首页 > 最新文献

Vox Sanguinis最新文献

英文 中文
Artificial intelligence and transfusion education, research and practice: The view from the ISBT Clinical Transfusion Working Party. 人工智能与输血教育、研究与实践:来自ISBT临床输血工作组的观点。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-19 DOI: 10.1111/vox.13793
Arwa Z Al-Riyami, Richard R Gammon, Jansen Seheult, Satyam Arora, Ruchika Goel

Background and objectives: Artificial intelligence (AI) has been gaining increasing interest in healthcare. During the 2024 International Society of Blood Transfusion (ISBT) Congress, the Clinical Transfusion Working Party (CTWP) conducted a session to explore the exciting intersection of AI in transfusion medicine (TM) practice, education and research. We report here the potential applications and the session outcome.

Materials and methods: A pre-workshop survey explored the participants' demographics and areas of use of AI and whether they have had any AI-specific training or education. The workshop included presentations on the regulatory aspects of AI use and its application in TM practice, education and research. These were followed by round-table discussions to explore participants' experience and concerns.

Results: The workshop had 72 attendees, with 38% falling in the 36-45-year age group. A total of 70% indicated the use of AI, but only 12% reported having specific training or education. Participants expressed interest in different potential applications but also shared concerns on over-reliance, potential loss of skills, the accuracy of provided information and content plagiarism.

Conclusion: The findings of the workshop highlight the need for training, educational resources, standards and regulatory frameworks to guide the use of AI tools in the field of TM.

背景和目标:人工智能(AI)在医疗保健领域越来越受到关注。在2024年国际输血学会(ISBT)大会期间,临床输血工作组(CTWP)举办了一场会议,探讨人工智能在输血医学(TM)实践、教育和研究中的令人兴奋的交叉点。我们在这里报告潜在的应用程序和会话结果。材料和方法:研讨会前的一项调查探讨了参与者的人口统计数据和人工智能的使用领域,以及他们是否接受过任何人工智能相关的培训或教育。研讨会包括介绍人工智能使用的监管方面及其在TM实践、教育和研究中的应用。随后是圆桌讨论,探讨与会者的经验和关切。结果:研讨会有72人参加,其中38%的人年龄在36-45岁之间。总共有70%的人表示使用了人工智能,但只有12%的人表示接受过具体的培训或教育。与会者对不同的潜在应用表达了兴趣,但也对过度依赖、潜在的技能流失、所提供信息的准确性和内容抄袭等问题表示担忧。结论:研讨会的研究结果强调了培训、教育资源、标准和监管框架的必要性,以指导人工智能工具在TM领域的使用。
{"title":"Artificial intelligence and transfusion education, research and practice: The view from the ISBT Clinical Transfusion Working Party.","authors":"Arwa Z Al-Riyami, Richard R Gammon, Jansen Seheult, Satyam Arora, Ruchika Goel","doi":"10.1111/vox.13793","DOIUrl":"https://doi.org/10.1111/vox.13793","url":null,"abstract":"<p><strong>Background and objectives: </strong>Artificial intelligence (AI) has been gaining increasing interest in healthcare. During the 2024 International Society of Blood Transfusion (ISBT) Congress, the Clinical Transfusion Working Party (CTWP) conducted a session to explore the exciting intersection of AI in transfusion medicine (TM) practice, education and research. We report here the potential applications and the session outcome.</p><p><strong>Materials and methods: </strong>A pre-workshop survey explored the participants' demographics and areas of use of AI and whether they have had any AI-specific training or education. The workshop included presentations on the regulatory aspects of AI use and its application in TM practice, education and research. These were followed by round-table discussions to explore participants' experience and concerns.</p><p><strong>Results: </strong>The workshop had 72 attendees, with 38% falling in the 36-45-year age group. A total of 70% indicated the use of AI, but only 12% reported having specific training or education. Participants expressed interest in different potential applications but also shared concerns on over-reliance, potential loss of skills, the accuracy of provided information and content plagiarism.</p><p><strong>Conclusion: </strong>The findings of the workshop highlight the need for training, educational resources, standards and regulatory frameworks to guide the use of AI tools in the field of TM.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transfusion efficacy of leucoreduced packed red blood cells prepared by two different methods: A randomized controlled trial in transfusion-dependent thalassaemia patients (FUEL trial). 两种不同方法制备的低白细胞填充红细胞的输血疗效:一项输血依赖性地中海贫血患者的随机对照试验(FUEL试验)。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-16 DOI: 10.1111/vox.13797
Adhikarimayum Arunkumari, Ashish Jain, Sheetal Malhotra, Hari Krishan Dhawan, Srinivasan Peyam, Sangeeta Kumari, Ratti Ram Sharma

Background and objectives: Great variations may be observed in the haemoglobin (Hb) content of packed red blood cell (PRBC) units prepared by different methods. This study aimed to assess the Hb increment in thalassaemia major patients transfused with leucoreduced PRBCs (LPRBCs) prepared by two different methods: (i) standard leucoreduced PRBCs (SLPRBCs) and (ii) leucoreduced PRBCs prepared by a new method where leucoreduction of whole blood is done first (NLPRBCs).

Materials and methods: This prospective, randomized, controlled trial included 80 adult thalassaemia major patients who were randomized into two groups of 40 each. Group I patients received SLPRBC and those of Group II received NLPRBC transfusions for 3 months.

