Pub Date : 2023-03-09DOI: 10.1183/23120541.lsc-2023.39
E. Mozaffari, A. Kalil, A. Chandak, H. Jiang, R. Gottlieb, E. Lee, C. Der-Torossian, S. Hollemeersch, M. Thrun, C. Chima-Melton
{"title":"COVID-19 pneumonia hospitalizations in different phases of the pandemic in the United States: patient characteristics and clinical outcomes","authors":"E. Mozaffari, A. Kalil, A. Chandak, H. Jiang, R. Gottlieb, E. Lee, C. Der-Torossian, S. Hollemeersch, M. Thrun, C. Chima-Melton","doi":"10.1183/23120541.lsc-2023.39","DOIUrl":"https://doi.org/10.1183/23120541.lsc-2023.39","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126730447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.2093
M. Detsika, E. Diamanti, K. Ampelakiotou, E. Jahaj, S. Tsipilis, N. Athanasiou, A. Zacharis, I. Dimopoulou, S. Orfanos, A. Tsirogianni, A. Kotanidou
{"title":"C3a and C5b-9 levels differentially predict COVID-19 severity and mortality.","authors":"M. Detsika, E. Diamanti, K. Ampelakiotou, E. Jahaj, S. Tsipilis, N. Athanasiou, A. Zacharis, I. Dimopoulou, S. Orfanos, A. Tsirogianni, A. Kotanidou","doi":"10.1183/13993003.congress-2022.2093","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.2093","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117192231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.1023
E. Rohrs, T. Bassi, K. Fernandez, J. Wittmann, M. Nicholas, M. Ornowska, M. Gani, S. Reynolds
{"title":"Improved atelectasis and lung homogeneity with diaphragm neurostimulation during mechanical ventilation in pigs with ARDS","authors":"E. Rohrs, T. Bassi, K. Fernandez, J. Wittmann, M. Nicholas, M. Ornowska, M. Gani, S. Reynolds","doi":"10.1183/13993003.congress-2022.1023","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1023","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123290067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.1628
J. Giamello, G. Martini, D. Prato, M. Santoro, Y. Arese, L. Bertolaccini, R. Melchio, C. Battle, T. Driscoll, A. Bono, A. Poggi, A. Bruno, A. Falcetta, A. Sciolla, C. Fulcheri, D. Caruso, G. Lauria
{"title":"STUMBL score for emergency department safe discharge of patients with minor blunt thoracic trauma","authors":"J. Giamello, G. Martini, D. Prato, M. Santoro, Y. Arese, L. Bertolaccini, R. Melchio, C. Battle, T. Driscoll, A. Bono, A. Poggi, A. Bruno, A. Falcetta, A. Sciolla, C. Fulcheri, D. Caruso, G. Lauria","doi":"10.1183/13993003.congress-2022.1628","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1628","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122458516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.520
D. Marsolais, N. Châteauvert, P. Blais-Lecours, P. Rola, T. Nguyen, F. Lellouche
Background: Sphingosine-1-phosphate (S1P) receptor ligands reduce lung damage and endothelial activation in models of virus-induced pneumonia. Feasibility of initiating S1P receptor ligand therapy during pneumonia needs confirmation. Objective(s): Evaluate safety/efficacy outcomes of ozanimod therapy in COVID-19 patients. Method(s): In a prospective multicentric open-label pilot trial, adults with COVID-19 requiring O were recruited (3 Canadian centres, starting Sept. 2020). Patients were randomized to standard of care (SOC) or SOC + ozanimod (per os). Modified WHO-adapted 6-points ordinal scale for clinical improvement was computed daily and adverse events were recorded. Result(s): As of Jan. 2022, 41 patients (out of 48) were enrolled and 18 received ozanimod. Stratification at randomization balanced groups for risk factors of poor outcome and initial O2 requirement. No serious drug reaction was reported. Asymptomatic bradycardia occurred with ozanimod. So far, 36 patients completed the study-ending phone call (day 90). Ordinal scale-related outcomes are shown in Table 1. Since enrollment is ongoing, data is shown for the whole cohort. Conclusion(s): This small scale trial provides the very first evidence supporting the possibility of initiating S1P receptor ligand therapy during active COVID-19 pneumonia.
