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Computer-aided Cervical Cancer Screening Method based on Multi-spectral Narrow-band Imaging 基于多光谱窄带成像的计算机辅助宫颈癌筛查方法
Zihan Yang, Dingrong Yi, Jiahao Shen
The contrast of white colposcopy images is low, which is not conducive to the computer assisted identification of different degrees of diseased tissue. In order to improve the sampling accuracy under the image guidance of colposcopy, in this paper, we propose a Computer-aided cervical cancer screening method based on Multi-spectral Narrow-Band Imaging (CMNBI). We sequentially get images of cervical tissue under different illumination sources including white light, narrow-band blue light at a center wavelength of 415nm, and narrow-band green light at a center wavelength of 540nm. The multi-spectral pathology diagnosis methods consist of two stages: the first one is image preprocessing and the other is tissue classification. The image preprocessing algorithm consists of the following steps: First, we perform filtering process on three modes of images to remove noises. Secondly, the sequentially obtained images are spatially co-registered. Thirdly, the multiple narrow-band spectral images are fused. In the stage of tissue classification, a two-class K-means clustering algorithm is used, using clinics manually identified diseased region as the seed points. To eliminate strong specular reflection points of cervical tissue, we then applied improved K-means clustering algorithm combined with contour coefficient method to improve robustness of the proposed computer-aided cervical cancer screening method. To evaluate the proposed method, we apply the method to both the fused narrow-band multispectral images as well as the conventional white light images. As a result, the sensitivity, specificity and accuracy of CMNBI are all improved with the fused narrow-band multispectral images over that of the conventional white light images.
阴道镜白色图像对比度低,不利于计算机辅助识别不同程度的病变组织。为了提高阴道镜图像引导下的采样精度,本文提出了一种基于多光谱窄带成像(CMNBI)的计算机辅助宫颈癌筛查方法。我们依次得到白光、中心波长415nm的窄带蓝光、中心波长540nm的窄带绿光等不同照明光源下的宫颈组织图像。多光谱病理诊断方法包括两个阶段:一是图像预处理,二是组织分类。图像预处理算法包括以下步骤:首先,我们对三种模式的图像进行滤波处理,去除噪声。其次,对序列图像进行空间共配准;第三,对多幅窄带光谱图像进行融合。在组织分类阶段,采用两类K-means聚类算法,以诊所人工识别的病变区域作为种子点。为了消除宫颈组织的强镜面反射点,我们将改进的K-means聚类算法与轮廓系数法相结合,提高所提出的计算机辅助宫颈癌筛查方法的鲁棒性。为了验证该方法的有效性,我们将该方法应用于融合窄带多光谱图像和传统白光图像。结果表明,与传统白光图像相比,融合窄带多光谱图像的CMNBI的灵敏度、特异度和准确性均有提高。
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引用次数: 2
Epileptic Seizure Classification based on the Combined Features 基于组合特征的癫痫发作分类
Jie Yu, Lirong Wang, Xueqin Chen
Electroencephalography (EEG) can provide a wealth of valuable information to help understand the mechanism of seizures. The automatic classification of EEG signals can help clinicians make effective judgments on whether seizures occur. In this work, a method based on combined features is proposed to classify epilepsy seizures. Firstly, discrete wavelet transform is applied to the signal, and the line length features, energy distribution proportion and approximate entropy of each sub-band signal are extracted. Then the statistical features of the raw signal are extracted, including mean, standard deviation, coefficient of variation, median absolute deviation (MAD) and interquartile range (IQR). All the features are combined and the dimension of the combined feature vector is reduced by the principal component analysis (PCA). Finally, the support vector machine (SVM) is used to classify the epileptic seizure. The dataset is from the epilepsy laboratory of the University of Bonn, Germany. The accuracy of 98.40% proves the validity of this method.
脑电图(EEG)可以提供丰富的有价值的信息,以帮助了解癫痫发作的机制。脑电图信号的自动分类可以帮助临床医生对癫痫是否发生做出有效的判断。本文提出了一种基于组合特征的癫痫发作分类方法。首先对信号进行离散小波变换,提取各子带信号的线长特征、能量分布比例和近似熵;然后提取原始信号的统计特征,包括均值、标准差、变异系数、中位数绝对偏差(MAD)和四分位间距(IQR)。将所有特征进行组合,并通过主成分分析(PCA)对组合后的特征向量进行降维。最后利用支持向量机(SVM)对癫痫发作进行分类。数据集来自德国波恩大学癫痫实验室。98.40%的准确率证明了该方法的有效性。
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引用次数: 3
Forecasting of Ventricular Tachyarrhythmia based on Multi-scale Entropy of Short-term Heart Rate Variability 基于短期心率变异性多尺度熵的室性心动过速预测
L. Qing, D. Hong-sheng, Ma Yin-yuan
The weighted integrated multi-scale entropy(WIMSE) is analyzed for the 135 about ten minutes RR interval series preceding the onset of ventricular tachycardia and ventricular fibrillation(called VT/VF series),and the change of WIMSE is discussed for the data samples of significant increase of heart rate (called SI_HR group) and no significant change of heart rate (called nSI_HR group) preceding the onset of VT/VF events. Results show that the WIMSE of VT/VF series has significantly reduction compared with normal sinus rhythm (scale:1--30, p<0.05),and the reduction of WIMSE is more significant for the VT/VF series of SI_HR group, the extracted complexity index (scale:1-10, p<10-6). Therefore the WIMSE may be an effective nonlinear predictive parameters for forecasting VT/VF events.
