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Successful Repair of a Post-opcabg Distal Ascending Aortic Pseudoaneurysm through Lateral Thoracotomy – A Case Report 外侧开胸术成功修复术后远端升主动脉假性动脉瘤1例
Pub Date : 2022-06-20 DOI: 10.3329/bhj.v37i1.60107
S. Gupta, S. Pervez, Jagadananda Roy, Bhabesh C Mandol, Mozibul Hoque, P. Chanda
A large ascending Aortic pseudoaneurysm is a rare life threatening complication after off pump coronary artery bypass surgery. We herein describe such a case of massive ascending Aortic pseudoaneurysm, with impending rupture which was adherent to undersurface of sternum, was successfully treated by us at Square Hospitals Limited.Bangladesh Heart Journal 2022; 37(1): 72-76
大升主动脉假性动脉瘤是冠状动脉旁路手术后罕见的危及生命的并发症。我们在此描述一例巨大的升主动脉假性动脉瘤,附着在胸骨下表面,即将破裂,我们在广场医院有限公司成功治疗。孟加拉国心脏杂志2022;37 (1): 72 - 76
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引用次数: 0
The Outcome of LM PCI: A Single Center Experience of First 50 Cases without In-site IVUS Facility LM PCI的结果:前50例无现场IVUS设备的单中心经验
Pub Date : 2022-06-20 DOI: 10.3329/bhj.v37i1.60098
MG Azam, Md. Shafiqul Islam, S. Mondal, Nobiul Islam, Mizanur Rahman, Abdullah Al Matin, N. Ahmed, M. Arefin
Introduction: Left main disease (LMD) is related to significant morbidity and mortality. This study was done to evaluate the clinical major adverse cardiovascular event (MACE), including unstable angina, myocardial infarction, heart failure, target vessel revascularization, stroke and death in patients undergoing left main stem stenting without availability of in-site intravascular imaging (IVUS). Methods & Materials: It was a prospective observational study done in National Institute of Cardiovascular Diseases & Hospital (NICVD) from March 2014 to June 2019. Our study included 50 patients who underwent Percutaneous Coronary Intervention for left main disease without use of IVUS. All the patients were followed up for 1 year & 2 years, one patient was lost to follow-up. Outcomes included in MACE were death, myocardial infarction, unstable angina, heart failure, stroke and target vessel revascularization (TVR). Results: Fifty patients (mean age 58.4 ± 4.1 years, 44 male, 06 female) were treated with a mean SYNTAX score of 24.8 ± 2.6. Thirty two (64%) patients had stable angina, 17 (34%) had unstable angina/non ST-elevation myocardial infarction, and 1 (02%) had ST-elevation Myocardial infarction. Among the risk factors, 21(42%) had DM, 33 (66%) were hypertensive, 22 (44%) were smoker, 19 (38%) had dyslipidemia, 09 (18%) had previous h/o MI, 11 (22%) had family h/o CAD & 01 (02%) had previous h/o CVD. Preprocedural LVEF was 49.92± 6.60 % and post procedural 54.84 ± 4.55% which showed significant improvement of LVEF after PCI (p=0.003). Most of the patients presented with LM with SVD (82%). Among all patients, 39 (78%) underwent complete revascularization in compare to 11 (22%) had incomplete revascularization. Thirty eight (76%) patients received a single-stent DES and 12 (24%) received two-stents DES. Among double stent strategy, majority underwent TAP (50%). All access was femoral & No reflow phenomena were found in any of the patients during the procedure. No perioperative mortalities were noted and no urgent coronary bypass graft surgery was required. One patient was lost to follow-up. After 1-year follow-up period, 1 (02%) patients had non-fatal myocardial infarction, 7 (14%) had episodes of unstable angina (UA) and 3 (06%) had heart failure (HF). After 2-years there was no new MI but 09 (18%) had UA & 4 (08%) patients had HF episode in total. TLR was 2 (04%) in first year and 3 (06%) in 2nd year. Total mortality was 1(02%) in first year & 3(06%) in 2nd year. The multivariable analysis showed a good prognosis in patients receiving LM PCI with a total event rate of 28% & mortality 6%. A multivariate regression analysis with risk factors for coronary artery disease as predictive variables showed that high SYNTAX score (p = 0.013), incomplete revascularization (p=0.002) & low post procedural LVEF (p= 0.001) was an independent predictor of MACE. Conclusion: Percutaneous coronary intervention of left main coronary disease without use of IVUS showed
