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Etiology of Chronic Leg Ulcers in a Dermatologic Wound Clinic: A Retrospective Observational Study. 皮肤伤口诊所慢性腿部溃疡的病因学:一项回顾性观察研究。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-08-01
Paola Monari, Giulio Gualdi, Sara Rovaris, Anna Venturuzzo, Chiara Rovati, Piergiacomo Calzavara Pinton

Background: Chronic leg ulcers affect approximately 1% to 2% of the European population, with an increasing prevalence. The treatment of chronic wounds is a socioeconomical problem worldwide.

Purpose: The main purpose of the current investigation was to detect the etiology of leg ulcers treated in a dermatologic wound clinic from January 1, 2010, to December 31, 2019.

Methods: This retrospective observational study was performed at the Dermatologic Clinic of Spedali Civili in Brescia, Italy. The authors enrolled 465 patients with chronic leg ulcers.

Results: The 3 most represented causes of ulcers were vascular (238 patients, 51.2%), inflammatory (71 patients, 15.3%) and traumatic (43 patients, 9.3%). Altogether, a total of 13 different entities were identified as a cause of leg ulcer.

Conclusion: Vascular genesis was the most common etiology of leg ulcers in this population, even though uncommon causes were also represented. These findings are in agreement with other studies reported in the literature.

背景:慢性腿部溃疡影响约1%至2%的欧洲人口,患病率呈上升趋势。慢性伤口的治疗是一个世界性的社会经济问题。目的:本研究的主要目的是检测2010年1月1日至2019年12月31日在皮肤科伤口诊所治疗的腿部溃疡的病因。方法:这项回顾性观察性研究是在意大利布雷西亚的Spedali Civili皮肤科诊所进行的。作者招募了465名患有慢性腿部溃疡的患者。结果:引起溃疡最常见的3种原因是血管(238例,51.2%)、炎症(71例,15.3%)和外伤性(43例,9.3%)。总共有13种不同的实体被确定为腿部溃疡的原因。结论:血管发生是该人群中最常见的腿部溃疡的病因,即使不常见的原因也有代表。这些发现与文献中报道的其他研究一致。
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引用次数: 0
Safety and Effectiveness of Moxibustion and Abdominal Massage in Hospitalized Older Patients With Constipation: A Retrospective Study. 艾灸加腹部按摩治疗住院老年便秘患者的安全性和有效性:一项回顾性研究。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-08-01
Kexin Li

Background: Evidence about moxibustion and abdominal massage for treating constipation in older hospitalized patients is limited.

Purpose: To investigate the safety and effectiveness of moxibustion and abdominal massage in hospitalized older patients with constipation.

Methods: Hospitalized older patients (age ≥60 years) with constipation were retrospectively categorized as 2 cohorts according to whether the patients received moxibustion and abdominal massage in addition to routine nursing care. Gastrointestinal symptoms, Constipation Assessment Scale (CAS) scores, and Geriatric Depression Scale (GDS) scores were compared before and after treatment between cohorts.

Results: The 2 cohorts (n = 100 for each) had similar baseline characteristics and gastrointestinal symptoms; the control cohort and the additional intervention cohort also had similar CAS scores (7.14 ± 3.67 vs 7.48 ± 2.96, respectively), and GDS scores (>17: 31% vs 29%, respectively). Improvement in the 2 scores from baseline was observed after 2 weeks in both the control cohort and the additional intervention cohort (CAS, 5.37 ± 5.34 and 3.80 ± 4.47, respectively; GDS, >17: 28% and 15%, respectively). The cohort with additional interventions had a lower ineffective rate (defined as persistent symptoms or absence of decrease in CAS, 49% vs 32%; P = .028) but had more diarrhea (9% vs 21%; P = .017).

Conclusion: Moxibustion and abdominal massage may help relieve constipation in hospitalized elderly patients, but attention should be paid to the increased occurrence of diarrhea. More study is needed.

