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Risk Factors of Relapse After Successful Electroconvulsive Therapy for Taiwanese Patients With Major Depression 台湾重性抑郁症患者成功电休克治疗后复发的危险因素
Pub Date : 2019-07-24 DOI: 10.1097/YCT.0000000000000619
Wei-Cheng Yang, Ching-Hua Lin, Cheng-Chung Chen
Objectives Major depressive disorder is a recurrent illness. Treatment strategies are generally focused on achieving remission and preventing relapse/recurrence. The aim of this study was to explore the risk factors associated with relapse for remitted patients during the 12-week follow-up. Methods This was an open-label trial for major depressive disorder patients receiving acute treatments with electroconvulsive therapy (ECT) and continuation medication in the 12-week follow-up. Symptom severity and psychosocial functioning were assessed using the 17-item Hamilton Rating Scale for Depression (HAMD-17) and the Work and Social Adjustment Scale at each visit. Remission was defined as a HAMD-17 of 7 or less after acute treatment. Relapse was defined as a HAMD-17 of 14 or greater. Subjects achieving remission after acute treatments were included for analysis. Survival analysis was used to investigate the factors associated with relapse. Results Sixty patients receiving ECT for acute treatment were enrolled for 12-week follow-up. Using Cox regression analysis, a greater number of previous major depressive episodes and greater baseline Work and Social Adjustment Scale scores were significantly associated with shorter time to relapse. Conclusions The goal of acute treatment should focus on functional remission to prevent relapse. Further studies related to more effective treatments to prevent relapse after acute ECT are required in the future.
目的重度抑郁症是一种复发性疾病。治疗策略通常侧重于实现缓解和防止复发/复发。本研究的目的是在12周的随访中探讨与缓解患者复发相关的危险因素。方法本研究是一项开放标签试验,在12周的随访中,接受电休克治疗(ECT)和持续药物治疗的重度抑郁症患者。在每次访问时,使用17项汉密尔顿抑郁评定量表(HAMD-17)和工作与社会适应量表对症状严重程度和心理社会功能进行评估。缓解被定义为急性治疗后HAMD-17为7或更低。复发的定义是HAMD-17评分为14或更高。急性治疗后达到缓解的受试者被纳入分析。生存率分析用于研究复发的相关因素。结果60例接受电痉挛治疗的急性期患者入选,随访12周。使用Cox回归分析,既往重度抑郁发作次数越多,基线工作和社会适应量表得分越高,复发时间越短。结论急性期治疗应以功能缓解为主,防止复发。未来需要进一步研究更有效的治疗方法来预防急性ECT后复发。
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引用次数: 3
Handbook of ECT: A Guide to Electroconvulsive Therapy for Practitioners 电痉挛治疗手册:从业人员电痉挛治疗指南
Pub Date : 2019-06-01 DOI: 10.1097/YCT.0000000000000591
W. McCall
Copyright © aimed at both practitioners and trainees who need a quick, up-to-date source about most aspects of clinical ECT. It is not meant to be an exhaustive text, rather a primer of technique.” In my reading of this book, I found that I agreed with Dr Kellner's assessment and directions on each aspect of the practice of ECT. The clinical directions provided in this book will place the reader squarely in the mainstream of ECT practice. Although the book intentionally avoids digressions into areas that lack consensus, ample references are provided for the reader whowants to delve more deeply into the science. Useful tables and figures are spaced throughout, and a comprehensive index helps readers quickly find specific topics. Blank pages at the end allow the reader to make their own notes as they go.
