Carlos Francisco Cabrera-Sánchez, J. Y. Sánchez-Godínez, Y. González
@https://dx.doi.org/00000000000 @ Neumol Cir Torax. 2021; 80 (4): 258-268 RESUMEN. El reposicionamiento de fármacos es una actividad que se realiza comúnmente por los laboratorios, y consiste en el uso comercial de un fármaco para un fin distinto para el que fue investigado o aprobado. En 2019 inició la pandemia de la COVID-19 causada por un nuevo virus, el SARS-CoV-2, un virus para el cual la población humana no tiene inmunidad, y tampoco se cuenta con un tratamiento eficaz. Como primera estrategia para tratar a los pacientes gravemente enfermos, se reposicionaron los fármacos que mostraban al menos teóricamente ser efectivos contra el SARS-CoV-2 para uso de emergencia. Una vez que se tuvieron resultados de los estudios clínicos, se evaluó su efectividad en la prevención de casos graves y/o mortales, si el fármaco mostraba una efectividad significativa, la Organización Mundial de la Salud (OMS) emitió la recomendación correspondiente para su uso, de lo contrario se emite la alerta de suspender su uso para la COVID-19. En esta revisión se describen los fármacos que se han reposicionado siguiendo este proceso así como los nuevos fármacos específicos para el SARS-CoV-2 que se encuentran en fase experimental y preclínica.
{"title":"Fármacos de reposicionamiento y fármacos específicos en fase preclínica para la COVID-19","authors":"Carlos Francisco Cabrera-Sánchez, J. Y. Sánchez-Godínez, Y. González","doi":"10.35366/103451","DOIUrl":"https://doi.org/10.35366/103451","url":null,"abstract":"@https://dx.doi.org/00000000000 @ Neumol Cir Torax. 2021; 80 (4): 258-268 RESUMEN. El reposicionamiento de fármacos es una actividad que se realiza comúnmente por los laboratorios, y consiste en el uso comercial de un fármaco para un fin distinto para el que fue investigado o aprobado. En 2019 inició la pandemia de la COVID-19 causada por un nuevo virus, el SARS-CoV-2, un virus para el cual la población humana no tiene inmunidad, y tampoco se cuenta con un tratamiento eficaz. Como primera estrategia para tratar a los pacientes gravemente enfermos, se reposicionaron los fármacos que mostraban al menos teóricamente ser efectivos contra el SARS-CoV-2 para uso de emergencia. Una vez que se tuvieron resultados de los estudios clínicos, se evaluó su efectividad en la prevención de casos graves y/o mortales, si el fármaco mostraba una efectividad significativa, la Organización Mundial de la Salud (OMS) emitió la recomendación correspondiente para su uso, de lo contrario se emite la alerta de suspender su uso para la COVID-19. En esta revisión se describen los fármacos que se han reposicionado siguiendo este proceso así como los nuevos fármacos específicos para el SARS-CoV-2 que se encuentran en fase experimental y preclínica.","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122756277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cuarta Reunión Anual de la Sociedad Latinoamericana de Fisiología Respiratoria 2020. Premiación de Trabajos libres","authors":"","doi":"10.35366/103458","DOIUrl":"https://doi.org/10.35366/103458","url":null,"abstract":"","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131759755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Carlos Vázquez-Minero, María de Jesús Villalba-Calderón, Arturo Chávez-Tinoco
{"title":"Evaluación educativa en tiempo de pandemia de COVID-19. ¿Cómo cambió en los ámbitos hospitalarios? Una propuesta","authors":"Juan Carlos Vázquez-Minero, María de Jesús Villalba-Calderón, Arturo Chávez-Tinoco","doi":"10.35366/102481","DOIUrl":"https://doi.org/10.35366/102481","url":null,"abstract":"","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128357165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Sancho-Hernández, L. Solorio-Rodríguez, Lourdes Mascareñas-Martínez, José Ariel Castillo-Moguel
. Introduction: Pharyngo-esophageal perforation represents a critical condition with high morbidity and mortality rates associated with a late diagnosis, current recommendations advocate conservative treatment, this report describes the usefulness of conservative and endoscopic treatment of a patient with spontaneous pharyng-esophageal perforation complicated with mediastinal abscess, the benefit of tissue adhesives in the closure of a residual fístula is detailed and a review of the literature applied to the pediatric population is proposed. Description of the case: A 16-year-old female adolescent who attended the emergency department with dysphagia, fever and subcutaneous emphysema of the neck and thorax, in esophagography and tomography, an upper esophageal perforation and the presence of a mediastinal abscess were corroborated, as the trans endoscopic route was considered insufficient for the patient a drainage of the septate mediastinal cavity and a left posterior cervical approach was decided, allowing mechanical debridement and drainage of 600 ml of purulent material; with clinical improvement, it persists with a pharyngo-cutaneous-mediastinal fístula and the decision was made to instill a solution of tissue adhesive inside the entire double fistulous tract and successful successful closure with a favorable evolution. Conclusions: An early recognition of pharyngoesophageal perforation, as well as aggressive debridement and appropriate drainage, allow tissue adhesives such as cyanoacrylate to promote successful and low morbidity closure by trans endoscopic in secondary sequelae and fistulas.