背景:艾灸加腹部按摩治疗老年住院患者便秘的证据有限。目的:探讨艾灸加腹部按摩治疗住院老年便秘患者的安全性和有效性。方法:根据住院的老年便秘患者(≥60岁)在常规护理的基础上是否接受艾灸和腹部按摩,回顾性分为2组。比较各组治疗前后胃肠道症状、便秘评估量表(CAS)评分和老年抑郁量表(GDS)评分。结果:两个队列(n = 100)具有相似的基线特征和胃肠道症状;对照组和额外干预组的CAS评分(分别为7.14±3.67 vs 7.48±2.96)和GDS评分(分别为>17:31% vs 29%)相似。2周后,对照组和额外干预组的2项评分均较基线有所改善(CAS分别为5.37±5.34和3.80±4.47);GDS >17,分别为28%和15%)。有额外干预的队列无效率(定义为持续症状或没有减少CAS)较低,分别为49%和32%;P = 0.028),但腹泻较多(9% vs 21%;P = .017)。结论:艾灸加腹部按摩有助于缓解住院老年患者便秘,但应注意腹泻发生率增高。需要更多的研究。
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引用次数: 0
Etiology of Chronic Leg Ulcers in a Dermatologic Wound Clinic: A Retrospective Observational Study. 皮肤科伤口诊所慢性腿部溃疡的病因:一项回顾性观察研究。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-08-01 DOI: 10.25270/wmp.2022.8.1215
P. Monari, G. Gualdi, S. Rovaris, A. Venturuzzo, C. Rovati, P. C. Pinton
BACKGROUNDChronic leg ulcers affect approximately 1% to 2% of the European population, with an increasing prevalence. The treatment of chronic wounds is a socioeconomical problem worldwide.PURPOSEThe main purpose of the current investigation was to detect the etiology of leg ulcers treated in a dermatologic wound clinic from January 1, 2010, to December 31, 2019.METHODSThis retrospective observational study was performed at the Dermatologic Clinic of Spedali Civili in Brescia, Italy. The authors enrolled 465 patients with chronic leg ulcers.RESULTSThe 3 most represented causes of ulcers were vascular (238 patients, 51.2%), inflammatory (71 patients, 15.3%) and traumatic (43 patients, 9.3%). Altogether, a total of 13 different entities were identified as a cause of leg ulcer.CONCLUSIONVascular genesis was the most common etiology of leg ulcers in this population, even though uncommon causes were also represented. These findings are in agreement with other studies reported in the literature.
背景慢性腿部溃疡约占欧洲人口的1%至2%,患病率不断上升。慢性伤口的治疗是世界范围内的一个社会经济问题。目的本研究的主要目的是检测2010年1月1日至2019年12月31日在皮肤科伤口诊所治疗的腿部溃疡的病因。方法本回顾性观察性研究在意大利布雷西亚的斯佩达利奇维利皮肤科诊所进行。作者招募了465名患有慢性腿部溃疡的患者。结果溃疡最常见的3个原因是血管性溃疡(238例,占51.2%)、炎症性溃疡(71例,占15.3%)和创伤性溃疡(43例,占9.3%)。结论血管发生是该人群中腿部溃疡最常见的病因,尽管也有不常见的病因。这些发现与文献中报道的其他研究一致。
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引用次数: 0
Content and Quality of Online Videos About Ostomy Pouch Changes: A Descriptive Study. 关于造口术后眼袋变化的在线视频内容和质量:一项描述性研究。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-08-01
Zeynep Temiz, Didem Kandemir

Background: Many health-related videos are available online. One type of health-related video is related to stoma pouch change. However, a system to evaluate the quality and content of these videos is lacking.

Purpose: To evaluate the content and quality of YouTube videos on colostomy pouch change.

Methods: A descriptive study was carried out by searching for videos on March 15, 2021, using the key words "colostomy care," "colostomy bag/pouch change," and "ostomy bag/pouch change." A 5-point Global Quality Scale was used to evaluate the quality of the videos, and a 10-point scale was used to evaluate the content. The videos were classified as "useful" or "useless" according to their content and quality scores.

