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Maternal Anemia and Fetal Doppler Indices in the Third Trimester of Pregnancy 妊娠晚期孕妇贫血与胎儿多普勒指数的关系
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1826
Mohamed Abu-Elfadle Mostafa, Abd-Elmonem Mohammed Zakaria, A. Saeed
Background : Complications for the mother and fetus are usually linked to maternal anemia. It may also cause a shift in fetal blood fl ow by decreasing the oxygen supply to the developing baby. Aim : The aim of this study is to assess the impact of maternal anemia on the umbilical artery and middle cerebral artery Doppler indices in the third trimester of pregnancy. Patients and methods : This was a prospective case-control study on 200 pregnant women separated into two groups at El-Hussein University Hospital: 100 pregnant women with varying degrees of anemia (Mild, Moderate, and Severe) were involved in group I (the study group), whereas 100 pregnant women without anemia (group II) served as the control group from January to June of 2021. Result : There was a high statistically signi fi cant decrease in middle cerebral artery (MCA) resistance index (RI), pulsatility index (PI), S/D ratio and an increase in uterine artery (UA) RI, PI, S/D ratio with the increase in severity of anemia in the studied groups. There was a high statistically signi fi cant difference in the C/U ratio between the studied groups ( P value < 0.001), it was lower than normal in moderate and severe anemic groups (1.08 ± 0.14 and 0.99 ± 0.12, respectively). Conclusion : Maternal anemia had a considerable impact on the fetal UA and MCA Doppler indices, and this impact grew as the anemia ' s severity rose.
背景:母体和胎儿的并发症通常与母体贫血有关。它还可能通过减少对发育中的婴儿的氧气供应而导致胎儿血流的改变。目的:探讨妊娠晚期产妇贫血对脐动脉和大脑中动脉多普勒指数的影响。患者和方法:这是一项前瞻性病例对照研究,将El-Hussein大学医院的200名孕妇分为两组:100名不同程度贫血(轻度、中度和重度)的孕妇作为第一组(研究组),而100名无贫血的孕妇(第二组)作为对照组,时间为2021年1月至6月。结果:随着贫血严重程度的增加,各组患者大脑中动脉(MCA)阻力指数(RI)、搏动指数(PI)、S/D比值均有显著降低,子宫动脉(UA)阻力指数(RI)、PI、S/D比值均有显著升高。C/U比值各组间差异有很高的统计学意义(P值< 0.001),中度和重度贫血组低于正常(分别为1.08±0.14和0.99±0.12)。结论:母体贫血对胎儿UA和MCA多普勒指标有较大影响,且随贫血程度的加重而增大。
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引用次数: 0
Value of Egy-Score in prediction of HCV response to sofosbuvir based therapy Egy-Score在预测丙型肝炎病毒对索非布韦治疗反应中的价值
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1729
Fathy Ghamry Abd El Razek, Adel Abdel-Fattah Al-Rkeeb, Mohamed Said El-Shourbagy, Z. Zakarya, Ahmed Mawad Abdel-Azeim
Background: Liver fibrosis (LF) develops as a result of nearly all chronic liver injuries. In order to foretell the development of the illness and monitor the effectiveness of therapy interventions, it is important to assess LF. The Egy-Score is a brand-new noninvasive score that could be utilized to predict severe LF. Objective: This research's objective is to look at whether Egy-Score can be used as a noninvasive panel of biomarkers for fibrosis for predicting the response to new hepatitis C antiviral treatments in Egyptian patients, determine if EgyScore will be affected broadly by treatment or not. Patients and methods: This study involved 100 HCV-infected patients, including chronic hepatitis and cirrhotic patients, who received new hepatitis C antiviral therapy. The patients were recruited from Kafr Elsheikh liver institute and liver clinic of Alexandria fever hospital, Egypt, and selected according to the Egyptian protocol for the treatment of hepatitis C virus. Results: Our study reported that cut-off for baseline EGY score to predict responder patients from nonresponder in all studied patients was ≤2.92, sensitivity was 77.53, Specificity 90.91, PPV was 98.6, NPV was 33.3. Cut off for baseline EGY score to predict responder patients from nonresponder in cirrhosis group was <4, sensitivity was 92.68, specificity 66.67, PPV was 92.7, NPV was 66.7. Conclusion: EgyScore showed good sensitivity, specificity, positive and negative predictive values of HCV response to sofosbuvir-based therapy, and overall accuracy for detecting different stages of hepatic fibrosis and cirrhosis in patients with chronic hepatitis C.
