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The study includes 50 patients with duodenal peptic ulcer who are classified into 2 groups: 1 gr. of 30 patients to whom biopsy was performed twice at a 14 day interval in order to study the reproducibility of the method in relation to the histological diagnosis; II group of 20 patients served for determination of the percentage of full value biopsies suitable for diagnosis. The results showed that the histological diagnosis based on the second examination coincided with the diagnosis from the first examination in 78% of the cases and by the single examination 33% of the biopsies showed gastritis of different severity from the rest. Most of the biopsies were of full value--84%, and the material of 19 mg obtained from mean 10 biopsies to a patient was sufficient. The endoscopic control following the biopsies revealed artificial erosions of incomplete type localized in the corpus and rarely single erosions in the antrum. The difference in the percentage of antral biopsies found by gastroscopy--6% and that found by histological examination--0.6% is a proof for the fundalization of the antral glands. The proposed method for multiple aspiration biopsy is informative, noninvasive and technically easy to perform.

In 24 patients with progressive systemic scleroderma the respiratory disturbances, X-ray, scintigraphic and clinical deviations as well as the statistical correlations between them are described. The functional examination of respiration revealed lowered diffusion capacity, restrictive type of ventilatory failure and hypoxemia as the most frequent disturbances. The functional examination of respiration is correlated with the X-ray changes in the lungs in these patients.

Two clinical cases of women with primary hyperaldosteronism are reported. The patients presented with arterial hypertension, muscular weakness and paresthesia. Severe hypokalemia was found which was resistant to intravenous infusions of potassium but was successfully treated with low daily doses (100-200 mg) of spironolacton, an aldacton antagonist, in the course of 3-4 days. In one of the patients the primary hyperaldosteronism was related to aldosterone secretion by the cells of a malignant corticosteroma, proved histologically. A successful operation led to full recovery of the patient. In the other patient there was an idiopathic form of primary hyper aldosteronism caused by bilateral hyperplasia of the suprarenal cortex. Contemporary diagnostic and therapeutic possibilities in primary hyperaldosteronism as well as the importance of the examination of potassium serum level and kaliuria in the patients with arterial hypertension for the timely and successful diagnosis and treatment of primary hyperaldosteronism are pointed out.

34 patients with chronic ulcerohemorrhagic colitis in exacerbation were treated with hyperbaric oxygenation in addition to the routine therapy. Two chambers model "Dräger" 1000 and 1200 were used. The total course of treatment included 10-12 seances with 60-75 min. exposition each. All patients improved significantly after the first 5-6 seances. The results of the treatment back up the use of hyperbaric oxygenation in the treatment of chronic ulcerohemorrhagic colitis.

In 151 obese patients an oral glucose tolerance test was carried out. In 118 patients (mean relative body mass 161.5 +/- 39%) the test was normal. In 33 patients (mean relative body mass 167 +/- 32.1%) the glucose tolerance was decreased. In these patients the mean duration of the pathologic overmass was 15.2 +/- 4.8 years. 4 basic types of curves of pathologic tolerance are described. Obesity in men is significantly more frequently complicated with pathologic glucose tolerance than in women (42.2% vs 15.5%). The great variety of glucose tolerance curves in the obese patient is probably related to various types of response of the insulin secretion and the contrainsular mechanisms.