版权所有©针对需要关于临床ECT大多数方面的快速,最新来源的从业人员和培训生。它不是一个详尽的文本,而是一个技术入门。”在我阅读这本书的过程中,我发现我同意凯尔纳医生对电休克疗法实践的每个方面的评估和指导。在这本书中提供的临床指导将把读者放在电痉挛疗法的主流实践中。虽然这本书有意避免离题到缺乏共识的领域,但为想要更深入地研究科学的读者提供了充足的参考资料。有用的表格和数字是间隔的,一个全面的索引帮助读者快速找到具体的主题。最后的空白页允许读者在阅读过程中做自己的笔记。
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引用次数: 8
The Madness of Fear—A History of Catatonia 恐惧的疯狂——紧张症的历史
Pub Date : 2018-12-01 DOI: 10.1097/YCT.0000000000000532
P. Sienaert
“T oday (...) catatonia is edging its way back to center stage as an independent disorder,” Shorter and Fink state in their new book on the history of this startling syndrome. Thanks, not least, to the authors' relentless effort. Edward Shorter is professor of the history of medicine at the University of Toronto. Max Fink, professor of psychiatry and neurology, emeritus, worked at Stony Brook School of Medicine, New York. The former has written extensively about the history of electroconvulsive therapy (ECT); the latter, Fink, is the history of ECT. One expects to read a history book. But The Madness of Fear is so much more than that. Some phrases are so literary that one cannot resist the temptation to read them aloud repetitively making one's family members frown. Here is one: “Buffeted by psychoanalysis and blinded by the prestige of German learning, clinicians let catatonia languish in the quagmire of schizophrenia” (p117). The authors “join other scholars in the growing disbelief about ‘schizophrenia’” (p120). Throughout the book, they don't pass up a chance to criticize the concept of schizophrenia that, according to Meduna, already in 1946, “doesn't mean anything more than ‘crazy’ or ‘cracked’” (p78). Not only do the authors unfold the history of catatonia, from Kahlbaum's predecessors in the early 19th century (chapter 2, “Catatonia Before Kahlbaum”) up to the so-called “resignation syndrome”marked by stupor among refugee children coming to Sweden, first described not more than 2 years ago. They also offer the reader a clinical lesson. Fink and Shorter want the reader to recognize the clinical picture of catatonia, to detect a severe condition that is fairly easy to cure. In an erawhere it is “bon ton” to hail dimensional diagnoses and demonize categorical labeling, Fink states it is our job as medical doctors to label our patients, provided that the label specifies an identifiable syndrome and brings a successful treatment (Fink, personal communication, May 6, 2018). A myriad of case descriptions with a sense of phenomenological detail that has
肖特和芬克在他们关于这种惊人综合症历史的新书中写道:“今天,紧张症作为一种独立的疾病正在慢慢回到舞台的中心。”尤其要感谢作者们不懈的努力。爱德华·肖特(Edward Shorter)是多伦多大学医学史教授。马克斯·芬克,精神病学和神经学名誉教授,曾在纽约石溪医学院工作。前者撰写了大量关于电休克疗法(ECT)的历史;后者,芬克,是电痉挛疗法的历史。人们期望读一本历史书。但《恐惧的疯狂》远不止于此。有些短语是如此的文学,以至于一个人无法抗拒大声朗读它们的诱惑,反复地让家人皱眉。这里有一个:“受到精神分析的打击,被德国学术的声望蒙蔽了眼睛,临床医生让紧张症在精神分裂症的泥潭中憔悴”(p117)。两位作者“加入了其他越来越不相信‘精神分裂症’的学者行列”(p120)。在整本书中,他们没有放过任何一个批评精神分裂症概念的机会,根据梅杜纳在1946年的说法,“精神分裂症的意思只不过是‘疯狂’或‘崩溃’”(p78)。作者不仅揭示了紧张症的历史,从19世纪初卡尔鲍姆的前辈(第二章,“卡尔鲍姆之前的紧张症”)到所谓的“辞职综合症”,以来到瑞典的难民儿童的麻木为标志,不到两年前首次被描述。他们也给读者上了一堂临床课。芬克和肖特希望读者认识到紧张症的临床症状,发现一种相当容易治愈的严重疾病。芬克说,在一个推崇维度诊断和妖魔化分类标签的地方,给病人贴上标签是医生的工作,前提是这个标签指定了一种可识别的综合征,并带来了成功的治疗(芬克,《个人沟通》,2018年5月6日)。无数的案例描述带有现象学的细节感
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引用次数: 45
International Society for ECT and Neurostimulation Annual Meeting Abstracts 2018 国际电痉挛和神经刺激学会2018年年会摘要
Pub Date : 2018-09-01 DOI: 10.1097/yct.0000000000000520
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引用次数: 0
Intramuscular Ketamine Protocol as an Alternative to Physical Restraints for Electroconvulsive Therapy Administration in a Psychotic Patient 肌注氯胺酮方案作为精神病人电休克治疗中物理约束的替代方案
Pub Date : 2018-07-01 DOI: 10.1097/00124509-900000000-99220