对室性心动过速和心室颤动发生前135个约10分钟RR间隔序列(称为VT/VF序列)的加权综合多尺度熵(WIMSE)进行分析,并对发生室性心动过速和心室颤动发生前心率显著升高(称为SI_HR组)和心率无显著变化(称为nSI_HR组)的数据样本讨论WIMSE的变化。结果显示,VT/VF组的WIMSE较正常窦性心律明显降低(量表:1—30,p<0.05),且SI_HR组VT/VF组的WIMSE降低更为显著,提取的复杂性指数(量表:1—10,p<10—6)。因此,WIMSE可以作为预测VT/VF事件的有效非线性预测参数。
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引用次数: 0
Facial Spot Contour Extraction based on Color Image Processing 基于彩色图像处理的人脸斑点轮廓提取
Xiaojin Liu, Jiuai Sun, Xiong Wang
In this paper we discuss the problem of automatic contour extraction of facial spot based on RGB images. Prior similar work has been frequently used for processing those hyperpigmentation skin conditions such as melasma and melanoma, where the separation between pigmented area and normal skin is easy to define. However the melanin under facial spots is normally deposited in a scatter way and distributed superficially, this makes the contrast between the area of spots and that of normal skin become small. As such it is difficult to directly extract the contour of the spots. After analyzing the individual three color channels of facial spot RGB skin image, we found that the blue channel provides the clearest edge of the spots, while the edge presents a certain amount of blur in the red channel. Therefore, this study proposed a new image processing strategy for facial spots analysis, i.e. to firstly separate the RGB channels to obtain the blue channel, then, the maximum entropy threshold segmentation and the Snake method are used to extract the contour of color spots. The experiments verified that the separated color channel and Snake-based method can help to reliably extract edge contours and preserve the color information of the spot.
本文讨论了基于RGB图像的人脸斑点轮廓自动提取问题。先前类似的工作经常用于处理那些色素沉着的皮肤状况,如黄褐斑和黑色素瘤,其中色素沉着区域与正常皮肤之间的分离很容易定义。然而,面部斑点下的黑色素通常呈散点沉积,分布在表面,这使得斑点面积与正常皮肤面积的反差变小。因此,很难直接提取斑点的轮廓。通过对面部斑点RGB皮肤图像单独的三个颜色通道进行分析,我们发现蓝色通道提供了斑点最清晰的边缘,而红色通道的边缘呈现出一定程度的模糊。因此,本研究提出了一种新的面部斑点分析的图像处理策略,即首先分离RGB通道获得蓝色通道,然后利用最大熵阈值分割和Snake方法提取彩色斑点的轮廓。实验验证了分离的颜色通道和基于snake的方法可以可靠地提取边缘轮廓并保留斑点的颜色信息。
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引用次数: 1
An Approach for Recognition of Enhancer-promoter Associations based on Random Forest 基于随机森林的增强子-启动子关联识别方法
Tianjiao Zhang, Yadong Wang
Enhancers are sequences in the genome that regulate gene expression and are usually located far from transcription start sites. Enhancers regulate gene expression by interacting with promoters. Therefore, the recognition of the association between enhancers and promoters is an important issue in the study of enhancer regulation. At present, computational methods to recognize the association between enhancers and promoters are mainly realized by designing machine learning methods based on the biological signals on the genome sequence. These recognition methods ignore evaluating the classification power of features, resulting in limited recognition performance. In this paper, the classification power of the feature signals near enhancers and promoters in the genome sequence was evaluated, and the features with strong classification power were picked up. This was conducive to improving the recognition accuracy. The correlation between enhancers and promoters was recognized by the random forest method. Compared with the five main recognition methods, the accuracy of the recognition method in this paper is higher.
