Bioorganic & Medicinal Chemistry最新文献

英文中文

Selective photo crosslinking to methylarginine readers by sulfonium peptides 磺酸肽选择性光交联甲基精氨酸读取器。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.118015

Ting Luo , Feng Feng , Kun Zou , Yumo Zhao , Yingxiao Gao , Mingxuan Wu

Arginine methylation is an important posttranslational modification that regulates epigenetics and pre-mRNA splicing. Similar to lysine methylation, reader proteins that bind site-specific modified proteins are key mediators for arginine methylation functions. Some arginine methylation has been shown significant functions from phenotype, but the molecular mechanisms remain elusive, probably due to lack of identification of the readers. Current methods rely on methylarginine peptide tools for pull-down or binding assays, but affinities to readers are usually tens to hundreds micromolar. As a consequence, development of chemical probes that crosslink specific readers is much in demand. We recently reported a methyllysine reader-selective crosslinking strategy by sulfonium peptides. NleS⁺me2 (norleucine-ε-dimethylsulfonium) imitate dimethyllysine and crosslink tryptophan or tyrosine inside binding pocket of readers. Arginine methylation readers contain aromatic cages for methylarginine binding, that is the similar binding mechanism for methyllysine. Therefore, we developed sulfonium probes that mimic methylarginine and crosslink tryptophan or tyrosine inside reader binding pockets. Because the single electron transfer from aromatic residue to sulfonium is binding-dependent, the conjugation showed high selectivity. Therefore, such sulfonium probes could be applied broadly for methylarginine readers investigations.

精氨酸甲基化是一个重要的翻译后修饰，调控表观遗传学和mrna前剪接。与赖氨酸甲基化类似，结合位点特异性修饰蛋白的解读蛋白是精氨酸甲基化功能的关键介质。一些精氨酸甲基化已经显示出显着的表型功能，但分子机制仍然难以捉摸，可能是由于缺乏对读者的识别。目前的方法依赖于甲基精氨酸肽工具的下拉或结合分析，但亲和阅读器通常是几十到几百微摩尔。因此，化学探针的发展交联特定的读者是非常需要的。我们最近报道了一个甲基赖氨酸读者选择性交联策略的磺化肽。NleS+me2（去甲亮氨酸-ε-二甲磺酸）模拟二甲赖氨酸和交联色氨酸或酪氨酸在阅读器的结合袋内。精氨酸甲基化解读器含有芳香笼，用于甲基精氨酸结合，这是与甲基赖氨酸类似的结合机制。因此，我们开发了模拟甲基精氨酸和交联色氨酸或酪氨酸的磺胺探针。由于从芳香残基到磺酸的单电子转移依赖于结合，因此偶联具有很高的选择性。因此，这种磺胺探针可以广泛应用于甲基精氨酸阅读器的研究。

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引用次数: 0

Discovery of acetohydroxyacid synthase inhibitors as anti-tuberculosis lead compounds from natural products 从天然产物中发现乙酰羟基酸合酶抑制剂作为抗结核先导化合物。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.118041

Yanhong Niu , Zhili Wu , Qianfang Hu , Yuchen Wu , Qihua Jiang , Xiaolan Yang

Acetohydroxy acid synthase (AHAS) is a key enzyme that catalyzes the synthesis of branched-chain amino acids, which is indispensable for the survival and growth of Mycobacterium tuberculosis (Mtb). Aim to discover new AHAS inhibitors from natural products, here we performed computer assistant target-based screening for Mtb-AHAS inhibitors using Discovery Studio on TCMSP and SELLECK libraries. Mtb-AHAS structure was first simulated and verified for docking, and 80 compounds with top LIBDOCK and CDDOCK scores were obtained. By experimental verification, four compounds namely Salvianolic acid A, Embelin, Celastrol and Wushanicaritin showed inhibition potency against Mtb-AHAS with IC50 ranging from 805.5 nM–32.36 μM. The most potential inhibitor Celastrol exhibited bacteriostatic activity for both Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC of 62.5 μM and 80 μM, respectively. This study revealed that Celastrol is the potential Mtb-AHAS inhibitor as an anti-tuberculosis lead compound.