背景:肝纤维化(LF)是几乎所有慢性肝损伤的结果。为了预测疾病的发展和监测治疗干预措施的有效性,对LF进行评估是很重要的。Egy-Score是一种全新的无创评分,可用于预测严重的LF。目的:本研究的目的是研究EgyScore是否可以作为一种无创的纤维化生物标志物,用于预测埃及患者对新型丙型肝炎抗病毒治疗的反应,确定EgyScore是否会受到治疗的广泛影响。患者和方法:本研究纳入了100例丙型肝炎感染患者,包括慢性肝炎和肝硬化患者,他们接受了新的丙型肝炎抗病毒治疗。这些患者是从埃及亚历山大发热医院Kafr Elsheikh肝脏研究所和肝脏诊所招募的,并根据埃及丙型肝炎病毒治疗方案进行选择。结果:我们的研究报告,基线EGY评分预测所有研究患者有反应患者和无反应患者的截止值≤2.92,敏感性为77.53,特异性为90.91,PPV为98.6,NPV为33.3。基线EGY评分预测肝硬化组有反应患者和无反应患者的临界值<4,敏感性为92.68,特异性为66.67,PPV为92.7,NPV为66.7。结论:EgyScore对索非布韦为基础治疗的HCV反应具有良好的敏感性、特异性、阳性和阴性预测值,对慢性丙型肝炎患者不同阶段肝纤维化和肝硬化的检测总体准确性较高。
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引用次数: 0
subfoveal choroidal thickness before and after intravitreal Ranibizumab injection in patients with choroidal neovascularization 玻璃体内注射雷尼单抗前后脉络膜新生血管患者的中央凹下脉络膜厚度
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1624
Elsayed Mostafa Elewah, A. Elghany, Mahmoud Ahmed Elabiad
Background : Ranibizumab is an antivascular endothelial growth factor agent made for intraocular use as a smaller antibody fragment that can penetrate the retina. Intravitreal ranibizumab therapy has been accepted as a predominant treatment for choroidal neovascularization (CNV) in recent years. Objective : The aim was to assess the potential adverse effects of ranibizumab on the choroid, variations in choroidal thickness were measured before and after ranibizumab treatment for CNV. Patients and methods : This prospective research study was carried out at the Ophthalmology Department of Al-Azhar University Hospitals on 20 patients from June 2021 till December 2021 to monitor changes of choroidal thickness before and after ranibizumab treatment for CNV to assess possible adverse effects of ranibizumab on the choroid. Results : There were highly statistically signi fi cant variations between before injection and after injection regarding choroidal thickness. The mean ± SD choroidal thickness before injection was 356.85 ± 127.10 SD, with range from 154.0 to 632.0, and the mean ± SD choroidal thickness after injection was 235.40 ± 75.60 SD, with range from 127.0 to 400.0. There was a highly statistically signi fi cant variation between before injection and after injection regarding central macular thickness (CMT). The mean ± SD CMT before injection was 302.80 ± 84.51, with range from 168 to 490, and the mean ± SD CMT after injection was 250.25 ± 53.44, with range from 150 to 331. Conclusion : Patients with CNV had a subfoveal choroidal thickness that was noticeably thicker in the affected eyes than in nonaffected contralateral eyes. SubFoveal Choroidal Thickness (SFCT) declined substantially after intravitreal ranibizumab administration, and this was associated with marginal reduction in retinal foveal thickness