L. Smith-Martinez, L. Chatham, Purushothaman Muthukanagaraj
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引用次数: 0
Successful Treatment With Electroconvulsive Therapy of a Patient With Chiari Malformation Type I 电休克疗法成功治疗1例I型基亚里畸形
Pub Date : 2018-06-01 DOI: 10.1097/00124509-900000000-99227
Dimitry Francois, Tiffany Huang
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引用次数: 0
Safety of Transcranial Magnetic Stimulation in an Obsessive-Compulsive Disorder Patient With Deep Brain Stimulation 经颅磁刺激治疗强迫症患者深部脑刺激的安全性
Pub Date : 2018-06-01 DOI: 10.1097/00124509-900000000-99224
J. Miron, Véronique Desbeaumes Jodoin, M. Fournier-Gosselin, P. Lespérance
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引用次数: 0
Electroconvulsive Therapy Revival in German Speaking Countries 电痉挛疗法在德语国家的复兴
Pub Date : 2018-02-01 DOI: 10.1097/yct.0000000000000488
M. Fink
I t has been 8 decades since seizures were successfully induced by electricity to quickly relieve the excitement of a delirious man, launching the electroshock era. The decades have been stormy with electroshock widely stigmatized, deprecated in the press and in film, practitioners placarded, and the treatments legislatively restricted. An ongoing resurgence of interest is well seen in these 2 reviews of electroshock in central European countries. The multiauthored professional text describes the widespread availabilty in almost all psychiatric facilities in the German-speaking countries. One essay describes the scene in Italy where the government in 1978 legislatively
80年前,人们成功地利用电流诱导癫痫发作,迅速缓解神志不清醒的人的兴奋情绪,从而开启了电击时代。在过去的几十年里,电击在媒体和电影中被广泛地污名化、贬斥,从业者被贴牌,治疗在法律上受到限制。在中欧国家的这两篇关于电击的综述中可以很好地看到人们对电击的兴趣正在重新抬头。多作者的专业文本描述了在德语国家几乎所有精神病院的广泛可用性。一篇文章描述了1978年意大利政府立法的场景
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引用次数: 1
ECT-Related Anxiety: A Systematic Review ect相关焦虑:一项系统综述
Pub Date : 2017-12-01 DOI: 10.1097/YCT.0000000000000383
J. Obbels, E. Verwijk, F. Bouckaert, P. Sienaert
Background A significant proportion of electroconvulsive therapy (ECT)–treated patients experience anxiety anticipating the treatment, often to such an extent that they refuse or discontinue a much-needed treatment. Despite its great impact on treatment adherence, anxiety in patients receiving ECT is underexposed in the scientific literature. Objectives We aimed to review the prevalence and specific subjects of ECT-related anxiety and therapeutic interventions to reduce it. Methods We performed a computerized search (EMBASE, MEDLINE, and PsycINFO) for articles meeting the following inclusion criteria: (1) qualitative (interview) studies, quantitative (questionnaire) studies, or experimental (interventional) studies that (2) report on anxiety that is related to a planned, ongoing, or past ECT treatment. Results Of 1160 search results, 31 articles were included. Electroconvulsive therapy–related anxiety is estimated to be present in 14% to 75% of patients and is most often linked to worries about memory impairment or brain damage. Only a few interventions (chlorpromazine, meprobamate, propofol, a talking-through technique, an information leaflet, and animal-assisted therapy) have been proposed to reduce patients’ ECT-related anxiety. Conclusions Electroconvulsive therapy–related anxiety is a highly prevalent phenomenon, and the literature provides little guidance for its clinical management. Most studies are of a low methodological quality and suffer from significant limitations, thereby hampering generalized conclusions. Given the clinical importance of ECT-related anxiety, further study on its nature and evolution through the course of treatment and on anxiety-reducing interventions is warranted.