乙酰羟基酸合成酶（Acetohydroxy acid synthase， AHAS）是催化支链氨基酸合成的关键酶，是结核分枝杆菌（Mycobacterium tuberculosis, Mtb）生存和生长所必需的。为了从天然产物中发现新的AHAS抑制剂，我们在TCMSP和SELLECK文库上使用Discovery Studio对Mtb-AHAS抑制剂进行了计算机辅助靶向筛选。首先对Mtb-AHAS结构进行对接模拟验证，得到了80个LIBDOCK和CDDOCK得分最高的化合物。经实验验证，丹参酚酸A、Embelin、Celastrol和巫山红豆素4种化合物对mmb - ahas具有抑制作用，IC50范围为805.5 nm ~ 32.36 μM。最具潜力的抑制剂Celastrol对耻垢分枝杆菌和结核分枝杆菌均有抑菌活性，MIC分别为62.5 μM和80 μM。本研究表明，雷公藤红素是潜在的抗结核先导化合物Mtb-AHAS抑制剂。

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引用次数: 0

Expanding horizons: genetic code expansion technology in the study of PTM functions 拓展视野：PTM功能研究中的遗传密码扩展技术。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.118049

Jingzhuo Chen, Hui Ye

Recent advancements in Genetic Code Expansion (GCE) have significantly enhanced our understanding of post-translational modifications (PTMs), which are critical for protein regulation. GCE facilitates the precise incorporation of unnatural amino acids (UAAs) at specific sites within proteins of interest (POIs), making it a powerful tool for modulating PTMs in vivo. This review summarizes the various UAAs utilized to directly incorporate PTMs into proteins through GCE, with a focus on their applications in both histone and non-histone PTMs research. We also discuss the challenges associated with incorporating certain PTMs into target proteins via GCE and provide an overview of the latest strategies developed to overcome these hurdles.

遗传密码扩展（GCE）的最新进展极大地增强了我们对翻译后修饰（PTMs）的理解，这对蛋白质调控至关重要。GCE促进了非天然氨基酸（UAAs）在目标蛋白（POIs）特定位点的精确结合，使其成为体内调节PTMs的有力工具。本文综述了通过GCE将PTMs直接结合到蛋白质中的各种uaa，重点介绍了它们在组蛋白和非组蛋白PTMs研究中的应用。我们还讨论了通过GCE将某些ptm纳入靶蛋白的挑战，并概述了为克服这些障碍而开发的最新策略。

引用次数: 0

Unsymmetric hydroxylamine and hydrazine BAM15 derivatives as potent mitochondrial uncouplers 不对称羟胺和肼BAM15衍生物作为有效的线粒体解偶联剂。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.118045

Joseph E. Quinlan , Joseph M. Salamoun , Christopher J. Garcia , Stefan Hargett , Martina Beretta , Riya Shrestha , Catherine Li , Kyle L. Hoehn , Webster L. Santos

Chemical mitochondrial uncouplers are protonophoric, lipophilic small molecules that transport protons from the mitochondrial intermembrane space into the matrix independent of ATP synthase, thus uncoupling nutrient oxidation from ATP production. Our previous work identified BAM15 (IC₅₀ 0.27 μM) as a potent and efficacious mitochondrial uncoupler with potential for obesity treatment. In this paper, we investigate in vitro and in vivo properties of hydroxylamine and hydrazine BAM15 derivatives and reveal the high uncoupling nature of these compounds. Our structure–activity relationship studies revealed that the hydroxylamine BAM15 analogs are more potent than hydrazine ones. For example, the most potent of the hydrazine series was 5a with an EC₅₀ value of 4.6 μM and 103 % activity of BAM15 while compound 4e was the best among the hydroxylamine series with EC₅₀ value of 340 nM and 118 % BAM15 mitochondrial uncoupling activity in rat L6 myoblasts. Pharmacokinetic profiling of 5a and 4e revealed low exposure (2–220 nM) and short half-life (15–27 min) in mice.

化学线粒体解偶联剂是一种亲脂性、亲质子性的小分子，它能将质子从线粒体膜间空间输送到基质中，不依赖ATP合酶，从而使营养氧化脱离ATP的产生。我们之前的研究发现BAM15 （IC50 0.27 μM）是一种有效的线粒体解偶联剂，具有治疗肥胖的潜力。本文研究了羟胺和肼类BAM15衍生物的体外和体内性质，揭示了这些化合物的高解偶联性质。我们的构效关系研究表明，羟胺BAM15类似物比肼类似物更有效。例如，联胺系列化合物5a对大鼠L6成肌细胞的EC50值为4.6 μM，对BAM15的活性为103%；羟胺系列化合物4e对大鼠L6成肌细胞的EC50值为340 nM，对BAM15的线粒体解偶联活性为118%，效果最好。5a和4e在小鼠体内的药代动力学分析显示其暴露量低（2 ~ 220 nM），半衰期短（15 ~ 27 min）。

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引用次数: 0

3-Halo-3-nitro-aza/thioflavanones: DNMT inhibitors with a two-site binding mode in the hDNMT3A catalytic pocket 3-Halo-3-nitro-aza/thioflavanones：在hDNMT3A催化口袋中具有双位点结合模式的DNMT抑制剂。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.117988