左主干疾病(LMD)是一种高发病率、高死亡率的疾病。本研究旨在评估没有血管内显像(IVUS)的左主干支架置入术患者的临床主要不良心血管事件(MACE),包括不稳定型心绞痛、心肌梗死、心力衰竭、靶血管重建术、卒中和死亡。方法与材料:2014年3月至2019年6月在美国国立心血管疾病与医院研究所(NICVD)进行的前瞻性观察性研究。我们的研究纳入了50例经皮冠状动脉介入治疗左主干疾病而不使用IVUS的患者。所有患者随访1年、2年,1例失访。MACE包括死亡、心肌梗死、不稳定型心绞痛、心力衰竭、卒中和靶血管重建术(TVR)。结果:50例患者(平均年龄58.4±4.1岁,男性44例,女性06例),SYNTAX平均评分24.8±2.6。稳定型心绞痛32例(64%),不稳定型心绞痛/非st段抬高型心肌梗死17例(34%),st段抬高型心肌梗死1例(02%)。其中糖尿病21例(42%),高血压33例(66%),吸烟者22例(44%),血脂异常19例(38%),既往h/o心肌梗死09例(18%),家族h/o冠心病11例(22%),既往h/o心血管疾病01例(02%)。术前LVEF为49.92±6.60%,术后LVEF为54.84±4.55%,PCI术后LVEF明显改善(p=0.003)。大多数患者表现为LM合并SVD(82%)。在所有患者中,39例(78%)接受了完全血运重建术,11例(22%)接受了不完全血运重建术。38例(76%)患者接受了单支架DES, 12例(24%)患者接受了双支架DES。在双支架策略中,大多数患者接受了TAP(50%)。所有患者均为股骨通道,手术过程中未发现血流现象。无围手术期死亡,无紧急冠状动脉搭桥手术。1例患者失访。随访1年后,1例(02%)患者发生非致死性心肌梗死,7例(14%)患者发生不稳定型心绞痛(UA), 3例(06%)患者发生心力衰竭(HF)。2年后,没有新的心肌梗死,但共有09例(18%)患者发生UA, 4例(08%)患者发生心衰。第一年TLR为2(04%),第二年TLR为3(06%)。第一年总死亡率为1例(02%),第二年为3例(06%)。多变量分析显示,接受LM PCI的患者预后良好,总事件发生率为28%,死亡率为6%。以冠状动脉疾病危险因素为预测变量的多因素回归分析显示,SYNTAX评分高(p= 0.013)、血运重建不完全(p=0.002)和术后低LVEF (p= 0.001)是MACE的独立预测因子。结论:经皮冠状动脉介入治疗左主干病变,不使用IVUS,随访1年、2年,预后良好。这不仅可以为医生节省手术时间,还可以避免病人在无法负担血管内成像费用时的经济负担。孟加拉国心脏杂志2022;37 (1): 1 - 9
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引用次数: 0
Redo MIDCAB in a Septuagenarian in our Setting, Fantasy or Fact? - A Case Report 在我们的设定中重做一个七十岁老人的MIDCAB,幻想还是现实?-个案报告
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56041
S. Gupta, Md Ali Haider, M. Uddin, Bhabesh C Mandol, P. Chanda
Worldwide growth in elderly population has led to an upsurge in the number of septuagenarian (>70 years of age) patients requiring surgical treatment for coronary artery disease. Elective coronary artery bypass grafting (CABG) in the older patients are associated with acceptable risks of adverse events and should be undertaken for appropriate indications without unnecessary hesitation. Redo coronary surgeries carries one of the highest mortality rates amongst redo cardiac surgeries, both separately or in combination with other pathologies. As a result, minimally-invasive direct coronary artery bypass (MIDCAB), was preferred to avoid the complications of re-sternotomy. We hereby present a case report of a septuagenarian patient with post CABG (2014) unstable angina with old myocardial infarction (extensive anterior) who was treated successfully, by us and to our best knowledge in the published articles this is probably the first time, a re-do MIDCAB technique has been implemented in our country.Bangladesh Heart Journal 2021; 36(2): 145-150
世界范围内老年人口的增长导致70多岁(>70岁)患者需要手术治疗冠状动脉疾病的人数激增。选择性冠状动脉旁路移植术(CABG)在老年患者中存在可接受的不良事件风险,应在适当的适应症下毫不犹豫地进行。重做冠状动脉手术是重做心脏手术中死亡率最高的手术之一,无论是单独的还是与其他病理相结合。因此,微创直接冠状动脉搭桥术(MIDCAB)可避免再胸骨切开的并发症。我们在此报告一例70多岁的CABG后患者(2014年)不稳定心绞痛合并陈旧性心肌梗死(广泛前壁),经我们治疗成功,据我们所知,在已发表的文章中,这可能是第一次,重新做MIDCAB技术已在我国实施。孟加拉国心脏杂志2021;36 (2): 145 - 150
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引用次数: 0
A Case Report on Chronic Digoxin Toxicity 慢性地高辛中毒1例报告
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56040
P. Bala, A. Reza, M. A. Ali, M. Khan, Nighat Islam, Sadeed Araf Reza
