Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0024
J. Pascual, P. van den Berg
Cough headache exists in a primary and secondary form. The latter is due to tonsillar descent or, more rarely, to other space-occupying lesions in the posterior fossa/foramen magnum. Up to 40% of patients have an underlying structural lesion. Most patients with primary cough headache respond to indomethacin and suboccipital craniectomy with posterior fossa reconstruction can relieve cough headache in Chiari type I malformation.
{"title":"Cough headache","authors":"J. Pascual, P. van den Berg","doi":"10.1093/med/9780198724322.003.0024","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0024","url":null,"abstract":"Cough headache exists in a primary and secondary form. The latter is due to tonsillar descent or, more rarely, to other space-occupying lesions in the posterior fossa/foramen magnum. Up to 40% of patients have an underlying structural lesion. Most patients with primary cough headache respond to indomethacin and suboccipital craniectomy with posterior fossa reconstruction can relieve cough headache in Chiari type I malformation.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134474154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0012
P. Parisi, D. Trenite, J. Carpay, L. Papetti, M. Paolino
Migraine and epilepsy are both characterized by transient attacks of altered brain function with a clinical, pathophysiological, and therapeutic overlap. Furthermore, epilepsy and migraine may mimic each other. In particular, occipital lobe seizures may be easily misinterpreted as migraine with visual aura, although there seems to be several clinical characteristics that can differentiate between visual auras of epileptic and migrainous origin
{"title":"Migraine and epilepsy","authors":"P. Parisi, D. Trenite, J. Carpay, L. Papetti, M. Paolino","doi":"10.1093/med/9780198724322.003.0012","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0012","url":null,"abstract":"Migraine and epilepsy are both characterized by transient attacks of altered brain function with a clinical, pathophysiological, and therapeutic overlap. Furthermore, epilepsy and migraine may mimic each other. In particular, occipital lobe seizures may be easily misinterpreted as migraine with visual aura, although there seems to be several clinical characteristics that can differentiate between visual auras of epileptic and migrainous origin","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114508684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0038
F. Amoozegar, Esma Dilli, R. Halker, A. Starling
Spontaneous intracranial hypotension (SIH) caused by a spontaneous cerebrospinal fluid (CSF) leak, results in CSF hypovolaemia. Owing to the variety of clinical presentations and numerous possible diagnostic investigations, diagnosis and appropriate treatment remains challenging in many patients. Although the typical presentation of SIH is an orthostatic headache, the clinical spectrum includes a variety of headache types, focal neurological symptoms, and even spinal manifestations. The underlying pathophysiology of SIH varies depending on the clinical scenario. However, a deeper understanding of the pathophysiology has led to the recognition of risk factors and an explanation for clinical symptoms and abnormalities on diagnostic investigations. Multiple diagnostic investigations can be used to determine if a CSF leak is present or not. Magnetic resonance imaging of the head with and without contrast is sensitive and non-invasive. However, computed tomography myelography remains the study of choice to locate the site of the leak. The rate of flow of the CSF leak can pose a challenge to standard diagnostic investigations. To date, a large-volume blind epidural blood patch is the mainstay of treatment, although more targeted approaches are used for more refractory cases.
{"title":"Headache attributed to spontaneous intracranial hypotension","authors":"F. Amoozegar, Esma Dilli, R. Halker, A. Starling","doi":"10.1093/med/9780198724322.003.0038","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0038","url":null,"abstract":"Spontaneous intracranial hypotension (SIH) caused by a spontaneous cerebrospinal fluid (CSF) leak, results in CSF hypovolaemia. Owing to the variety of clinical presentations and numerous possible diagnostic investigations, diagnosis and appropriate treatment remains challenging in many patients. Although the typical presentation of SIH is an orthostatic headache, the clinical spectrum includes a variety of headache types, focal neurological symptoms, and even spinal manifestations. The underlying pathophysiology of SIH varies depending on the clinical scenario. However, a deeper understanding of the pathophysiology has led to the recognition of risk factors and an explanation for clinical symptoms and abnormalities on diagnostic investigations. Multiple diagnostic investigations can be used to determine if a CSF leak is present or not. Magnetic resonance imaging of the head with and without contrast is sensitive and non-invasive. However, computed tomography myelography remains the study of choice to locate the site of the leak. The rate of flow of the CSF leak can pose a challenge to standard diagnostic investigations. To date, a large-volume blind epidural blood patch is the mainstay of treatment, although more targeted approaches are used for more refractory cases.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117138261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0014
M. Láinez, V. Grozeva
The chapter is a review of the possible treatment options for acute migraine. This primary headache disorder has a huge social and economic impact. The combination of a correct diagnosis, good general management and the election of the most appropriate pharmacological treatment can significantly reduce the patient’s disability. Here we provide a thorough description of the most commonly used specific (ergots and triptans) and nonspecific (analgesics, NSAIDs, dopamine antagonists, etc.) medications, as well as some of their effective combinations. We discuss how to use the different medications in relation with the clinical presentation of the migraine attacks and in special situations as status migrainosus, or refractoriness to conventional treatment. Advantages and disadvantages of the most used strategies are pointed out to assist professionals to choose the best individual treatment for their patients with acute migraine attack.