Alexandra Serhouni , Francesco Calzaferri , Yannick Bessina , Arie van der Lee , Paola B. Arimondo , Maxime Louet , Jean-Yves Winum , Marie Lopez

Flavonoid derivatives are natural product analogues that have shown great interest for therapeutic applications as modulators of DNA methylation. In this article we report new synthesis pathways to access ten novel flavonoid derivatives (i.e. 3-halo-3-nitro-aza/thioflavanones) to be used as potential DNA methyltransferase inhibitors. These compounds have a micromolar inhibition against human DNA methyltransferase 3A in our in vitro fluorescence-based assay. Importantly, a docking study of representative compounds of this series in the enzyme pocket highlights a mode of interaction in the catalytic pocket of hDNMT3A that has never been described.

类黄酮衍生物是天然产物类似物，作为DNA甲基化调节剂在治疗应用中表现出极大的兴趣。在本文中，我们报道了新的合成途径，以获得10种新的类黄酮衍生物（即3-卤-3-硝基-aza/硫代黄酮），作为潜在的DNA甲基转移酶抑制剂。在我们的体外荧光检测中，这些化合物对人DNA甲基转移酶3A具有微摩尔抑制作用。重要的是，对酶口袋中该系列代表性化合物的对接研究突出了hDNMT3A催化口袋中从未描述过的相互作用模式。

引用次数: 0

Decoding the protein methylome: Identification, validation, and functional insights 解码蛋白质甲基组：鉴定，验证和功能见解。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.118056

Ying Meng, Rong Huang

Protein methylation regulates diverse cellular processes including gene expression and DNA repair. This review discusses the methods of identifying and validating substrates for protein methyltransferases (MTases), as well as the biological roles of methylation. Meanwhile, we outline continued efforts necessary to fully map MTase-substrate pairs and uncover the complex regulatory roles of protein methylation in cellular function.

蛋白质甲基化调节多种细胞过程，包括基因表达和DNA修复。本文综述了蛋白质甲基转移酶（MTases）底物的鉴定和验证方法，以及甲基化的生物学作用。同时，我们概述了全面绘制mase -底物对和揭示蛋白质甲基化在细胞功能中的复杂调节作用所需要的持续努力。

引用次数: 0

Exploring the antiproliferative and proapoptotic activities of new pyridopyrimidine derivatives and their analogs 探索新型吡啶嘧啶衍生物及其类似物的抗增殖和促凋亡活性。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.118053

Hadeer M. Ali , Mohamed A. Said , Shady Allam , Hatem A. Abdel-Aziz , Sahar M. Abou-Seri

This study investigates a series of newly synthesized compounds, including pyridopyrimidine derivatives (9a-g), tricyclic pyridotriazolopyrimidine analogs (18a-d), and dihydropyrimidinones (22a-i), as apoptotic inducers and inhibitors of phosphatidylinositol-3-kinase α (PI3Kα), with potential anticancer activity. An initial in vitro screening of 60 cancer cell lines identified pyridopyrimidine derivatives 9a-g as promising broad-spectrum anticancer agents, with compound 9e demonstrating the strongest inhibitory activity, particularly against T-47D breast cancer cells. Notably, the antitumor potency of compound 9e surpassed that of Pictilisib, inducing G2-M phase cell cycle arrest and initiating apoptosis through the intrinsic apoptotic pathway. Molecular docking studies further indicated that compound 9e binds to PI3Kα in a similar fashion to the co-crystallized ligand. Moreover, compound 9e exhibited favorable drug-like properties, including compliance with Lipinski’s rule and Veber’s rule, good solubility, acceptable TPSA, and high gastrointestinal absorption reinforcing its potential as a highly effective anticancer agent.

本研究研究了一系列新合成的化合物，包括吡啶嘧啶衍生物（9a-g）、三环吡啶三唑嘧啶类似物（18a-d）和二氢嘧啶类化合物（22a-i），作为凋亡诱导剂和磷脂酰肌醇-3-激酶α (PI3Kα)的抑制剂，具有潜在的抗癌活性。对60个癌细胞系的初步体外筛选发现，吡啶嘧啶衍生物9a-g是一种很有前途的广谱抗癌药物，其中化合物9e表现出最强的抑制活性，特别是对T-47D乳腺癌细胞。值得注意的是，化合物9e的抗肿瘤能力超过Pictilisib，通过内在凋亡途径诱导G2-M期细胞周期阻滞并启动细胞凋亡。分子对接研究进一步表明，化合物9e以与共结晶配体相似的方式与PI3Kα结合。此外，化合物9e表现出良好的药物样性质，包括符合Lipinski规则和Veber规则、良好的溶解度、可接受的TPSA和高胃肠道吸收，增强了其作为高效抗癌剂的潜力。