{"title":"A pilot trial for ozanimod therapy in hospitalized COVID-19 patients","authors":"D. Marsolais, N. Châteauvert, P. Blais-Lecours, P. Rola, T. Nguyen, F. Lellouche","doi":"10.1183/13993003.congress-2022.520","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.520","url":null,"abstract":"Background: Sphingosine-1-phosphate (S1P) receptor ligands reduce lung damage and endothelial activation in models of virus-induced pneumonia. Feasibility of initiating S1P receptor ligand therapy during pneumonia needs confirmation. Objective(s): Evaluate safety/efficacy outcomes of ozanimod therapy in COVID-19 patients. Method(s): In a prospective multicentric open-label pilot trial, adults with COVID-19 requiring O were recruited (3 Canadian centres, starting Sept. 2020). Patients were randomized to standard of care (SOC) or SOC + ozanimod (per os). Modified WHO-adapted 6-points ordinal scale for clinical improvement was computed daily and adverse events were recorded. Result(s): As of Jan. 2022, 41 patients (out of 48) were enrolled and 18 received ozanimod. Stratification at randomization balanced groups for risk factors of poor outcome and initial O2 requirement. No serious drug reaction was reported. Asymptomatic bradycardia occurred with ozanimod. So far, 36 patients completed the study-ending phone call (day 90). Ordinal scale-related outcomes are shown in Table 1. Since enrollment is ongoing, data is shown for the whole cohort. Conclusion(s): This small scale trial provides the very first evidence supporting the possibility of initiating S1P receptor ligand therapy during active COVID-19 pneumonia.","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117000473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.3107
W. Alhazzani, K. Parhar, J. Weatherald, Z. Al Duhailib, M. Alshahrani, A. Al-Fares, S. Buabbas, S. Cherian, L. Munshi, E. Fan, F. Al-Hameed, J. Chalabi, A. Rahmatullah, E. Duan, J. Tsang, K. Lewis, F. Lauzier, J. Centofanti, B. Rochwerg, S. Culgin, K. Nelson, S. Abdukahil, K. Fiest, H. Stelfox, H. Tlayjeh, M. Meade, D. Perri, K. Solverson, D. Niven, R. Lim, M. Møller, E. Belley-Côté, L. Thabane, H. Tamim, D. Cook, Y. Arabi
{"title":"Awake Prone Positioning in Acute Hypoxemic Respiratory Failure from COVID-19: A Randomized Clinical Trial","authors":"W. Alhazzani, K. Parhar, J. Weatherald, Z. Al Duhailib, M. Alshahrani, A. Al-Fares, S. Buabbas, S. Cherian, L. Munshi, E. Fan, F. Al-Hameed, J. Chalabi, A. Rahmatullah, E. Duan, J. Tsang, K. Lewis, F. Lauzier, J. Centofanti, B. Rochwerg, S. Culgin, K. Nelson, S. Abdukahil, K. Fiest, H. Stelfox, H. Tlayjeh, M. Meade, D. Perri, K. Solverson, D. Niven, R. Lim, M. Møller, E. Belley-Côté, L. Thabane, H. Tamim, D. Cook, Y. Arabi","doi":"10.1183/13993003.congress-2022.3107","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.3107","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"194 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117084463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.4254
H. Ahmad, S. Soman, R. Varghese, K. Dewan, R. Chapman, J. Tong, R. Kumari, U. Ekeowa, R. Ragatha, P. Russell, S. Kuckreja, M. Long, M. Anwar
{"title":"To assess the diagnostic and prognostic ability of CXRs in COVID-19 pneumonitis","authors":"H. Ahmad, S. Soman, R. Varghese, K. Dewan, R. Chapman, J. Tong, R. Kumari, U. Ekeowa, R. Ragatha, P. Russell, S. Kuckreja, M. Long, M. Anwar","doi":"10.1183/13993003.congress-2022.4254","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.4254","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124550058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.4043
J. Marín Corral, F. Parrilla, M. Restrepo, S. Pascual-Guardia, A. Rodríguez, J. C. Ballesteros, S. Sancho, L. Socias, E. Diaz, A. Albaya-Moreno, J. Masclans
Objectives: To evaluate the impact of combined non-invasive support strategies in critically ill COVID-19 patients [high-flow nasal cannula (HFNC), non-invasive ventilation (NIV) or both]. Method(s): Prospective observational multicenter study in 73 Spanish ICU with data obtained from the SEMICYUC registry. All confirmed COVID-19 patients admitted due to respiratory failure were included. They were classified according to the ventilatory strategy used on admission and subsequently according to success, failure, or strategy change. Demographic data, comorbidities, severity at admission, respiratory, biomarkers, failure, length of stay and mortality were evaluated. Result(s): We analyzed 3,889 patients, 33% receiving HFNC, and 11% NIV at ICU admission. NIV group compared to HFNC were more severely ill with more shock on admission. When NIV was received as a first-choice higher failure rates and mortality were shown vs HFNC (68% vs 61%, p=0.016 and 27% vs 20%, p=0.003). Among patients who initially received HFNC, 57% failed and 7.4% switched to NIV, with no change in mortality. Among patients who were switched to NIV, 66% failed presenting a higher mortality trend than the intubated patients after the HFNC starting (40% vs 30%, p=0.098). Among patients who initially received NIV, 60% failed and 20% switched to HFNC. Patients in whom NIV was switched to HFNC, had lower mortality than patients who initially failed (18% vs 40%, p<0.001). Among patients who were switched to HFNC, 43% failed, presenting the same mortality as the intubated patients after the NIV starting (38% vs 38%, p=0.934). Conclusion(s): Patients receiving NIV at admission have worse outcomes than those receiving HFNC. Changing the strategy in patients who received HFNC as a first choice without success can worsen the prognosis.