背景:雷尼单抗是一种抗血管内皮生长因子药物,作为一种可穿透视网膜的小抗体片段,用于眼内使用。近年来,玻璃体内雷尼珠单抗治疗已被认为是脉络膜新生血管(CNV)的主要治疗方法。目的:评估雷尼单抗对脉络膜的潜在不良影响,测量雷尼单抗治疗CNV前后脉络膜厚度的变化。患者和方法:本前瞻性研究于2021年6月至2021年12月在爱兹哈尔大学附属医院眼科对20例患者进行研究,监测兰尼单抗治疗CNV前后脉络膜厚度的变化,以评估兰尼单抗对脉络膜可能产生的不良影响。结果:注射前后脉络膜厚度差异具有高度统计学意义。注射前脉络膜厚度平均值±SD为356.85±127.10 SD,范围为154.0 ~ 632.0;注射后脉络膜厚度平均值±SD为235.40±75.60 SD,范围为127.0 ~ 4000.0。注射前与注射后黄斑中央厚度(CMT)差异具有高度统计学意义。注射前平均±SD CMT为302.80±84.51,范围为168 ~ 490;注射后平均±SD CMT为250.25±53.44,范围为150 ~ 331。结论:CNV患者患侧眼的中央凹下脉络膜厚度明显大于未患侧眼。在玻璃体内给予雷尼单抗后,视网膜中央凹下脉络膜厚度(SFCT)显著下降,这与视网膜中央凹厚度的边际减少有关
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引用次数: 0
C-Reactive Protein and Procalcitonin in Predicting Treatment Failure in Community Acquired Pneumonia c反应蛋白和降钙素原在预测社区获得性肺炎治疗失败中的作用
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1718
T. Ghatas, M. Elfaizy
Introduction : There has been rising attention in the evaluation of procalcitonin, and C-reactive protein serum levels for predicting treatment ef fi cacy of patients who hospitalized for community acquired pneumonia. Methods : Taken of blood samples for measurement of (CRP) and (PCT), on the day of admittance (PCT-D1; and CRP-D1), within (48 e 72) hours after the admittance (PCT-D3; and CRP-D3), also in 144 e 192 h next to admission. CURB 65 in adding to the (Pneumonia Severity Index) were evaluated on the day of admittance. Results : 112 hospitalized patients with CAP were involved in the work. Failure of treatment was recognized in 30 individuals (26.7%). Patients experienced early treatment failure displayed highly signi fi cant results of; PCT D1, D3, and CRP D3, PCT D3/D1 ratio, and CRP D3/D1 ratio than in those whose treatment was successful. CRP D1 values were similar in both groups. Patients experienced late treatment failure displayed highly signi fi cant elevated values of PCT3, PCT D3/D1, PCT D7, PCT D7/D1, CRP D3, CRP D3/D1, CRP D7, and CRP D7/D1 than in patients who had treatment success. The PCT D1 values augmented with elevating severity of pneumonia. Nevertheless, the results of (CRP-D1) were not. Conclusions : (PCT) should be de fi ned sequentially not on admittance alone to expect the therapy outcome in hospitalized community acquired pneumonia patients.
