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Subnormal Clusters in the Context of the Current COVID-19 Outbreak: Challenges for Brazilian Public Health 当前COVID-19疫情背景下的亚正常聚集:巴西公共卫生面临的挑战
Pub Date : 2020-10-09 DOI: 10.36959/856/496
T. Sc
The recent Coronavirus Disease 2019 (COVID-19) outbreak, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has rapidly become a worldwide public health concern. On February 3, 2020, the Brazilian government declared the COVID-19 pandemic as a public health emergency; thus, the following question is raised: What is the current situation in the Brazilian subnormal clusters popularly known as favelas seven months later?
最近由严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)疫情已迅速成为全球关注的公共卫生问题。2020年2月3日,巴西政府宣布COVID-19大流行为突发公共卫生事件;因此,提出了以下问题:七个月后,巴西被称为“贫民窟”的次正常集群的现状如何?
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引用次数: 0
The Greatest Risk to Malaysian Healthcare Workers during COVID-19 Crisis: Lies of Patients 在COVID-19危机期间,马来西亚医护人员面临的最大风险:患者的谎言
Pub Date : 2020-07-30 DOI: 10.36959/856/494
Allaham Shereen, Zakieh Omar, Salim Faizul Nizam Abu, Choong Abigail AL, Manikam Logan
1Department of Epidemiology and Public Health, University College London Institute of Epidemiology and Health Care, London, UK 2Aceso Global Health Consultants Limited, London, UK 3Imperial College London School of Medicine, UK 4Ministry of Health Malaysia, Federal Territory of Putrajaya, Malaysia 5Department of Community Health, National University of Malaysia, Malaysia 6Department of Paediatrics, Hospital Sultan Haji Ahmad Shah, Temerloh, Malaysia
1伦敦大学学院流行病学和保健研究所流行病学和公共卫生系,伦敦,英国2Aceso全球健康顾问有限公司,伦敦,英国3伦敦帝国理工学院医学院,英国4马来西亚布城联邦领土马来西亚卫生部5马来西亚国立大学社区卫生系,马来西亚6马来西亚特默洛苏丹哈吉艾哈迈德沙阿医院儿科部
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引用次数: 0
Primary Sjögren's Syndrome and the Therapeutic Response to Rituximab: Case Report 原发性Sjögren综合征和利妥昔单抗的治疗反应:病例报告
Pub Date : 2019-09-30 DOI: 10.36959/856/490
J. Lorandi, D. Rb
The physiopathology is resumed as the lymphocytic infiltration and B cell hyperactivity around the epithelium of the affected tissues. The etiology is still unknown, although genetic and environmental factors are believed to play a very important role in the manifestation of pSS. The diagnosis and classification are made based on pre-established criteria that consider the clinical manifestations, biological markers and cytopathological alterations. The treatment is widely based on the symptoms and clinic presented by the patient, for severe extraglandular manifestations, B-cell-targeted therapies have been showing great results especially in cryoglobulinemia, vasculitis, severe parotid swelling, inflammatory arthritis, pulmonary disease and peripheral neuropathy.
病理生理恢复为受累组织上皮周围淋巴细胞浸润和B细胞过度活跃。病因尚不清楚,但遗传和环境因素被认为在pSS的表现中起着非常重要的作用。诊断和分类是基于预先建立的标准,考虑临床表现,生物标志物和细胞病理学改变。治疗广泛基于患者的症状和临床表现,对于严重的腺外表现,b细胞靶向治疗已经取得了很大的效果,特别是在冷球蛋白血症、血管炎、严重腮腺肿胀、炎症性关节炎、肺部疾病和周围神经病变。
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引用次数: 0
Disparities in Genetic Referrals for Breast Cancer among the Asian Immigrant Populations: How Can We Eliminate Them? 亚洲移民人群乳腺癌遗传转诊差异:如何消除?
