Context: Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in normal women and those with DHEA-deficient states. Evidence Acquisition: A review of the literature from 1985 to 2021 on the potential benefits and risks of androgen prohormones in women. Evidence Synthesis: Studies have examined the potential benefit of DHEA therapy for anti-aging, sexual dysfunction, infertility, metabolic bone health, cognition, and wellbeing in hormone-deficient states such as primary adrenal insufficiency, hypopituitarism, and anorexia as well as administration to normal women across the lifespan. Conclusions: Data support small benefits in quality of life and mood but not for anxiety or sexual function in women with primary or secondary adrenal insufficiency or anorexia. No consistent beneficial effects of DHEA administration have been observed for menopausal symptoms, sexual function, cognition, or overall wellbeing in normal women. Local administration of DHEA shows benefit in vulvovaginal atrophy. Use of DHEA to improve induction of ovulation response in women with diminished ovarian reserve is not recommended. Risks of high physiologic or pharmacologic use of DHEA include androgenic and estrogenic side effects which are of concern for long-term administration. Clinical Case: A 49-year-old woman with Addison’s disease who is on low dose estrogen with cyclic progesterone therapy for menopausal symptoms returns for follow-up. She is on a stable glucocorticoid replacement strategy of hydrocortisone 10 mg in the morning and 5 mg in the early afternoon and fludrocortisone 0.05 mg each morning. She has read on the internet that additional therapy with DHEA may help her overall quality of life and libido. She asks whether she should add this therapy to her regimen and at what dose.
{"title":"Should Dehydroepiandrosterone be administered to women?","authors":"Wierman Me, Kiseljak-Vassiliades K","doi":"10.1530/ey.19.8.14","DOIUrl":"https://doi.org/10.1530/ey.19.8.14","url":null,"abstract":"Context: Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in normal women and those with DHEA-deficient states. Evidence Acquisition: A review of the literature from 1985 to 2021 on the potential benefits and risks of androgen prohormones in women. Evidence Synthesis: Studies have examined the potential benefit of DHEA therapy for anti-aging, sexual dysfunction, infertility, metabolic bone health, cognition, and wellbeing in hormone-deficient states such as primary adrenal insufficiency, hypopituitarism, and anorexia as well as administration to normal women across the lifespan. Conclusions: Data support small benefits in quality of life and mood but not for anxiety or sexual function in women with primary or secondary adrenal insufficiency or anorexia. No consistent beneficial effects of DHEA administration have been observed for menopausal symptoms, sexual function, cognition, or overall wellbeing in normal women. Local administration of DHEA shows benefit in vulvovaginal atrophy. Use of DHEA to improve induction of ovulation response in women with diminished ovarian reserve is not recommended. Risks of high physiologic or pharmacologic use of DHEA include androgenic and estrogenic side effects which are of concern for long-term administration. Clinical Case: A 49-year-old woman with Addison’s disease who is on low dose estrogen with cyclic progesterone therapy for menopausal symptoms returns for follow-up. She is on a stable glucocorticoid replacement strategy of hydrocortisone 10 mg in the morning and 5 mg in the early afternoon and fludrocortisone 0.05 mg each morning. She has read on the internet that additional therapy with DHEA may help her overall quality of life and libido. She asks whether she should add this therapy to her regimen and at what dose.","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78195616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Y, Lorgeat V, Coriolan B, K. z, Vincent R, V. Je, Altenor K
{"title":"Validation study and outcomes of the diabetes quality of life in youth instrument in Haitian youth with type 1 diabetes residing in Haiti","authors":"Victor Y, Lorgeat V, Coriolan B, K. z, Vincent R, V. Je, Altenor K","doi":"10.1530/ey.19.13.11","DOIUrl":"https://doi.org/10.1530/ey.19.13.11","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83229043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huang R, D. Y, Nuyt Am, L. E., Wei Sq, J. P., Fraser Wd, Luo Zc
