用火焰光度计和原子吸收光谱仪测定了蜂蜜样品中必需元素(Na、K、Ca)和有毒重金属(Pb、Cd、Hg、As)的浓度。结果表明,蜂蜜样品的水分平均值为20.6 ~ 25.1%,略高于法典规定的20%,pH平均值为4.12 ~ 4.74,游离酸当量为20 ~ 27 m = /kg,总溶解物为646 ~ 994 ppm,比电导率为638.5 ~ 1004 μS/cm。钾等矿物质(mg/kg)浓度平均值为1120.1 ~ 1980.6,钠为506.8 ~ 804.6,钙为923.92 ~ 1117.5,铅为2.42 ~ 10.98,镉为0.125 ~ 0.150,汞为0.021 ~ 0.10,砷为0.006 ~ 0.018。结果表明,蜂蜜样品中汞和砷的含量限定在国际食品法典规定的范围内,而铅和镉的含量限定在国际食品法典规定的范围内。蜂蜜研究可能有助于评估环境污染物的存在。
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引用次数: 8
Microwave Assisted Synthesis of Zinc Oxide Nanoparticles and Its Antimicrobial Efficiency 微波辅助合成氧化锌纳米颗粒及其抑菌效果研究
Pub Date : 2019-03-31 DOI: 10.30799/JNST.215.19050116
. R.Deepa, . D.Muthuraj, . E.Kumar, . V.Veeraputhiran
Article history: Received 05 March 2019 Accepted 27 March 2019 Available online 31 March 2019 Zinc oxide (ZnO) nanoparticles have been synthesized via microwave-assisted method. The structural analysis was carried out using X-ray diffractometer. It showed that the ZnO nanoparticle exhibited hexagonal structure. Further the ZnO product was investigated by FT-IR and SEM analysis. Also antimicrobial efficiency in different concentrations have been studied and found good activity against Escherichia coli.
文章历史:2019年3月5日接收2019年3月27日接收2019年3月31日在线提供2019年3月31日通过微波辅助方法合成氧化锌(ZnO)纳米颗粒。用x射线衍射仪进行了结构分析。结果表明,ZnO纳米颗粒呈六边形结构。进一步用FT-IR和SEM对ZnO产物进行了表征。并对不同浓度下的抑菌效果进行了研究,发现对大肠杆菌有良好的抑菌活性。
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引用次数: 4
Synthesis and Investigation of Antimicrobial Activity of Tin Oxide Nanoparticles by Microwave Assisted Solution Method 微波辅助溶液法制备氧化锡纳米颗粒及其抑菌活性研究
Pub Date : 2019-03-31 DOI: 10.30799/JNST.214.19050115
. S.Rajeswari, . J.UmaMaheswari, . D.Muthuraj, . E.Kumar, . V.Veeraputhiran
Article history: Received 05 March 2019 Accepted 27 March 2019 Available online 31 March 2019 Tin oxide (SnO2) nanoparticles have been synthesized via microwave-assisted solution method. The structural analysis was carried out using X-ray diffraction. It showed that the SnO2 nanoparticle exhibited primitive tetragonal structure. The SnO2 product was investigated by FT-IR, UV, SEM and antimicrobial activity studies of SnO2 have confirmed that they have biomedical applications.
文章历史:2019年3月5日接收2019年3月27日在线提供2019年3月31日通过微波辅助溶液法合成了氧化锡(SnO2)纳米颗粒。用x射线衍射进行了结构分析。结果表明,SnO2纳米颗粒具有原始的四方结构。通过红外光谱(FT-IR)、紫外光谱(UV)、扫描电镜(SEM)对SnO2产物进行了研究,并对SnO2的抗菌活性进行了研究,证实其具有生物医学应用价值。
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引用次数: 3
Synthesis and Characterization of ZrO2 Nanoparticles using Microwave Assisted Method and Its Antimicrobial Activity 微波辅助法制备ZrO2纳米颗粒及其抑菌活性研究
Pub Date : 2019-03-31 DOI: 10.30799/JNST.216.19050117
. S.BabyAsha, . D.Muthuraj, . E.Kumar, . V.Veeraputhiran
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引用次数: 0
Synthesis and Structural Characteristics of Fe Doped ZnO Nanoparticles at Different Molarities and Temperatures 不同摩尔浓度和温度下Fe掺杂ZnO纳米颗粒的合成及结构特性
Pub Date : 2019-03-31 DOI: 10.30799/JNST.213.19050118
Anup Kr Kalita, S. Karmakar
Article history: Received 04 March 2019 Accepted 30 March 2019 Available online 30 April 2019 Iron doped zinc oxide (Fe:ZnO) nanoparticles are prepared by wet chemical method at different molarities (0.025 M, 0.05 M and 0.1 M) and different temperatures (RT and 473 K). The nanoparticles are studied by X-ray diffraction (XRD), transmission electron microscopy (TEM) techniques. Crystallite sizes and lattice strain of nanoparticles are calculated by Williamson Hall (W-H) method. The average particle size of the nanoparticle is also calculated by Scherrer formula. Uniform deformation model (UDM), unifrom stress deformation model (USDM) and uniform deformation energy density model (UDEDM) are used to calculate stress, strain, and energy density involved in the sample. We get different particle sizes of nano particle perpendicular to different (hkl) planes. This shows that particles are not spherical in nature, particles are like rectangular block. It has been also observed from transmission electron micrograph that particles are of rectangular block types. The annealed sample shows larger particle size compared to the sample prepared at room temperature, which is an input for band gap engineering studies.
采用湿化学法制备了不同摩尔浓度(0.025 M, 0.05 M和0.1 M)和不同温度(RT和473 K)下的铁掺杂氧化锌(Fe:ZnO)纳米颗粒,并通过x射线衍射(XRD)、透射电子显微镜(TEM)技术对纳米颗粒进行了研究。采用Williamson Hall (W-H)法计算了纳米颗粒的晶粒尺寸和晶格应变。用Scherrer公式计算了纳米颗粒的平均粒径。采用均匀变形模型(UDM)、均匀应力变形模型(USDM)和均匀变形能量密度模型(UDEDM)计算试样所涉及的应力、应变和能量密度。我们得到了垂直于不同(hkl)平面的不同粒径的纳米粒子。这说明粒子本质上不是球形的,粒子像矩形块。从透射电子显微照片上也观察到颗粒为矩形块状。与室温下制备的样品相比,退火后的样品显示出更大的粒度,这是带隙工程研究的一个输入。
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引用次数: 1
Synthesis and Characterization of Copper and Boron Codoped TiO2 Nanomaterials for the Photocatalytic Degradation of Methyl Orange Dye 光催化降解甲基橙染料用铜硼共掺杂TiO2纳米材料的合成与表征
Pub Date : 2019-03-25 DOI: 10.30799/JNST.209.19050113
S. A. Alim, T. Rao, M. R. Kumar
{"title":"Synthesis and Characterization of Copper and Boron Codoped TiO2 Nanomaterials for the Photocatalytic Degradation of Methyl Orange Dye","authors":"S. A. Alim, T. Rao, M. R. Kumar","doi":"10.30799/JNST.209.19050113","DOIUrl":"https://doi.org/10.30799/JNST.209.19050113","url":null,"abstract":"","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80053139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Volume 5,Issue 1,2019
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