Results: SLPRBCs had a mean (±SD) volume of 275.50 ± 17.07 mL, while it was 316.46 ± 1.42 mL for NLPRBCs (p < 0.001). The mean Hb content of SLPRBCs was 50.60 ± 5.12 g, while that of NLPRBCs was 56.98 ± 5.92 g (p < 0.001). The mean Hb increment in Group I patients was 2.11 ± 0.89 g/dL, while that of Group II patients was 2.48 ± 0.88 g/dL (p < 0.001). The mean transfusion interval for Group I patients was 20.30 ± 3.75 days, while it was 21.34 ± 5.13 days for Group II patients (p < 0.045). A significant positive correlation was observed between the Hb dose transfused and the Hb increment with both SLPRBC (ρ = 0.4, p < 0.001) and NLPRBC (ρ = 0.19, p = 0.011) transfusions.

Conclusion: NLPRBCs had significantly higher Hb content than the SLPRBCs, leading to a better Hb increment post transfusion, which may potentially prolong the transfusion interval in thalassaemia major patients.

背景和目的:不同方法制备的填充红细胞(PRBC)单位的血红蛋白(Hb)含量可能存在很大差异。本研究旨在评估地中海贫血重症患者输注经两种不同方法制备的降白细胞(lprbc)后的Hb增加情况:(i)标准降白细胞(slprbc)和(ii)先进行全血降白细胞的新方法制备的降白细胞(nlprbc)。材料与方法:本前瞻性、随机、对照试验纳入80例成年地中海贫血重症患者,随机分为两组,每组40例。第一组患者接受SLPRBC输注,第二组患者接受NLPRBC输注,输注时间为3个月。结果:slprbc的平均(±SD)体积为275.50±17.07 mL, nlprbc的平均(±SD)体积为316.46±1.42 mL (p)结论:nlprbc的Hb含量明显高于slprbc,导致输血后Hb增量更好,可能延长地中海贫血重症患者的输血间隔时间。
{"title":"Transfusion efficacy of leucoreduced packed red blood cells prepared by two different methods: A randomized controlled trial in transfusion-dependent thalassaemia patients (FUEL trial).","authors":"Adhikarimayum Arunkumari, Ashish Jain, Sheetal Malhotra, Hari Krishan Dhawan, Srinivasan Peyam, Sangeeta Kumari, Ratti Ram Sharma","doi":"10.1111/vox.13797","DOIUrl":"https://doi.org/10.1111/vox.13797","url":null,"abstract":"<p><strong>Background and objectives: </strong>Great variations may be observed in the haemoglobin (Hb) content of packed red blood cell (PRBC) units prepared by different methods. This study aimed to assess the Hb increment in thalassaemia major patients transfused with leucoreduced PRBCs (LPRBCs) prepared by two different methods: (i) standard leucoreduced PRBCs (SLPRBCs) and (ii) leucoreduced PRBCs prepared by a new method where leucoreduction of whole blood is done first (NLPRBCs).</p><p><strong>Materials and methods: </strong>This prospective, randomized, controlled trial included 80 adult thalassaemia major patients who were randomized into two groups of 40 each. Group I patients received SLPRBC and those of Group II received NLPRBC transfusions for 3 months.</p><p><strong>Results: </strong>SLPRBCs had a mean (±SD) volume of 275.50 ± 17.07 mL, while it was 316.46 ± 1.42 mL for NLPRBCs (p < 0.001). The mean Hb content of SLPRBCs was 50.60 ± 5.12 g, while that of NLPRBCs was 56.98 ± 5.92 g (p < 0.001). The mean Hb increment in Group I patients was 2.11 ± 0.89 g/dL, while that of Group II patients was 2.48 ± 0.88 g/dL (p < 0.001). The mean transfusion interval for Group I patients was 20.30 ± 3.75 days, while it was 21.34 ± 5.13 days for Group II patients (p < 0.045). A significant positive correlation was observed between the Hb dose transfused and the Hb increment with both SLPRBC (ρ = 0.4, p < 0.001) and NLPRBC (ρ = 0.19, p = 0.011) transfusions.</p><p><strong>Conclusion: </strong>NLPRBCs had significantly higher Hb content than the SLPRBCs, leading to a better Hb increment post transfusion, which may potentially prolong the transfusion interval in thalassaemia major patients.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Notification of blood donors who test positive for transfusion-transmissible infections. 通知输血传播感染检测呈阳性的献血者。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-14 DOI: 10.1111/vox.13796
Sheila F O'Brien, Kiyuri Naicker, Lori Osmond, Kelly Holloway, Steven J Drews, Mark Bigham, Mindy Goldman

Background and objectives: Despite screening procedures, a few blood donors confirm positive for transfusion-transmissible infections and are deferred. Effective notification of laboratory results is essential to ensure that donors are advised of confirmed results and to seek medical care. Here we report results from post-notification interviews of Canadian Blood Services donors.

Materials and methods: Over 17 years, 2006-2022, all donors with confirmed positive results for hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell lymphotropic virus (HTLV) and syphilis were notified by registered mail of their result and advised to see a physician. In a separate communication, all donors were later invited to participate in a scripted interview asking whether they tested positive for an infection; if yes, which one, what their reaction was, whether they consulted a physician and whether public health contacted them. Frequencies of responses were calculated.

Results: Of 2654 donors with confirmed positive test results, 876 (33%) participated; 90% said they were informed of a positive test result. Of these, about a quarter did not know for which infection they were positive. Most were surprised, and some were sad or disappointed. Most saw a physician after notification (77%). About two-thirds with HBV or HCV said they were contacted by public health, slightly fewer (58%) with syphilis, 27% of those with HTLV.

