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Mortality and Thromboembolic Events in Hypercoagulable States from Rotational Thromboelastography (ROTEM) in Patients Who Undergo Coronary Bypass Surgery 冠状动脉搭桥手术患者旋转血栓弹性成像(ROTEM)的高凝状态死亡率和血栓栓塞事件
Pub Date : 2019-09-29 DOI: 10.4236/wjcs.2019.910015
S. Laohathai, P. Samankatiwat
Purpose: This study is to identify the prevalence of preoperative hypercoagulability in Thailand high-risk population assessed by Rotational thromboelastography (ROTEM) and test hypothesis that the pre-surgical ROTEM statuses are related to MACCE at 1, 12, 60 months after coronary bypass graft surgery (CABG). Method: This is a prospective cohort in consecutive patients who underwent on-pump CABG between 2013-2015. Blood samplings were collected and analyzed using ROTEM preoperatively. Hypercoagulable state was defined as any clotting time (CT) or clot formation time (CFT) below the lower normal limit or amplitude 10 min after CT (A10), Maximum clot firmness (MCF) in ROTEM measurement is above the upper normal limit of EXTEM, INTEM and FIBTEM. Results: 43% of CABG patients who were diagnosed as hypercoagulability state assessed by ROTEM. Mortality rate was slightly higher in hypercoagulable patients without statistical significance (9% vs 5.1%; P = 0.461). However, overall combined uneventful rate was significantly increased in hypercoagulable patients in 5 years follow-up (27.2% vs 8.6%; P = 0.012). In univariate analysis, ROTEM hypercoagulability is associated major adverse cardiovascular and cerebral event (MACCE) in 5-years follow up [OR (95% CI) = 3.975 (1.28 - 12.32); P = 0.017]. Conclusion: Hypercoagulable patients were identified 43 percent of patients associated with combine uneventful in 5 years follow-up. ROTEM could be applied as a useful tool in the prediction of outcome after CABG surgery.
目的:本研究旨在通过旋转血栓弹性成像(ROTEM)评估泰国高危人群术前高凝性的患病率,并验证冠状动脉搭桥手术(CABG)后1、12、60个月术前ROTEM状态与MACCE相关的假设。方法:这是一项前瞻性队列研究,研究对象为2013-2015年间连续接受无泵搭桥手术的患者。术前采集血样,采用ROTEM进行分析。高凝状态定义为在CT (A10)后10分钟凝血时间(CT)或凝块形成时间(CFT)低于正常下限或振幅,ROTEM测量中的最大凝块硬度(MCF)高于EXTEM、interm和fitem的正常上限。结果:43%的CABG患者经ROTEM评估为高凝状态。高凝患者的死亡率略高,但无统计学意义(9% vs 5.1%;P = 0.461)。然而,在5年的随访中,高凝患者的总体联合平安无事率显著增加(27.2% vs 8.6%;P = 0.012)。在单因素分析中,ROTEM高凝与5年随访的主要心血管和大脑不良事件(MACCE)相关[OR (95% CI) = 3.975 (1.28 - 12.32);P = 0.017]。结论:在5年的随访中,高凝患者中有43%与联合用药相关。ROTEM可作为预测冠脉搭桥术后预后的有效工具。
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引用次数: 0
Initial Experience with Open Heart Surgery in Sub-Saharan Africa: Challenges in Mali with Minimum Standards for Practice 撒哈拉以南非洲心脏直视手术的初步经验:马里最低实践标准的挑战
Pub Date : 2019-09-05 DOI: 10.4236/wjcs.2019.99013
S. Togo, Ouattara Ma, A. A. Maïga, M. Bazongo, I. Maiga, Cheik Amed Sekou Touré, I. Coulibaly, S. Diop, A. Ombotimbé, S. Illiassou, S. Coulibaly, M. Koita, Koumba Nelly Dora Ignanga, S. D. Koné, Moussa Oscar Kamano, F. Konaté, A. Koné, A. Sidibé, A. Dramé, Nouhoum Oueloguem, B. Kané, B. Dramé, S. Koumare, Z. Sanogo, S. Yena