Digitalis glycosides are among the oldest drugs used in cardiology. Nowadays, due to the limited indications for their use (advanced heart failure, usually concomitant with atrial fibrillation), cases of toxicity induced by this class of drugs are rarely observed. Digoxin produces a positive inotropic and bathmotropic effect on the heart, but has a negative chronotropic and dromotropic effect. Cardiac glycosides have a narrow therapeutic window, so digitalis treatment can easily lead to symptoms of overdose. In patients taking digoxin, the drug therapeutic level should be maintained at 1-2 ng/ml; the toxic effects occur at concentrations > 2.8 ng/ml and are mainly related to disturbances of cardiac function and of the circulatory system, as well as gastrointestinal symptoms and CNS disturbances. Here, a 65-years-old patient who was hospitalized following chronic ingestion with acute renal impairment. In spite of rapidly applied gastric irrigation and administration of activated charcoal, the drug level in the patient’s blood was estimated at 8.5 ng/ml. During her stay on the ward, typical symptoms of severe toxicity were observed: from gastric symptoms (severe nausea, vomiting) to conduction disturbances. Type I, moitz type 1 and 2 AV blocks were detected, as well as some supraventricular extrasystoles. These conduction disorders required the use of temporary endocardial pacing. Due to the unavailability of specific antidotes (antidigitalis antibodies) and lack of efficient methods of extracorporeal elimination of the drug, symptomatic treatment comprising the correction of electrolyte disturbances and heart rate control remains the most effective.Bangladesh Heart Journal 2021; 36(2): 139-144
洋地黄苷是用于心脏病学的最古老的药物之一。目前,由于其使用适应症有限(晚期心力衰竭,通常伴有心房颤动),这类药物引起的毒性病例很少观察到。地高辛对心脏有正性的肌力和促深作用,但有负性的促时和促深作用。心脏糖苷的治疗窗口很窄,所以洋地黄治疗容易导致过量的症状。服用地高辛的患者应维持1 ~ 2 ng/ml的药物治疗水平;浓度为bb0 ~ 2.8 ng/ml时发生毒性作用,主要与心功能和循环系统紊乱以及胃肠道症状和中枢神经系统紊乱有关。这是一位65岁的患者,因慢性摄入而住院,并发急性肾功能损害。尽管迅速进行了胃冲洗和给药活性炭,但患者血液中的药物水平估计为8.5 ng/ml。在她住院期间,观察到典型的严重毒性症状:从胃症状(严重恶心、呕吐)到传导障碍。检测到I型、moitz型和2型房室传导阻滞,以及一些室上早搏。这些传导障碍需要使用临时心内膜起搏。由于无法获得特异性解毒剂(抗地黄抗体)和缺乏有效的体外消除药物的方法,包括纠正电解质紊乱和控制心率的对症治疗仍然是最有效的。孟加拉国心脏杂志2021;36 (2): 139 - 144
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引用次数: 0
Prognostic Value of Electrocardiographic Abnormalities and Troponin-I Elevation in Hospitalized COVID-19 Patients 住院COVID-19患者心电图异常及肌钙蛋白-1升高的预后价值
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56036
A. Awal, Kazi Shamim Al Mamun, M. Karim, Md Saif Uddin Azad, Fannana Ahmed
Background: Corona Virus Disease (COVID -19) patients present mainly with respiratory manifestations and viral pneumonia. The cardiovascular presentation includes early signs of acute myocardial injury. Troponin elevation is a frequent laboratory finding in hospitalized patients with the disease, and may reflect direct vascular injury or nonspecific supply-demand imbalance. In this work, we assessed the correlation between different ranges of Troponin elevation, Electrocardiographic (ECG) abnormalities and mortality.Methods and materials: It was a prospective observational study, conducted in four tertiary care Private Hospitals of Chattogram City of Bangladesh. The study enrolled 181 consecutive patients admitted to hospital from June 01, 2020 to December 31, 2020 due to Covid-19 disease on the basis of presentation of signs and symptoms severity. Upon admission, routine investigations cTnI and ECG were carried out.Results: Mean age of the patients was 54.3±7.3 years with 63.5% male. Hypertension was the most common comorbidity followed by diabetes and obesity. 