{"title":"Perforación faringoesofágica espontánea complicada con absceso mediastinal en niño","authors":"R. Sancho-Hernández, L. Solorio-Rodríguez, Lourdes Mascareñas-Martínez, José Ariel Castillo-Moguel","doi":"10.35366/97967","DOIUrl":"https://doi.org/10.35366/97967","url":null,"abstract":". Introduction: Pharyngo-esophageal perforation represents a critical condition with high morbidity and mortality rates associated with a late diagnosis, current recommendations advocate conservative treatment, this report describes the usefulness of conservative and endoscopic treatment of a patient with spontaneous pharyng-esophageal perforation complicated with mediastinal abscess, the benefit of tissue adhesives in the closure of a residual fístula is detailed and a review of the literature applied to the pediatric population is proposed. Description of the case: A 16-year-old female adolescent who attended the emergency department with dysphagia, fever and subcutaneous emphysema of the neck and thorax, in esophagography and tomography, an upper esophageal perforation and the presence of a mediastinal abscess were corroborated, as the trans endoscopic route was considered insufficient for the patient a drainage of the septate mediastinal cavity and a left posterior cervical approach was decided, allowing mechanical debridement and drainage of 600 ml of purulent material; with clinical improvement, it persists with a pharyngo-cutaneous-mediastinal fístula and the decision was made to instill a solution of tissue adhesive inside the entire double fistulous tract and successful successful closure with a favorable evolution. Conclusions: An early recognition of pharyngoesophageal perforation, as well as aggressive debridement and appropriate drainage, allow tissue adhesives such as cyanoacrylate to promote successful and low morbidity closure by trans endoscopic in secondary sequelae and fistulas.","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129770133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Gochicoa-Rangel, J. Vázquez-García, Claudia Vargas-Domínguez, Mónica Velázquez-Uncal, Ramiro Martínez-Andrade, Isabel Salas-Escamilla, Anaid Bautista-Bernal, Mónica Silva-Cerón, R. Mejía-Alfaro, Luis Torre-Bouscoulet
The bronchial challenge test with exercise (BCTE) is designed to evaluate the effect of exercise on spirometric parameters, as it makes it possible to explore whether exercise induces bronchial obstruction. This test is particularly useful in those patients that present symptoms of bronchial obstruction but whose at-rest spirometry is normal, and in others who present respiratory symptoms only while doing exercise. Although general recommendations for conducting BCTE have been published, we consider that certain aspects related to the technique of test performance and interpretation of results are not suffi ciently well defi ned. With the goal of improving quality control and facilitating test performance, this article reviews the existing international recommendations related to this procedure and presents guidelines that may contribute to achieving a better standardization process.
{"title":"Prueba de reto bronquial con ejercicio. Recomendaciones y procedimiento","authors":"Laura Gochicoa-Rangel, J. Vázquez-García, Claudia Vargas-Domínguez, Mónica Velázquez-Uncal, Ramiro Martínez-Andrade, Isabel Salas-Escamilla, Anaid Bautista-Bernal, Mónica Silva-Cerón, R. Mejía-Alfaro, Luis Torre-Bouscoulet","doi":"10.35366/NTS192M","DOIUrl":"https://doi.org/10.35366/NTS192M","url":null,"abstract":"The bronchial challenge test with exercise (BCTE) is designed to evaluate the effect of exercise on spirometric parameters, as it makes it possible to explore whether exercise induces bronchial obstruction. This test is particularly useful in those patients that present symptoms of bronchial obstruction but whose at-rest spirometry is normal, and in others who present respiratory symptoms only while doing exercise. Although general recommendations for conducting BCTE have been published, we consider that certain aspects related to the technique of test performance and interpretation of results are not suffi ciently well defi ned. With the goal of improving quality control and facilitating test performance, this article reviews the existing international recommendations related to this procedure and presents guidelines that may contribute to achieving a better standardization process.","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133842328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Sancho-Hernández, Francisco J. Cuevas-Schacht, Gabriel Gutiérrez-Morales, A. Alva-Chaire, L. Solorio-Rodríguez