Introduction: There has been limited experience with Open Heart Surgeries (OHS) in Sub-Saharan Africa. In west Africa especially in Mali, most fledgling centers are unable to overcome the myriad of challenges encountered in establishing OHS though there is a high prevalence of surgically correctable heart diseases. The aim of this paper is to review our initial experience of our first cases in developing OHS program and discuss the challenges and prospects that need to be overcome to further develop it. Methods: A total of 6 patients who underwent OHS during the first “cardiac mission” in July 2016 were included in this retrospective study. The medical records of the patients were examined and data on age, sex, diagnosis, EuroSCORE, type of surgery, cardiopulmonary bypass details, complications and length of hospital stay were extracted. Results: Six patients with a male to female ratio of 1, ages ranging between 12 and 35 years (mean of 22.5 ± 12 years) were studied. The mean of EuroSCORE was 6 ± 41. Pericardial patch closure of isolated atrial septal defect was performed in one patient. One patient had mitral valve repair for rheumatic mitral regurgitation consisting of chordal shortening with a tricuspid valvuloplasty. Three patients had mitral valve replacement with tricuspid valvuloplasty. Four patients had mitral valve replacement. Sixty-day mortality was 0%. Conclusion: Safe conduct of open heart surgery in Mali Hospital setting is feasible. Grant financial aid is required for rapid growth of Open-Heart Surgery in this part of Sub-Saharan Africa.
导言:在撒哈拉以南非洲开展心脏直视手术(OHS)的经验有限。在西非,特别是在马里,尽管外科手术可治愈的心脏病发病率很高,但大多数新兴中心都无法克服建立职业健康安全所遇到的无数挑战。本文的目的是回顾我国在职业健康安全管理方面的初步经验,并讨论进一步发展职业健康安全管理需要克服的挑战和前景。方法:回顾性分析2016年7月第一次“心脏任务”期间接受OHS治疗的6例患者。检查患者的医疗记录,提取年龄、性别、诊断、EuroSCORE、手术类型、体外循环细节、并发症和住院时间等数据。结果:6例患者,男女比例为1,年龄12 ~ 35岁,平均22.5±12岁。EuroSCORE平均值为6±41。对孤立性房间隔缺损行心包补片封闭术1例。一例患者因风湿性二尖瓣返流而行二尖瓣修复术,包括索索缩短和三尖瓣成形术。3例患者行二尖瓣置换术合并三尖瓣成形术。4例患者行二尖瓣置换术。60天死亡率为0%。结论:在马里医院安全开展心脏直视手术是可行的。在撒哈拉以南非洲的这一地区,开放心脏手术的快速发展需要赠款财政援助。
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引用次数: 0
Management of Thoracic Impalement Injury in Ghana: A Five-Year Experience at the Komfo Anokye Teaching Hospital 加纳胸穿刺伤的管理:在Komfo Anokye教学医院的五年经验
Pub Date : 2019-09-05 DOI: 10.4236/wjcs.2019.99014
I. Okyere, S. G. Brenu, P. Okyere
Impalement injuries are rare and among the most spectacular and dramatic traumatic injuries especially of the chest. The survival of a patient with a thoracic impalement injury can be extremely rare. Herein we present and discuss our successes of the management of 7 rare cases of thoracic impalement injuries over a 5-year period from January 2014 to June 2019 at the Komfo Anokye Teaching Hospital, Kumasi in Ghana. We discuss the presentation, diagnosis, treatment and outcomes of the seven cases encountered.
