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Volume 8: Fluids Engineering; Heat Transfer and Thermal Engineering最新文献

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Designing a Particle Flow Control Apparatus 粒子流控制装置的设计
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-94820
Sheharyar Malik, K. Anderson, N. Goel, T. Otanicar, S. Karimi
Flow control within a particle-based Concentrated Solar Power (CSP) system is essential in determining the heat transfer coefficient, and therefore, the power generation capability of these systems. There are three areas where particle flow control is significant: the receivers, storage tanks, and particle-sCO2 heat exchangers. The focus of this paper is on designing a new mechanism to control the flow in the particle-sCO2 heat exchangers due to the simplicity and potential cost savings when compared to the other areas of interest. The goal is for this new design to have quicker response times in terms of particle flowrate than a slide gate or flow control valve, which are designs currently used. The design resembles that of a chuck mechanism within a drill where a rotation of the sleeve elicits movement of the jaws both vertically and horizontally to close the outlet area of the nozzle. Additionally, this design will utilize the current actuator that is already used within these heat exchangers to reduce the complexity of implementation. The jaws are designed to be closed at an angle of 76° which is just slightly steeper than the hopper leading to the mechanism. Furthermore, this design can be tuned to limit particle bridging and other particle flow phenomena that result in blockages. The prototypes were 3D printed out of polylactic acid (PLA) and scaled up to 100%, 200%, and 400% to be able to observe the velocity profiles of the mechanism more clearly. Experiments are performed with this prototype to compare the inlet and outlet mass flow rates at different configurations of the jaws. The particles used in these experiments are 0.3mm HSP 40/70 that are commonly used in particle-based CSP systems.
基于颗粒的聚光太阳能(CSP)系统的流动控制是决定传热系数的关键,因此也决定了这些系统的发电能力。有三个区域的颗粒流控制是重要的:接收器,储罐和颗粒- sco2热交换器。本文的重点是设计一种新的机制来控制颗粒- sco2热交换器中的流动,因为与其他感兴趣的领域相比,这种机制简单且潜在的成本节约。目标是使这种新设计在颗粒流速方面的响应时间比目前使用的滑动闸板或流量控制阀更快。该设计类似于钻头内的卡盘机构,套筒的旋转引起钳口的垂直和水平运动,以关闭喷嘴的出口区域。此外,这种设计将利用目前已经在这些热交换器中使用的执行器,以减少实现的复杂性。颚被设计成以76°的角度关闭,这比导致机构的料斗略陡。此外,这种设计可以调整到限制粒子桥接和其他导致阻塞的粒子流现象。这些原型是用聚乳酸(PLA) 3D打印出来的,并按比例放大到100%、200%和400%,以便能够更清楚地观察该机制的速度分布。用该原型机进行了实验,比较了不同结构下的入口和出口质量流量。这些实验中使用的颗粒是0.3mm HSP 40/70,通常用于颗粒基CSP系统。
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引用次数: 0
Performance Enhancement of Two Stages EHD Gas Pump in a Rectangular Channel With Uneven Voltages 电压不均匀矩形通道中两级EHD气泵性能的提高
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-96022
A. K. M. Monayem H. Mazumder
In this study, performance enhancement of a two stage electrohydrodynamic (EHD) gas pump in a rectangular channel has been evaluated by experimental measurement and numerical simulations. This study is implemented by a two stage EHD gas pump with uneven voltages for 8 emitting electrodes configuration to seek the relation between the number of stages and applied voltages. The EHD pump is evaluated for a combination of three different operating voltages (20 kV, 24 kV, and 28 kV) for further enhancement in its performance. To achieve the maximum enhancement, the emitting electrodes of the EHD gas pump are flush mounted on the channel walls so that the corona wind produced directly disturbs the boundary layer thickness and improves gas pumping. Velocities are measured at three cross-sections along the tube length and then integrated to obtain the volume flow rate. The numerical results enable vivid flow visualizations inside the channel, providing a great understanding of the development of the flow. The two stages EHD gas pump, which can be produced and sustained air flows with a maximum volume flow rate is considered more efficient when it is operated with uneven applied voltages. The results show that EHD technique has a great potential for many engineering applications.