Conclusion: Most donors recalled being notified and were aware of their positive test, but details of the infection were sometimes not understood or recalled, and not all donors consulted a physician about the infection.

背景和目的:尽管有筛查程序,但少数献血者确认输血传播感染呈阳性并被推迟。有效通知化验结果对于确保将确认结果告知捐赠者并寻求医疗护理至关重要。在这里,我们报告从通知后采访加拿大血液服务献血者的结果。材料和方法:在2006-2022年的17年中,所有乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、人t细胞嗜淋巴病毒(HTLV)和梅毒确诊阳性的献血者都通过挂号邮件通知结果,并建议他们去看医生。在另一份单独的通讯中,所有捐赠者随后都被邀请参加一次事先安排好的采访,询问他们是否被检测出感染呈阳性;如果是,是哪一个,他们的反应是什么,他们是否咨询了医生,公共卫生部门是否联系了他们。计算反应频率。结果:在2654例检测结果确认阳性的献血者中,876例(33%)参与;90%的人表示他们被告知检测结果呈阳性。其中,大约四分之一的人不知道自己是哪种感染的阳性。大多数人感到惊讶,有些人感到悲伤或失望。大多数人在接到通知后去看医生(77%)。大约三分之二的乙肝病毒或丙肝病毒感染者表示,公共卫生部门与他们有过接触,梅毒感染者略少(58%),乙型肝炎病毒感染者为27%。结论:大多数献血者回忆说,他们收到了通知,知道自己的检测结果呈阳性,但感染的细节有时不清楚或回忆不起来,并非所有献血者都就感染咨询过医生。
{"title":"Notification of blood donors who test positive for transfusion-transmissible infections.","authors":"Sheila F O'Brien, Kiyuri Naicker, Lori Osmond, Kelly Holloway, Steven J Drews, Mark Bigham, Mindy Goldman","doi":"10.1111/vox.13796","DOIUrl":"https://doi.org/10.1111/vox.13796","url":null,"abstract":"<p><strong>Background and objectives: </strong>Despite screening procedures, a few blood donors confirm positive for transfusion-transmissible infections and are deferred. Effective notification of laboratory results is essential to ensure that donors are advised of confirmed results and to seek medical care. Here we report results from post-notification interviews of Canadian Blood Services donors.</p><p><strong>Materials and methods: </strong>Over 17 years, 2006-2022, all donors with confirmed positive results for hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell lymphotropic virus (HTLV) and syphilis were notified by registered mail of their result and advised to see a physician. In a separate communication, all donors were later invited to participate in a scripted interview asking whether they tested positive for an infection; if yes, which one, what their reaction was, whether they consulted a physician and whether public health contacted them. Frequencies of responses were calculated.</p><p><strong>Results: </strong>Of 2654 donors with confirmed positive test results, 876 (33%) participated; 90% said they were informed of a positive test result. Of these, about a quarter did not know for which infection they were positive. Most were surprised, and some were sad or disappointed. Most saw a physician after notification (77%). About two-thirds with HBV or HCV said they were contacted by public health, slightly fewer (58%) with syphilis, 27% of those with HTLV.</p><p><strong>Conclusion: </strong>Most donors recalled being notified and were aware of their positive test, but details of the infection were sometimes not understood or recalled, and not all donors consulted a physician about the infection.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engaging with young professionals in transfusion medicine: Insights from a needs assessment survey targeting an international cohort. 与输血医学中的年轻专业人员接触:来自针对国际队列的需求评估调查的见解。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-12 DOI: 10.1111/vox.13783
Eunike C McGowan, Antoine Lewin, Jian Ou-Yang, Saikat Mandal, Nour Almozain, Abiy Belay Ambaye, Jannison Karlly Cavalcante Ribeiro, Lilian Antwi Boateng, Carla Luana Dinardo, Praiseldy Langi Sasongko

Background and objectives: Professionals who work or study in transfusion medicine under 40 years of age are considered young professionals (YPs) by the International Society of Blood Transfusion (ISBT). While the ISBT provides opportunities for YPs, their needs have to be assessed to customize initiatives in a way that could potentially improve their engagement. This survey aimed to assess the needs of YPs in transfusion medicine and understand their perspectives on future ISBT initiatives.

Materials and methods: Between January and February 2023, a 28-question online survey was accessible through a generalized link across the ISBT network. Skip-logic responses from 352 YPs, including 151 ISBT members and 201 non-members, were analysed. Each question varied in the number of responders and, consequently, the number of responses.

Results: Firstly, the most important needs of YPs from the survey were educational opportunities and training programmes, with 70% of respondents indicating for educational content in specific fields of transfusion. Secondly, Transfusion Today published by the ISBT (46.9%) ranked the highest in engagement, while ISBT Academy and Academy funding ranked the lowest (12.8%). ISBT members reported attending ISBT activities or using ISBT resources more often than non-members, although this was not statistically significant. The primary barrier preventing both non-members and ISBT members from engaging in ISBT activities was a lack of awareness.

Conclusion: Raising awareness on a regular basis, a customized communication style (e.g., by a representative or different languages) and activities for non-members may be key to improving YP engagement and expanding the ISBT network.