Results: A total of 128 videos were found; 94 videos met the criteria and were included in the study. The content of the 94 videos was examined by 2 independent researchers. The overall content score of the videos was 8.24 ± 1.56, and the overall quality score was 3.14 ± 0.97. A total of 66 (70.21%) videos were useful, and 28 (29.79%) videos were useless. The mean scores of useful videos for content (9.09 ± 0.83) and the average Global Quality Scale scores (3.53 ± 0.76) were significantly higher than those of useless videos (6.17 ± 0.90 and 2.25 ± 0.75, respectively; (P < .05). The results showed that 57.6% of the useful videos were uploaded by universities, professional organizations, and health care professionals, and 67.9% of the useless videos were uploaded by patients; the difference was statistically significant (P < .05).

Conclusions: Results indicated that the majority of online videos evaluated were accurate. Most of these videos were uploaded by universities, professional organizations, health care professionals, or medical advertisers. Although there were many limitations to this study, the authors suggest that health care professionals can direct their patients to these sources after hospital discharge. However, future studies are needed..

背景:网上有许多与健康相关的视频。一种与健康相关的视频与造口袋变化有关。但是,目前还缺乏评价这些视频的质量和内容的系统。目的:评价YouTube视频中结肠造口术后小袋更换的内容和质量。方法:以“结肠造口护理”、“结肠造口袋/袋更换”、“造口袋/袋更换”为关键词,通过搜索2021年3月15日的视频进行描述性研究。5分的全球质量量表被用来评估视频的质量,10分的量表被用来评估内容。这些视频根据内容和质量得分被分为“有用”和“无用”两类。结果:共找到128个视频;94个视频符合标准并被纳入研究。94个视频的内容由两名独立研究人员进行了检查。视频的整体内容得分为8.24±1.56分,整体质量得分为3.14±0.97分。有用视频66个(70.21%),无用视频28个(29.79%)。有用视频的内容平均得分(9.09±0.83)和全球质量量表平均得分(3.53±0.76)显著高于无用视频(6.17±0.90)和2.25±0.75);(p < 0.05)。结果显示,57.6%的有用视频是由高校、专业机构和医护人员上传的,67.9%的无用视频是由患者上传的;差异有统计学意义(P < 0.05)。结论:结果表明,大多数在线视频的评估是准确的。这些视频大多是由大学、专业组织、医疗保健专业人员或医疗广告商上传的。尽管这项研究有许多局限性,但作者建议医疗保健专业人员可以在出院后指导患者使用这些来源。然而,还需要进一步的研究。
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引用次数: 0
Content and Quality of Online Videos About Ostomy Pouch Changes: A Descriptive Study. 关于造口术包变化的在线视频的内容和质量:一项描述性研究。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-08-01 DOI: 10.25270/wmp.2022.8.2532
Zeynep Temiz, Didem Kandemir
BACKGROUNDMany health-related videos are available online. One type of health-related video is related to stoma pouch change. However, a system to evaluate the quality and content of these videos is lacking.PURPOSETo evaluate the content and quality of YouTube videos on colostomy pouch change.METHODSA descriptive study was carried out by searching for videos on March 15, 2021, using the key words "colostomy care," "colostomy bag/pouch change," and "ostomy bag/pouch change." A 5-point Global Quality Scale was used to evaluate the quality of the videos, and a 10-point scale was used to evaluate the content. The videos were classified as "useful" or "useless" according to their content and quality scores.RESULTSA total of 128 videos were found; 94 videos met the criteria and were included in the study. The content of the 94 videos was examined by 2 independent researchers. The overall content score of the videos was 8.24 ± 1.56, and the overall quality score was 