导论:评价降钙素原和c反应蛋白血清水平用于预测社区获得性肺炎住院患者的治疗效果已受到越来越多的关注。方法:入院当日采血测定CRP和PCT (PCT- d1;和CRP-D1),在入院后48 ~ 72小时内(PCT-D3;CRP-D3),也在入院后144h ~ 192h。入院当天对患者肺炎严重程度指数(肺炎严重程度指数)进行检测。结果:112例住院CAP患者参与了工作。治疗失败30例(26.7%)。早期治疗失败的患者表现出高度显著的结果;PCT D1、D3、CRP D3、PCT D3/D1比值、CRP D3/D1比值均高于治疗成功组。两组CRP D1值相近。晚期治疗失败患者的PCT3、PCT D3/D1、PCT D7、PCT D7/D1、CRP D3、CRP D3/D1、CRP D7、CRP D7/D1均显著高于治疗成功患者。PCT D1值随肺炎严重程度的升高而升高。然而,(CRP-D1)的结果并非如此。结论:在社区获得性肺炎住院患者中,PCT应按顺序确定,而不是仅在入院时预测治疗结果。
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引用次数: 0
Clinical outcome of corpus callosotmy for management of drug resistant epilepsy 胼胝体治疗耐药癫痫的临床效果
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1813
Islam Magdy Ali Ibrahim, Mamoun Abo Shosha, Mohamed Meligy Rabea Hamed
Background : One of most common chronic neurologic disorders is epilepsy, incapability of signi fi cantly reduce percentage of studied cases resistant to all available antiepileptic treatments without producing unacceptable side effects is particularly frustrating. Aim : Aim of the research was to investigate seizure result following corpus callosotomy in relation to extent of resection in pediatric studied cases with Symptomatic generalized epilepsy with normal preoperative brain imaging on MRI Brain. Patients and methods : Research entails prospective analysis of data from 20 pediatric patients who were treated for intractable symptomatic generalized epilepsy by corpus callosotomy. Results : In the patient series, 13 patient suffered from generalized tonic clonic fi tts (56.3%) and 7 patient is multi focal fi tts (43.8%) one of them is Lennox gustate syndrome, no statistically signi fi cant variation ( P value ¼ 0.101) among grade II and grade III studied cases as regard presentation. Conclusion : Corpus callosotomy affords a good outcome for drop attacks, at least 70% of patients will experience free from these attacks, a so it will abolish the harmful effects like bodily injury, limited activity and caregivers ’ dependency. In pediatricstudiedcases,thereisnovariationinresultamongtotalandanterior2/3colostomyexceptsomecasesmaycomplicate intotalcolostomywithdisconnectionsyndrome,butanywaythesecasesshowbetterimprovementthanadultcases.
背景:癫痫是最常见的慢性神经系统疾病之一,不能显著降低研究病例对所有现有抗癫痫治疗的耐药性而不产生不可接受的副作用的百分比尤其令人沮丧。目的:探讨有症状的全身性癫痫患儿行胼胝体切开术后癫痫发作结果与切除范围的关系。患者和方法:研究需要对20例顽固性症状性全身性癫痫患儿的数据进行前瞻性分析,这些患儿接受胼胝体切开术治疗。结果:本组患者中,全身性强直性阵挛13例(56.3%),多灶性阵挛7例(43.8%),其中1例为Lennox味觉综合征,II级与III级患者表现差异无统计学意义(P值为0.101)。结论:胼胝体切开术治疗跌落发作效果良好,至少70%的患者不再遭受跌落发作,从而消除了身体损伤、活动受限和对护理者的依赖等有害影响。在儿科研究病例中,除了某些病例可能合并全结肠造口并伴有断开综合征外,全结肠造口和前2/3造口的结果没有变化,但无论如何,这些病例比成人病例表现出更好的改善。
{"title":"Clinical outcome of corpus callosotmy for management of drug resistant epilepsy","authors":"Islam Magdy Ali Ibrahim, Mamoun Abo Shosha, Mohamed Meligy Rabea Hamed","doi":"10.58675/2682-339x.1813","DOIUrl":"https://doi.org/10.58675/2682-339x.1813","url":null,"abstract":"Background : One of most common chronic neurologic disorders is epilepsy, incapability of signi fi cantly reduce percentage of studied cases resistant to all available antiepileptic treatments without producing unacceptable side effects is particularly frustrating. Aim : Aim of the research was to investigate seizure result following corpus callosotomy in relation to extent of resection in pediatric studied cases with Symptomatic generalized epilepsy with normal preoperative brain imaging on MRI Brain. Patients and methods : Research entails prospective analysis of data from 20 pediatric patients who were treated for intractable symptomatic generalized epilepsy by corpus callosotomy. Results : In the patient series, 13 patient suffered from generalized