背景和目的:40岁以下从事输血医学工作或学习的专业人员被国际输血学会(ISBT)视为年轻专业人员(YPs)。虽然ISBT为yp提供了机会,但必须评估他们的需求,以便以一种可能提高他们参与度的方式定制计划。本调查旨在评估YPs在输血医学中的需求,并了解他们对未来ISBT倡议的看法。材料和方法:在2023年1月至2月期间,通过ISBT网络的通用链接可访问28个问题的在线调查。分析了352个yp的跳过逻辑反应,其中包括151个ISBT成员和201个非成员。每个问题的回答人数各不相同,因此,回答的数量也各不相同。结果:首先,从调查来看,YPs最重要的需求是教育机会和培训计划,70%的受访者表示需要输血特定领域的教育内容。其次,ISBT出版的《今日输血》(46.9%)在参与度方面排名最高,而ISBT学院和学院资助排名最低(12.8%)。ISBT成员报告参加ISBT活动或使用ISBT资源的频率高于非成员,尽管这在统计上并不显著。阻碍非成员和ISBT成员参与ISBT活动的主要障碍是缺乏意识。结论:定期提高意识,定制沟通方式(例如,由代表或不同的语言)和针对非会员的活动可能是提高YP参与度和扩大ISBT网络的关键。
{"title":"Engaging with young professionals in transfusion medicine: Insights from a needs assessment survey targeting an international cohort.","authors":"Eunike C McGowan, Antoine Lewin, Jian Ou-Yang, Saikat Mandal, Nour Almozain, Abiy Belay Ambaye, Jannison Karlly Cavalcante Ribeiro, Lilian Antwi Boateng, Carla Luana Dinardo, Praiseldy Langi Sasongko","doi":"10.1111/vox.13783","DOIUrl":"https://doi.org/10.1111/vox.13783","url":null,"abstract":"<p><strong>Background and objectives: </strong>Professionals who work or study in transfusion medicine under 40 years of age are considered young professionals (YPs) by the International Society of Blood Transfusion (ISBT). While the ISBT provides opportunities for YPs, their needs have to be assessed to customize initiatives in a way that could potentially improve their engagement. This survey aimed to assess the needs of YPs in transfusion medicine and understand their perspectives on future ISBT initiatives.</p><p><strong>Materials and methods: </strong>Between January and February 2023, a 28-question online survey was accessible through a generalized link across the ISBT network. Skip-logic responses from 352 YPs, including 151 ISBT members and 201 non-members, were analysed. Each question varied in the number of responders and, consequently, the number of responses.</p><p><strong>Results: </strong>Firstly, the most important needs of YPs from the survey were educational opportunities and training programmes, with 70% of respondents indicating for educational content in specific fields of transfusion. Secondly, Transfusion Today published by the ISBT (46.9%) ranked the highest in engagement, while ISBT Academy and Academy funding ranked the lowest (12.8%). ISBT members reported attending ISBT activities or using ISBT resources more often than non-members, although this was not statistically significant. The primary barrier preventing both non-members and ISBT members from engaging in ISBT activities was a lack of awareness.</p><p><strong>Conclusion: </strong>Raising awareness on a regular basis, a customized communication style (e.g., by a representative or different languages) and activities for non-members may be key to improving YP engagement and expanding the ISBT network.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the impact of mitochondrial DNA: Insights into blood transfusion reactions and mitigation strategies. 调查线粒体DNA的影响:对输血反应和缓解策略的见解。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-08 DOI: 10.1111/vox.13794
Saeede Bagheri, Fatemeh Hajiabadi, Reihaneh Vahabzadeh, Mohammad Hossein Ahmadi

Background and objectives: Although transfusion reactions occur in less than 2% of recipients, they are currently one of the most serious concerns in blood transfusion. Damage-associated molecular patterns (DAMPs) are released from injured, stressed or dead cells, leading to inflammation and immune system activation. One of the recognized DAMPs is mitochondrial DNA (mtDNA). It is found in various blood products, including fresh frozen plasma (FFP), red blood cell units (RBCUs) and platelet concentrates (PCs), and can induce adverse reactions in recipients by stimulating the innate immune system and inflammatory cellular pathways. The aim of this study was to investigate the factors influencing the release of mtDNA in various blood products and its subsequent impact on transfusion reactions.

Materials and methods: In this study, mtDNA, mitochondrial DNA, mtDNA DAMPs, extracellular mtDNA, blood products, blood components and transfusion reactions between 2009 and 2023 were searched in Google Scholar, PubMed and Scopus databases.

Results: This study has demonstrated the presence of mtDNA in the extracellular milieu of various blood products, including PCs, FFP and RBCUs. Understanding the determinants of mtDNA release and its implications for transfusion safety is critical. Strategies aimed at reducing mtDNA release, such as optimizing preparation techniques and donor selection criteria, hold promise for reducing transfusion-related complications.

Conclusion: By addressing these factors, healthcare providers can enhance the safety and efficacy of blood transfusion practices, ultimately improving patient outcomes.