3.14 ± 0.97. A total of 66 (70.21%) videos were useful, and 28 (29.79%) videos were useless. The mean scores of useful videos for content (9.09 ± 0.83) and the average Global Quality Scale scores (3.53 ± 0.76) were significantly higher than those of useless videos (6.17 ± 0.90 and 2.25 ± 0.75, respectively; (P < .05). The results showed that 57.6% of the useful videos were uploaded by universities, professional organizations, and health care professionals, and 67.9% of the useless videos were uploaded by patients; the difference was statistically significant (P < .05).CONCLUSIONSResults indicated that the majority of online videos evaluated were accurate. Most of these videos were uploaded by universities, professional organizations, health care professionals, or medical advertisers. Although there were many limitations to this study, the authors suggest that health care professionals can direct their patients to these sources after hospital discharge. However, future studies are needed..
背景许多与健康相关的视频都可以在线观看。一种与健康相关的视频与造口袋的变化有关。然而,缺乏一个评估这些视频质量和内容的系统。目的评估YouTube上关于结肠造口术改变的视频的内容和质量。方法于2021年3月15日通过搜索视频进行描述性研究,关键词为“结肠造口护理”、“结肠造口袋/袋变化”和“造口袋/囊变化”。使用5分全球质量量表评估视频质量,使用10分量表评估内容。根据视频的内容和质量分数,这些视频被分为“有用”或“无用”。结果共发现128个视频;94个视频符合标准并被纳入研究。两名独立研究人员对94段视频的内容进行了检查。视频的整体内容得分为8.24±1.56,整体质量得分为3.14±0.97。共有66个(70.21%)视频是有用的,28个(29.79%)视频是无用的。有用视频的内容平均得分(9.09±0.83)和全球质量量表平均得分(3.53±0.76)显著高于无用视频(6.17±0.90和2.25±0.75);(P<0.05)。结果显示,57.6%的有用视频由大学、专业组织和卫生保健专业人员上传,67.9%的无用视频由患者上传;差异具有统计学意义(P<0.05)。结论结果表明,大多数在线视频评估是准确的。这些视频大多是由大学、专业组织、医疗保健专业人员或医疗广告商上传的。尽管这项研究有很多局限性,但作者建议,医疗保健专业人员可以在出院后将患者引导到这些来源。然而,还需要进一步的研究。。
{"title":"Content and Quality of Online Videos About Ostomy Pouch Changes: A Descriptive Study.","authors":"Zeynep Temiz, Didem Kandemir","doi":"10.25270/wmp.2022.8.2532","DOIUrl":"https://doi.org/10.25270/wmp.2022.8.2532","url":null,"abstract":"BACKGROUND\u0000Many health-related videos are available online. One type of health-related video is related to stoma pouch change. However, a system to evaluate the quality and content of these videos is lacking.\u0000\u0000\u0000PURPOSE\u0000To evaluate the content and quality of YouTube videos on colostomy pouch change.\u0000\u0000\u0000METHODS\u0000A descriptive study was carried out by searching for videos on March 15, 2021, using the key words \"colostomy care,\" \"colostomy bag/pouch change,\" and \"ostomy bag/pouch change.\" A 5-point Global Quality Scale was used to evaluate the quality of the videos, and a 10-point scale was used to evaluate the content. The videos were classified as \"useful\" or \"useless\" according to their content and quality scores.\u0000\u0000\u0000RESULTS\u0000A total of 128 videos were found; 94 videos met the criteria and were included in the study. The content of the 94 videos was examined by 2 independent researchers. The overall content score of the videos was 8.24 ± 1.56, and the overall quality score was 3.14 ± 0.97. A total of 66 (70.21%) videos were useful, and 28 (29.79%) videos were useless. The mean scores of useful videos for content (9.09 ± 0.83) and the average Global Quality Scale scores (3.53 ± 0.76) were significantly higher than those of useless videos (6.17 ± 0.90 and 2.25 ± 0.75, respectively; (P < .05). The results showed that 57.6% of the useful videos were uploaded by universities, professional organizations, and health care professionals, and 67.9% of the useless videos were uploaded by patients; the difference was statistically significant (P < .05).