tonic clonic fi tts (56.3%) and 7 patient is multi focal fi tts (43.8%) one of them is Lennox gustate syndrome, no statistically signi fi cant variation ( P value ¼ 0.101) among grade II and grade III studied cases as regard presentation. Conclusion : Corpus callosotomy affords a good outcome for drop attacks, at least 70% of patients will experience free from these attacks, a so it will abolish the harmful effects like bodily injury, limited activity and caregivers ’ dependency. In pediatricstudiedcases,thereisnovariationinresultamongtotalandanterior2/3colostomyexceptsomecasesmaycomplicate intotalcolostomywithdisconnectionsyndrome,butanywaythesecasesshowbetterimprovementthanadultcases.","PeriodicalId":256725,"journal":{"name":"Al-Azhar International Medical Journal","volume":"106 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116159565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Study Between Iliac Bone Grafting verses Latarjet Procedure For Surgical Management Of Anterior Shoulder Instability With Glenoid Bone defect 髂骨移植术与Latarjet手术治疗肩关节前路不稳伴肩关节骨缺损的比较研究
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1700
Ibrahim ahmed hussine, Emad Mohamed Zayid, Mahmoud Salah Tork
Background and aim : Anatomical glenoid restoration by iliac graft transplant versus latarjet surgery is competing as a management option for recurrent traumatic anterior dislocation of the shoulder associated with glenoid bone loss. All patients, who have recurrent traumatic anterior dislocation of the shoulder with loss of glenoid bone rime, will be assessed effectively for their responses to the Latarjet or the Iliac Graft Transfer. Patients and methods : There were 40 patients presented with Anterior dislocation of the shoulder who had open Latarjet operation or ICBGT operation in this prospective random research. Rowe and ASES ratings, satisfaction level, evaluation of range of motion, and instability were all conducted before surgery and after 6, 12, and 24 months following surgery. All patients were followed up with radiographys and CT scans before and after surgery and over the time of follow-up and recorded. Results : There is no statistically signi fi cant difference between both groups for management of recurrent traumatic anterior dislocation ( P < 0.05). Conclusion : It has been observed during the follow-up over this period, and as a result of the measurements or radiographs, that there is no difference between them except the Latarjet group ' s signi fi cantly decreased exterior rotation capacity.
背景和目的:作为复发性外伤性肩关节前脱位伴肩胛骨丢失的治疗选择,髂移植物移植与椎弓根手术的解剖性肩关节恢复是相互竞争的。所有复发性外伤性肩前脱位伴肩关节骨时间缺失的患者,将对其对Latarjet或髂骨移植物的反应进行有效评估。患者与方法:本前瞻性随机研究40例肩前位脱位患者行开放性Latarjet手术或ICBGT手术。术前、术后6个月、12个月和24个月对Rowe和ASES评分、满意度、活动范围和不稳定性进行评估。所有患者在手术前后及随访期间均进行了x线摄影和CT扫描并进行了记录。结果:两组治疗复发性外伤性前脱位的疗效差异无统计学意义(P < 0.05)。结论:在这段时间的随访中,通过测量或x线片观察到,除了Latarjet组外旋能力明显降低外,它们之间没有区别。
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引用次数: 0
Supermaximal Monocular Recession-Resection Versus Large Bilateral Lateral Rectus Recession in large Angle Exotropia 大角度外斜视的最大单眼退行切除与双侧大侧直肌退行
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1840
Fatma Fakhry, Abdel Khalek Ragab, W. Madbouly, Hanan S Saied, Mohamed Hegazy
Background : Strabismus surgery aims to improve the ocular alignment of the visual axis and the cosmetic appearance of the studied cases with strabismus. The most common functional bene fi ts are the restoration of binocular vision, with the elimination of diplopia and compensatory head posture. In cases of large-angle exotropia, many surgical methods have been performed. Bilateral lateral rectus recession and medial rectus resection with lateral rectus recession are the most frequently used. Aim : To evaluate the outcome of supermaximal monocular recession e resection versus large bilateral lateral rectus recession in large-angle exotropia. Patients and methods : This was a prospective, interventional, nonrandomized study. This study was conducted