{"title":"Large birth size, infancy growth pattern, insulin resistance and β-cell function","authors":"Huang R, D. Y, Nuyt Am, L. E., Wei Sq, J. P., Fraser Wd, Luo Zc","doi":"10.1530/ey.19.2.22","DOIUrl":"https://doi.org/10.1530/ey.19.2.22","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83411773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. D., Warr N, Yesil G, H. K. Eker, Bas F, Poyrazoglu S, Darendeliler F, Direk G, Hatipoglu N, E. M, Z. Y. Abalı, B. G. Tosun, Kaygusuz Sb, T. S. Menevşe, Helvacioglu D, Turan S, Bereket A, Reeves R, S. M, M. M., T. L., Greenfield A, G. T
{"title":"Broad-spectrum XX and XY gonadal dysgenesis in patients with a homozygous L193S variant in PPP2R3C","authors":"C. D., Warr N, Yesil G, H. K. Eker, Bas F, Poyrazoglu S, Darendeliler F, Direk G, Hatipoglu N, E. M, Z. Y. Abalı, B. G. Tosun, Kaygusuz Sb, T. S. Menevşe, Helvacioglu D, Turan S, Bereket A, Reeves R, S. M, M. M., T. L., Greenfield A, G. T","doi":"10.1530/ey.19.6.5","DOIUrl":"https://doi.org/10.1530/ey.19.6.5","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85425395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robertson Kj, Ariza Aj, S. K., Quadri M, M. C., Neault S, Davis Ee, Binns Hj
{"title":"Testing for rare genetic causes of obesity: findings and experiences from a pediatric weight management program","authors":"Robertson Kj, Ariza Aj, S. K., Quadri M, M. C., Neault S, Davis Ee, Binns Hj","doi":"10.1530/ey.19.11.1","DOIUrl":"https://doi.org/10.1530/ey.19.11.1","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74817792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CJ de Blok, Wiepjes Cm, D. V. Velzen, Staphorsius As, Nota Nm, Gooren Lj, Kreukels Bp, M. Heijer
{"title":"Mortality trends over five decades in adult transgender people receiving hormone treatment: a report from the Amsterdam cohort of gender dysphoria","authors":"CJ de Blok, Wiepjes Cm, D. V. Velzen, Staphorsius As, Nota Nm, Gooren Lj, Kreukels Bp, M. Heijer","doi":"10.1530/ey.19.6.16","DOIUrl":"https://doi.org/10.1530/ey.19.6.16","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72834183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhutta Za, Salam Ra, Gomber A, L. L., Narang T, Mbanya Jc, A. G.
{"title":"A century past the discovery of insulin: global progress and challenges for type 1 diabetes among children and adolescents in low-income and middle-income countries","authors":"Bhutta Za, Salam Ra, Gomber A, L. L., Narang T, Mbanya Jc, A. G.","doi":"10.1530/ey.19.10.1","DOIUrl":"https://doi.org/10.1530/ey.19.10.1","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72907020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trarbach Eb, Trivellin G, Grande Ipp, Duarte Fhg, Jorge Aal, do Nascimento Fbp, Garmes Hm, Nery M, Mendonça Bb, Stratakis Ca, B. Md, Jallad Rs
{"title":"Genetics, clinical features and outcomes of non-syndromic pituitary gigantism: experience of a single center from Sao Paulo, Brazil","authors":"Trarbach Eb, Trivellin G, Grande Ipp, Duarte Fhg, Jorge Aal, do Nascimento Fbp, Garmes Hm, Nery M, Mendonça Bb, Stratakis Ca, B. Md, Jallad Rs","doi":"10.1530/ey.19.1.10","DOIUrl":"https://doi.org/10.1530/ey.19.1.10","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75920999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obesity class impacts adverse maternal and neonatal outcomes independent of diabetes","authors":"Neal K, U. S, Glastras Sj","doi":"10.1530/ey.19.2.20","DOIUrl":"https://doi.org/10.1530/ey.19.2.20","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78755267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Welsch S, S. K., Brichard B, D. Ville, A. Damme, Boulanger C, Lysy P
{"title":"Characterization and risk factors of hyperglycaemia during treatment of childhood hematologic malignancies","authors":"Welsch S, S. K., Brichard B, D. Ville, A. Damme, Boulanger C, Lysy P","doi":"10.1530/ey.19.9.3","DOIUrl":"https://doi.org/10.1530/ey.19.9.3","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"11 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78794622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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