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Egyptian Journal of Obesity, Diabetes and Endocrinology最新文献

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Study of serum S100P level and its relation to diabetic peripheral neuropathy in patients with type-2 diabetes 2型糖尿病患者血清S100P水平及其与糖尿病周围神经病变关系的研究
Pub Date : 1900-01-01 DOI: 10.4103/ejode.ejode_20_21
Reem Fathalla, T. Aaty, M. Rizk, Rehab Elnemr, Aya Ali
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引用次数: 0
Evaluation of arterial stiffness in maintenance hemodialysis patients using pulse wave analysis and serum biomarkers of bone turnover 使用脉搏波分析和骨转换的血清生物标志物评估维持性血液透析患者的动脉僵硬度
Pub Date : 1900-01-01 DOI: 10.4103/ejode.ejode_19_21
GhadeerA Shawky, Yasser Nienaa, Abeer El Hadidi, N. Elkholy
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引用次数: 0
Study of the relation between the serum level of male sex hormone and peripheral vascular disease in elderly men 老年男性血清男性性激素水平与外周血管疾病关系的研究
Pub Date : 1900-01-01 DOI: 10.4103/2356-8062.200937
Doaa Badreldin, M. Mehanna, Nany Elgayar, Rania Swelem
Introduction Testosterone hormone decreases consistently with advancing age. Many studies have shown a possible relationship between decreasing level of testosterone and atherosclerosis. Objective The objective of our study was to demonstrate the relationship between male sex hormone [testosterone and sex hormone-binding globulin (SHBG)] concentration and peripheral vascular disease in elderly men. Background Few studies have explored the relationship between serum sex hormones and lower-extremity peripheral arterial disease (PAD) in men. Patients and methods Our study was conducted on 20 elderly men older than 65 years with peripheral vascular disease and 10 healthy age-matched men as controls. Lower-extremity PAD was defined as ankle brachial index less than 0.90 and diagnosis was confirmed with Doppler ultrasound. Radioimmunoassay measured serum levels of total testosterone and SHBG, and we calculated free androgen index level from the mass action equations. Results The results show that serum level of total testosterone, SHBG, and free androgen index were lower in men with peripheral vascular disease than in those without. There is a positive correlation between total testosterone, SHBG, free androgen index, and ankle brachial index. Conclusion Low serum level of total testosterone, SHBG, and free androgen index are significantly and independently associated with the presence of PAD in elderly men.
睾丸激素随着年龄的增长而持续下降。许多研究表明睾酮水平下降与动脉粥样硬化之间可能存在联系。目的探讨老年男性男性性激素(睾酮和性激素结合球蛋白)浓度与外周血管疾病的关系。背景很少有研究探讨血清性激素与男性下肢外周动脉疾病(PAD)的关系。患者和方法本研究选取了20名65岁以上患有外周血管疾病的老年男性和10名年龄匹配的健康男性作为对照。下肢PAD定义为踝肱指数小于0.90,多普勒超声确诊。放射免疫法测定血清总睾酮和SHBG水平,并根据质量作用方程计算游离雄激素指数水平。结果外周血管病变患者血清总睾酮水平、SHBG及游离雄激素指数均低于无外周血管病变患者。总睾酮、SHBG、游离雄激素指数与踝肱指数呈正相关。结论低血清总睾酮水平、SHBG水平和游离雄激素指数与老年男性PAD存在显著且独立相关。
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引用次数: 0
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Egyptian Journal of Obesity, Diabetes and Endocrinology
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