\u0000\u0000\u0000CONCLUSIONS\u0000Results indicated that the majority of online videos evaluated were accurate. Most of these videos were uploaded by universities, professional organizations, health care professionals, or medical advertisers. Although there were many limitations to this study, the authors suggest that health care professionals can direct their patients to these sources after hospital discharge. However, future studies are needed..","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47104796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Feasibility of Temporary Ileostomy in Older Patients: A Retrospective Study. 老年患者临时回肠切开术的安全性和可行性:一项回顾性研究。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-07-01 DOI: 10.25270/wmp.2022.7.1824
S. Maeda, A. Ouchi, K. Komori, T. Kinoshita, Taihei Oshiro, Yoshihisa Numata, S. Ito, T. Abe, Y. Shimizu
BACKGROUNDTemporary ileostomy reduces the incidence of severe anastomotic leakage and postoperative mortality. However, little is known about ileostomy-related complications in older adults.PURPOSETo clarify the safety and feasibility of temporary ileostomy for rectal cancer in older patients.METHODSData were collected from a prospectively created database and complemented by secondary chart review for consecutive patients with rectal malignancy who underwent curative proctectomy with diverting loop ileostomy between 2013 and 2018. Ileostomy construction and closure were compared between two groups (defined as elderly and non-elderly patients). Data for 22 patients who were 75 years of age and older (elderly group) and 160 patients who were younger than 75 years (non-elderly group) were analyzed.RESULTSThe median maximum fecal output was significantly higher in the non-elderly group compared with the elderly group. No significant differences were observed between the two groups in postoperative intravenous hydration, creatinine ratio, and ileostomy-related complication rate. Although the elderly group had a higher rate of early stoma closure, the causes were not related to those complications.CONCLUSIONTemporary ileostomy was a safe and feasible procedure in this population of older patients with rectal malignancies.
背景临时回肠造口术可降低严重吻合口瘘的发生率和术后死亡率。然而,对老年人回肠造口术相关并发症知之甚少。目的阐明老年直肠癌患者临时回肠造瘘术的安全性和可行性。方法从前瞻性创建的数据库中收集数据,并对2013年至2018年间连续接受直肠切除术和回肠转移环造口术的直肠恶性肿瘤患者进行二次图表审查。比较两组(定义为老年患者和非老年患者)的回肠切开术结构和闭合情况。分析了22名75岁及以上患者(老年组)和160名75岁以下患者(非老年组)的数据。结果与老年组相比,非老年组的中位最大排泄量显著较高。两组在术后静脉水合作用、肌酸酐比率和回肠造口术相关并发症发生率方面无显著差异。尽管老年组早期造口闭合率较高,但其原因与这些并发症无关。结论临时回肠造口术是一种安全可行的治疗老年直肠恶性肿瘤的方法。
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引用次数: 0
A Proposed Algorithm to Diagnose and Treat Lower Extremity Hematomas. 一种诊断和治疗下肢血肿的算法。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-07-01
Windy Cole, Stacey Coe, Sarah Messina, Valeria Marmolejo

