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Considering COVID-19 Infectiousness with Esteem to Blood Groups 从血型角度考虑COVID-19传染性
Pub Date : 2022-06-30 DOI: 10.36959/856/531
Fidan Vural
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引用次数: 0
An Unusual Case of Acute Postoperative Hypokalemic Thyrotoxic Periodic Paralysis 术后急性低钾性甲状腺毒性周期性麻痹1例
Pub Date : 2022-06-30 DOI: 10.36959/856/529
Mora Isabel, Zaveri Sahil, S. Bhavin, Mendez Dianelys, Farooqi Iqra, Melki Gabriel, Singhal Monisha
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引用次数: 0
Coronavirus Fusion and Entry are Targets for New Therapies 冠状病毒融合和进入是新疗法的目标
Pub Date : 2022-01-29 DOI: 10.36959/856/527
Hawley H Bradford
The current treatments for coronavirus infections consist of monoclonal antibodies to prevent spike protein attachment and antiviral agents to block RNA-dependent RNA polymerase interrupting viral replication. Fusion and entry of coronaviruses present new opportunities for therapy and are explained and summarized in this report. Additional effective treatments for current and future coronavirus infections will be of great benefit globally. Abstract The current therapies for coronavirus infections are directed at only two targets. Monoclonal antibodies prevent virus attachment to the host cell membrane and antiviral agents attack RNA-dependent RNA polymerase to interrupt replication of the virus. The fusion and entry stage of coronavirus infection can proceed through an endocomal route of a direct plasma membrane route. Molecular virology has provided detailed knowledge of these processes and each step presents an opportunity for therapeutic intervention. Currently available drugs have been repurposed and new compounds have been identified as potential coronavirus treatment options which target fusion and entry of these viruses.
目前对冠状病毒感染的治疗包括防止刺突蛋白附着的单克隆抗体和阻断阻断病毒复制的RNA依赖性RNA聚合酶的抗病毒药物。冠状病毒的融合和进入为治疗提供了新的机会,本报告对此进行了解释和总结。针对当前和未来冠状病毒感染的额外有效治疗将为全球带来巨大利益。目前针对冠状病毒感染的治疗方法仅针对两个靶点。单克隆抗体阻止病毒附着在宿主细胞膜上,抗病毒药物攻击依赖RNA的RNA聚合酶以中断病毒的复制。冠状病毒感染的融合和进入阶段可以通过直接的质膜途径进行。分子病毒学提供了这些过程的详细知识,每一步都为治疗干预提供了机会。目前可用的药物已被重新利用,新的化合物已被确定为针对这些病毒融合和进入的潜在冠状病毒治疗方案。
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引用次数: 0
Predictive Values of Whole Campus Wastewater Surveillance for SARS-CoV-2 校园污水监测对SARS-CoV-2的预测价值
Pub Date : 2022-01-29 DOI: 10.36959/856/528
G. Evangeline, Barlow Deborah, Rostama Bahman, Berkner Paul, May Meghan
Screening university wastewater for SARS-CoV-2 emerged as an attractive method to provide ancillary data to bolster detection of viral circulation, as it had the potential to detect the presence of asymptomatic cases or cases that are part of the campus community but not the student population. Our objective was to evaluate the positive and negative predictive values of wastewater screening for COVID-19 cases. We developed and undertook a pilot wastewater screening program for the Fall semester of 2020. Homogenized wastewater influent was collected once per 24 hours, and extracted nucleic acids were interrogated for the presence of SARS-CoV-2 by quantitative reverse-transcriptase PCR. Dates of positive detection were overlayed with dates of confirmed cases in the student population to determine assay sensitivity. SARS-CoV-2 was detected numerous times and was often, but not always, followed by cases of COVID-19. Positive student cases were preceded by detection of SARS-CoV-2 in wastewater by up to 48 hours at each detection. The positive predictive value of wastewater detection for student COVID-19 cases was 0.8105, and the negative predictive value was 0.991. Wastewater screening has the potential to serve as a tool for community-level SARS-CoV-2 surveillance, and is particularly powerful as a negative predictor of disease activity.