刺穿伤是罕见的,是最引人注目和戏剧性的创伤之一,尤其是胸部。胸椎穿刺伤患者的存活率是极其罕见的。在此,我们介绍并讨论了2014年1月至2019年6月期间在加纳库马西Komfo Anokye教学医院成功治疗的7例罕见胸穿刺损伤病例。我们讨论的表现,诊断,治疗和结果遇到的七个病例。
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引用次数: 0
Significance of Cold Renal Perfusion on Renal Function and Clinical Outcomes When Renal Ischemia Time Exceeded 30 Min during Pararenal and Juxtarenal Abdominal Aortic Aneurysm Surgery 肾旁、肾旁腹主动脉瘤手术中肾缺血时间超过30 Min时冷肾灌注对肾功能及临床结局的影响
Pub Date : 2019-09-05 DOI: 10.4236/wjcs.2019.99012
K. Furukawa, K. Mori, Yukie Shirasaki, H. Ishii, Kunihide Nakamura
Objectives: To investigate the influence of cold renal perfusion on renal function and clinical outcomes in cases where the renal ischemia time exceeded 30 min during pararenal and juxtarenal abdominal aortic aneurysm (P/JAAA) surgery. Methods and Results: Fifty-four patients who underwent open repair for P/JAAAs were retrospectively analyzed. Thirty-nine patients received renal perfusion with cold Ringer’s solution (perfusion group) and 15 patients did not receive renal perfusion (non-perfusion group). There were no significant differences in preoperative serum creatinine level (Cr) (1.08 ± 0.42 vs. 1.35 ± 0.71 mg/dL, p = 0.09), percentage of patients with Cr > 2 mg/dL [2/38 (5%) vs. 2/15 (13%), p = 0.8], and renal ischemia time during proximal aortic clamping (49 ± 21 vs. 47 ± 11 min; p = 0.8) between the groups. Postoperative Cr was significantly lower in the perfusion group than in the non-perfusion group (1.48 ± 0.76 vs. 2.23 ± 1.21 mg/dL, p 2 mg/dL was also significantly lower in the perfusion group than in the non-perfusion group [5 (13%) vs. 7 (47%), p Conclusion: Renal artery perfusion with cold Ringer’s solution clearly reduced the deterioration of postoperative renal function compared to non-renal perfusion.
目的:探讨肾旁、肾旁腹主动脉瘤(P/JAAA)手术中肾缺血时间超过30 min时,冷肾灌注对肾功能及临床结局的影响。方法与结果:回顾性分析54例P/ jaaa开放性修复患者。39例患者接受冷林格液肾灌注(灌注组),15例患者未接受肾灌注(非灌注组)。术前血清肌酐水平(Cr)(1.08±0.42∶1.35±0.71 mg/dL, p = 0.09)、Cr > 2 mg/dL患者比例[2/38(5%)∶2/15 (13%),p = 0.8]、主动脉近端夹持期间肾缺血时间(49±21∶47±11 min;P = 0.8)。灌注组术后Cr显著低于非灌注组(1.48±0.76 vs. 2.23±1.21 mg/dL), p2mg /dL也显著低于非灌注组[5 (13%)vs. 7(47%)]。p结论:冷林格液肾动脉灌注较非肾灌注明显减轻术后肾功能恶化。
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引用次数: 1
Literature Review for the Management of Isolated Internal Mammary Artery Injury and a Case Managed by Mini-Thoracotomy 孤立性乳腺内动脉损伤及小开胸术1例的文献回顾
Pub Date : 2019-08-22 DOI: 10.4236/WJCS.2019.98010
Mohammad Miah, M. Uddin, J. B. Saeid, S. A. Nahian, A. Karim, A. Ashoub
Penetrating injuries to anterior chest may result in life-threatening complications such as massive haemothorax, as a result of injury to the internal mammary artery. Isolated internal mammary injury is a very rare cause of massive haemothorax and associated with high mortality. We are presenting this 32-year-old gentleman who sustained a thoracic stab wound and had an emergency right anterior mini-thoracotomy by extending the stab wound rather than standard thoracotomy or sternotomy. This case of isolated penetrating IMA injury managed with mini-thoracotomy is the only documented case so far. We are publishing this case report with patient’s both written and informed consent and institutional approval. This potentially life-threating injury can be managed by mini-thoracotomy with enhanced recovery; however, it is case specific and needs proper judgement.