本文通过实验测量和数值模拟,对矩形通道中两级电液动力(EHD)气泵的性能增强进行了评价。以电压不均匀的两级EHD气泵为研究对象,采用8个发射电极配置,寻求级数与施加电压之间的关系。EHD泵在三种不同的工作电压(20kv、24kv和28kv)下进行组合评估,以进一步提高其性能。为了达到最大的增强效果,将EHD气泵的发射电极平齐安装在通道壁上,从而产生的电晕风直接扰动边界层厚度,改善了气体的抽运。沿着管道长度在三个横截面测量速度,然后积分得到体积流速。数值结果使通道内的流动可视化更加生动,对流动的发展有了更好的了解。两级EHD气泵可以产生并维持最大体积流量的气流,当施加电压不均匀时,被认为效率更高。结果表明,EHD技术具有广泛的工程应用潜力。
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引用次数: 0
Designing a Physical Model for the Emsworth Lock and Dam Filling and Emptying System 埃姆斯沃斯水闸灌泄系统的物理模型设计
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-95481
Nathan Doshi, Jacob Hancox, Polakrit Karkhai, Cameryn Smith, Adam Tawakkol, S. White, E. Bristow, A. Hill, Brad C. McCoy, Margaret Nowicki
Currently, the system of locks and dams within the United States operate where each system has a different component and needs different parts to complete the routine maintenance checks and procedures. Having unique components and parts for each lock and dam system drastically increases the costs required for the United States Army Corps of Engineers (USACE) to operate and maintain these locks and dams. One way to reduce these costs is to work towards and recommend standardized components for a lock and dam system. This process, especially for construction projects, is vital because it allows for simplification in the build and production stages of a project as well as life cycle maintenance. Understanding hydraulic design for the inflow and outflow of a lock system was an important consideration for this design project. Reducing hawser forces while maximizing the efficiency of the filling and emptying process is the overall goal for the design. To minimize hawser forces, mitigating the effects of hydrodynamic and hydrostatic forces is essential. This research also strives to gain additional understanding of the dynamic, turbulent nature of water in a lock and dam system. In the Emsworth Lock and Dam system, the top of rock for the riverbed is significantly higher than normal presenting unique challenges for modeling and simulation, as well as physical model construction. Critical to the design of a physical model is the determination of an adequate scaling factor that will not significantly affect the natural hydraulic processes within the system. As such, it is essential that appropriate theories are applied to remain consistent with proven methods of hydraulic scaling. Before selecting a scaling ratio, determining space limitations and a conceptual design of the model was necessary. This assisted in visualizing the model in the available spaces to ensure the design and manufacturing plan was realistic. The model contains three components: a main lock chamber, a higher elevation water reservoir, and a lower elevation water reservoir. The component that is most controlling to the design is the main lock chamber; this component cannot be altered in any way to meet the requirements of the floor space because any modifications would affect the results of the hawser force testing, and the model would not appropriately match reality. The physical model will be verified using the Froude equation — an equation that drives performance of models that are dependent on gravity. As such, when conducting any inflow or outflow of the water in the system, it is essential that the velocity is controlled such that the Froude value is consistent with that of the actual Emsworth Lock and Dam. The model must match a Froude number of 0.052 to effectively represent reality.
目前,美国的水闸和水坝系统运行时,每个系统都有不同的组成部分,需要不同的部件来完成日常维护检查和程序。每个水闸和水坝系统都有独特的组件和部件,这大大增加了美国陆军工程兵团(USACE)运营和维护这些水闸和水坝所需的成本。降低这些成本的一种方法是为水闸和大坝系统开发并推荐标准化的组件。这个过程,特别是对于建筑项目,是至关重要的,因为它允许简化项目的构建和生产阶段以及生命周期维护。了解水闸系统进流和出流的水力设计是本设计项目的重要考虑因素。减少锚索力,同时最大限度地提高填充和排空过程的效率是设计的总体目标。为了使锚索力最小化,必须减轻水动力和水静力的影响。这项研究还努力获得更多的了解动态,湍流性质的水在一个船闸和大坝系统。在埃姆斯沃斯水闸和大坝系统中,河床的岩石顶部明显高于正常水平,这对建模和仿真以及物理模型构建提出了独特的挑战。设计物理模型的关键是确定适当的比例因子,该比例因子不会显著影响系统内的自然水力过程。因此,应用适当的理论来保持与已证实的水力结垢方法的一致性是至关重要的。在选择比例之前,确定空间限制和模型的概念设计是必要的。这有助于在可用空间中可视化模型,以确保设计和制造计划是现实的。该模型由三部分组成:主船闸室、高标高水库和低标高水库。对设计控制最大的部件是主锁室;不能以任何方式改变该组件以满足占地面积的要求,因为任何修改都会影响锚索力测试的结果,并且模型将无法适当地匹配实际情况。物理模型将使用弗劳德方程进行验证,该方程驱动依赖重力的模型的性能。因此,在系统中进行任何水的流入或流出时,至关重要的是控制速度,使弗劳德值与实际的埃姆斯沃思水闸和大坝的值一致。模型必须匹配0.052的弗劳德数才能有效地代表现实。
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引用次数: 0
Analysis and Management of Thermal Energy Release During Quench in a Superconducting Magnet 超导磁体淬火过程中热能释放的分析与管理
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-95762
N. Hasan, V. Ganni, P. Knudsen
In low temperature superconducting (LTS) magnets built using (cryogenic) liquid cooled superconductors, such as those designed for particle accelerators and thermonuclear fusion reactors, the operating stability and quench (sudden transition from superconducting to normal state) is a complex phenomenon. In most cases, the quenched magnet is isolated from the rest of the cryogenic system and the cryogenic fluid (helium) is expelled from the cryostat via a pressure relief valve (PRV) to prevent over-pressurization. This loss of cryogenic coolant (release to atmosphere), as well as the associated stored refrigeration results in increased operational cost (to replenish the helium), and recovery time for the LTS magnet to be operational following a quench. A novel concept for energy and cryogenic inventory management during a LTS magnet quench using direct contact (fluid mixing) heat exchange in a cryogenic buffer volume has been proposed and demonstrated. Development of a semi-analytical, one-dimensional, transient model to predict the boil-off flow generated during a quench, and the subsequent energy absorption (and pressurization) in the cryogenic buffer volume is discussed. The developed model can be used as a simplified tool for process and mechanical design of such a system.