{"title":"Treatment and management of migraine","authors":"M. Láinez, V. Grozeva","doi":"10.1093/med/9780198724322.003.0014","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0014","url":null,"abstract":"The chapter is a review of the possible treatment options for acute migraine. This primary headache disorder has a huge social and economic impact. The combination of a correct diagnosis, good general management and the election of the most appropriate pharmacological treatment can significantly reduce the patient’s disability. Here we provide a thorough description of the most commonly used specific (ergots and triptans) and nonspecific (analgesics, NSAIDs, dopamine antagonists, etc.) medications, as well as some of their effective combinations. We discuss how to use the different medications in relation with the clinical presentation of the migraine attacks and in special situations as status migrainosus, or refractoriness to conventional treatment. Advantages and disadvantages of the most used strategies are pointed out to assist professionals to choose the best individual treatment for their patients with acute migraine attack.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124277878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0026
D. Holle, D. Dodick
Hypnic headache (HH) is a rare primary headache disorder. Its main clinical features are strict sleep-related headache attacks that awaken patients from sleep. As headache attacks often occur at the same time at night, HH has also been referred to as ‘alarm clock headache’. Currently, 225 cases have been reported in the literature. Patients are generally older than 50 years of age at headache onset, but occurrence in younger patients and even children has been described. More women than man are affected. The headache may be bilateral or unilateral. Some migrainous features, such as nausea or photophobia, or mild cranial autonomic symptoms, such as lacrimation, may accompany HH and create diagnostic uncertainty. While most patients display some motor activity during the headache attacks, the agitation and motor restlessness that is characteristic of cluster headache does not appear. The pathophysiology of HH is still enigmatic. Hypothalamic involvement has been considered on the basis of the circadian rhythmicity, relationship with sleep, and imaging evidence of a decrease in grey matter volume within the posterior hypothalamus. Caffeine, lithium carbonate, and indomethacin may be effective for the prevention of attacks, but randomized, placebo-controlled trials are not yet available.
{"title":"Hypnic headache","authors":"D. Holle, D. Dodick","doi":"10.1093/med/9780198724322.003.0026","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0026","url":null,"abstract":"Hypnic headache (HH) is a rare primary headache disorder. Its main clinical features are strict sleep-related headache attacks that awaken patients from sleep. As headache attacks often occur at the same time at night, HH has also been referred to as ‘alarm clock headache’. Currently, 225 cases have been reported in the literature. Patients are generally older than 50 years of age at headache onset, but occurrence in younger patients and even children has been described. More women than man are affected. The headache may be bilateral or unilateral. Some migrainous features, such as nausea or photophobia, or mild cranial autonomic symptoms, such as lacrimation, may accompany HH and create diagnostic uncertainty. While most patients display some motor activity during the headache attacks, the agitation and motor restlessness that is characteristic of cluster headache does not appear. The pathophysiology of HH is still enigmatic. Hypothalamic involvement has been considered on the basis of the circadian rhythmicity, relationship with sleep, and imaging evidence of a decrease in grey matter volume within the posterior hypothalamus. Caffeine, lithium carbonate, and indomethacin may be effective for the prevention of attacks, but randomized, placebo-controlled trials are not yet available.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127814636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0033
Juan A. Pareja, Carrie E. Robertson
Nummular headache is characterized by head pain exclusively felt in a sharply contoured, rounded, or elliptical area of the scalp, fixed in size and shape, and typically 1–6 cm in diameter. The affected area may show variable combinations of hypoaesthesia, dysaesthesia, paraesthesia, allodynia, and/ or tenderness. The symptomatic area may be localized in any part of the head but mostly in the parietal region. Rarely, the disorder may be multifocal, with each symptomatic area retaining all the characteristics of nummular headache. The pain is continuous or intermittent, and generally chronic. Nummular headache is a primary condition.