增强子是基因组中调节基因表达的序列,通常位于远离转录起始位点的位置。增强子通过与启动子相互作用调节基因表达。因此,认识增强子和启动子之间的关联是增强子调控研究中的一个重要问题。目前,识别增强子和启动子之间关联的计算方法主要是基于基因组序列上的生物信号设计机器学习方法来实现的。这些识别方法忽略了对特征分类能力的评估,导致识别性能受到限制。本文对基因组序列中增强子和启动子附近的特征信号进行分类能力评估,选取分类能力强的特征。这有利于提高识别精度。增强子和启动子之间的相关性用随机森林方法识别。与五种主要识别方法相比,本文方法的识别准确率更高。
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引用次数: 1
Practical Fall Detection Algorithm based on Adaboost 基于Adaboost的实用跌倒检测算法
Wenqiang Cai, Lishen Qiu, Wanyue Li, Jie Yu, Lirong Wang
In order to improve the accuracy and efficiency of the fall detection, we proposed a fall detection algorithm based on Adaboost with single-layer decision tree under six-axis acceleration (three-axis acceleration, three-axis angular acceleration) time features. We set two thresholds for the resultant linear acceleration. When the value of the resultant linear acceleration is within these two thresholds, the algorithm of fall detection classifier is triggered. The fixed window is used to intercept the time waveform of the six-axis acceleration and extract the time features. We selected seven features with less computational complexity, and finally used these seven features to construct a fall detection model based on Adaboost with single-layer decision tree. Our algorithm can achieve 99.08% accuracy in the data set collected by ourselves, and has high specificity and sensitivity. The most critical point is that the algorithm proposed in this paper has a small computational cost and can be transplanted onto the embedded system, which is a practical and reliability fall detection method.
为了提高跌倒检测的精度和效率,提出了一种基于Adaboost的六轴加速度(三轴加速度、三轴角加速度)时间特征下单层决策树的跌倒检测算法。我们为产生的线性加速度设置了两个阈值。当生成的线性加速度值在这两个阈值内时,触发跌落检测分类器算法。利用固定窗口截取六轴加速度的时间波形,提取时间特征。我们选取了计算复杂度较低的7个特征,最后利用这7个特征构建了基于Adaboost的单层决策树跌倒检测模型。我们的算法在我们自己采集的数据集中准确率达到99.08%,并且具有很高的特异性和灵敏度。最关键的一点是本文提出的算法计算量小,可以移植到嵌入式系统中,是一种实用可靠的跌落检测方法。
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引用次数: 4
Application of Euler Elastica Regularized Logistic Regression on Resting-state fMRI for Identification of Alzheimer's Disease 欧拉弹性正则化Logistic回归在静息态fMRI诊断阿尔茨海默病中的应用
W. Guo, L. Yao, Zhi-ying Long
Many machine-learning methods have been widely applied to predict Alzheimer's disease based on functional magnetic resonance imaging (fMRI) data. In our previous study, we proposed the Euler Elastica Regularized Logistic Regression (EELR) method and demonstrated its advantages over the other classifiers. In this study, we applied EELR to resting-state fMRI (RS-fMRI) data of 24 healthy aged subjects and 22 Alzheimer's disease (AD) patients for the identification of Alzheimer's disease. Moreover, in order to reveal the neural discriminative pattern, permutation test was performed to test the differences of EELR weight between AD and healthy aged subject. The results showed that EELR classifier could successfully classify AD and healthy aged subject. Moreover, EELR revealed that the amplitude of low-frequency fluctuations (ALFF) of posterior cingulate cortex, prefrontal cortex and hippocampus are the important biomarkers for distinguishing AD and healthy aged subject.
许多机器学习方法已被广泛应用于基于功能磁共振成像(fMRI)数据的阿尔茨海默病预测。在我们之前的研究中,我们提出了Euler Elastica正则化逻辑回归(EELR)方法,并证明了它相对于其他分类器的优势。在本研究中,我们将EELR应用于24名健康老年受试者和22名阿尔茨海默病(AD)患者的静息态功能磁共振成像(RS-fMRI)数据,用于阿尔茨海默病的识别。此外,为了揭示神经鉴别模式,我们采用置换检验来检验老年痴呆与健康老年人EELR权重的差异。结果表明,EELR分类器能较好地对AD和健康老年人进行分类。此外,EELR显示,后扣带皮层、前额叶皮层和海马的低频波动幅度(ALFF)是区分AD与健康老年人的重要生物标志物。
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引用次数: 0
Region-based High-resolution Siamese Network for Robust Visual Tracking 基于区域的高分辨率Siamese网络鲁棒视觉跟踪
Chunbao Li, Bo Yang
Visual tracking is an active and challenging research topic in computer vision, as objects often undergo significant appearance variations caused by occlusion, deformation and background clutter. In recent years, many convolutional neural network based trackers have achieved impressive performance by integrating multi-layer features. However, in order to conduct multi-scale feature fusion, most of these trackers recover high-resolution presentations from low-resolution representations produced by a high-to-low resolution network, which tend to result in inaccurate feature maps or lose of details of the target object. In this paper, we propose an end-to-end region-based high-resolution fully convolutional Siamese network for tracking. In the tracker, we propose to extract the spatial information and semantic information of the target object using a high-resolution network that maintains rich high-resolution representations of the target object through the whole process. Furthermore, a set of position-sensitive score maps are obtained for all regions of the target template, and an adaptive weighting method is proposed to fuse score maps of multiple regions. Experimental results on the OTB50 and OTB100 benchmark datasets demonstrate that our tracker performs better than several state-of-the-art trackers while running in real-time.