在低温超导磁体(LTS)中,使用(低温)液冷超导体制造的磁体,如用于粒子加速器和热核聚变反应堆的磁体,其运行稳定性和猝灭(从超导到正常状态的突然转变)是一个复杂的现象。在大多数情况下,淬火磁体与低温系统的其余部分隔离,低温流体(氦)通过减压阀(PRV)从低温恒温器中排出,以防止过压。低温冷却剂的损失(释放到大气中),以及相关的储存致冷剂导致运行成本(补充氦气)的增加,以及LTS磁铁在淬火后恢复运行的时间。提出并论证了一种在低温缓冲体中使用直接接触(流体混合)热交换的LTS磁体淬火过程中能量和低温库存管理的新概念。本文讨论了一种半解析的一维瞬态模型的发展,以预测在淬火过程中产生的沸腾流,以及随后在低温缓冲体中的能量吸收(和加压)。所建立的模型可作为该系统工艺设计和机械设计的简化工具。
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引用次数: 0
A Reduced Three-Phase Model for Solidification of Liquid in Large Tanks 大型储罐中液体凝固的简化三相模型
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-95217
Shashank Terala, S. Mazumder, G. Matharu, Dhaval Vaishnav, Syed Ali
A liquid water-urea mixture is stored onboard diesel vehicles and used for exhaust aftertreatment. In cold weather conditions, the mixture may freeze and the freezing process may span over a day. In the first part of our study (Journal of Thermal Science and Engineering Applications — Transactions of the ASME, Vol. 13, p. 011008, 2021) it was shown that traditional computational methods are impractical for modeling such large-duration freezing processes because of restrictions in the time-step size posed by numerical stability and physical time-scale considerations. A model, in which natural convection driven thermal transport is treated as a diffusive process, was developed and demonstrated. Since the flow field was not computed in this model, the computations were found to be orders of magnitude more efficient than traditional methods. This preliminary model did not account for the expansion of ice. Here, a new model that accounts for the expansion of ice and the consequent rise of the initial air-water/ice interface (ice dome formation) is presented. An additional conservation equation for excess volume fraction is introduced to this end and is solved using the unstructured finite-volume procedure and sub-time-stepping. Since the flow field is not computed, the air-water/ice interface is tracked using a new algorithm similar to the traditional volume-of-fluid method, but one that constructs fluxes using a diffusive formulation rather than an advective one. Validation studies in full-scale three-dimensional tanks show good agreement with measured temperature-time data. It is found that the air-water/ice interface first evolves to a concave shape before finally becoming a convex ice dome after full solidification.