胸部前部的穿透性损伤可能导致危及生命的并发症,如大量的血胸,这是由于乳房内动脉受伤造成的。孤立的乳房内部损伤是一个非常罕见的原因大出血胸和高死亡率。我们要介绍的是一位32岁的男士,他胸部被刺伤,并接受了紧急右前小开胸术,通过扩大刺伤而不是标准的开胸术或胸骨切开术。该病例为孤立性穿透性IMA损伤,采用小开胸术治疗,是迄今为止唯一记录在案的病例。我们在获得患者书面和知情同意以及机构批准的情况下发表本病例报告。这种可能危及生命的损伤可以通过小型开胸术来治疗,并增强恢复;然而,这是具体情况,需要适当的判断。
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引用次数: 0
Ivabradine—The Final Crusader for Postoperative Junctional Ectopic Tachycardia, a Case Report with Literature Review 伊伐布雷丁是术后结缔性异位性心动过速的最后斗士,一例报告并文献复习
Pub Date : 2019-08-22 DOI: 10.4236/WJCS.2019.98009
M. Sahu, H. Niraghatam, N. Bansal, S. Singh, P. Rajashekar, S. Choudhary
Background: Junctional ectopic tachycardia (JET) is one troublesome supraventricular arrhythmia in postoperative pediatric cardiac surgical patients. Unless treated timely and effectively it may lead to morbidity and even mortality. Aim: To understand the role of Ivabradine in the treatment of JET in postoperative pediatric cardiac surgical patients. Case: We present a postoperative case of complete repair of Tetralogy of Fallot who was in normal sinus rhythm in the preoperative period and developed JET 4 hours later in postoperative period which was persistent despite measures to optimize the internal milieu of the body and conventional antiarrhythmics, that was successfully treated with Ivabradine at a dose of 0.05 mg/kg/12 hourly. Conclusion: Ivabradine can be used to successfully treat postoperative JET in cases ofrefractory to other antiarrhythmic drugs like Digoxin and Amiodarone.
背景:结缔性异位性心动过速(JET)是小儿心脏手术后困扰患者的一种室上性心律失常。除非得到及时有效的治疗,否则可能导致发病甚至死亡。目的:了解伊伐布雷定在小儿心脏手术患者术后JET中的作用。病例:我们报告一例法洛四联症术后完全修复的病例,术前窦性心律正常,术后4小时出现JET,尽管采取了优化体内环境和常规抗心律失常措施,但仍持续存在,以0.05 mg/kg/12小时剂量的伊伐布雷定治疗成功。结论:对地高辛、胺碘酮等抗心律失常药物难治的患者,伊伐布雷定可成功治疗术后JET。
{"title":"Ivabradine—The Final Crusader for Postoperative Junctional Ectopic Tachycardia, a Case Report with Literature Review","authors":"M. Sahu, H. Niraghatam, N. Bansal, S. Singh, P. Rajashekar, S. Choudhary","doi":"10.4236/WJCS.2019.98009","DOIUrl":"https://doi.org/10.4236/WJCS.2019.98009","url":null,"abstract":"Background: Junctional ectopic tachycardia (JET) is one troublesome supraventricular arrhythmia in postoperative pediatric cardiac surgical patients. Unless treated timely and effectively it may lead to morbidity and even mortality. Aim: To understand the role of Ivabradine in the treatment of JET in postoperative pediatric cardiac surgical patients. Case: We present a postoperative case of complete repair of Tetralogy of Fallot who was in normal sinus rhythm in the preoperative period and developed JET 4 hours later in postoperative period which was persistent despite measures to optimize the internal milieu of the