筛选大学废水中的SARS-CoV-2成为提供辅助数据以加强病毒循环检测的一种有吸引力的方法,因为它有可能检测到无症状病例的存在,或者是校园社区的一部分,但不是学生群体的病例。我们的目的是评估废水筛查对COVID-19病例的阳性和阴性预测值。我们为2020年秋季学期制定并实施了一项试点废水筛选计划。每24小时收集1次匀浆后的污水,提取核酸,采用定量逆转录酶PCR检测是否存在SARS-CoV-2。阳性检测的日期与学生人群中确诊病例的日期重叠,以确定测定的敏感性。SARS-CoV-2被多次检测到,并且经常(但并非总是)随后出现COVID-19病例。在出现阳性学生病例之前,每次在废水中检测到SARS-CoV-2长达48小时。学生新冠肺炎病例废水检测阳性预测值为0.8105,阴性预测值为0.991。废水筛查有可能作为社区层面SARS-CoV-2监测的工具,并且作为疾病活动的负面预测指标尤其强大。
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引用次数: 0
COVID-19 and Individuals with Learning Disabilities COVID-19和学习障碍患者
Pub Date : 2021-12-31 DOI: 10.36959/856/523
M. Rabiu, Alkundi Alamin
A lot has been written about the larger portion of the human population who can understand the implication and impact of the ongoing COVID-19 pandemic and adjust to regulations for self-protection. We hope to bring the challenges of care for individuals with learning difficulties during this ongoing pandemic to the fore and how to maximize care and protection for them.
关于大多数人能够理解正在进行的COVID-19大流行的影响和影响,并适应自我保护法规的情况,已经写了很多文章。我们希望在这场持续的大流行期间,突出照顾有学习困难的个人的挑战,以及如何最大限度地照顾和保护他们。
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引用次数: 0
Vitamin D and its Effects on COVID-19 维生素D及其对COVID-19的影响
Pub Date : 2021-09-18 DOI: 10.36959/856/522
Iyyuni Sravya, I. Michael, S. Anand
Vitamin D plays an important role in supporting the immune system. Its expression on vital immune cells like B, T, and antigen-presenting cells has become an important topic of research in response to the current COVID-19 pandemic. The purpose of vitamin D is vital not only to supporting the role of bones and muscle development, but also in its involvement in the regulation of mood and the immune system. This “sunshine vitamin”, due to its role in developing immunity within both adaptive and innate forms, is important to investigate with regards to disease prevention. There has been a recent push by many researchers to increase the recommended dosage of vitamin D because research shows that vitamin D deficiency can increase susceptibility to communicable diseases such as SARS-CoV-2. In this paper, we plan to highlight the immediate need to increase the national recommended dosage for Vitamin D due to the current population statistics indicating a significant overall deficiency, especially in areas with a high population density and within many minority groups. The purpose of this paper is also to highlight how the public’s vitamin D deficiency may also be contributing to the COVID-19 pandemic crisis as well.
维生素D在支持免疫系统方面起着重要作用。它在B细胞、T细胞和抗原提呈细胞等重要免疫细胞上的表达已成为应对当前COVID-19大流行的重要研究课题。维生素D的作用是至关重要的,它不仅支持骨骼和肌肉的发育,而且还参与调节情绪和免疫系统。这种"阳光维生素",由于其在发展适应性和先天形式的免疫方面的作用,在疾病预防方面的研究很重要。最近,许多研究人员都在推动增加维生素D的推荐剂量,因为研究表明,维生素D缺乏会增加对SARS-CoV-2等传染病的易感性。在这篇论文中,我们计划强调迫切需要增加维生素D的国家推荐剂量,因为目前的人口统计数据表明,维生素D总体缺乏,特别是在人口密度高的地区和许多少数民族中。本文的目的还在于强调公众维生素D缺乏也可能导致COVID-19大流行危机。
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引用次数: 0
Comparison between the 2020 Coronavirus-19 and the 1665 Great Plague of London 2020年冠状病毒-19与1665年伦敦大瘟疫的比较
Pub Date : 2021-09-18 DOI: 10.36959/856/521
Mananga Eugene Stephane, Rusmeha Lamisa