57.1% of the patients had abnormal ECG. Abnormal axis deviation [26 % (left axis deviation 23.9% vs right axis deviation 2.0%)], Poor R wave progression (22.9%), T inversion (14.5%), left ventricular hypertrophy (LVH) (11.4%) followed by ST segment depression (8.3%) were major findings observed in the study population. Presence of LVH (p=0.008), ST segment elevation (p≤0.001), ST segment depression (p≤0.001) and T inversion (p=0.003) showed statistically significant association with Severe COVID-19 disease. 48.2% had raised cTnI level. Thirteen (7.2%) patients expired in hospital. The mortality rate increased with incrementally higher troponin group: 12/18 than mildly elevated troponin 1/63 (p < 0.01). The presence of an abnormal ECG finding resulted in significant in the intermediate Troponin elevation group (0.05-1 ng/ml) but not in the low (<0.05 ng/ml) or high (> 1 ng/ml) Troponin elevation groups. There were statistically significant association between between cTnI level and death; and between ECG findings and death.Conclusion: Study conclude that Troponin-I level and ECG are a prognostic factor for mortality in hospitalized COVID-19 patients.Bangladesh Heart Journal 2021; 36(2): 105-112
背景:冠状病毒病(COVID -19)患者主要表现为呼吸道症状和病毒性肺炎。心血管表现包括急性心肌损伤的早期征象。肌钙蛋白升高是该疾病住院患者常见的实验室检查结果,可能反映了直接的血管损伤或非特异性供需失衡。在这项工作中,我们评估了不同范围的肌钙蛋白升高、心电图异常和死亡率之间的相关性。方法和材料:这是一项前瞻性观察研究,在孟加拉国Chattogram市的四家三级私立医院进行。该研究纳入了2020年6月1日至2020年12月31日期间因Covid-19疾病住院的181例连续患者,基于体征和症状严重程度的表现。入院后进行常规cTnI和ECG检查。结果:患者平均年龄54.3±7.3岁,男性占63.5%。高血压是最常见的合并症,其次是糖尿病和肥胖。57.1%的患者心电图异常。轴偏异常[26%(左轴偏23.9% vs右轴偏2.0%)],R波进展差(22.9%),T倒置(14.5%),左室肥厚(11.4%),ST段凹陷(8.3%)是研究人群中观察到的主要表现。LVH (p=0.008)、ST段抬高(p≤0.001)、ST段下降(p≤0.001)、T位倒置(p=0.003)与COVID-19重症相关,均有统计学意义。48.2%的患者cTnI水平升高。13例(7.2%)患者在医院死亡。肌钙蛋白升高组死亡率为12/18,高于肌钙蛋白轻度升高组(p < 0.01)。在肌钙蛋白中度升高组(0.05-1 ng/ml)出现异常心电图,但在低肌钙蛋白升高组(1 ng/ml)无明显异常。cTnI水平与死亡有统计学意义;心电图结果和死亡之间的联系结论:肌钙蛋白-1水平和心电图是影响COVID-19住院患者死亡的预后因素。孟加拉国心脏杂志2021;36 (2): 105 - 112
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引用次数: 0
Extremely Late Stent Thrombosis in a First Generation Drug- Eluting Stent 10 Years After Stent Deployment: A Case Report 第一代药物洗脱支架在支架放置10年后的极迟支架血栓形成:一例报告
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56044
Fazila-tun-nesa Malik, -. Md Kalimuddin, N. Ahmed, M. Badiuzzaman
Stent thrombosis is one of the gravest complications of percutaneous coronary intervention which usually manifest as ST-segment elevation myocardial infarction or sudden death. There are a very few case reports in the literature regarding extremely late stent thrombosis in a drug-eluting stent. Here we report a case of extremely late stent thrombosis in a first generation drug-eluting stent in a 54 year old gentleman. To the best of our knowledge, this is the first case report with the longest duration (10 years) after sirolimus eluting first-generation DES in Bangladesh.Bangladesh Heart Journal 2021; 36(2): 164-168
支架内血栓形成是经皮冠状动脉介入治疗最严重的并发症之一,通常表现为st段抬高心肌梗死或猝死。文献中很少有关于药物洗脱支架中极晚期支架血栓形成的病例报道。在这里,我们报告一个54岁的男士在第一代药物洗脱支架中发生极迟支架血栓的病例。据我们所知,这是孟加拉国第一例西罗莫司洗脱第一代DES后持续时间最长(10年)的病例报告。孟加拉国心脏杂志2021;36 (2): 164 - 168
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引用次数: 0
Requirement of Postoperative Ventilation and analgesics during Off-Pump Coronary Artery Bypass (OPCAB) surgery – A Comparison between Combined High Thoracic Epidural Anaesthesia (HTEA) with GA and GA Alone 非体外循环冠状动脉搭桥术(OPCAB)术后对通气和镇痛的要求——胸廓高位硬膜外麻醉(HTEA)联合GA与单独GA的比较
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56032
S. Azad, A. Beg
