Wyatt P, Berry Se, Finlayson G, O'Driscoll R, Hadjigeorgiou G, Drew Da, Khatib Ha, Nguyen Lh, Linenberg I, Chan At, Spector Td, Franks Pw, W. J., Blundell J, Valdes Am
{"title":"Postprandial glycaemic dips predict appetite and energy intake in healthy individuals","authors":"Wyatt P, Berry Se, Finlayson G, O'Driscoll R, Hadjigeorgiou G, Drew Da, Khatib Ha, Nguyen Lh, Linenberg I, Chan At, Spector Td, Franks Pw, W. J., Blundell J, Valdes Am","doi":"10.1530/ey.19.15.2","DOIUrl":"https://doi.org/10.1530/ey.19.15.2","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89302309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. A., Yokubynas N, T. K, Saleh D, Wherrett Dk, S. R, Bassilious E, C. P, Lawrence Se
{"title":"Transient vs permanent congenital hypothyroidism in Ontario, Canada: predictive factors and scoring system","authors":"M. A., Yokubynas N, T. K, Saleh D, Wherrett Dk, S. R, Bassilious E, C. P, Lawrence Se","doi":"10.1530/ey.19.3.8","DOIUrl":"https://doi.org/10.1530/ey.19.3.8","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79842708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health-related quality of life and fatigue perception in children with congenital adrenal hyperplasia: a developing nation perspective","authors":"Daniel R, Yadav J, K. R., Malhi P, S. A, Dayal D","doi":"10.1530/ey.19.13.17","DOIUrl":"https://doi.org/10.1530/ey.19.13.17","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77274938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akin L, Rizzoti K, Gregory Lc, Corredor B, Stabej P Le Quesne, W. H., Buonocore F, Mouilleron S, Capra V, McGlacken-Byrne Sm, Martos-Moreno Ga, Azmanov Dn, Kendirci M, Kurtoglu S, Suntharalingham Jp, Galichet C, Gustincich S, Tasic V, Acherman Jc, A. A, Filipovska A, Tuilpakov A, Maghnie M, Gucev Z, Gonen Zb, P. La, R. I., Lovell-Badge R, Argente J, Dattani Mt
{"title":"Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency","authors":"Akin L, Rizzoti K, Gregory Lc, Corredor B, Stabej P Le Quesne, W. H., Buonocore F, Mouilleron S, Capra V, McGlacken-Byrne Sm, Martos-Moreno Ga, Azmanov Dn, Kendirci M, Kurtoglu S, Suntharalingham Jp, Galichet C, Gustincich S, Tasic V, Acherman Jc, A. A, Filipovska A, Tuilpakov A, Maghnie M, Gucev Z, Gonen Zb, P. La, R. I., Lovell-Badge R, Argente J, Dattani Mt","doi":"10.1530/ey.19.1.7","DOIUrl":"https://doi.org/10.1530/ey.19.1.7","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83469770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhang Qy, Ye Xp, Z. Z, Zhu Cf, L. R., Fang Y, Zhang Rj, L. L, L. W, W. Z, Song Sy, Luthfi Sy, Zhao Sx, Lin Jn, Song Hd
{"title":"Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimotos thyroiditis","authors":"Zhang Qy, Ye Xp, Z. Z, Zhu Cf, L. R., Fang Y, Zhang Rj, L. L, L. W, W. Z, Song Sy, Luthfi Sy, Zhao Sx, Lin Jn, Song Hd","doi":"10.1530/ey.19.3.11","DOIUrl":"https://doi.org/10.1530/ey.19.3.11","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"223 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83478352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robertson Kj, Ariza Aj, S. K., Quadri M, M. C., Neault S, Davis Ee, Binns Hj
{"title":"Testing for rare genetic causes of obesity: findings and experiences from a pediatric weight management program","authors":"Robertson Kj, Ariza Aj, S. K., Quadri M, M. C., Neault S, Davis Ee, Binns Hj","doi":"10.1530/ey.19.11.1","DOIUrl":"https://doi.org/10.1530/ey.19.11.1","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74817792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. D., Warr N, Yesil G, H. K. Eker, Bas F, Poyrazoglu S, Darendeliler F, Direk G, Hatipoglu N, E. M, Z. Y. Abalı, B. G. Tosun, Kaygusuz Sb, T. S. Menevşe, Helvacioglu D, Turan S, Bereket A, Reeves R, S. M, M. M., T. L., Greenfield A, G. T