We are currently encountering one of the most disruptive pandemics in modern history. The outbreak of COVID-19 was first reported in the Chinese province of Hubei, which has now spread throughout the world resulting in about 81.5 million Covid-19 cases and 1.8 million deaths across 217 countries. Where we stand today, it is yet as dubious whether the number of cases will continue to rise and cause destruction or will it come to a halt. But it is certain that this is a crucial moment and that we are enduring a historic event that will reconstruct our societies both fundamentally and irreversibly. As we wade into this new age of pandemic, it is critical to rethink the history of pandemics and acknowledge the effective measures to combat these pandemics. With a conviction that the past helps us to comprehend the present and that the present should help us to rethink the past, we turn to one of the most destructive pandemics in history, the great plague of London in 1965, which is comparable to the COVID-19 in many aspects. This paper will describe the havoc caused by COVID-19 in all arrays of life, the impact of the pandemic in the United States, specifically in New York City, the similarity between the enduring effect of COVID-19 pandemic and the great plague of London in 1965, Sir Isaac Newton’s way of enforcing his time in quarantine during the Great Plague and the probable outlook of the world after the COVID-19 pandemic. Check for updates types, coronaviruses keep appearing and evolving, causing human and veterinary outbreaks [4]. According to the CDC [5], SARS-CoV-2 spreads predominantly when an affected person is in close contact with a non-affected person because small droplets and aerosols containing the virus can easily spread from an infected person’s nose and mouth when they breathe, cough or sneeze. Studies show that 101 out of every 10,000 cases develop symptoms after 14 days of active monitoring or quarantine [6]. SARS-CoV-2 infection can stimulate innate and adaptive immune responses. But the uncontrolled inflammatory innate responses and impaired adaptive immune responses may result in harmful tissue damage, both locally and Citation: Mananga ES, Rusmeha L (2021) Comparison between the 2020 Coronavirus-19 and the 1665 Great Plague of London. Ann Public Health Reports 5(2):216-223 Mananga and Rusmeha. Ann Public Health Reports 2021, 5(2):216-223 Open Access | Page 217 | [13]. The NYC and New York State public health laboratories began testing hospitalized patients at the end of February and early March. DOHMH (New York City Department of Health and Mental Hygiene) reinforced patients with mild symptoms to stay at home rather than seek health care in the hospital because of shortages of personal protective equipment and laboratory tests at hospitals and clinics. The increased case fatality rate among hospitalized patients during the pinnacle of reported cases suggests that health care system ability constraints might have resulted in
我们目前正在遭遇现代史上最具破坏性的流行病之一。新冠肺炎疫情首先在中国湖北省报告,目前已蔓延到世界各地,在217个国家造成约8150万例新冠肺炎病例和180万人死亡。在我们今天的情况下,病例数量是否会继续上升并造成破坏,还是会停止,这一点仍然值得怀疑。但可以肯定的是,这是一个关键时刻,我们正在经历一个历史性事件,它将从根本上和不可逆转地重建我们的社会。当我们步入这个大流行病的新时代时,必须重新思考大流行病的历史,并认识到防治这些大流行病的有效措施。我们坚信,过去有助于我们理解现在,而现在应该帮助我们重新思考过去,因此我们转向历史上最具破坏性的流行病之一,即1965年伦敦大瘟疫,它在许多方面与COVID-19相当。本文将描述COVID-19对生活中所有方面造成的破坏,大流行在美国,特别是在纽约市的影响,COVID-19大流行与1965年伦敦大瘟疫的持久影响之间的相似性,艾萨克·牛顿爵士在大瘟疫期间执行隔离时间的方式以及COVID-19大流行后世界的可能前景。查看最新情况类型,冠状病毒不断出现和演变,导致人类和兽医爆发[4]。根据美国疾病控制与预防中心的说法,SARS-CoV-2主要在感染者与非感染者密切接触时传播,因为含有病毒的小飞沫和气溶胶在感染者呼吸、咳嗽或打喷嚏时很容易从他们的鼻子和嘴巴传播。研究表明,每1万名患者中有101人在积极监测或隔离14天后出现症状。SARS-CoV-2感染可刺激先天性和适应性免疫反应。但不受控制的炎症先天反应和适应性免疫反应受损可能导致局部和有害的组织损伤。引用本文:Mananga ES, Rusmeha L(2021) 2020年冠状病毒-19与1665年伦敦大瘟疫的比较。Ann公共卫生报告5(2):216-223 Mananga和Rusmeha。