Beckground: This is often difficult to achieve optimal pain relief after coronary artery bypass surgery and also great challenge to choice appropriate analgesics with minimize the duration of mechanical ventilation. In the postoperative period inadequate analgesia may increase morbidity by causing adverse haemodynamic, metabolic, immunologic and haemostatic attentions and prolong mechanical ventilation with more ICU stay. High Thoracic Epidural Anaesthesia (HTEA) as an adjunct to general anaesthesia has been shown to be potentially beneficial in postoperative pain relief and the requirement of mechanical ventilationin patients with off-pump coronary artery bypass surgery (OPCAB). HTEA provides good protection from stress response, ensures hemodynamic stability, improves distribution of coronary blood flow with reducing demand of oxygen, less requirement of postoperative analgesia , mechanical ventilation and ICU stay.Objective: This study has been undertaken with a view to compare requirement of postoperative mechanical ventilation and analgesics in OPCAB surgery between HTEA with GA and GA alone.Methods: This prospective, randomized case control comparative study was carried out in sixty patients without having left main coronary artery disease, left ventricular ejection fraction <30% or contraindication of regional anaesthesia scheduled for OPCAB. They were divided into two groups, thirty in each group. Group A received GA alone and group B received high thoracic epidural anaesthesia with GA. Requirement of postoperative analgesics, pain score, consciousness score, sedation score, satisfection level and duration of ventilation with length of stay in intensive care unit were recorded in the post-operative period.Results: Rescue analgesics received and found 16(53.3%) and 6(20.0%) needed analgesia in group A and group B respectively and the difference was statistically significant (p<0.05). Regarding the pain score (VAS) during maintenance with ventilator with awareness at first fourth hour significant (p<0.05) change between two groups. After extubation at rest in different time interval and found significant (p<0.05) change between two groups in all follow-up times. Post-operative pain score (VAS) after extubation at movement in different time interval and found significant (p<0.05) change between two groups. Post-operative pain score (VAS) after extubation at during coughing in different time interval and found significant (p<0.05) change between two groups. Post-operative sedation score at first six hour (hourly) and found significant (p<0.05) change between two groups except 1st hour, which was not significant (p>0.05). The mean extubation hours were 7.4±1.09 hours in group A and 5.3±0.81 hours in group B. The mean ICU stay was 72.9±9.2 hours in group A and 57.1±12.0 hours in group B and the difference was statistically significant (p<0.05) in unpaired t-test. No postoperative complication was observed in both groups.Conclusion: HTEA wit
贝克地:冠状动脉搭桥术后通常很难达到最佳的疼痛缓解,选择合适的镇痛药并尽量减少机械通气时间也是一个很大的挑战。术后不适当的镇痛可引起不良的血流动力学、代谢、免疫和止血反应,延长机械通气时间,延长ICU住院时间,从而增加发病率。高胸段硬膜外麻醉(HTEA)作为全身麻醉的辅助,已被证明对非体外循环冠状动脉搭桥手术(OPCAB)患者术后疼痛缓解和机械通气需求有潜在的益处。HTEA对应激反应具有良好的保护作用,保证了血流动力学的稳定性,改善了冠状动脉血流分布,减少了供氧需求,减少了术后镇痛、机械通气和ICU住院时间。目的:比较HTEA联合GA与单独GA对OPCAB术后机械通气和镇痛药物的需求。方法:对60例无左主干冠状动脉疾病(左室射血分数0.05)的患者进行前瞻性、随机病例对照研究。A组平均拔管时间为7.4±1.09小时,B组平均拔管时间为5.3±0.81小时,A组平均ICU停留时间为72.9±9.2小时,B组平均ICU停留时间为57.1±12.0小时,非配对t检验差异有统计学意义(p<0.05)。两组均无术后并发症。结论:在OPCAB手术中,HTEA联合GA似乎是最可靠的术后疼痛缓解,缩短了机械通气时间,缩短了ICU住院时间。36 (2): 74 - 81
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引用次数: 1
Comparison of Angiographic Severity of Coronary Artery Disease between Premenopausal and Postmenopausal Women with Acute Coronary Syndrome 绝经前和绝经后急性冠状动脉综合征妇女冠状动脉病变血管造影严重程度的比较
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56037