body and conventional antiarrhythmics, that was successfully treated with Ivabradine at a dose of 0.05 mg/kg/12 hourly. Conclusion: Ivabradine can be used to successfully treat postoperative JET in cases ofrefractory to other antiarrhythmic drugs like Digoxin and Amiodarone.","PeriodicalId":23646,"journal":{"name":"World Journal of Cardiovascular Surgery","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87274756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anomalous Origin and Course of Coronary Artery—Presentation of Three Cases 冠状动脉异常起源与病程——附3例报告
Pub Date : 2019-08-21 DOI: 10.4236/wjcs.2019.98011
A. Maheshwari, S. Saha, T. Mondal, H. Minhas, M. Geelani
Anomalous origin of coronary arteries may be encountered coincidentally in the presence of unrelated pathology or when these are affected directly. This may directly be responsible for affecting the procedure or outcome. Various types of anomalies of origin, as well as course of coronary arteries, have been classified in the past. Here we report 3 cases of anomalous origin of coronary arteries in different scenarios. First case had anomalous coronary with bicuspid aortic valve with dilated ascending aorta for which Bentall’s procedure was done, while the second and third cases were anomalous coronaries with coronary artery disease for which coronary artery bypass grafting was done.
冠状动脉的异常起源可能在不相关的病理存在或当冠状动脉直接受到影响时偶然发生。这可能直接影响手术过程或结果。各种类型的异常的起源,以及冠状动脉的进程,已被分类在过去。在此,我们报告3例冠状动脉异常起源的不同情况。1例为冠状动脉异常伴二尖瓣主动脉瓣扩张伴升主动脉扩张,行本特尔手术;2、3例为冠状动脉异常伴冠状动脉病变,行冠状动脉旁路移植术。
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引用次数: 0
Right Atrial Blood Cyst Incidentally Detected by Computed Tomography for Metastatic Breast Cancer in an Adult Female Patient: A Case Report 计算机断层扫描偶然发现的右心房血囊肿转移性乳腺癌1例报告
Pub Date : 2019-05-30 DOI: 10.4236/WJCS.2019.95006
Kazuhiro Higuchi, K. Furukawa, E. Nakamura, E. Nakamura, Y. Asada, H. Nakada, Kunihide Nakamura
Cardiac blood cysts are benign congenital cardiovascular tumors that are rare in adults. A 70-year-old woman who underwent left mastectomy for left breast cancer 9 years ago was referred to our institution for a right atrial mass that measured 35 × 30 mm and was detected incidentally by computed tomography for metastatic breast cancer and transthoracic echocardiography. The mass was attached to the interatrial septum by a stalk. Although it was asymptomatic, surgical resection was performed because of the risk of pulmonary embolism. The mass contained blood, and histopathological findings were suggestive of a blood cyst. We described a rare case of a right atrial blood cyst incidentally found during evaluation for metastatic breast cancer in a woman.