{"title":"Broad-spectrum XX and XY gonadal dysgenesis in patients with a homozygous L193S variant in PPP2R3C","authors":"C. D., Warr N, Yesil G, H. K. Eker, Bas F, Poyrazoglu S, Darendeliler F, Direk G, Hatipoglu N, E. M, Z. Y. Abalı, B. G. Tosun, Kaygusuz Sb, T. S. Menevşe, Helvacioglu D, Turan S, Bereket A, Reeves R, S. M, M. M., T. L., Greenfield A, G. T","doi":"10.1530/ey.19.6.5","DOIUrl":"https://doi.org/10.1530/ey.19.6.5","url":null,"abstract":"","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85425395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in normal women and those with DHEA-deficient states. Evidence Acquisition: A review of the literature from 1985 to 2021 on the potential benefits and risks of androgen prohormones in women. Evidence Synthesis: Studies have examined the potential benefit of DHEA therapy for anti-aging, sexual dysfunction, infertility, metabolic bone health, cognition, and wellbeing in hormone-deficient states such as primary adrenal insufficiency, hypopituitarism, and anorexia as well as administration to normal women across the lifespan. Conclusions: Data support small benefits in quality of life and mood but not for anxiety or sexual function in women with primary or secondary adrenal insufficiency or anorexia. No consistent beneficial effects of DHEA administration have been observed for menopausal symptoms, sexual function, cognition, or overall wellbeing in normal women. Local administration of DHEA shows benefit in vulvovaginal atrophy. Use of DHEA to improve induction of ovulation response in women with diminished ovarian reserve is not recommended. Risks of high physiologic or pharmacologic use of DHEA include androgenic and estrogenic side effects which are of concern for long-term administration. Clinical Case: A 49-year-old woman with Addison’s disease who is on low dose estrogen with cyclic progesterone therapy for menopausal symptoms returns for follow-up. She is on a stable glucocorticoid replacement strategy of hydrocortisone 10 mg in the morning and 5 mg in the early afternoon and fludrocortisone 0.05 mg each morning. She has read on the internet that additional therapy with DHEA may help her overall quality of life and libido. She asks whether she should add this therapy to her regimen and at what dose.
{"title":"Should Dehydroepiandrosterone be administered to women?","authors":"Wierman Me, Kiseljak-Vassiliades K","doi":"10.1530/ey.19.8.14","DOIUrl":"https://doi.org/10.1530/ey.19.8.14","url":null,"abstract":"Context: Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in normal women and those with DHEA-deficient states. Evidence Acquisition: A review of the literature from 1985 to 2021 on the potential benefits and risks of androgen prohormones in women. Evidence Synthesis: Studies have examined the potential benefit of DHEA therapy for anti-aging, sexual dysfunction, infertility, metabolic bone health, cognition, and wellbeing in hormone-deficient states such as primary adrenal insufficiency, hypopituitarism, and anorexia as well as administration to normal women across the lifespan. Conclusions: Data support small benefits in quality of life and mood but not for anxiety or sexual function in women with primary or secondary adrenal insufficiency or anorexia. No consistent beneficial effects of DHEA administration have been observed for menopausal symptoms, sexual function, cognition, or overall wellbeing in normal women. Local administration of DHEA shows benefit in vulvovaginal atrophy. Use of DHEA to improve induction of ovulation response in women with diminished ovarian reserve is not recommended. Risks of high physiologic or pharmacologic use of DHEA include androgenic and estrogenic side effects which are of concern for long-term administration. Clinical Case: A 49-year-old woman with Addison’s disease who is on low dose estrogen with cyclic progesterone therapy for menopausal symptoms returns for follow-up. She is on a stable glucocorticoid replacement strategy of hydrocortisone 10 mg in the morning and 5 mg in the early afternoon and fludrocortisone 0.05 mg each morning. She has read on the internet that additional therapy with DHEA may help her overall quality of life and libido. She asks whether she should add this therapy to her regimen and at what dose.","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78195616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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