Pub Date : 2024-08-19eCollection Date: 2024-01-01DOI: 10.29399/npa.28418
Levent Öcek, Tuğba Demir Özen, Özge Öcek, Alp Sarıteke, Ufuk Şener
Introduction: In this study, we aimed to investigate the clinical effects of COVID-19 infection and vaccines on Myasthenia gravis (MG) during the pandemic.
Methods: A total of 141 MG patients between April 2020 and December 2021 were retrospectively analyzed. Data including demographic and clinical characteristics of patients, COVID-19 test results, and vaccine types (mRNA-BNT162b2 and/or inactivated-CoronaVac) were recorded. All patients were followed by face-to-face interviews and/or phone calls. Worsening MG symptoms after COVID-19 infection or vaccines were noted.
Results: A total of 60 patients were diagnosed with COVID-19, and reverse transcriptase-polymerase chain reaction test results were COVID-19 positive in 54 (90%) patients. Twenty-eight (46.7%) patients had lung involvement, while 20(33.3%) patients were followed in the ward. Twelve (20%) patients were followed in the intensive care unit, and two of them (3.3%) died. Both deceased patients were unvaccinated. The most common symptoms were fatigue (78.3%), and 13(21.7%) patients were asymptomatic. Of the patients, 96(68%) received at least one dose BNT162b2 or CoronaVac, while 30.4% of the patients received ≥3 doses of vaccines. The local skin irritation and fatigue rate was significantly higher with BNT162b2 vaccine than CoronaVac (p<0.001 and p=0.004, respectively). No serious side effect was observed with either vaccine. Five patients had worsening MG symptoms after vaccination during a six-week follow-up. None of the patients experienced myasthenic crises.
Conclusion: Our study results suggest that COVID-19 infection affects MG similar to the general population and does not lead to worsening MG symptoms. Both mRNA and inactivated vaccines with proven efficacy can be used safely in MG patients.
{"title":"Evaluation of Clinical Effects of COVID-19 Infection and Vaccines on Myasthenia Gravis.","authors":"Levent Öcek, Tuğba Demir Özen, Özge Öcek, Alp Sarıteke, Ufuk Şener","doi":"10.29399/npa.28418","DOIUrl":"10.29399/npa.28418","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we aimed to investigate the clinical effects of COVID-19 infection and vaccines on Myasthenia gravis (MG) during the pandemic.</p><p><strong>Methods: </strong>A total of 141 MG patients between April 2020 and December 2021 were retrospectively analyzed. Data including demographic and clinical characteristics of patients, COVID-19 test results, and vaccine types (mRNA-BNT162b2 and/or inactivated-CoronaVac) were recorded. All patients were followed by face-to-face interviews and/or phone calls. Worsening MG symptoms after COVID-19 infection or vaccines were noted.</p><p><strong>Results: </strong>A total of 60 patients were diagnosed with COVID-19, and reverse transcriptase-polymerase chain reaction test results were COVID-19 positive in 54 (90%) patients. Twenty-eight (46.7%) patients had lung involvement, while 20(33.3%) patients were followed in the ward. Twelve (20%) patients were followed in the intensive care unit, and two of them (3.3%) died. Both deceased patients were unvaccinated. The most common symptoms were fatigue (78.3%), and 13(21.7%) patients were asymptomatic. Of the patients, 96(68%) received at least one dose BNT162b2 or CoronaVac, while 30.4% of the patients received ≥3 doses of vaccines. The local skin irritation and fatigue rate was significantly higher with BNT162b2 vaccine than CoronaVac (p<0.001 and p=0.004, respectively). No serious side effect was observed with either vaccine. Five patients had worsening MG symptoms after vaccination during a six-week follow-up. None of the patients experienced myasthenic crises.</p><p><strong>Conclusion: </strong>Our study results suggest that COVID-19 infection affects MG similar to the general population and does not lead to worsening MG symptoms. Both mRNA and inactivated vaccines with proven efficacy can be used safely in MG patients.</p>","PeriodicalId":23735,"journal":{"name":"世界华人消化杂志","volume":"14 1","pages":"213-220"},"PeriodicalIF":1.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11382557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86285305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.236
Qing-Lin Chen, Wei-Bing Ge, Gang Wu, Ye-Lan Lu
{"title":"Comparison of effects of sufentanil and fentanyl target-controlled infusion on quality of awakening from anesthesia, intrapulmonary oxygenation, and oxidative-antioxidant system in patients undergoing radical surgery for colorectal cancer","authors":"Qing-Lin Chen, Wei-Bing Ge, Gang Wu, Ye-Lan Lu","doi":"10.11569/wcjd.v32.i3.236","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.236","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"15 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140371980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.216
Guo-He Hu, Jing-Bo Pei
{"title":"Progress in understanding of impact of Helicobacter pylori eradication on gastrointestinal microecology","authors":"Guo-He Hu, Jing-Bo Pei","doi":"10.11569/wcjd.v32.i3.216","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.216","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140369385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.199
Yan-Hong Wang
{"title":"Advances in minimally invasive endoscopic treatment of pancreatic divisum","authors":"Yan-Hong Wang","doi":"10.11569/wcjd.v32.i3.199","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.199","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"136 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140369878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.203
Xue Wei, Jian-Yu Hao
{"title":"Progress in understanding of relationship between smoking and pancreatic injury","authors":"Xue Wei, Jian-Yu Hao","doi":"10.11569/wcjd.v32.i3.203","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.203","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"28 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.208
Ling-Li Yang, Xiu-qin Zhu, Xiao-Li Cai
{"title":"Progress in hospital-home transitional care for patients with inflammatory bowel disease","authors":"Ling-Li Yang, Xiu-qin Zhu, Xiao-Li Cai","doi":"10.11569/wcjd.v32.i3.208","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.208","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"81 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.182
Jia-Chen Yang, Yu-hang Zhang, Bing Hu
{"title":"Gastric organoids: Rise of a latecomer","authors":"Jia-Chen Yang, Yu-hang Zhang, Bing Hu","doi":"10.11569/wcjd.v32.i3.182","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.182","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"12 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.171
Si-Qi Zhao, Wen-Tian Liu
{"title":"Progress in artificial intelligence assisted digestive endoscopy diagnosis of digestive system diseases","authors":"Si-Qi Zhao, Wen-Tian Liu","doi":"10.11569/wcjd.v32.i3.171","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.171","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.11569/wcjd.v32.i3.221
Yuqing Mao, Shaopeng Sun, Bin Lv, Yi-Hong Fan
{"title":"Progress in understanding of relationship between use of biological agents and risk of malignant tumors in patients with inflammatory bowel disease","authors":"Yuqing Mao, Shaopeng Sun, Bin Lv, Yi-Hong Fan","doi":"10.11569/wcjd.v32.i3.221","DOIUrl":"https://doi.org/10.11569/wcjd.v32.i3.221","url":null,"abstract":"","PeriodicalId":23735,"journal":{"name":"World Chinese Journal of Digestology","volume":"65 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140371604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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