), ) ). ABSTRACT. Introduction: Interstitial emphysematous disease (IED) is a group of conditions that affect ectopic air trapping in the pulmonary interstitium of the child in the context of an infectious process and secondary damage generated by mechanical ventilation; a functional-radiological-clinical classification that allows a diagnostic and therapeutic approach is proposed. Methods: A descriptive, retrospective and observational study in cases series with 13 patients with diagnoses confirmed by pathology IED and radiological and functional evaluation. They were divided into 3 groups: interstitial lobar emphysema acquired (ILEA), neonatal interstitial emphysema (NIE) and interstitial emphysema and barotrauma (IEB), congenital causes were excluded, infectious and mechanical ventilation factors, response to conservative and surgical approaches, mortality and complications were investigated. Results: In ILEA group: 3 persistent bronchiolitis obliterans diagnosed interstitial emphysema, pulmonary resection was performed with satisfactory outcome and other diagnostic biopsy with insidious evolution of their hypertensive vascular disease; NIE: 4, 3 lobectomy eradicated hypertension and pulmonary short circuit and progression broncodisplasia avoided, and another responded to conservative management with high frequency ventilation; IEB: 6 were treated with pleural drainage and represent the largest group lethality associated with pneumonia and a high ventilatory pressures. Conclusions: This classification allows a diagnostic and therapeutic orientation: ILEA and NIE group forecasts show improvement with lung resection if conservative options have failed; In the EIB group, and mild ventilatory are
{"title":"Experiencia en el tratamiento conservador y quirúrgico en niños con secuelas y complicaciones enfisematosas secundaria a ventilación mecánica: serie de casos y revisión de la literatura","authors":"R. Sancho-Hernández, Francisco J. Cuevas-Schacht, Gabriel Gutiérrez-Morales, A. Alva-Chaire, L. Solorio-Rodríguez","doi":"10.35366/NT191B","DOIUrl":"https://doi.org/10.35366/NT191B","url":null,"abstract":"), ) ). ABSTRACT. Introduction: Interstitial emphysematous disease (IED) is a group of conditions that affect ectopic air trapping in the pulmonary interstitium of the child in the context of an infectious process and secondary damage generated by mechanical ventilation; a functional-radiological-clinical classification that allows a diagnostic and therapeutic approach is proposed. Methods: A descriptive, retrospective and observational study in cases series with 13 patients with diagnoses confirmed by pathology IED and radiological and functional evaluation. They were divided into 3 groups: interstitial lobar emphysema acquired (ILEA), neonatal interstitial emphysema (NIE) and interstitial emphysema and barotrauma (IEB), congenital causes were excluded, infectious and mechanical ventilation factors, response to conservative and surgical approaches, mortality and complications were investigated. Results: In ILEA group: 3 persistent bronchiolitis obliterans diagnosed interstitial emphysema, pulmonary resection was performed with satisfactory outcome and other diagnostic biopsy with insidious evolution of their hypertensive vascular disease; NIE: 4, 3 lobectomy eradicated hypertension and pulmonary short circuit and progression broncodisplasia avoided, and another responded to conservative management with high frequency ventilation; IEB: 6 were treated with pleural drainage and represent the largest group lethality associated with pneumonia and a high ventilatory pressures. Conclusions: This classification allows a diagnostic and therapeutic orientation: ILEA and NIE group forecasts show improvement with lung resection if conservative options have failed; In the EIB group, and mild ventilatory are","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132087354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tratamiento ambulatorio de COVID-19: un aprendizaje pendiente","authors":"Cristóbal Guadarrama-Pérez","doi":"10.35366/108492","DOIUrl":"https://doi.org/10.35366/108492","url":null,"abstract":"","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116366994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RESUMEN. A pesar de los avances tecnológicos para el diagnóstico de la hipertensión pulmonar, la historia clínica y la exploración física aún se consideran fundamentales como método de escrutinio siempre y cuando se dominen los aspectos teóricos, sus fundamentos y sus limitaciones. Con la identificación de los factores de riesgo, la exclusión de aquellas entidades que forman parte del diagnóstico diferencial, una adecuada auscultación y el análisis del conjunto de variables clínicas obtenidas, se provee de importantes pistas que pudieran auxiliar en la detección lo más oportunamente posible de la enfermedad o contribuir en el seguimiento de estos pacientes.
{"title":"La clínica en la hipertensión pulmonar del adulto","authors":"R. A. Flores-Franco, Daniel Arturo Frías-Fierro","doi":"10.35366/nt193j","DOIUrl":"https://doi.org/10.35366/nt193j","url":null,"abstract":"RESUMEN. A pesar de los avances tecnológicos para el diagnóstico de la hipertensión pulmonar, la historia clínica y la exploración física aún se consideran fundamentales como método de escrutinio siempre y cuando se dominen los aspectos teóricos, sus fundamentos y sus limitaciones. Con la identificación de los factores de riesgo, la exclusión de aquellas entidades que forman parte del diagnóstico diferencial, una adecuada auscultación y el análisis del conjunto de variables clínicas obtenidas, se provee de importantes pistas que pudieran auxiliar en la detección lo más oportunamente posible de la enfermedad o contribuir en el seguimiento de estos pacientes.","PeriodicalId":246416,"journal":{"name":"NCT Neumología y Cirugía de Tórax","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134633905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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