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引用次数: 0

Quantitative profiling of PTM stoichiometry by DNA mass tags DNA质量标签定量分析PTM化学计量学。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-02-01 DOI: 10.1016/j.bmc.2024.118050

Yuanpei Li , Yuan Liu , Chu Wang

Protein post-translational modification (PTM) serves as an important mechanism for regulating protein function. Accurate assay of PTM stoichiometry, or PTM occupancy, which refers to the proportion of proteins that contain specific modifications, is important for understanding the function of PTMs. We previously developed a novel chemoproteomic strategy “STO-MS” to quantify the PTM stoichiometry in complex biological samples, which employs a resolvable polymer mass tag to differentiate modified proteins and utilizes liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) techniques to measure PTM stoichiometry. However, the resolution of STO-MS is constrained by the relatively low molecular weight of the mass tag, and the incorporation of isotopic labels not only complicates the sample preparation but also restricts the measurement throughput. To address these challenges, we herein developed “STO-MS+”, an enhanced workflow, that incorporates an optimized DNA mass tag and employs a label-free quantitative data analysis approach. We applied STO-MS+ to measure stoichiometry of three distinct PTMs, including endogenous carbonylation induced by arachidonic acid (AA), itaconation, and endogenous O-GlcNAcylation. Our work marks a notable improvement in chemoproteomic methodologies for quantifying post-translational modifications and provides a powerful analytical tool for PTM research.

蛋白质翻译后修饰（PTM）是调节蛋白质功能的重要机制。准确测定PTM化学计量学或PTM占用率（指含有特定修饰的蛋白质的比例）对于理解PTM的功能非常重要。我们之前开发了一种新的化学蛋白质组学策略“STO-MS”来量化复杂生物样品中的PTM化学计量，该策略采用可分辨的聚合物质量标签来区分修饰的蛋白质，并利用液相色谱-串联质谱（LC-MS/MS）技术来测量PTM化学计量。然而，STO-MS的分辨率受到质量标签相对较低分子量的限制，并且同位素标签的加入不仅使样品制备复杂化，而且限制了测量吞吐量。为了应对这些挑战，我们在此开发了“STO-MS+”，这是一种增强的工作流程，包含优化的DNA质量标签，并采用无标签的定量数据分析方法。我们使用STO-MS+测量了三种不同PTMs的化学计量，包括花生四烯酸（AA）诱导的内源性羰基化、itaconation和内源性o - glcn酰化。我们的工作标志着用于定量翻译后修饰的化学蛋白质组学方法的显著改进，并为PTM研究提供了强大的分析工具。

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引用次数: 0

Discovery of 3-indolylbenzoquinone derivatives with therapeutic potential for breast cancer

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-01-31 DOI: 10.1016/j.bmc.2025.118094

Mingli Hu , Lang Zheng , Ailing Li , Xiao Li , Wengxue Liang , Yuanhao Zhu , Aoxue Wang , Ling He , Xiuxiu Liu , Qiu Sun

Breast cancer is one of the most prevalent malignant tumors in women, but the side effects and drug resistance limit the long-term effectiveness of existing drugs. To address these issues, we designed and synthesized a series of novel mono- and bis-indole-substituted 3-indolylbenzoquinone derivatives and evaluated their inhibitory activity against breast cancer. Among them, compound 1b demonstrated the most potent inhibitory activity against the MDA-MB-231 breast cancer cell line (IC₅₀ = 3.2 µM) as well as the drug-resistant variant, MCF-7/ADR (IC₅₀ = 8.36 µM). It demonstrated minimal toxicity and superior tumor suppression in a Balb/c mouse model of 4 T1 breast cancer. Mechanistically, compound 1b induced apoptosis and cell cycle arrest at the G2/M phase. Through computational study and CESTA assay, we implicated phosphoinositide 3-kinase α (PI3Kα) as a potential target. Thus, we present compound 1b as a lead candidate for the development of novel, safe, and effective small-molecule therapies against breast cancer.