背景和目的:虽然输血反应发生在不到2%的受血者中,但它们目前是输血中最严重的问题之一。损伤相关分子模式(DAMPs)从受伤、应激或死亡的细胞中释放出来,导致炎症和免疫系统激活。其中一个公认的DAMPs是线粒体DNA (mtDNA)。它存在于各种血液制品中,包括新鲜冷冻血浆(FFP)、红细胞单位(rbcu)和血小板浓缩物(PCs),并可通过刺激先天免疫系统和炎症细胞途径诱导受体的不良反应。本研究的目的是探讨各种血液制品中mtDNA释放的影响因素及其对输血反应的影响。材料与方法:本研究在谷歌Scholar、PubMed和Scopus数据库中检索2009 - 2023年间的mtDNA、线粒体DNA、mtDNA DAMPs、细胞外mtDNA、血液制品、血液成分和输血反应。结果:本研究证实mtDNA存在于多种血液制品的细胞外环境中,包括pc、FFP和rbcu。了解mtDNA释放的决定因素及其对输血安全的影响至关重要。旨在减少mtDNA释放的策略,如优化制备技术和供体选择标准,有望减少输血相关并发症。结论:通过解决这些因素,医疗保健提供者可以提高输血实践的安全性和有效性,最终改善患者的预后。
{"title":"Investigating the impact of mitochondrial DNA: Insights into blood transfusion reactions and mitigation strategies.","authors":"Saeede Bagheri, Fatemeh Hajiabadi, Reihaneh Vahabzadeh, Mohammad Hossein Ahmadi","doi":"10.1111/vox.13794","DOIUrl":"https://doi.org/10.1111/vox.13794","url":null,"abstract":"<p><strong>Background and objectives: </strong>Although transfusion reactions occur in less than 2% of recipients, they are currently one of the most serious concerns in blood transfusion. Damage-associated molecular patterns (DAMPs) are released from injured, stressed or dead cells, leading to inflammation and immune system activation. One of the recognized DAMPs is mitochondrial DNA (mtDNA). It is found in various blood products, including fresh frozen plasma (FFP), red blood cell units (RBCUs) and platelet concentrates (PCs), and can induce adverse reactions in recipients by stimulating the innate immune system and inflammatory cellular pathways. The aim of this study was to investigate the factors influencing the release of mtDNA in various blood products and its subsequent impact on transfusion reactions.</p><p><strong>Materials and methods: </strong>In this study, mtDNA, mitochondrial DNA, mtDNA DAMPs, extracellular mtDNA, blood products, blood components and transfusion reactions between 2009 and 2023 were searched in Google Scholar, PubMed and Scopus databases.</p><p><strong>Results: </strong>This study has demonstrated the presence of mtDNA in the extracellular milieu of various blood products, including PCs, FFP and RBCUs. Understanding the determinants of mtDNA release and its implications for transfusion safety is critical. Strategies aimed at reducing mtDNA release, such as optimizing preparation techniques and donor selection criteria, hold promise for reducing transfusion-related complications.</p><p><strong>Conclusion: </strong>By addressing these factors, healthcare providers can enhance the safety and efficacy of blood transfusion practices, ultimately improving patient outcomes.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International Forum on Genotyping of Blood Antigens in Donors: Responses. 献血者血液抗原基因分型国际论坛:反应。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-07 DOI: 10.1111/vox.13791
Jennie Haw, Kelly Holloway, Gwen Clarke, Galit Eliyahu Nuni, Liora Muncher, James Daly, Jacqui Martin, Klaus Rieneck, Morten H Dziegiel, Cinzia Paccapelo, Luisa Ronzoni, Diarmaid O'Donghaile, Helen Ryan, Celina Montemayor Garcia, Cheuk-Kwong Lee, Wai-Chiu Tsoi, Hironori Kobayashi, Hiroyuki Igarashi, Tuulia Palukka, Katri Haimila, Nuria Nogues, Cecilia Gonzalez-Santesteban, Aaron J Gottschalk, Åsa Hellberg, Martin L Olsson, Thierry Peyrard, Ute Jentsch, Ai Leen Ang, Chew Yen Phang, Lorna Wall, Dhana Gounder, Nancy Dunbar
{"title":"International Forum on Genotyping of Blood Antigens in Donors: Responses.","authors":"Jennie Haw, Kelly Holloway, Gwen Clarke, Galit Eliyahu Nuni, Liora Muncher, James Daly, Jacqui Martin, Klaus Rieneck, Morten H Dziegiel, Cinzia Paccapelo, Luisa Ronzoni, Diarmaid O'Donghaile, Helen Ryan, Celina Montemayor Garcia, Cheuk-Kwong Lee, Wai-Chiu Tsoi, Hironori Kobayashi, Hiroyuki Igarashi, Tuulia Palukka, Katri Haimila, Nuria Nogues, Cecilia Gonzalez-Santesteban, Aaron J Gottschalk, Åsa Hellberg, Martin L Olsson, Thierry Peyrard, Ute Jentsch, Ai Leen Ang, Chew Yen Phang, Lorna Wall, Dhana Gounder, Nancy Dunbar","doi":"10.1111/vox.13791","DOIUrl":"https://doi.org/10.1111/vox.13791","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing reagents and techniques for identifying RhCE variants in routine serological testing. 评估常规血清学检测中识别RhCE变异的试剂和技术。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-07 DOI: 10.1111/vox.13792
Tatiane Aparecida de Paula Vendrame, Carine Prisco Arnoni, Giovana Faria Devides, Nayara Moraes Silva, Afonso José Pereira Cortez, Flavia Roche Moreira Latini, Lilian Castilho

Background and objectives: Identifying RhCE variants is essential to prevent alloimmunization and manage complex cases. Unfortunately, these variants are often only detected after antibody formation, as they may go unnoticed in serological tests. This study aimed to assess monoclonal antisera using various methodologies to define the reactivity patterns of some variants by variable expression of RhCE antigens.

Materials and methods: Samples were chosen based on atypical reactivity on routine RhCE typing of donors, screening of Afro-descendant donors using tube testing and patient samples with antibodies against their own antigens. All 53 samples were tested using tube, gel and microplate tests with five antisera. Antigen expression was assessed by flow cytometry, and RhCE variants were molecularly classified.

Results: Tube test screening of African descent donors proved more effective in identifying a broad range of weak or partial antigens, particularly when using anti-e composed of MS-21, MS-16, MS63 clones and anti-c from the MS8011531019 clone. Automated instrument phenotyping successfully identified samples with RHCE*ceJAL allele, while most other variants were detected as positive (4+), similar to gel test, which intensified most reactions. When comparing methods and antisera for detecting variant e antigens, tube test identified a higher percentage of weak samples (63%-77%) compared with microplate (35%) and gel tests (14%).

