Pub Date : 2016-11-07DOI: 10.24217/2530-4984.16V1.00003
R. Hernández, A. Rico, Peggy Rios, E. Ramírez
We present the case of an 88-year-old male, not known allergies,with medical history of arterial hypertension, Grade IV chronic kidney disease . His last hospitalisation was 1 month ago for a pneumonia, acute kidney injury, atrial fibrillation and pancytopenia. Two weeks later, he went to the Urgency Department for severe deterioration of the general condition, fever, and a skin rash which were attributed to an allergic late reaction to levofloxacin. His treatment was wich acetylsalicylic acid 100 mg, digoxin, methamizole, pantoprazole, valsartan/amlodipine The Lab results showed pancytopenia . It was performed a bone marrow aspirate suggestive of leishmaniosis. It was initiated treatment intravenous with LAB at 3 mg / kg / day . The first day of treatment, the patient showed a severe bronchospasm, exacerbation of previous rash by quinolones, was treated with corticosteroids, antihistamines, aerosoltherapy and oxygen therapy with full recovery. During the following days LAB was administrated at a slower administration and premedication (corticosteroids, and antihistamines) with appropriate tolerance. The fifth day of the treatment the patient started with an abdominal pain radiating in belt, anorexia and vomiting. The lab result of amylase was 431 IU/L. An abdominal scanner showed edematous pancreatitis. After 48 hours lab results of amylase and lipase were normal. And the abdominal Scanner was repeated with no changes. The evolution of patient was towards worsening to multiple organs failure and few days later he died.
我们报告一例88岁男性，不知道过敏，有动脉高血压病史，IV级慢性肾脏疾病。他最后一次住院是在一个月前，原因是肺炎、急性肾损伤、心房颤动和全血细胞减少症。两周后，他去了急诊科，一般情况严重恶化，发烧，皮疹，这是由于左氧氟沙星晚期过敏反应。给予乙酰水杨酸100 mg、地高辛、甲氨咪唑、泮托拉唑、缬沙坦/氨氯地平治疗。骨髓抽吸提示利什曼病。开始静脉滴注LAB，剂量为3mg / kg /天。治疗第一天，患者出现严重支气管痉挛，喹诺酮类药物使既往皮疹加重，经皮质类固醇、抗组胺药、气雾剂及氧疗治疗后完全恢复。在接下来的几天里，在适当的耐受性下，以较慢的给药和预用药(皮质类固醇和抗组胺药)给药。治疗第5天，患者开始出现放射状腹痛、厌食、呕吐。淀粉酶实验室检测结果为431 IU/L。腹部扫描显示水肿性胰腺炎。48小时后，淀粉酶和脂肪酶化验结果正常。腹部扫描重复进行，没有变化。患者病情逐渐恶化至多器官功能衰竭，几天后死亡。
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Pub Date : 2016-06-02DOI: 10.24217/2530-4984.16v1.00001
A. Borobia, Antonio J. Carcas
{"title":"Ciencia Iberoamericana para el Mundo","authors":"A. Borobia, Antonio J. Carcas","doi":"10.24217/2530-4984.16v1.00001","DOIUrl":"https://doi.org/10.24217/2530-4984.16v1.00001","url":null,"abstract":"","PeriodicalId":257309,"journal":{"name":"IBJ Clinical Pharmacology","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124308129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-02DOI: 10.24217/2530-4984.16V1.00002
A. Borobia, Antonio J. Carcas
Implementacion de la farmacogenetica en la practica clinica: hacia las estrategias de genotipado anticipado
药物遗传学在临床实践中的实施:面向预期基因分型策略
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