Ann Public Health Reports, 2021, 5(2):216-223 Open Access | Page 217 |[13]。纽约市和纽约州公共卫生实验室于2月底和3月初开始对住院患者进行检测。纽约市卫生和心理卫生局强调,由于医院和诊所缺乏个人防护设备和实验室检测,症状轻微的病人应留在家中,而不是去医院就医。在报告病例的高峰期间住院患者的病死率增加表明,卫生保健系统能力的限制可能导致了患者的结果。因此,医疗制度和社会经济地位对COVID-19患者的健康结果起着重要作用。新冠肺炎疫情严重影响了纽约市的经济,失业率达到了最高点。例如,小企业关闭的时间越长,它们重新开业的可能性就越小。据《纽约时报》报道,纽约7月份的失业率为15.9%,在各州和哥伦比亚特区中排名第二;根据Bankrate的数据,纽约7月份的抵押贷款拖欠率为8.38%,排名第11位。高失业率和高破产率表明,纽约市的经济受到了大流行的严重影响。纽约市曾是世界上最重要的COVID-19热点,但在6月底至7月初,该市也出现了美国所有主要城市中最大的政治困境,示威活动的参与者和另一个政治后果几乎不同意社交距离和口罩规则。调查和研究发现,对于保持社会距离、戴口罩等防疫措施的接受度和遵守度,以及开放后恢复日常生活的舒适感,各政党之间存在差异。由于美国政治领导人不承认戴口罩和保持社交距离对预防新冠肺炎感染的重要性,在民众中产生了巨大的误解。因此,一些人拒绝遵守疾病预防控制中心批准的COVID-19预防指南,导致感染水平迅速上升。因此,新冠肺炎疫情的突然出现在纽约市引发了政治动荡,导致纽约市新冠肺炎感染率上升,这是不争的事实。由于新冠肺炎大流行,纽约市的教育系统面临许多复杂问题。
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引用次数: 0
Distribution of Dengue Virus Serotypes in Jazan Region, Southwest Saudi Arabia 沙特阿拉伯西南部吉赞地区登革热病毒血清型分布
Pub Date : 2021-08-31 DOI: 10.36959/856/520
Dafalla Ommer, Hakami Abdulaziz, Noureldin Elsiddig, Abdelwahab Siddig, Hejri Yehya, Khawaji Tareq, Ghzwani Jaber, Mashi Omar, Shrwani Khalid, Hamzi Tariq, Matabi Abdullatif, Aghamdi Abdullah, Eisa Zaki
Nearly half of the world's population are at risk of dengue fever (DF) which is a serious threat to the majority of international public health. Recently, Dengue viruses (DENVs) considered a re-emerging arthropod-borne viral disease that has been growing its transmission in numerous geographic areas across the world, causing dengue-endemic in more than 125 countries globally.
世界上近一半的人口面临登革热的风险,这对大多数国际公共卫生构成严重威胁。最近,登革热病毒(denv)被认为是一种重新出现的节肢动物传播的病毒性疾病,它在世界各地许多地理区域的传播不断增加,在全球超过125个国家造成登革热流行。
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引用次数: 1
Experience and Lessons of Tuberculosis Prevention and Control During COVID-19 Pandemic in Clinic 新冠肺炎大流行期间临床结核病防治的经验教训
Pub Date : 2021-06-23 DOI: 10.36959/856/519
Jian-qin Liang
The coronavirus disease 2019 (COVID-19) and pulmonary tuberculosis (PTB) are respiratory infectious diseases spread by droplets. It is difficult to distinguish COVID-19 and PTB by their clinical symptoms and radiographic features. PTB prevention and treatment have become challenges during the COVID-19 pandemic. Here in, as long-term frontline health care workers (HCWs) in the TB department, we have summed up the following experience and lessons from a large number of clinical practices.
2019冠状病毒病(COVID-19)和肺结核(PTB)是通过飞沫传播的呼吸道传染病。从临床症状和影像学特征很难区分COVID-19和PTB。在COVID-19大流行期间,结核病的预防和治疗已成为挑战。在这里,作为结核病科的长期一线医护人员,我们从大量的临床实践中总结出以下经验和教训。
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引用次数: 0
The Four Critical Links of SARS-CoV-2 in Latin America and the Caribbean: Challenges for Health from the South 拉丁美洲和加勒比地区SARS-CoV-2的四个关键环节:来自南方的卫生挑战
Pub Date : 2021-05-06 DOI: 10.36959/856/517
Basile Gonzalo
Based on a review of the country experiences and the critical documentary analysis of contents, policies and actions, this paper characterizes the critical links in the response to the public health emergency of SARS-CoV-2 with comprehensive, reproducible claims, unique, monocultural and universal applied both to the State and to Latin American and Caribbean societies.
基于对国家经验的回顾和对内容、政策和行动的批判性文献分析,本文描述了应对SARS-CoV-2突发公共卫生事件的关键环节,包括全面、可重复的主张、独特、单一文化和普遍适用于国家以及拉丁美洲和加勒比社会的主张。
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引用次数: 1
期刊
Annals of Public Health Reports
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