Pub Date : 2019-05-23 DOI: 10.36959/856/489
Kamaraju Sailaja, J. Amanda, S. Samantha, Geurts Jennifer, D. Morgan, Olson Jessica, Chaudhary Lubna, Chitambar Christopher, Neuner Joan, Cheng Yee Chung
Despite major advances in genetic testing for breast cancer, access to genetic counseling and testing are significantly lower among immigrant and refugee populations. Both patient related barriers and provider-based factors contribute to disparities in genetic referrals and testing. Previous studies addressing genetic referral patterns among the minorities have focused on African Americans, however, there are no reports addressing disparities in genetic referrals and testing in Asian immigrant and refugee populations living in the United States (US). Given the rapid influx of these populations and increasing rates of breast cancer among Asian immigrant populations in the US, this area remains unexplored. This review addresses the current data on familial breast cancer syndromes, describe the various barriers, and attempts to provide suggestions to eliminate the disparities in genetic referral patterns. Citation: Kamaraju S, Jacquart A, Stachowiak S, Geurts J, Depas M, et al. (2019) Disparities in Genetic Referrals for Breast Cancer among the Asian Immigrant Populations: How Can We Eliminate Them?. Ann Public Health Reports 3(1):35-40 Kamaraju et al. Ann Public Health Reports 2019, 3(1):35-40 Open Access | Page 36 | acterized by early-onset breast cancer, soft tissue and bone sarcomas, leukemia, broncho-alveolar cancer, adrenocortical cancer, choroid plexus, and brain cancers. The lifetime cancer risks for individuals with LFS are significant. However, cancer-specific risks for individuals with LFS are currently unknown and are likely influenced by genotype, personal risk factors, environment, and modifier genes. The risk of developing at least one LFS-associated cancer is estimated to be 50% by age 30 and 90% by age 60 [18]. A recent study reported nine different TP53 pathogenic variants in an attempt to better determine the cancer-specific risks between Korean and Caucasian patients with LFS. Two novel frameshift pathogenic variants were reported in the TP53 gene at p.Pro98Leufs*25 and p.Pro27Leufs*17. Recurrent missense pathogenic variants were also reported at codons 31 (p.Val31I1e), 175 (p.Arg175His) and 273 (p.Arg273Cys) [19]. Individuals with LFS have a high lifetime risk of developing cancer, will often develop cancer at an early age, and may develop more than one primary cancer throughout their lifetime. Although germline TP53 pathogenic variants are rare, comprehensive hereditary cancer risk assessment needs to be performed in any individual diagnosed with breast cancer under age 31 years and in families with multiple, rare tumors occurring at early ages [18]. Cowden syndrome: Pathogenic variants in the PTEN gene are associated with PTEN hamartoma tumor syndrome (PHTS) a spectrum of highly variable conditions with overlapping features including Cowden syndrome (CS) [20]. CS is characterized by hamartomas, papillomas of the lips, mucous membranes, acral skin keratosis, and macrocephaly. Affected individuals are also at an increased risk t
据估计,携带BRCA1或BRCA2致病变异的个体患乳腺癌的风险约为43-87%,患卵巢癌的风险为15-63%,患前列腺癌的风险为16-20%,患男性乳腺癌的风险为1-7%,在一些家庭中患胰腺癌的风险为7%或更高[9,10]。多项研究报道了亚洲人BRCA1和BRCA2致病变异的患病率。在一项未选择的826名中国女性卵巢癌患者队列中,据报道,在接受生殖系分析的女性中,BRCA1的患病率为20.8%,BRCA2的患病率为7.6%。在致病变异的携带者中,85.5%的患者在较年轻的年龄被诊断为疾病晚期(III-IV)。最近在印度次大陆一家三级医院进行的一项研究表明,在24例符合HBOC综合征标准的患者中,13例(54%)存在BRCA致病变异,这表明需要对这些人群的遗传性癌症综合征进行彻底评估[10]。三阴性乳腺癌(TNBC)是乳腺癌的一种亚型,据报道在非裔美国人和拉丁裔妇女中预后较差。考虑到其对预后的影响,我们对不同人口统计学因素的TNBC患者中BRCA致病变异的存在进行了评估[10]。在这项回顾性研究中,450名患者有可评估的基因检测结果。作者报告了139例(30.8%)BRCA1 (n = 106)或BRCA2 (n = 32)致病变异。在本报告中,BRCA致病变异患病率为:非洲裔美国人(20.4%),德系犹太人(50%),亚洲人(28.5%),高加索人(33.3%)和西班牙裔(20%)。致病变异的患病率也因诊断年龄而异:< 40岁(43.8%)、4049岁(27.4%)、50-59岁(25.3%)、60-69岁(12.5%)和> 70岁(16.6%)>。在125例中国TNBC患者中也报道了一种BRCA1移码致病变异(rs80350973),患病率为(7.2%)[14]。这种高患病率可能有助于了解这一特定患者群体的基因型-表型相关性。对于有以下个人病史和/或家族史的个体,应考虑进一步的HBOC综合征遗传风险评估:50岁以下或等于50岁的乳腺癌,60岁以下或等于60岁的TNBC,卵巢癌,男性乳腺癌,胰腺癌,转移性乳腺癌,转移性前列腺癌,以及同一个人中的多种brca相关癌症[8,15-17]。其他遗传性乳腺癌综合症
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引用次数: 0
The Prevalence Rate of Cigarette Smoking among Congestive Heart Failure Patients at a Local Family Health Center 某地家庭保健中心充血性心力衰竭患者吸烟率调查
Pub Date : 2019-01-19 DOI: 10.36959/856/488
Salome Kapella-Mshigeni, Eunice Kimunai, C. Cross
The prevalence rate of smoking is well documented in the general population, but little is known among patients with Congestive Heart Failure (CHF). The mortality rate of CHF in San Bernardino county is nearly double (18.7 per 100,000 deaths) than that of the State of California (10.8 per 100,000 deaths). There is a need to fill knowledge gaps for CHF patients and identify evidence-based interventions that will help reduce health disparities among populations.
吸烟的流行率在一般人群中有很好的记录,但在充血性心力衰竭(CHF)患者中却知之甚少。圣贝纳迪诺县的瑞士法郎死亡率(每10万人死亡18.7人)几乎是加利福尼亚州的两倍(每10万人死亡10.8人)。有必要填补心力衰竭患者的知识空白,并确定以证据为基础的干预措施,以帮助缩小人群之间的健康差距。
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引用次数: 0
Coronavirus (COVID-19) Pandemic – A Comprehensive Review of Demographics, Comorbidities, Vaccines, Therapeutic Development, Blood Type, and Long Covid 冠状病毒(Covid -19)大流行——人口统计学、合并症、疫苗、治疗发展、血型和长冠状病毒的综合综述
Pub Date : 1900-01-01 DOI: 10.36959/856/540
Bhattacharyya Arinjita, S. Anand, Rai Shesh N
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引用次数: 0
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