心脏血囊肿是一种少见的良性先天性心血管肿瘤。一名70岁女性,9年前因左乳腺癌行左乳切除术,因右心房肿块被转介至我院,该肿块尺寸为35 × 30 mm,偶然通过计算机断层扫描和经胸超声心动图检测到转移性乳腺癌。肿块通过一根柄附着在房间隔上。虽然无症状,但由于肺栓塞的风险,手术切除。肿块含血,组织病理学结果提示为血囊肿。我们描述了一个罕见的病例右心房血囊肿偶然发现在评估转移性乳腺癌的妇女。
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引用次数: 0
Left Ventricular Pseudoaneurysm Caused by a Left Ventricular Venting Catheter via the Right Superior Pulmonary Vein during Thoracic Aortic Surgery: A Case Report 胸主动脉手术中经右上肺静脉置管引起左心室假性动脉瘤1例
Pub Date : 2019-04-22 DOI: 10.4236/WJCS.2019.94005
Taiju Watanabe, Tetsuya Yoshida
A left ventricular (LV) pseudoaneurysm is one of the complications of acute myocardial infarction. It is also reported after chest trauma, cardiac surgery, and endocarditis. We report a rare case of an LV pseudoaneurysm induced by an LV venting catheter through the right superior pulmonary vein during thoracic aortic surgery. A 77-year-old man was referred for surgical repair of a distal aortic arch aneurysm. He underwent total aortic arch reconstruction with the frozen elephant trunk technique. The early postoperative period was uneventful. Postoperative contrast computed tomography and transthoracic echocardiography (TTE) revealed a pseudoaneurysm with a narrow neck at the apex of the LV that had sub-clinically progressed. Because of the risk of spontaneous rupture, an urgent aneurysmectomy was performed via a repeat sternotomy. Under cardioplegic arrest, the pseudoaneurysm was opened and the small orifice, which communicated with the LV, was confirmed. No myocardial ischemic changes were observed around the orifice. The pseudoaneurysm was thought to be induced by endocardial laceration by the tip of the venting catheter. The pseudoaneurysm was closed by linear repair reinforced with felt strips. The patient recovered well and was discharged 18 days after the second surgery. TTE showed no recurrence of LV aneurysm at the last follow-up.
左室假性动脉瘤是急性心肌梗死的并发症之一。在胸部外伤、心脏手术和心内膜炎后也有报道。我们报告一例罕见的左室假性动脉瘤由左室通气导管通过右上肺静脉在胸主动脉手术。一位77岁的男性因主动脉弓远端动脉瘤进行手术修复。他接受了全主动脉弓重建与冷冻象鼻技术。术后早期平安无事。术后对比计算机断层扫描和经胸超声心动图(TTE)显示左室顶端有一个假性动脉瘤,颈部狭窄,亚临床进展。由于自发性破裂的风险,通过重复胸骨切开术进行了紧急动脉瘤切除术。在心脏骤停下,打开假性动脉瘤,确认与左室相通的小口。孔口周围未见心肌缺血改变。假性动脉瘤被认为是由导管尖端的心内膜撕裂引起的。假性动脉瘤用毛毡条加固线性修复关闭。患者恢复良好,第二次手术后18天出院。在最后一次随访中,TTE未发现左室动脉瘤复发。
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引用次数: 1
Right Ventricular Failure Following Acute Type A Aortic Dissection: An Alternative Strategy 急性A型主动脉夹层右心衰竭:一种替代策略
Pub Date : 2019-03-29 DOI: 10.4236/WJCS.2019.93004
R. Mashar, R. Birla, P. Waterworth
Coronary malperfusion is a complication of aortic dissection, and can lead to ventricular failure. We report 2 cases of right ventricular (RV) failure, following aortic dissection, successfully bridged to recovery using right ventricular assist devices (RVADs). The first was a 54 year-old man, who had difficulty weaning from bypass due to a stunned RV following aortic root replacement. The second was a 34 year-old woman, who after replacement of the ascending aorta, suffered episodes of ventricular fibrillation (VF), and RV failure. Both had an RVAD implanted, allowing eventual recovery. We recommend more widespread use of VADs in such cases.
冠状动脉灌注不良是主动脉夹层的并发症,可导致心室衰竭。我们报告了2例右心室(RV)衰竭,在主动脉夹层后,使用右心室辅助装置(RVADs)成功桥接恢复。第一位患者是一名54岁的男性,由于主动脉根部置换术后右心室休克,难以从旁路手术中脱机。第二例是一名34岁的女性,她在升主动脉置换术后出现心室颤动(VF)和心室心室功能衰竭。两人都植入了RVAD,最终得以康复。我们建议在这种情况下更广泛地使用vad。
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引用次数: 2
期刊
World Journal of Cardiovascular Surgery
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