{"title":"Nummular headache","authors":"Juan A. Pareja, Carrie E. Robertson","doi":"10.1093/med/9780198724322.003.0033","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0033","url":null,"abstract":"Nummular headache is characterized by head pain exclusively felt in a sharply contoured, rounded, or elliptical area of the scalp, fixed in size and shape, and typically 1–6 cm in diameter. The affected area may show variable combinations of hypoaesthesia, dysaesthesia, paraesthesia, allodynia, and/ or tenderness. The symptomatic area may be localized in any part of the head but mostly in the parietal region. Rarely, the disorder may be multifocal, with each symptomatic area retaining all the characteristics of nummular headache. The pain is continuous or intermittent, and generally chronic. Nummular headache is a primary condition.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0015
A. Charles, S. Evers
A significant percentage of individuals with migraine, by some estimates as many as 25%, are candidates for preventive therapy, also known as prophylactic therapy. These are treatments that are administered to pre-empt headache attacks, as opposed to acute treatments that are administered once a headache attack has occurred (although many treatments may be effective both as preventive and acute therapies). There are a variety of options for preventive therapy with widely varying mechanisms of action, and there is no clear-cut single choice for any individual patient. Preventive therapies can be broadly grouped as antihypertensive medications, anticonvulsant medications, antidepressants, vitamins, natural therapies, neurotoxins, and neuromodulation approaches. Early clinical trials indicate that antibody therapies may play an important role as future migraine preventive therapies. While current therapies are effective for some patients, there is a critical need for better means of identifying which strategy is the best for each individual patient, and also for new approaches that are more effective and better tolerated for prevention of migraine overall.
{"title":"Treatment and management of migraine","authors":"A. Charles, S. Evers","doi":"10.1093/med/9780198724322.003.0015","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0015","url":null,"abstract":"A significant percentage of individuals with migraine, by some estimates as many as 25%, are candidates for preventive therapy, also known as prophylactic therapy. These are treatments that are administered to pre-empt headache attacks, as opposed to acute treatments that are administered once a headache attack has occurred (although many treatments may be effective both as preventive and acute therapies). There are a variety of options for preventive therapy with widely varying mechanisms of action, and there is no clear-cut single choice for any individual patient. Preventive therapies can be broadly grouped as antihypertensive medications, anticonvulsant medications, antidepressants, vitamins, natural therapies, neurotoxins, and neuromodulation approaches. Early clinical trials indicate that antibody therapies may play an important role as future migraine preventive therapies. While current therapies are effective for some patients, there is a critical need for better means of identifying which strategy is the best for each individual patient, and also for new approaches that are more effective and better tolerated for prevention of migraine overall.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133231732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0009
B. Grosberg, C. Sollars
The relationship between migraine and a large number of other diseases has been studied to varying degrees. Both clinical and population-based studies, cross-sectional and longitudinal, have been performed, indicating a relationship of migraine with ischaemic stroke, epilepsy, vertigo, psychiatric disorders, sleep disorders, pain disorders, and others. The association of migraine with depression is one of the most extensively studied comorbidities. The bidirectional nature of this comorbidity indicates possible shared genetic factors. Furthermore, the risk of migraine chronification is increased in migraine patients with a depression. Also, anxiety and bipolar disorder show clear associations with migraine. Sleep disorders have been reported to occur more often in migraineurs than in persons without migraine. A clear association was found for restless legs syndrome and familial advanced sleep phase syndrome. Furthermore, associations have been described with insomnia, daytime sleepiness, sleep apnoea, and narcolepsy. Among pain disorders associated with migraine are low back pain, fibromyalgia, and abdominal pain. The magnitude and the background of these comorbidities remain unclear, and should be further investigated. Other described comorbidities of migraine include syncope, movement disorders, asthma and allergies, gynaecological disturbances, obesity, diabetes, multiple sclerosis, and cancer.