RA Ahmed, Pinaki Das, A. Tushar, T. Saha, Mahboob Ali, A. Choudhury, N. Kar, M. A. Razzaque, J. Saha
Background: The risk of coronary artery disease in women after menopause sharply rises in contrast to that of women before menopause because of hormonal protection against atherosclerosis. No research work has been done so far to see the angiographic pattern and severity of coronary artery disease in premenopausal women and their comparison with those of postmenopausal women. This study will help understand the pattern and severity of CAD both in premenopausal and postmenopausal women.Methods: This cross sectional analytical study was conducted over 100 ACS female patients who were purposively selected and agreed to do coronary angiogram during index hospital admission. Among them 50 patients were premenopausal status with CAD constituted study group I and another 50 postmenopausal women with CAD constituted study group II. The main objective of the study was to compare the angiographic severity of coronary artery disease between premenopausal and postmenopausal women with acute coronary syndrome. Angiographic severity of CAD was assessed by vessel score, Gensini score and Friesinger score.Results: LAD was the common artery involved (76% vs. 56%) followed by RCA (72% vs. 36%) and LCX (62% vs. 30%) in group-II compared to group-I and involvement of individual coronary artery was statistically significant (P values were 0.03, 0.003 and 0.001 respectively). Critical stenosis (70-99%) involving the all three major epicardial vessels (LAD, LCX and RCA) were found most frequently in group-II and the percentage of lesions were 56% vs. 30%; 56% vs. 22% and 54% vs. 22% respectively (p< 0.05). The vessel score of the study patients revealed that singe vessel involvement was significantly higher in group-I (52% vs. 24%) (p=0.003) and triple vessel involvement was found significantly higher in group-II (40% vs. 12%) (p=0.001). Severity assessment by Friesinger score showed normal (0) and low (1-4) Friesinger score significantly higher in group-I patients (P=0.04 and P=0.007 respectively) and high Friesinger score (11-15) was found significantly higher in patients in group II (p=0.001). Severity assessment by Gensini score of the study patients revealed significantly higher mild Gensini score in group-I patients (P=0.002) and severe Gensini score in group II patients (p=0.002).Conclusion: Coronary artery disease is one of the major important problems not only in postmenopausal women but in premenopausal women also. Postmenopausal women suffer from more triple vessels involvement, more diffuse and severe disease. This study results point out that premenopausal women suffer from less severe coronary artery disease and there is a trend to involve mid LAD more frequently in comparison to other two major coronary arteries and LM coronary artery in comparison to postmenopausal women.Bangladesh Heart Journal 2021; 36(2): 113-123
背景:由于激素对动脉粥样硬化的保护作用,绝经后妇女患冠状动脉疾病的风险明显高于绝经前妇女。到目前为止,还没有研究工作来观察绝经前妇女的血管造影模式和冠状动脉疾病的严重程度,以及它们与绝经后妇女的比较。这项研究将有助于了解绝经前和绝经后妇女冠心病的模式和严重程度。方法:对100多名ACS女性患者进行横断面分析研究,这些患者是有目的选择并同意在索引住院期间做冠状动脉造影的。其中绝经前冠心病患者50例为研究ⅰ组,绝经后冠心病患者50例为研究ⅱ组。该研究的主要目的是比较绝经前和绝经后急性冠状动脉综合征妇女冠状动脉疾病的血管造影严重程度。采用血管评分、Gensini评分和Friesinger评分评价冠心病的血管造影严重程度。结果:与ⅰ组相比,ⅱ组LAD为累及总动脉(76%比56%),其次为RCA(72%比36%)和LCX(62%比30%),累及单个冠状动脉有统计学意义(P值分别为0.03、0.003和0.001)。重度狭窄(70-99%)累及所有三条主要心外膜血管(LAD、LCX和RCA)在ii组最常见,病变比例为56%比30%;56% vs. 22%, 54% vs. 22% (p< 0.05)。研究患者的血管评分显示,ⅰ组患者单支血管受累明显高于对照组(52% vs. 24%) (p=0.003),ⅲ组患者三支血管受累明显高于对照组(40% vs. 12%) (p=0.001)。用Friesinger评分评价病情严重程度,ⅰ组患者正常(0分)和低(1-4分)评分显著高于对照组(P=0.04和P=0.007),ⅱ组患者高(11-15分)评分显著高于对照组(P= 0.001)。通过Gensini评分对研究患者的严重程度进行评估,结果显示,ⅰ组患者轻度Gensini评分显著高于ⅱ组患者重度Gensini评分(P=0.002)。结论:冠状动脉疾病不仅是绝经后妇女的重要疾病之一,也是绝经前妇女的重要疾病之一。绝经后妇女患更多的三支血管受累,更弥漫性和严重的疾病。本研究结果指出,与绝经后妇女相比,绝经前妇女患冠状动脉疾病的严重程度较低,与其他两大冠状动脉相比,中冠状动脉的发生率有增加的趋势,与绝经后妇女相比,中冠状动脉的发生率有增加的趋势。孟加拉国心脏杂志2021;36 (2): 113 - 123