Conclusion: The results highlight the critical role of tube test in serological routines and the need to select clones capable of identifying RhCE variants. Detecting reduced RhCE antigen expression during routine serological testing can guide further molecular investigations and help prevent Rh alloimmunization.

背景和目的:识别RhCE变异对于预防同种异体免疫和处理复杂病例至关重要。不幸的是,这些变异通常只能在抗体形成后检测到,因为它们可能在血清学测试中被忽视。本研究旨在评估单克隆抗血清,使用各种方法来定义一些变体的反应模式,通过RhCE抗原的可变表达。材料和方法:根据献血者常规RhCE分型非典型反应性、非裔献血者试管检测和患者自身抗原抗体选择样本。所有53份样本均采用5种抗血清进行试管、凝胶和微孔板检测。通过流式细胞术评估抗原表达,并对RhCE变异进行分子分类。结果:非洲人后裔供体的试管试验筛选证明在识别大范围的弱抗原或部分抗原方面更有效,特别是当使用由MS-21、MS-16、MS63克隆和MS8011531019克隆的抗-c组成的抗-e时。自动化仪器表型分析成功地鉴定出含有RHCE*ceJAL等位基因的样品,而大多数其他变异检测为阳性(4+),类似于凝胶试验,这加剧了大多数反应。在比较检测变异e抗原的方法和抗血清时,试管试验鉴定出的弱样本比例(63%-77%)高于微孔板试验(35%)和凝胶试验(14%)。结论:该结果强调了试管试验在血清学常规中的重要作用,以及选择能够识别RhCE变异的克隆的必要性。在常规血清学检测中检测RhCE抗原表达降低可以指导进一步的分子调查,并有助于预防Rh同种异体免疫。
{"title":"Assessing reagents and techniques for identifying RhCE variants in routine serological testing.","authors":"Tatiane Aparecida de Paula Vendrame, Carine Prisco Arnoni, Giovana Faria Devides, Nayara Moraes Silva, Afonso José Pereira Cortez, Flavia Roche Moreira Latini, Lilian Castilho","doi":"10.1111/vox.13792","DOIUrl":"https://doi.org/10.1111/vox.13792","url":null,"abstract":"<p><strong>Background and objectives: </strong>Identifying RhCE variants is essential to prevent alloimmunization and manage complex cases. Unfortunately, these variants are often only detected after antibody formation, as they may go unnoticed in serological tests. This study aimed to assess monoclonal antisera using various methodologies to define the reactivity patterns of some variants by variable expression of RhCE antigens.</p><p><strong>Materials and methods: </strong>Samples were chosen based on atypical reactivity on routine RhCE typing of donors, screening of Afro-descendant donors using tube testing and patient samples with antibodies against their own antigens. All 53 samples were tested using tube, gel and microplate tests with five antisera. Antigen expression was assessed by flow cytometry, and RhCE variants were molecularly classified.</p><p><strong>Results: </strong>Tube test screening of African descent donors proved more effective in identifying a broad range of weak or partial antigens, particularly when using anti-e composed of MS-21, MS-16, MS63 clones and anti-c from the MS8011531019 clone. Automated instrument phenotyping successfully identified samples with RHCE*ceJAL allele, while most other variants were detected as positive (4+), similar to gel test, which intensified most reactions. When comparing methods and antisera for detecting variant e antigens, tube test identified a higher percentage of weak samples (63%-77%) compared with microplate (35%) and gel tests (14%).</p><p><strong>Conclusion: </strong>The results highlight the critical role of tube test in serological routines and the need to select clones capable of identifying RhCE variants. Detecting reduced RhCE antigen expression during routine serological testing can guide further molecular investigations and help prevent Rh alloimmunization.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International Forum on Genotyping of Blood Antigens in Donors: Summary. 献血者血液抗原基因分型国际论坛:综述。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-07 DOI: 10.1111/vox.13790
Jennie Haw, Kelly Holloway, Gwen Clarke, Galit Eliyahu Nuni, Liora Muncher, James Daly, Jacqui Martin, Klaus Rieneck, Morten H Dziegiel, Cinzia Paccapelo, Luisa Ronzoni, Diarmaid O'Donghaile, Helen Ryan, Celina Montemayor Garcia, Cheuk-Kwong Lee, Wai-Chiu Tsoi, Hironori Kobayashi, Hiroyuki Igarashi, Tuulia Palukka, Katri Haimila, Nuria Nogues, Cecilia Gonzalez-Santesteban, Aaron J Gottschalk, Åsa Hellberg, Martin L Olsson, Thierry Peyrard, Ute Jentsch, Ai Leen Ang, Chew Yen Phang, Lorna Wall, Dhana Gounder, Nancy Dunbar
{"title":"International Forum on Genotyping of Blood Antigens in Donors: Summary.","authors":"Jennie Haw, Kelly Holloway, Gwen Clarke, Galit Eliyahu Nuni, Liora Muncher, James Daly, Jacqui Martin, Klaus Rieneck, Morten H Dziegiel, Cinzia Paccapelo, Luisa Ronzoni, Diarmaid O'Donghaile, Helen Ryan, Celina Montemayor Garcia, Cheuk-Kwong Lee, Wai-Chiu Tsoi, Hironori Kobayashi, Hiroyuki Igarashi, Tuulia Palukka, Katri Haimila, Nuria Nogues, Cecilia Gonzalez-Santesteban, Aaron J Gottschalk, Åsa Hellberg, Martin L Olsson, Thierry Peyrard, Ute Jentsch, Ai Leen Ang, Chew Yen Phang, Lorna Wall, Dhana Gounder, Nancy Dunbar","doi":"10.1111/vox.13790","DOIUrl":"https://doi.org/10.1111/vox.13790","url":null,"abstract":"","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between blood test results and vasovagal reactions: An intra-individual comparative retrospective analysis of blood donor data in Japan. 血液检查结果与血管迷走神经反应之间的关系:日本献血者数据的个体内比较回顾性分析。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-02 DOI: 10.1111/vox.13787
Taeko Chijiiwa, Akie Hirata, Tasuku Okui, Junko Iwasaki, Naoki Nakashima, Midori Kumagawa