{"title":"Discovery of 3-indolylbenzoquinone derivatives with therapeutic potential for breast cancer","authors":"Mingli Hu , Lang Zheng , Ailing Li , Xiao Li , Wengxue Liang , Yuanhao Zhu , Aoxue Wang , Ling He , Xiuxiu Liu , Qiu Sun","doi":"10.1016/j.bmc.2025.118094","DOIUrl":"10.1016/j.bmc.2025.118094","url":null,"abstract":"<div><div>Breast cancer is one of the most prevalent malignant tumors in women, but the side effects and drug resistance limit the long-term effectiveness of existing drugs. To address these issues, we designed and synthesized a series of novel mono- and bis-indole-substituted 3-indolylbenzoquinone derivatives and evaluated their inhibitory activity against breast cancer. Among them, compound <strong>1b</strong> demonstrated the most potent inhibitory activity against the MDA-MB-231 breast cancer cell line (IC<sub>50</sub> = 3.2 µM) as well as the drug-resistant variant, MCF-7/ADR (IC<sub>50</sub> = 8.36 µM). It demonstrated minimal toxicity and superior tumor suppression in a Balb/c mouse model of 4 T1 breast cancer. Mechanistically, compound <strong>1b</strong> induced apoptosis and cell cycle arrest at the G2/M phase. Through computational study and CESTA assay, we implicated phosphoinositide 3-kinase α (PI3Kα) as a potential target. Thus, we present compound <strong>1b</strong> as a lead candidate for the development of novel, safe, and effective small-molecule therapies against breast cancer.</div></div>","PeriodicalId":255,"journal":{"name":"Bioorganic & Medicinal Chemistry","volume":"120 ","pages":"Article 118094"},"PeriodicalIF":3.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon monoxide potentiates the effect of corticosteroids in suppressing inflammatory responses in cell culture

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry

Pub Date : 2025-01-31 DOI: 10.1016/j.bmc.2025.118092

Wen Lu , Xiaoxiao Yang , Binghe Wang

Inflammation is a pathology implicated in a wide range of human diseases. Recent years have seen tremendous progress in developing new types of anti-inflammatory agents for the treatment of inflammation of various origins. However, each has its own strengths and weaknesses. The very fact that there needs to have multiple types of anti-inflammatory agents underlines the complexity of inflammatory diseases and conditions, their molecular origins, and their treatment. Such complexity dictates the need to search for new approaches with improved potency and efficacy as well as reduced side effects. For these reasons, we are interested in exploring the possibility of generating synergy between carbon monoxide (CO), an endogenously produced cytoprotective agent, and known anti-inflammatory agents. Herein, we report the potentiating actions of CO on the anti-inflammatory effects of cortisone and dexamethasone as demonstrated in their ability to suppress the expression of TNF-α and IL-6 induced by either LPS or the S protein of SARS-CoV-2. Such effects are reflected in the substantially increased potency as well efficacy, when the efficacy of the corticosteroid alone does not allow for complete suppression of the expression of these cytokines. Further, increased attenuation of p65 phosphorylation is at least part of the molecular mechanism for the observed potentiating effects. We hope our work will stimulate a high level of activity along the same direction, leading to anti-inflammatory strategies with improved potency and efficacy and reduced side effects.

{"title":"Carbon monoxide potentiates the effect of corticosteroids in suppressing inflammatory responses in cell culture","authors":"Wen Lu , Xiaoxiao Yang , Binghe Wang","doi":"10.1016/j.bmc.2025.118092","DOIUrl":"10.1016/j.bmc.2025.118092","url":null,"abstract":"<div><div>Inflammation is a pathology implicated in a wide range of human diseases. Recent years have seen tremendous progress in developing new types of anti-inflammatory agents for the treatment of inflammation of various origins. However, each has its own strengths and weaknesses. The very fact that there needs to have multiple types of anti-inflammatory agents underlines the complexity of inflammatory diseases and conditions, their molecular origins, and their treatment. Such complexity dictates the need to search for new approaches with improved potency and efficacy as well as reduced side effects. For these reasons, we are interested in exploring the possibility of generating synergy between carbon monoxide (CO), an endogenously produced cytoprotective agent, and known anti-inflammatory agents. Herein, we report the potentiating actions of CO on the anti-inflammatory effects of cortisone and dexamethasone as demonstrated in their ability to suppress the expression of TNF-α and IL-6 induced by either LPS or the S protein of SARS-CoV-2. Such effects are reflected in the substantially increased potency as well efficacy, when the efficacy of the corticosteroid alone does not allow for complete suppression of the expression of these cytokines. Further, increased attenuation of p65 phosphorylation is at least part of the molecular mechanism for the observed potentiating effects. We hope our work will stimulate a high level of activity along the same direction, leading to anti-inflammatory strategies with improved potency and efficacy and reduced side effects.</div></div>","PeriodicalId":255,"journal":{"name":"Bioorganic & Medicinal Chemistry","volume":"120 ","pages":"Article 118092"},"PeriodicalIF":3.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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