{"title":"Retinal migraine","authors":"B. Grosberg, C. Sollars","doi":"10.1093/med/9780198724322.003.0009","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0009","url":null,"abstract":"The relationship between migraine and a large number of other diseases has been studied to varying degrees. Both clinical and population-based studies, cross-sectional and longitudinal, have been performed, indicating a relationship of migraine with ischaemic stroke, epilepsy, vertigo, psychiatric disorders, sleep disorders, pain disorders, and others. The association of migraine with depression is one of the most extensively studied comorbidities. The bidirectional nature of this comorbidity indicates possible shared genetic factors. Furthermore, the risk of migraine chronification is increased in migraine patients with a depression. Also, anxiety and bipolar disorder show clear associations with migraine. Sleep disorders have been reported to occur more often in migraineurs than in persons without migraine. A clear association was found for restless legs syndrome and familial advanced sleep phase syndrome. Furthermore, associations have been described with insomnia, daytime sleepiness, sleep apnoea, and narcolepsy. Among pain disorders associated with migraine are low back pain, fibromyalgia, and abdominal pain. The magnitude and the background of these comorbidities remain unclear, and should be further investigated. Other described comorbidities of migraine include syncope, movement disorders, asthma and allergies, gynaecological disturbances, obesity, diabetes, multiple sclerosis, and cancer.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"9 9-10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114038562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0043
S. Graff‐Radford, A. Newman
Orofacial pain involves pain conditions associated with the hard and soft tissues of the head, face, neck, and all the intra-oral structures. The field of orofacial pain encompasses diagnosis and treatment of primary headaches, temporomandibular disorders, neuropathic pain, cervical pain, and myofascial pain. The evaluation and treatment of orofacial pain has evolved into a shared responsibility between the dentist and physician, with considerable overlap, distinguished only by the practitioner’s knowledge and training.
{"title":"Orofacial pain","authors":"S. Graff‐Radford, A. Newman","doi":"10.1093/med/9780198724322.003.0043","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0043","url":null,"abstract":"Orofacial pain involves pain conditions associated with the hard and soft tissues of the head, face, neck, and all the intra-oral structures. The field of orofacial pain encompasses diagnosis and treatment of primary headaches, temporomandibular disorders, neuropathic pain, cervical pain, and myofascial pain. The evaluation and treatment of orofacial pain has evolved into a shared responsibility between the dentist and physician, with considerable overlap, distinguished only by the practitioner’s knowledge and training.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":" 1016","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141218474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1093/med/9780198724322.003.0048
D. Holle, J. Pascual
Chiari malformation is a rare medical condition that is characterized by downward displacement of the cerebellar tonsils through the foramen magnum. The clinical presentation of Chiari malformation is diverse, but headache is the most often reported symptom. The typical Chiari malformation headache is localized in the occipital part of the head and aggravated by coughing, other Valsalva manoeuvres, or physical exertion. The prevalence of other episodic primary headache disorders such as tension-type headache and migraine is not increased in patients with Chiari malformation. The underlying pathophysiology of headache in Chiari malformation is still enigmatic, but alteration of intrathecal pressure was suggested to be involved. Controlled treatment trials for CM-related headaches are not available and treatment recommendations are mainly based on case reports, small case series and clinical experience. Therefore, no firm recommendation regarding surgical treatment can be made.
{"title":"Headache and Chiari malformation","authors":"D. Holle, J. Pascual","doi":"10.1093/med/9780198724322.003.0048","DOIUrl":"https://doi.org/10.1093/med/9780198724322.003.0048","url":null,"abstract":"Chiari malformation is a rare medical condition that is characterized by downward displacement of the cerebellar tonsils through the foramen magnum. The clinical presentation of Chiari malformation is diverse, but headache is the most often reported symptom. The typical Chiari malformation headache is localized in the occipital part of the head and aggravated by coughing, other Valsalva manoeuvres, or physical exertion. The prevalence of other episodic primary headache disorders such as tension-type headache and migraine is not increased in patients with Chiari malformation. The underlying pathophysiology of headache in Chiari malformation is still enigmatic, but alteration of intrathecal pressure was suggested to be involved. Controlled treatment trials for CM-related headaches are not available and treatment recommendations are mainly based on case reports, small case series and clinical experience. Therefore, no firm recommendation regarding surgical treatment can be made.","PeriodicalId":281151,"journal":{"name":"Oxford Textbook of Headache Syndromes","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124822687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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