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引用次数: 0
Coronavirus Disease 2019: One Year Experience at Tertiary Care Cardiac Hospital 2019冠状病毒病:在三级保健心脏医院工作一年
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56034
Fazila-tun-nesa Malik, -. Md Kalimuddin, -. Mir Ishraquzzaman, M. Al Mamun, Ashok Dutta, Md. Habibur Rahman, Smita Kanungo, N. Laila, Md. Shamim Chowdhury, S. Choudhury
Background: The Coronavirus Disease 2019 (COVID-19) pandemic is a significant challenge particularly for low and middle-income countries like Bangladesh. Interventions such as home isolation, frequent hand washing, wearing face mask, maintaining social distancing are difficult to implement in densely populated areas. The aim of the study was to delineate demographics, clinical manifestations, treatment modalities and outcomes of COVID-19 affected patients of our hospital.Methods: This prospective observational study was carried out at National Heart Foundation Hospital & Research Institute of Bangladesh between 08 March 2020 to 07 March 2021. During this period all admitted patients who subsequently were diagnosed as COVID positive and health care personnel of this hospital, who experienced fever or respiratory symptoms or came in close contact with COVID-19 patients at home or their workplace & become COVID positive were included.Results: During this one-year period a total of 769 COVID positive patients were detected in our hospital. Mean age of the patients was 48.16 ±15.63 years (range 1-92 years). Two third were male (64.9% vs 35.1%) and had multiple co-morbidities. One fifth of the patients were (19%) asymptomatic. The mean duration of onset of symptoms to test was 3.72±3.7 days. Most common symptoms were fever (65.3%), cough (37.1%), shortness of breath (33.6%) and fatigue (27.8%). Other symptoms were bodyache (18.6%), headache (16.6%), anosmia 16%), sore throat (12.1%), diarrhoea (6.8%), dizziness (5.3%), generalized itching (3.8%). Nearly two third of the COVID positive patients (63.2%) had a diagnosed cardiovascular disease at onset and remaining 36.8% patients presented with only COVID-19 disease. About 75% patients received ivermectin, 5.1% patients received favipiravir and 4.4% patients received remdesivir. Three fourth (74.38%) of patients were hospitalized and remaining one fourth (25.62%) patients were treated either in home isolation or in institutional isolation. Most of the patients recovered, with a case fatality rate of 3.5%. Diabetes, hypertension and age ≥50 years were the independent predictors of mortality.Conclusion: Although most of the patients had good outcome the study revealed 3.5% case fatality. Male with multiple co-morbidities were predominantly affected by COVID 19. Fever, cough, shortness of breath and fatigue were common presenting symptoms.Bangladesh Heart Journal 2021; 36(2): 89-97
背景:2019冠状病毒病(COVID-19)大流行是一项重大挑战,特别是对孟加拉国等低收入和中等收入国家而言。在人口稠密地区难以实施家庭隔离、勤洗手、戴口罩、保持社交距离等干预措施。本研究旨在了解我院新冠肺炎患者的人口统计学特征、临床表现、治疗方式及转归。方法:这项前瞻性观察性研究于2020年3月8日至2021年3月7日在孟加拉国国家心脏基金会医院和研究所进行。在此期间,包括所有随后被诊断为COVID阳性的住院患者和该医院的卫生保健人员,他们出现发烧或呼吸道症状,或在家中或工作场所与COVID-19患者密切接触并成为COVID阳性。结果:1年期间,我院共检出新型冠状病毒阳性患者769例。患者平均年龄48.16±15.63岁(1 ~ 92岁)。三分之二为男性(64.9% vs 35.1%),有多种合并症。五分之一的患者(19%)无症状。出现症状至检测的平均时间为3.72±3.7天。最常见的症状为发热(65.3%)、咳嗽(37.1%)、呼吸急促(33.6%)和疲劳(27.8%)。其他症状为身体疼痛(18.6%)、头痛(16.6%)、嗅觉丧失(16%)、喉咙痛(12.1%)、腹泻(6.8%)、头晕(5.3%)、全身瘙痒(3.8%)。近三分之二的COVID阳性患者(63.2%)在发病时诊断为心血管疾病,其余36.8%的患者仅表现为COVID-19疾病。约75%的患者接受伊维菌素治疗,5.1%的患者接受法匹拉韦治疗,4.4%的患者接受瑞德西韦治疗。四分之三(74.38%)的患者住院治疗,其余四分之一(25.62%)的患者在家庭隔离或机构隔离中接受治疗。大多数患者康复,病死率为3.5%。糖尿病、高血压和年龄≥50岁是死亡率的独立预测因素。结论:虽然大多数患者预后良好,但研究显示病死率为3.5%。合并多种合并症的男性主要受COVID - 19影响。发烧、咳嗽、呼吸急促和疲劳是常见的症状。孟加拉国心脏杂志2021;36 (2): 89 - 97
