Vutreshni bolesti最新文献

In 31 patients with chronic active pyelonephritis and 10 clinically healthy controls the following indices were followed up: the serum level of the endoperoxides and several parameters of humoral and cell immunity (T-lymphocytes, active T-lymphocytes, T-helpers, T-suppressors, B-lymphocytes, NK-cells, immunoglobulins G, A and (M), as well as the lysing activity of the natural killers towards the cell line K-562. The patients with chronic pyelonephritis were classified into two groups: I group--patients examined for serum peroxides in the acute phase of the inflammatory process and II group--patients examined in the subacute phase. A statistically significant differences was found for the serum endoperoxides between the patients form the I group (in the acute phase of the disease) and the healthy controls (respectively) 52.0 +/- 17.3 nmol MDA and 9.0 +/- 6.9 nmol MDA, p less than 0.001). The difference between the patients in the subacute phase and the healthy controls was insignificant (p less than 0.1). No significant deviations were found in the immunologic indices studied. The findings show that the immunologic mechanisms probably do not play a leading role in the pathogenesis of chronic pyelonephritis. The endoperoxides level is an index of the activity of inflammatory process in this disease.

The aim of the study is to find out the optimum time for reading of the rapid bronchodilation inhalatory test with atrovent in asthmatic patients. The changes of the forced vital capacity, the forced expiratory flow for I s and the maximum expiratory flow were followed up in 21 asthmatic patients 15 min after atrovent inhalation and in 10 patients--20 and 30 min after the inhalation. The results showed a minimum bronchodilation response after 15 min which does not give information about the reversibility of the bronchial obstruction in bronchial asthma. A well-expressed bronchodilation, statistically significant, was found 30 min after the inhalation of atrovent.

The plasma cortisol and adrenocorticotrophic hormone (ACTH) levels were studied in 12 patients with clinical, laboratory and ECG data for acute myocardial infarction. The changes were followed up during the 1, 3, 8 and 14 day after the onset of the chest pain attack. Increased ACTH and cortisol levels were established in these patients up to the 5 day. The regulatory principle of action of the opposite relation between these two hormones as well as their 24 hour rhythm were disturbed. These stress-induced hormonal changes should be kept in mind in determining the therapeutic conduct in the patients with acute myocardial infarction.

A case of a 73 years old man with macronodular liver cirrhosis, ascites, jaundice and a primary hepatocellular carcinoma is presented. The patient died suddenly and at the post mortem embolism of the pulmonary artery was found caused by tumor fragments. The tumor had infiltrated the wall and penetrated into the lumen of vena cava inferior.

56 patients, aged from 28 up to 60 years, with ischemic heart disease II-III functional class according to the Canadian classification were treated with the original Hungarian drug Sensit in out-patient conditions. The number of patients with anginal pain fell from 56 to 12 and the overall effect of the Sensit treatment was 84% (47 patients improved). The physical load tolerance significantly increased--from 58.2 to 67.4 W. Sensit influences the pathological ECG changes--ST segment lowering after physical load. It must be emphasized that the effect of the Sensit treatment is seen after a 3 week course of treatment at least. The drug is suitable for an out-patient treatment.

9 patients with postmenopausal and 5 patients with steroid-induced osteoporosis, mean age 57.9 +/- 7.76 years, were treated in the course of one year with sodium fluoride (Fluosen) in a dose of 45 mg/24 h in combination with calcium gluconate (2 g/24 h) and oil solution of vit D2 (2 mg/week). In the course of the treatment a considerable easing of the pains in the most affected parts of the skeleton was found and the height remained at the same level before and after the treatment. This correlates with the statistically significant increase of the serum levels of the total alkaline phosphatase and its bone isoenzyme by keeping a normal kalium phosphorous balance as well as with the x-ray data for retaining the bone changes liked with the osteoporosis.

The fasting carcinoembryonal antigen (CEA) concentrations in the serum and duodenal juice and after venous stimulation of the exocrine pancreas with the hormones CCK and secretin (Boots) were studied. Radioimmunologic test with a kit of the firm "Labimex"--PPR was used. 28 patients with clinically proved chronic pancreatitis and a control group of 27 healthy persons were examined. The fasting CEA serum concentrations in the patients with chronic pancreatitis were statistically significantly higher than those of the healthy persons--mean--16.5 ng/ml vs mean--8.2 ng/ml (p less than 0.001). In 14% of the healthy persons and 57% of of the patients with chronic pancreatitis the basic CEA concentrations were significantly increased. After stimulation with CCK and secretin the serum CEA concentration did not change substantially. The duodenal juice CEA concentrations after CCK and secretin stimulation were about 11 times higher than those in the serum--mean--113 ng/ml and mean--104 ng/ml for the control group vs mean--118 ng/ml and mean--110 ng/ml for the patients with chronic pancreatitis. No statistically significant difference between the patients with chronic pancreatitis and the control group of healthy persons was established. The results reveal the low specificity of the CEA as a "tumor marker".