Pub Date : 2020-09-30DOI: 10.47363/JVRR/2020(1)101
Aamir Jalal Al-Mosawi
It was known earlier that although, SARS-CoV was controlled more than a decade ago, more SARS-like coronaviruses which have been isolated in bats can use the human angiotensin converting enzyme-2 (ACE2) receptor to replicate to high levels in primary human airway, and they had the potential to cause new epidemics. Now, we should remember that it was concluded from earlier experiences that the first and most effective line of defense against a new viral pandemic in the early phases, are antiviral drugs not vaccines developed after rather a lengthy time. The unexpected high mortality associated with the ongoing SARS-CoV-2 in countries like the United States and the United Kingdom confirmed the earlier scientific prediction of the inadequate preparedness of the world to victoriously combat a new virus pandemic. The rational scientific approach to face a potentially fatal viral pandemic with no known effective specific therapies dictate the early use of all the useful preliminary research evidence with prioritizing emphasis on safety to avoid making more harm than good in such situation. We have previously published an evidence-based keys to the therapeutic challenge associated with the emergence of SARS-CoV-2 pandemic. The aim of this paper is to provide and important updates to keys to the therapeutic challenge which are hoped to help in cracking the padlock of SARS-CoV-2.
{"title":"The Use of the Available Research Evidence to Crack the Padlock of Sars-CoV-2","authors":"Aamir Jalal Al-Mosawi","doi":"10.47363/JVRR/2020(1)101","DOIUrl":"https://doi.org/10.47363/JVRR/2020(1)101","url":null,"abstract":"It was known earlier that although, SARS-CoV was controlled more than a decade ago, more SARS-like coronaviruses which have been isolated in bats can use the human angiotensin converting enzyme-2 (ACE2) receptor to replicate to high levels in primary human airway, and they had the potential to cause new epidemics. Now, we should remember that it was concluded from earlier experiences that the first and most effective line of defense against a new viral pandemic in the early phases, are antiviral drugs not vaccines developed after rather a lengthy time. The unexpected high mortality associated with the ongoing SARS-CoV-2 in countries like the United States and the United Kingdom confirmed the earlier scientific prediction of the inadequate preparedness of the world to victoriously combat a new virus pandemic. The rational scientific approach to face a potentially fatal viral pandemic with no known effective specific therapies dictate the early use of all the useful preliminary research evidence with prioritizing emphasis on safety to avoid making more harm than good in such situation. We have previously published an evidence-based keys to the therapeutic challenge associated with the emergence of SARS-CoV-2 pandemic. The aim of this paper is to provide and important updates to keys to the therapeutic challenge which are hoped to help in cracking the padlock of SARS-CoV-2.","PeriodicalId":247504,"journal":{"name":"Journal of Virology Research & Reports","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130601784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-30DOI: 10.47363/jvrr/2020(1)104
M. Leclerc
Immunocompetent cells were described in the sea star Asterina gibbosa: they recognize specifically various antigens as HRP (Horse-radish peroxydase) ,Alkalin phosphatase, trypsin ....On the other hand when certain Asterina gibbosa were immunized with Bence-Jones protein , other ones with Rat IGG: a crossed immune reaction occurs. The potential sea star immune system is not broad enough to detect such antigens.
{"title":"Does the Sea Star Discriminate Bence - Jones protein From Rat Igg as Antigens?","authors":"M. Leclerc","doi":"10.47363/jvrr/2020(1)104","DOIUrl":"https://doi.org/10.47363/jvrr/2020(1)104","url":null,"abstract":"Immunocompetent cells were described in the sea star Asterina gibbosa: they recognize specifically various antigens as HRP (Horse-radish peroxydase) ,Alkalin phosphatase, trypsin ....On the other hand when certain Asterina gibbosa were immunized with Bence-Jones protein , other ones with Rat IGG: a crossed immune reaction occurs. The potential sea star immune system is not broad enough to detect such antigens.","PeriodicalId":247504,"journal":{"name":"Journal of Virology Research & Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129131367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-22DOI: 10.32474/CTBM.2020.02.000129
Birhanu Gizaw
How the single virus is forceful and shakes the world is eye witness during this contemporary COVID19 pandemic time. People primarily think of viruses such as HIV, Ebola, Zika, Influenza, Tobacco mosaic virus or whatever new outbreak like SARS, Corona are all viruses worst and non-beneficial. However, not all viruses are detrimental and influential to human, animal and plant health. In fact some viruses have beneficial properties for their hosts in a symbiotic relationship and scientific research in many disciplines. Understanding the microbial world is very critical and crucial thing that they are driving force and governing the physical world and biosphere at all. The virus and other microbial life those of bacteria, fungi, prion, viroid, viron are requiring great attention and research to enhance their utilization from majority of useful aspects of microbial genetic resource. The secret behind of every industry, agriculture, health and environment are the application of microbes and their products are too high for human being and environment. Without microbes all life would be cease on earth. However some microbes are very dangerous like Corona virus, HIV, Ebola, Mycobacterium and others that destroy human life, but majority of microorganisms are too useful to promote development. Through building and strengthening microbial culture collection centers and through strong conservation strategy, it is possible to exploit more from the unseen microbial genetic resource. This paper will review the harmful and use full aspect of virus in respect with health, environment, agriculture and biotechnological application during this Covid19 pandemic time to raise awareness about virus at all.
{"title":"Corona and Other Virus: Their Useful and Harmful Aspects","authors":"Birhanu Gizaw","doi":"10.32474/CTBM.2020.02.000129","DOIUrl":"https://doi.org/10.32474/CTBM.2020.02.000129","url":null,"abstract":"How the single virus is forceful and shakes the world is eye witness during this contemporary COVID19 pandemic time. People primarily think of viruses such as HIV, Ebola, Zika, Influenza, Tobacco mosaic virus or whatever new outbreak like SARS, Corona are all viruses worst and non-beneficial. However, not all viruses are detrimental and influential to human, animal and plant health. In fact some viruses have beneficial properties for their hosts in a symbiotic relationship and scientific research in many disciplines. Understanding the microbial world is very critical and crucial thing that they are driving force and governing the physical world and biosphere at all. The virus and other microbial life those of bacteria, fungi, prion, viroid, viron are requiring great attention and research to enhance their utilization from majority of useful aspects of microbial genetic resource. The secret behind of every industry, agriculture, health and environment are the application of microbes and their products are too high for human being and environment. Without microbes all life would be cease on earth. However some microbes are very dangerous like Corona virus, HIV, Ebola, Mycobacterium and others that destroy human life, but majority of microorganisms are too useful to promote development. Through building and strengthening microbial culture collection centers and through strong conservation strategy, it is possible to exploit more from the unseen microbial genetic resource. This paper will review the harmful and use full aspect of virus in respect with health, environment, agriculture and biotechnological application during this Covid19 pandemic time to raise awareness about virus at all.","PeriodicalId":247504,"journal":{"name":"Journal of Virology Research & Reports","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123683219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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