视觉跟踪是计算机视觉中一个活跃而富有挑战性的研究课题,由于遮挡、变形和背景杂波等原因,物体的外观往往会发生显著变化。近年来,许多基于卷积神经网络的跟踪器通过集成多层特征,取得了令人印象深刻的性能。然而,为了进行多尺度特征融合,这些跟踪器大多是从高到低分辨率网络产生的低分辨率表示中恢复高分辨率表示,这往往导致不准确的特征映射或丢失目标物体的细节。在本文中,我们提出了一个端到端基于区域的高分辨率全卷积Siamese网络用于跟踪。在跟踪器中,我们提出使用高分辨率网络提取目标物体的空间信息和语义信息,该网络在整个过程中保持目标物体丰富的高分辨率表示。在此基础上,对目标模板的所有区域获得了一组位置敏感的评分图,并提出了一种融合多区域评分图的自适应加权方法。在OTB50和OTB100基准数据集上的实验结果表明,我们的跟踪器在实时运行时的性能优于几种最先进的跟踪器。
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引用次数: 0
Three-dimensional Reconstruction of Optical Coherence Tomography Images of Esophagus 食道光学相干断层成像的三维重建
Sihan Nao, Miao Zhang, Lirong Wang, Yongjin Xu, Xiaohe Chen
The combination of optical coherence tomography (OCT) and endoscope can take images of the body tissues for clinical diagnosis. OCT images are difficult to photograph with regular imaging devices, such as the esophagus and gastrointestinal tract. Three-dimensional reconstruction of the two-dimensional sequence images can help the doctor understand the clinical situation of the body tissue, therefore improve the accuracy of diagnosis. In this paper, Ray Casting method is used to reconstruct three-dimensional image of OCT cross-section images of guinea pig esophagus. Preprocessing including image segmentation, coordinate transformation, angle correction is used to achieve a better result in three-dimensional reconstruction. The performance of the algorithm is discussed and can achieve the same effect as what of commercial software.
光学相干断层扫描(OCT)与内窥镜相结合,可以对人体组织进行成像,用于临床诊断。常规成像设备(如食道和胃肠道)很难拍摄OCT图像。二维序列图像的三维重建可以帮助医生了解身体组织的临床情况,从而提高诊断的准确性。本文采用射线投射法重建豚鼠食管OCT横切面图像的三维图像。预处理包括图像分割、坐标变换、角度校正等,以达到较好的三维重建效果。讨论了该算法的性能,可以达到与商业软件相同的效果。
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引用次数: 0
Automatic Sleep Staging based on Curriculum Learning Approach 基于课程学习方法的自动睡眠分级
Xingjun Wang, Ziyao Xu
Automatic sleep staging is helpful to improve diagnosis efficiency of sleep-related diseases. This work introduces the many-to-many formulation for automatic sleep staging, which means using a many-to-many mapping to convert the contextual input to the corresponding contextual output. We use convolutional neural networks (CNNs) to perform the many-to-many mapping, and use multilayer perceptron (MLP) to merge the contextual output into the final prediction for a particular epoch. In order to avoid the influence of unobvious characteristic waves and wrong labels on the training process, this work leverages the technology of curriculum learning. By clustering algorithm based on local density, the training set is divided into several subsets according to the signal quality. We design a learning strategy by successively leveraging these subsets. To the best of our current knowledge, this is the first work using curriculum learning for automatic sleep staging. It is showed by experiments that our scheme yields an accuracy comparable to the state-of-the-art on the public dataset Sleep-EDF.
自动睡眠分期有助于提高睡眠相关疾病的诊断效率。这项工作引入了自动睡眠分期的多对多公式,这意味着使用多对多映射将上下文输入转换为相应的上下文输出。我们使用卷积神经网络(cnn)来执行多对多映射,并使用多层感知器(MLP)将上下文输出合并到特定时代的最终预测中。为了避免不明显的特征波和错误的标签对训练过程的影响,本工作利用了课程学习技术。通过基于局部密度的聚类算法,将训练集根据信号质量划分为多个子集。我们通过依次利用这些子集来设计学习策略。据我们目前所知,这是第一个使用课程学习进行自动睡眠分期的工作。实验表明,我们的方案产生的精度可与公共数据集Sleep-EDF上的最新技术相媲美。
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引用次数: 0
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Proceedings of the 4th International Conference on Biomedical Signal and Image Processing
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