目的:评价联合无创支持策略[高流量鼻插管(HFNC)、无创通气(NIV)或两者结合]对危重症COVID-19患者的影响。方法:前瞻性观察性多中心研究，73个西班牙ICU的数据来自SEMICYUC注册表。纳入所有因呼吸衰竭而入院的新冠肺炎确诊患者。根据入院时使用的通气策略以及随后的成功、失败或策略改变进行分类。评估了人口统计数据、合并症、入院时严重程度、呼吸系统、生物标志物、衰竭、住院时间和死亡率。结果:我们分析了3,889例患者，33%在ICU入院时接受HFNC, 11%接受NIV。与HFNC组相比，NIV组病情更严重，入院时休克更多。当NIV作为首选时，失败率和死亡率高于HFNC(68%对61%，p=0.016, 27%对20%，p=0.003)。在最初接受HFNC的患者中，57%的患者失败，7.4%的患者改用NIV，死亡率没有变化。在切换为NIV的患者中，66%的患者在HFNC开始后失败，死亡率趋势高于插管患者(40% vs 30%， p=0.098)。在最初接受NIV的患者中，60%失败，20%改用HFNC。将NIV转换为HFNC的患者死亡率低于最初失败的患者(18% vs 40%， p<0.001)。在切换到HFNC的患者中，43%的患者失败，与插管患者在NIV开始后的死亡率相同(38% vs 38%， p=0.934)。结论:入院时接受NIV治疗的患者预后差于接受HFNC治疗的患者。对于接受HFNC作为第一选择而没有成功的患者，改变策略可能会使预后恶化。
{"title":"Impact of combined non-invasive support strategies use during acute respiratory failure due to COVID-19.","authors":"J. Marín Corral, F. Parrilla, M. Restrepo, S. Pascual-Guardia, A. Rodríguez, J. C. Ballesteros, S. Sancho, L. Socias, E. Diaz, A. Albaya-Moreno, J. Masclans","doi":"10.1183/13993003.congress-2022.4043","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.4043","url":null,"abstract":"Objectives: To evaluate the impact of combined non-invasive support strategies in critically ill COVID-19 patients [high-flow nasal cannula (HFNC), non-invasive ventilation (NIV) or both]. Method(s): Prospective observational multicenter study in 73 Spanish ICU with data obtained from the SEMICYUC registry. All confirmed COVID-19 patients admitted due to respiratory failure were included. They were classified according to the ventilatory strategy used on admission and subsequently according to success, failure, or strategy change. Demographic data, comorbidities, severity at admission, respiratory, biomarkers, failure, length of stay and mortality were evaluated. Result(s): We analyzed 3,889 patients, 33% receiving HFNC, and 11% NIV at ICU admission. NIV group compared to HFNC were more severely ill with more shock on admission. When NIV was received as a first-choice higher failure rates and mortality were shown vs HFNC (68% vs 61%, p=0.016 and 27% vs 20%, p=0.003). Among patients who initially received HFNC, 57% failed and 7.4% switched to NIV, with no change in mortality. Among patients who were switched to NIV, 66% failed presenting a higher mortality trend than the intubated patients after the HFNC starting (40% vs 30%, p=0.098). Among patients who initially received NIV, 60% failed and 20% switched to HFNC. Patients in whom NIV was switched to HFNC, had lower mortality than patients who initially failed (18% vs 40%, p<0.001). Among patients who were switched to HFNC, 43% failed, presenting the same mortality as the intubated patients after the NIV starting (38% vs 38%, p=0.934). Conclusion(s): Patients receiving NIV at admission have worse outcomes than those receiving HFNC. Changing the strategy in patients who received HFNC as a first choice without success can worsen the prognosis.","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128062644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.1240
C. Yujen, C. Shuhua, H. Yaochuan
{"title":"Ventilator alarms that received no intervention:an analysis of ventilator alarm relationship in intensive care unit","authors":"C. Yujen, C. Shuhua, H. Yaochuan","doi":"10.1183/13993003.congress-2022.1240","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1240","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126012299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-04DOI: 10.1183/13993003.congress-2022.1634
G. Martini, J. Giamello, P. Crida, Y. Arese, L. Bertolaccini, S. Abram, E. Basile, E. Bernardi, F. Morra, F. Corsini, F. Tosello, G. Sobrero, G. Greco, L. Barutta, M. Bironzo, G. Lauria
{"title":"Higher Crystalloids Volumes Predict Adverse Outcomes in Emergency Department Patients with Blunt Thoracic Trauma","authors":"G. Martini, J. Giamello, P. Crida, Y. Arese, L. Bertolaccini, S. Abram, E. Basile, E. Bernardi, F. Morra, F. Corsini, F. Tosello, G. Sobrero, G. Greco, L. Barutta, M. Bironzo, G. Lauria","doi":"10.1183/13993003.congress-2022.1634","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1634","url":null,"abstract":"","PeriodicalId":289883,"journal":{"name":"02.01 - Acute critical care","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130140707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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