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引用次数: 0
Comparison of Risk Factors & Angiographic Profiles between Young Patients with ST Segment Elevation Myocardial Infarction and Non-ST Segment Elevation Myocardial Infarction 年轻ST段抬高型心肌梗死与非ST段抬高型心肌梗死的危险因素及血管造影比较
Pub Date : 2021-10-31 DOI: 10.3329/bhj.v36i2.56038
Sayeedur Rahman Khan, Fazila-tun-nesa Malik, M. Ahmed, A. Biswas, Mainul Islam, Bivash Kumer Sheel, Sharmin Tahmina Khan, H. Iqbal, Md. Rafiqul Islam
Background: Coronary artery disease is the leading cause of death in the world. Advancing age is a well-recognized risk factor for acute myocardial infarction (AMI). Myocardial infarction is less common in young adults. Prevalence of acute coronary syndrome in young individuals is increasing progressively. These patients have different risk profile, presentation and prognosis. Early recognition and risk factor modification in this population sub-set is of key importance.Objectives: The purpose of the present study was to determine the differences in risk factors and coronary angiographic profile of young patients with ST-segment elevated myocardial infarction (STEMI) vs. those with non-ST-segment elevated myocardial infarction (NSTEMI). Methods: In this cross sectional analytical study total 135 patients (70 STEMI and 65 NSTEMI) aged ≤45 years were enrolled to see the differences of risk factors and angiographic profile.Results: The mean age of the study population was 39.39±5.12 years and the study showed male predominance (90.40 % was male and 9.60 % was female). Smoking/tobacco consumption was significantly higher in STEMI patients, whereas diabetes mellitus and hypertension were more prevalent in NSTEMI patients. The frequency of single vessel disease and involvement of left anterior descending artery was significantly higher in young STEMI patients. In case of young NSTEMI patients frequency of triple vessel disease, noncritical coronary artery disease and involvement of left circumflex coronary was significantly higher. The frequency of double vessel disease and involvement of left main coronary artery was also nonsignificantly higher in young NSTEMI patients. There was no significant difference regarding involvement of right coronary artery.Conclusion: There are significant differences between young STEMI and young NSTEMI patients in respect to risk factors and angiographic profile. Key words: Young patient, STEMI, NSTEMI, Risk factors, Coronary angiographic profile.Bangladesh Heart Journal 2021; 36(2): 124-132
背景:冠状动脉疾病是世界上导致死亡的主要原因。高龄是急性心肌梗死(AMI)的一个公认的危险因素。心肌梗塞在年轻人中不太常见。急性冠状动脉综合征在年轻人中的患病率正在逐渐增加。这些患者有不同的风险特征、表现和预后。这一人群的早期识别和危险因素的改变是至关重要的。目的:本研究的目的是确定年轻st段抬高型心肌梗死(STEMI)患者与非st段抬高型心肌梗死(NSTEMI)患者的危险因素和冠状动脉造影特征的差异。方法:本横断面分析研究共纳入135例年龄≤45岁的STEMI和NSTEMI患者(70例和65例),观察危险因素和血管造影特征的差异。结果:研究人群平均年龄为39.39±5.12岁,以男性为主(男性占90.40%,女性占9.60%)。吸烟/烟草消费在STEMI患者中明显更高,而糖尿病和高血压在NSTEMI患者中更为普遍。年轻STEMI患者出现单血管病变和累及左前降支的频率明显高于年轻STEMI患者。年轻NSTEMI患者出现三支血管病变、非危重性冠状动脉病变和左旋冠状动脉受累的频率明显较高。年轻NSTEMI患者出现双支病变和左主干冠状动脉受累的频率也无显著性增高。两组在右冠状动脉受累方面无显著差异。结论:年轻STEMI患者与年轻NSTEMI患者在危险因素和血管造影方面存在显著差异。关键词:年轻患者,STEMI,非STEMI,危险因素,冠状动脉造影孟加拉国心脏杂志2021;36 (2): 124 - 132
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引用次数: 1
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Bangladesh Heart Journal
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