Background: Pretibial injury is common. Although the mechanism of injury may be minor, in a specific patient population, misdiagnosis and delay in appropriate treatment can lead to dire consequences. The ability to identify and properly treat these patients early has the potential to reduce the need for surgical intervention, hospitalization, and prolonged care.

Methods: A literature review was performed to develop the Lower Extremity Hematoma Algorithm (LEHA) to aid in identifying and managing these injuries in the patient population at greatest risk.

Results: A case example is provided to demonstrate how implementation of the LEHA may have led to early diagnosis and treatment, avoiding expensive advanced and prolonged care.

Conclusion: Implementation of the LEHA may expedite the identification of patients at risk for deep dissecting hematomas, enabling faster implementation of appropriate treatment and thereby helping to contain health care costs through avoiding surgical intervention.

背景:胫骨前损伤是常见的。虽然损伤的机制可能是轻微的,但在特定的患者群体中,误诊和延误适当的治疗可能导致可怕的后果。早期识别和正确治疗这些患者的能力有可能减少手术干预、住院和长期护理的需要。方法:进行文献综述,以开发下肢血肿算法(LEHA),以帮助识别和管理这些损伤的患者人群在最大的风险。结果:提供了一个案例来证明LEHA的实施可能导致早期诊断和治疗,避免昂贵的晚期和长期护理。结论:LEHA的实施可以加快识别有深度解剖血肿风险的患者,从而更快地实施适当的治疗,从而通过避免手术干预来帮助控制医疗费用。
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引用次数: 0
A Proposed Algorithm to Diagnose and Treat Lower Extremity Hematomas. 一种诊断和治疗下肢血肿的算法。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-07-01 DOI: 10.25270/wmp.2022.7.1117
Windy E. Cole, Stacey Coe, Sarah Messina, Valeria Marmolejo
BACKGROUNDPretibial injury is common. Although the mechanism of injury may be minor, in a specific patient population, misdiagnosis and delay in appropriate treatment can lead to dire consequences. The ability to identify and properly treat these patients early has the potential to reduce the need for surgical intervention, hospitalization, and prolonged care.METHODSA literature review was performed to develop the Lower Extremity Hematoma Algorithm (LEHA) to aid in identifying and managing these injuries in the patient population at greatest risk.RESULTSA case example is provided to demonstrate how implementation of the LEHA may have led to early diagnosis and treatment, avoiding expensive advanced and prolonged care.CONCLUSIONImplementation of the LEHA may expedite the identification of patients at risk for deep dissecting hematomas, enabling faster implementation of appropriate treatment and thereby helping to contain health care costs through avoiding surgical intervention.
背景:胫骨前损伤是常见的。虽然损伤的机制可能是轻微的,但在特定的患者群体中,误诊和延误适当的治疗可能导致可怕的后果。早期识别和正确治疗这些患者的能力有可能减少手术干预、住院和长期护理的需要。方法回顾文献,开发下肢血肿算法(LEHA),以帮助识别和管理高危患者群体中的这些损伤。结果提供了一个案例,说明LEHA的实施如何导致早期诊断和治疗,避免了昂贵的晚期和长期护理。结论LEHA的实施可以加快对深解剖血肿风险患者的识别,从而更快地实施适当的治疗,从而有助于通过避免手术干预来控制医疗费用。
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引用次数: 0
Safety and Feasibility of Temporary Ileostomy in Older Patients: A Retrospective Study. 老年患者临时回肠造口术的安全性和可行性:一项回顾性研究。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-07-01
Shingo Maeda, Akira Ouchi, Koji Komori, Takashi Kinoshita, Taihei Oshiro, Yoshihisa Numata, Seiji Ito, Tetsuya Abe, Yasuhiro Shimizu

Background: Temporary ileostomy reduces the incidence of severe anastomotic leakage and postoperative mortality. However, little is known about ileostomy-related complications in older adults.

Purpose: To clarify the safety and feasibility of temporary ileostomy for rectal cancer in older patients.

Methods: Data were collected from a prospectively created database and complemented by secondary chart review for consecutive patients with rectal malignancy who underwent curative proctectomy with diverting loop ileostomy between 2013 and 2018. Ileostomy construction and closure were compared between two groups (defined as elderly and non-elderly patients). Data for 22 patients who were 75 years of age and older (elderly group) and 160 patients who were younger than 75 years (non-elderly group) were analyzed.

Results: The median maximum fecal output was significantly higher in the non-elderly group compared with the elderly group. No significant differences were observed between the two groups in postoperative intravenous hydration, creatinine ratio, and ileostomy-related complication rate. Although the elderly group had a higher rate of early stoma closure, the causes were not related to those complications.

Conclusion: Temporary ileostomy was a safe and feasible procedure in this population of older patients with rectal malignancies.