背景:很大一部分接受电休克治疗的患者在治疗前会出现焦虑,通常会达到拒绝或停止急需治疗的程度。尽管焦虑对治疗依从性有很大影响,但在科学文献中,接受ECT的患者的焦虑并未得到充分的曝光。我们的目的是回顾ect相关焦虑的患病率和特定受试者,以及减少焦虑的治疗干预措施。方法:我们对符合以下纳入标准的文章进行计算机检索(EMBASE、MEDLINE和PsycINFO):(1)定性(访谈)研究、定量(问卷)研究或实验性(介入性)研究,(2)报告与计划的、正在进行的或过去的ECT治疗相关的焦虑。结果在1160条检索结果中,共纳入31篇文献。据估计,14%至75%的患者存在与电痉挛疗法相关的焦虑,这种焦虑最常与对记忆障碍或脑损伤的担忧有关。只有少数干预措施(氯丙嗪、甲氧丙酸酯、异丙酚、通话技术、信息传单和动物辅助治疗)被建议减少患者与ect相关的焦虑。结论电惊厥治疗相关性焦虑是一种非常普遍的现象,文献对其临床治疗指导甚微。大多数研究的方法学质量都很低,而且有很大的局限性,因此不利于得出普遍的结论。鉴于ect相关焦虑的临床重要性,有必要进一步研究其性质和治疗过程中的演变以及减少焦虑的干预措施。
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引用次数: 32
Time Trends and Variations in Electroconvulsive Treatment in Denmark 2008 to 2014: A Nationwide Register-Based Study 2008年至2014年丹麦电休克治疗的时间趋势和变化:一项基于全国登记的研究
Pub Date : 2017-12-01 DOI: 10.1097/YCT.0000000000000381
Eva Hundrup, M. Osler, M. Jørgensen
Objective The aim of this study was to determine status and variations in the practice of electroconvulsive treatment (ECT) in Denmark in patient characteristics, indications, treatment patterns, and hospital region. Method All 140,627 ECTs registered in the Danish National Patient Registry between 2008 and 2014 were retrieved together with information on patient characteristics. Annual treated person rates were calculated for sex, age, admission diagnosis, and region. Results The overall ECT treatment rate was 36 (95% confidence interval, 34–38) per 100,000 resident population during the study period. The rate was highest in women and increased with age. There were modest, however, stable regional differences in rates (extremal quotient = 1.4). Electroconvulsive treatment was most commonly used in patients with depression with (19.4%) or without (54.9%) psychotic symptoms. The median number of ECTs administered per patient was 10 and highest in patients with schizophrenia, schizoaffective, or bipolar disorders. A total of 51%, 14%, and 33% of ECTs were administered with bilateral, unilateral, and unspecified electrode placement, respectively. There were regional differences in electrode placement specification and use. Conclusions Although some variation was seen across hospital regions and electrode placement, ECT in Denmark was provided with relative stability over time and indications compared with most other countries in Europe and North America.
目的:本研究的目的是确定丹麦电休克治疗(ECT)在患者特征、适应症、治疗模式和医院地区的现状和变化。方法检索2008 - 2014年在丹麦国家患者登记处登记的140,627例ECTs以及患者特征信息。按性别、年龄、入院诊断和地区计算年治疗率。结果研究期间,每10万常住人口中有36例(95%可信区间34-38)接受了ECT治疗。这一比例在女性中最高,并且随着年龄的增长而增加。然而,在发病率方面存在适度的稳定的区域差异(极值商= 1.4)。电休克治疗最常用于有(19.4%)或无(54.9%)精神病症状的抑郁症患者。每位患者接受ECTs的中位数为10个,其中精神分裂症、分裂情感性或双相情感障碍患者的ECTs最多。总共51%、14%和33%的ECTs分别采用双侧、单侧和未指定电极放置。在电极放置规范和使用方面存在区域差异。结论:尽管在不同的医院地区和不同的电极位置存在一些差异,但与欧洲和北美的大多数其他国家相比,丹麦的ECT在时间和适应症上相对稳定。
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引用次数: 20
期刊
The Journal of ECT
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