Background and objectives: To determine whether intra-individual differences in pre-donation blood test results were associated with vasovagal reactions (VVRs).

Materials and methods: The study included donors who voluntarily donated 400 mL of whole blood at least twice during a 5-year blood collection period of the Japanese Red Cross, including both donations with and without a VVR. A conditional logistic regression analysis by age group and sex was conducted, using each donor as a stratum, together with an analysis of deviance to test the significance of including an interaction term between age group and blood data in the regression model.

Results: A total of 1873 donors were included in the analysis. Haemoglobin, haematocrit, total protein and albumin values prior to donation were higher when a VVR was observed than when it was not for each age group and sex. The regression analysis showed significant positive associations between each of these blood parameters and VVR in all combinations of age groups and sex. A particularly strong positive association between haemoglobin and VVRs is seen in women aged ≥50 years (odds ratio, OR [95% confidence interval, CI]: 1.844 [1.457, 2.333]).

Conclusion: Haemoglobin, haematocrit, total protein and albumin levels within individual donors were significantly higher at donation with a VVR. This was most notable in women aged ≥50 years. Comparing the pre-donation haemoglobin value with past values in the same donor at the donation site would help raise awareness of the risk of VVRs.

背景和目的:确定献血前血液检查结果的个体差异是否与血管迷走神经反应(VVRs)相关。材料与方法:研究对象为在日本红十字会5年采血期间至少两次自愿捐献400ml全血的献血者,包括带和不带VVR的献血者。以每个献血者为层,按年龄和性别进行条件logistic回归分析,并进行偏差分析,以检验回归模型中加入年龄和血液数据之间的交互项的显著性。结果:共有1873名献血者被纳入分析。捐献前的血红蛋白、红细胞压积、总蛋白和白蛋白值在观察VVR时均高于未观察VVR时。回归分析显示,在所有年龄组和性别组合中,这些血液参数与VVR之间存在显著的正相关。在≥50岁的女性中,血红蛋白和vvr之间存在特别强的正相关(优势比OR[95%可信区间,CI]: 1.844[1.457, 2.333])。结论:单个献血者的血红蛋白、红细胞压积、总蛋白和白蛋白水平明显高于VVR献血者。这在年龄≥50岁的女性中最为显著。将捐献前的血红蛋白值与捐献地点同一献血者过去的值进行比较,将有助于提高对vvr风险的认识。
{"title":"The relationship between blood test results and vasovagal reactions: An intra-individual comparative retrospective analysis of blood donor data in Japan.","authors":"Taeko Chijiiwa, Akie Hirata, Tasuku Okui, Junko Iwasaki, Naoki Nakashima, Midori Kumagawa","doi":"10.1111/vox.13787","DOIUrl":"https://doi.org/10.1111/vox.13787","url":null,"abstract":"<p><strong>Background and objectives: </strong>To determine whether intra-individual differences in pre-donation blood test results were associated with vasovagal reactions (VVRs).</p><p><strong>Materials and methods: </strong>The study included donors who voluntarily donated 400 mL of whole blood at least twice during a 5-year blood collection period of the Japanese Red Cross, including both donations with and without a VVR. A conditional logistic regression analysis by age group and sex was conducted, using each donor as a stratum, together with an analysis of deviance to test the significance of including an interaction term between age group and blood data in the regression model.</p><p><strong>Results: </strong>A total of 1873 donors were included in the analysis. Haemoglobin, haematocrit, total protein and albumin values prior to donation were higher when a VVR was observed than when it was not for each age group and sex. The regression analysis showed significant positive associations between each of these blood parameters and VVR in all combinations of age groups and sex. A particularly strong positive association between haemoglobin and VVRs is seen in women aged ≥50 years (odds ratio, OR [95% confidence interval, CI]: 1.844 [1.457, 2.333]).</p><p><strong>Conclusion: </strong>Haemoglobin, haematocrit, total protein and albumin levels within individual donors were significantly higher at donation with a VVR. This was most notable in women aged ≥50 years. Comparing the pre-donation haemoglobin value with past values in the same donor at the donation site would help raise awareness of the risk of VVRs.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community screening for iron deficiency in reproductive aged women: Lessons learnt from Australia. 育龄妇女铁缺乏症社区筛查:澳大利亚的经验教训。
IF 1.8 4区 医学 Q3 HEMATOLOGY Pub Date : 2025-01-01 Epub Date: 2024-10-13 DOI: 10.1111/vox.13750
Beth MacLean, Jayne Lim, Jess Fuller, Riki Wylie, Judie Yeleen Joo, Annas Al-Sharea, Jaahnavi Cheyyur, Henry Ng, Sijing Zhang, Mubashshira Ahmed, Cory Dugan, Toby Richards

Background and objectives: Reproductive-aged women are at an increased risk of developing iron deficiency (ID). We aimed to develop a non-invasive screening tool to identify ID in women and assess the acceptability of screening.

