Kohei Kinoshita, Akihiro Maenaka, Ivy A. Rosales, Ahmad Karadagi, Toshihide Tomosugi, David Ayares, Seth Lederman, Robert B. Colvin, Tatsuo Kawai, Richard N. Pierson, Takaaki Kobayashi, David K. C. Cooper
Antibody‐mediated rejection (AMR) is a common cause of graft failure after pig‐to‐nonhuman primate organ transplantation, even when the graft is from a pig with multiple genetic modifications. The specific factors that initiate AMR are often uncertain. We report two cases of pig kidney transplantation into immunosuppressed baboons in which we identify novel factors associated with the initiation of AMR. In the first, membranous nephropathy was the initiating factor that was then associated with the apparent loss of the therapeutic anti‐CD154 monoclonal antibody in the urine when severe proteinuria was present. This observation suggests that proteinuria may be associated with the loss of any therapeutic monoclonal antibody, for example, anti‐CD154 or eculizumab, in the urine, resulting in xenograft rejection. In the second case, the sequence of events and histopathology tentatively suggested that pyelonephritis may have initiated acute‐onset AMR. The association of a urinary infection with graft rejection has been well‐documented in ABO‐incompatible kidney allotransplantation based on the expression of an antigen on the invading microorganism shared with the kidney graft, generating an immune response to the graft. To our knowledge, these potential initiating factors of AMR in pig xenografts have not been highlighted previously.
抗体介导的排斥反应(AMR)是猪对非人灵长类器官移植后移植物失败的常见原因,即使移植物来自经过多种基因修饰的猪。引发 AMR 的具体因素往往不确定。我们报告了两例猪肾移植给免疫抑制狒狒的病例,在这两例病例中,我们发现了与启动 AMR 相关的新因素。在第一个病例中,膜性肾病是诱发因素,当出现严重蛋白尿时,尿液中抗 CD154 单克隆抗体的治疗性明显丧失。这一观察结果表明,蛋白尿可能与任何治疗性单克隆抗体(如抗 CD154 或 eculizumab)在尿液中的丢失有关,从而导致异种移植排斥反应。在第二个病例中,事件发生的顺序和组织病理学初步表明,肾盂肾炎可能引发了急性AMR。在ABO血型不相容的肾脏异体移植中,泌尿系统感染与移植物排斥反应之间的联系已被充分证明,其基础是入侵的微生物与肾脏移植物共享抗原的表达,从而对移植物产生免疫反应。据我们所知,猪异种移植中AMR的这些潜在启动因素以前从未被强调过。
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The call for applications for the Dr. med. vet. Dr. med. Ernst von Wnuck Award, endowed with 3000 EUR, is aimed at heads of research groups and young scientists working in the field of xenogeneic heart transplantation. The spectrum of relevant work includes basic research, development of suitable donor pigs, preclinical transplantation models, and innovative approaches to clinical translation. Applicants should have relevant, outstanding research and demonstrate a scientific focus in their career. Please send your application documents of maximum two pages on the current status of your scientific work, planned own projects in the field as well as five representative publications together with your CV by May 31, 2024 to Prof. Dr. Eckhard Wolf, Gene Center, LMU Munich, Germany (ewolf@genzentrum.lmu.de).
征集兽医医学博士的申请Dr. med.Ernst von Wnuck奖,奖金为3000欧元,面向异种心脏移植领域的研究小组负责人和年轻科学家。相关工作的范围包括基础研究、合适供体猪的开发、临床前移植模型以及临床转化的创新方法。申请者应拥有相关的杰出研究成果,并在其职业生涯中展现出对科学的专注。请在2024年5月31日之前将最长不超过两页的申请文件,包括您的科研工作现状、在该领域计划开展的项目以及五篇有代表性的论文,连同您的简历,寄给德国慕尼黑大学基因中心的Eckhard Wolf教授(ewolf@genzentrum.lmu.de)。
{"title":"Call for applications for the Dr. med. vet. Dr. med. Ernst von Wnuck Award 2024 for Cardiovascular Research","authors":"Eckhard Wolf","doi":"10.1111/xen.12856","DOIUrl":"https://doi.org/10.1111/xen.12856","url":null,"abstract":"<p>The call for applications for the Dr. med. vet. Dr. med. Ernst von Wnuck Award, endowed with 3000 EUR, is aimed at heads of research groups and young scientists working in the field of xenogeneic heart transplantation. The spectrum of relevant work includes basic research, development of suitable donor pigs, preclinical transplantation models, and innovative approaches to clinical translation. Applicants should have relevant, outstanding research and demonstrate a scientific focus in their career. Please send your application documents of maximum two pages on the current status of your scientific work, planned own projects in the field as well as five representative publications together with your CV by May 31, 2024 to Prof. Dr. Eckhard Wolf, Gene Center, LMU Munich, Germany (ewolf@genzentrum.lmu.de).</p>","PeriodicalId":23866,"journal":{"name":"Xenotransplantation","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}