背景:临时回肠造口术降低了严重吻合口漏的发生率和术后死亡率。然而,对于老年人的回肠造口相关并发症知之甚少。目的:探讨老年直肠癌患者临时回肠造口术的安全性和可行性。方法:从前瞻性创建的数据库中收集数据,并辅以2013年至2018年期间接受治疗性直肠恶性肿瘤直肠切除术合并回肠袢转流造口术的连续患者的二次图表回顾。比较两组(定义为老年和非老年患者)回肠造口建设和闭合情况。分析了22例75岁及以上患者(老年组)和160例75岁以下患者(非老年组)的数据。结果:非老年组最大排便量中位数明显高于老年组。两组术后静脉补水、肌酐比值、回肠造口相关并发症发生率无显著差异。虽然老年组早期造口率较高,但其原因与这些并发症无关。结论:对于老年直肠恶性肿瘤患者,临时回肠造口术是一种安全可行的治疗方法。
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引用次数: 0
Effect of Topical Application and/or Systemic Use of Red Ginseng Extract on Wound Healing in Rats With Experimentally Induced Diabetes. 红参提取物的局部应用和/或全身应用对实验性糖尿病大鼠伤口愈合的影响。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2022-06-01 DOI: 10.25270/wmp.2022.6.2837
X. Xxxxxxx, M. Duymus, H. A. Aydin, Abdullah Bulğurcu, Z. Bayramoğlu, A. Durhan, Salih M Salih, M. R. Pekcici, K. Kısmet
BACKGROUNDRed ginseng (Rg) is an herbal product that has been used in traditional medicine in Asian and European countries for many years.PURPOSETo study the effects of Rg extract on wound healing when used systemically, locally, or in combination in rats with experimentally induced diabetes.METHODSA total of 60 rats were randomly divided into 4 groups: saline (control), local Rg (LRg), systemic Rg (SRg), and local + systemic = combined Rg (CRg). A full-thickness wound (2 cm × 1 cm) was created on the back of the rats, and treatment protocols were carried out for 14 days. Wound areas of all rats were measured on days 0 and 14. Tissue samples were taken from the wound areas for histopathologic evaluation of inflammation, epithelialization, and fibrosis. Vascular endothelial growth factor (VEGF), CD4+, and CD8+ expressions were examined by immunohistochemistry.RESULTSWound contraction measurements were 63.8%, 80.5%, 88.5%, and 86.6% in the control, LRg, SRg and CRg groups, respectively. Although significant differences were observed for all treated groups (LRg, SRg, and CRg) compared with the control group in terms of wound contraction, there was no difference among the treatment groups. VEGF-positive vessel/mm2 was observed 4.00 ± 0.75, 5.93 ± 0.70, 5.93 ± 1.93, and 7.93 ± 0.70 in the control, LRg, SRg and CRg groups, respectively. There was no difference between LRg and SRg in terms of VEGF expression, but there was significant difference for all other groups compared with each other.CONCLUSIONAll usage methods of Rg extract increased wound contraction, and differences were observed compared with the control group. However, the authors believe that the combined usage was more effective due to higher VEGF expression levels and lower CD4+:CD8+ ratio.
人参(Rg)是一种草药产品,在亚洲和欧洲国家的传统医学中使用了多年。目的研究Rg提取物在实验性糖尿病大鼠全身、局部或联合使用时对伤口愈合的影响。方法将60只大鼠随机分为4组:生理盐水(对照组)、局部Rg(LRg)、全身Rg(SRg)和局部+全身=联合Rg(CRg)。在大鼠背部形成全层伤口(2cm×1cm),并进行为期14天的治疗方案。在第0天和第14天测量所有大鼠的伤口面积。从伤口区域采集组织样本,用于炎症、上皮化和纤维化的组织病理学评估。通过免疫组织化学检测血管内皮生长因子(VEGF)、CD4+和CD8+的表达。结果对照组、LRg组、SRg组和CRg组的声收缩率分别为63.8%、80.5%、88.5%和86.6%。尽管在伤口收缩方面,所有治疗组(LRg、SRg和CRg)与对照组相比都有显著差异,但治疗组之间没有差异。对照组、LRg组、SRg组和CRg组VEGF阳性血管/mm2分别为4.00±0.75、5.93±0.70、5.93士1.93和7.93士0.70。LRg和SRg在VEGF表达方面没有差异,但所有其他组之间存在显著差异。结论Rg提取物的各种使用方法均能增加创面收缩,与对照组比较有显著性差异。然而,作者认为,联合使用更有效,因为VEGF表达水平更高,CD4+:CD8+比率更低。
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Wound management & prevention
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