Study design and methods: We screened women (age 18-49 years) in the community of Western Australia.

Primary outcome: acceptability of screening, assessed by the feasibility of recruiting the required sample size (n = 323).

Secondary outcomes: Hand grip strength, finger prick haemoglobin concentration (Hb), prevalence of heavy menstrual bleeding (HMB), diet, pregnancy history, blood donation, symptoms of ID and history of ID or anaemia (Hb < 120 g/L). Those with Hb <130 g/L and no history of iron therapy in the past 2 years were given referrals for venous full blood count and ferritin sampling.

Results: Across 5 days, we recruited 640 eligible women. Of which, 178 (28%) had HMB and 79 (12%) were anaemic. Mean age was 33.5 ± 9.2 years, and mean Hb was 132.4 ± 11.9 g/L. In the past 2 years: 335 (52%) were diagnosed with ID or anaemia; 322 (50%) had taken oral iron; and 210 (33%) had an intravenous iron infusion. Vegetarian diets were followed by 89 (14%); 40 (6%) were regular blood donors; 290 (45%) had a previous pregnancy. HMB increased the risk of symptoms of ID and having prior ID/anaemia diagnosis (67% vs. 47%) or treatment (p < 0.022). Hand grip strength showed a positive relationship with both Hb (adjusted R2 = 0.012, p = 0.004) and ferritin (adjusted R2 = 0.135, p = 0.005).

Conclusion: ID screening was well accepted by women in the community, with high recruitment rates over a short period. Future screening tool development may consider incorporating hand grip strength and HMB assessment.

背景和目的:育龄妇女患缺铁症(ID)的风险较高。我们旨在开发一种非侵入性筛查工具,以识别女性体内的缺铁性贫血,并评估筛查的可接受性:主要结果:筛查的可接受性,通过招募所需样本量(n = 323)的可行性进行评估:次要结果:手部握力、指刺血红蛋白浓度(Hb)、月经过多(HMB)、饮食、妊娠史、献血、ID 症状、ID 或贫血史(Hb 结果:我们在 5 天内招募了 640 名符合条件的妇女。其中,178 人(28%)患有 HMB,79 人(12%)贫血。平均年龄为 33.5 ± 9.2 岁,平均血红蛋白为 132.4 ± 11.9 克/升。在过去两年中335人(52%)被诊断患有ID或贫血症;322人(50%)曾口服铁剂;210人(33%)曾静脉输注铁剂。89人(14%)素食;40人(6%)定期献血;290人(45%)曾怀孕。HMB会增加出现ID症状、曾被诊断出ID/贫血(67%对47%)或接受治疗(P 2 = 0.012,P = 0.004)和铁蛋白(调整后R2 = 0.135,P = 0.005)的风险:社区妇女对 ID 筛查的接受度很高,短时间内的招募率也很高。未来筛查工具的开发可考虑纳入手部握力和 HMB 评估。
{"title":"Community screening for iron deficiency in reproductive aged women: Lessons learnt from Australia.","authors":"Beth MacLean, Jayne Lim, Jess Fuller, Riki Wylie, Judie Yeleen Joo, Annas Al-Sharea, Jaahnavi Cheyyur, Henry Ng, Sijing Zhang, Mubashshira Ahmed, Cory Dugan, Toby Richards","doi":"10.1111/vox.13750","DOIUrl":"10.1111/vox.13750","url":null,"abstract":"<p><strong>Background and objectives: </strong>Reproductive-aged women are at an increased risk of developing iron deficiency (ID). We aimed to develop a non-invasive screening tool to identify ID in women and assess the acceptability of screening.</p><p><strong>Study design and methods: </strong>We screened women (age 18-49 years) in the community of Western Australia.</p><p><strong>Primary outcome: </strong>acceptability of screening, assessed by the feasibility of recruiting the required sample size (n = 323).</p><p><strong>Secondary outcomes: </strong>Hand grip strength, finger prick haemoglobin concentration (Hb), prevalence of heavy menstrual bleeding (HMB), diet, pregnancy history, blood donation, symptoms of ID and history of ID or anaemia (Hb < 120 g/L). Those with Hb <130 g/L and no history of iron therapy in the past 2 years were given referrals for venous full blood count and ferritin sampling.</p><p><strong>Results: </strong>Across 5 days, we recruited 640 eligible women. Of which, 178 (28%) had HMB and 79 (12%) were anaemic. Mean age was 33.5 ± 9.2 years, and mean Hb was 132.4 ± 11.9 g/L. In the past 2 years: 335 (52%) were diagnosed with ID or anaemia; 322 (50%) had taken oral iron; and 210 (33%) had an intravenous iron infusion. Vegetarian diets were followed by 89 (14%); 40 (6%) were regular blood donors; 290 (45%) had a previous pregnancy. HMB increased the risk of symptoms of ID and having prior ID/anaemia diagnosis (67% vs. 47%) or treatment (p < 0.022). Hand grip strength showed a positive relationship with both Hb (adjusted R<sup>2</sup> = 0.012, p = 0.004) and ferritin (adjusted R<sup>2</sup> = 0.135, p = 0.005).</p><p><strong>Conclusion: </strong>ID screening was well accepted by women in the community, with high recruitment rates over a short period. Future screening tool development may consider incorporating hand grip strength and HMB assessment.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":"22-31"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Vox Sanguinis
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1