背景:斜视手术旨在改善所研究的斜视患者的视轴排列和外观。最常见的功能益处是恢复双眼视力,消除复视和补偿性头部姿势。对于大角度外斜视,有许多手术方法。双侧外直肌切除术和内侧直肌切除术合并外直肌切除术是最常用的。目的:评价大角度外斜视的单眼最大后退手术与双侧大直肌后退手术的疗效。患者和方法:这是一项前瞻性、介入性、非随机研究。这项研究是
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引用次数: 0
A clinico-hematological study of sickle cell disease among adult patients in Makkah, Saudi Arabia. 沙特阿拉伯麦加成年患者镰状细胞病的临床血液学研究
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1684
A. Arbaeen
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引用次数: 0
The correlation between Intra-abdominal Adhesions and body mass index in Women Undergoing elective repeated Cesarean Section 选择性重复剖宫产术妇女腹内粘连与体重指数的关系
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1715
Mostafa M. Mohamed, A. Elboghdady, M. Mohamed
{"title":"The correlation between Intra-abdominal Adhesions and body mass index in Women Undergoing elective repeated Cesarean Section","authors":"Mostafa M. Mohamed, A. Elboghdady, M. Mohamed","doi":"10.58675/2682-339x.1715","DOIUrl":"https://doi.org/10.58675/2682-339x.1715","url":null,"abstract":"","PeriodicalId":256725,"journal":{"name":"Al-Azhar International Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129482210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Patients with Acute Visual Loss 急性视力丧失患者的研究
Pub Date : 2023-01-01 DOI: 10.58675/2682-339x.1865
N. A. Metwally, A. F. El-Hadad, Ghada A. Salem
Background : Acute vision loss can be transient (lasting < 24 h) or persistent (lasting > 24 h). When evaluating a patient with acute vision loss, it is important to determine whether the vision loss affected one eye or both eyes. The World Health Organization (WHO) estimates that 90% of the 285 million visually impaired people in the world live in low-income countries. Aim : To Study the possible neurological causes in the patients presented by acute visual loss. Patients and methods : This prospective observational study included 60 patients with acute visual loss of different ages, and sex recruited from the Neurology department and out patients referred from ophthalmology departments of Al-Azher University Hospital (Assiut) from beginning of March 2021 to the end of August 2021. Results : Our study revealed that the most common cause of acute visual loss in the studied patients was optic neuritis which observed in 22 (36.67%), followed by Non-arteritic -AION in 18 (30.00%) of patients, the least etiology was Functional (8.33%). Conclusion : Among different diseases, vascular conditions may present monocularly or binocularly in the form of ischemic optic neuropathies or cerebral infarction. Diagnosis of functional vision loss must be considered after excluding all other organic causes of acute vision loss.
背景:急性视力丧失可为短暂性(持续时间< 24小时)或持续性(持续时间≤24小时)。在评估急性视力丧失患者时,重要的是确定视力丧失是影响单眼还是双眼。世界卫生组织(世卫组织)估计,世界上2.85亿视障人士中有90%生活在低收入国家。目的:探讨急性视力丧失患者可能的神经学原因。患者和方法:本前瞻性观察性研究纳入了60例不同年龄、性别的急性视力丧失患者,这些患者于2021年3月初至2021年8月底从Al-Azher大学医院(Assiut)的神经内科和眼科转诊的门诊患者中招募。结果:本组患者急性视力丧失最常见的病因为视神经炎22例(36.67%),其次为非动脉性aion 18例(30.00%),功能性病因最少(8.33%)。结论:在不同的疾病中,血管状况可以单眼或双眼表现为缺血性视神经病变或脑梗死。诊断功能性视力丧失必须考虑排除所有其他器质性原因的急性视力丧失。
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引用次数: 0
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Al-Azhar International Medical Journal
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