液态水-尿素混合物储存在柴油车辆上,用于尾气后处理。在寒冷的天气条件下,混合物可能会冻结,冻结过程可能会持续一天。在我们研究的第一部分(热科学与工程应用杂志-美国机械工程师学会学报,第13卷,第011008页,2021)中,由于数值稳定性和物理时间尺度考虑对时间步长造成的限制,传统的计算方法对于模拟这种长时间冻结过程是不切实际的。建立并论证了将自然对流驱动的热输运视为扩散过程的模型。由于该模型没有计算流场,因此计算效率比传统方法提高了几个数量级。这个初步模型没有考虑到冰的膨胀。在这里,提出了一个新的模型来解释冰的膨胀和随之而来的初始空气-水/冰界面(冰穹形成)的上升。为此引入了多余体积分数的附加守恒方程,并采用非结构化有限体积法和子时间步进法求解。由于没有计算流场,因此使用一种类似于传统的流体体积法的新算法来跟踪空气-水/冰界面,但该算法使用扩散公式而不是平流公式来构建通量。在全尺寸三维储罐中进行的验证研究与测量的温度-时间数据吻合良好。研究发现,空气-水/冰界面在完全凝固后首先演变为凹形,最后演变为凸形冰穹。
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引用次数: 0
Separating Oil-Water Mixtures Using Bump Arrays 使用碰撞阵列分离油水混合物
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-95920
J. Bamberger, L. Pease, C. Burns, M. Minette
Particle separation is an important process step across many fields. One technique being applied for separating solids such as blood components or sand particles from carrier fluids is the use of arrays of aligned posts called deterministic lateral arrays to bump particles to one side in the flow stream to induce separation. This technique may be useful for separation of deformable particles including oil droplets. The ability to efficiently separate two-phase industrial (oil/water) mixtures is key for future use of valuable resources. The ability to reclaim petroleum production water may be critical for the Central High Plains (Colorado, Kansas, New Mexico, Oklahoma, and Texas). Current drawdown trends in the High Plains alone suggest loss of up to 40% of the aquifer area by 2100 that will cause the switch from irrigated to dryland farming. Proving this technology is key to reuse of petroleum production water for crop irrigation or to replace water from currently failing aquifers in rich agricultural lands of the Central High Plains. We conducted experiments applying mesofluidic separation for flowing two-phase (oil/water) mixtures. Experiments were conducted using oil with water as the carrier fluid; separation was achieved over a range of oil-water concentrations. We describe the results of these experiments in this paper.
颗粒分离是许多领域的重要工艺步骤。一种用于从载体流体中分离诸如血液成分或砂粒等固体的技术是使用一组被称为确定性横向阵列的排列桩,将流中的颗粒撞击到一侧以诱导分离。该技术可用于分离包括油滴在内的可变形颗粒。有效分离两相工业(油/水)混合物的能力是未来利用宝贵资源的关键。对于中部平原(科罗拉多、堪萨斯、新墨西哥、俄克拉何马州和德克萨斯州)来说,回收石油生产水的能力可能至关重要。目前仅高平原地区的蓄水减少趋势就表明,到2100年,含水层面积将减少40%,这将导致从灌溉农业向旱地农业的转变。证明这项技术是将石油生产用水重新用于作物灌溉或替代中部高原肥沃农田中目前日益枯竭的含水层用水的关键。我们对流动的两相(油/水)混合物进行了介流分离实验。以油加水为载液进行了实验;在一定的油水浓度范围内实现了分离。我们在本文中描述了这些实验的结果。
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引用次数: 0
Experimental Investigation of Taper Angle and Airflow Rate on Air-Injected Bubble Squeezing in a Tapered Microgap 锥形微隙中注入气泡挤压的锥度角和气流速率实验研究
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-97020
Maharshi Y. Shukla, S. Kandlikar
Squeezing bubbles in a tapered microgap has proved to be effective for improving flow stability in flow boiling. A previous study from our research group has successfully demonstrated using tapered microgap for transforming pool boiling into a self-sustained flow boiling-like system for cooling CPU through thermosiphon. To overcome the imaging challenges with nucleating vapor bubbles, the present work investigates the squeezing behaviour of air-injected bubbles between a tapered microgap with taper angles of 5°, 10°, and 15°. The air bubbles are injected at a rate of 3 ml/min, 15ml/min, and 30 ml/min in a pool of water. The bubble squeezing is recorded at 2000fps using a Photron high-speed camera. The experimental analysis compares the displacement and velocity of the advancing and receding bubble interfaces. The analysis found that in certain test cases, multiple bubbles coalesced while exiting the tapered microgap. In all the test cases, the receding interface of the bubble slingshots after detaching pushes the bubble out of the tapered microgap. The result from the current study provides an insight into the bubble flow and squeezing behavior that can be used for optimizing taper microgap geometries to enhance critical heat flux and heat transfer coefficient of two-phase, and air-injected single-phase heat transfer systems.
在锥形微隙中挤压气泡已被证明是改善流动沸腾过程中流动稳定性的有效方法。我们研究小组之前的一项研究已经成功地证明了使用锥形微间隙将池沸腾转化为通过热虹吸冷却CPU的自持续流沸腾系统。为了克服成核蒸汽气泡的成像挑战,本工作研究了在锥形角为5°、10°和15°的锥形微间隙中注入空气的气泡的挤压行为。将气泡以3ml /min、15ml/min、30ml /min的速率注入池中。用光子高速相机以2000帧/秒的速度记录气泡挤压过程。实验分析比较了气泡前进界面和后退界面的位移和速度。分析发现,在某些测试案例中,多个气泡在退出锥形微间隙时合并。在所有的测试案例中,气泡弹弓分离后的后退界面将气泡推出锥形微间隙。本研究的结果提供了对气泡流动和挤压行为的深入了解,可用于优化锥形微间隙几何形状,以提高两相和空气注入单相传热系统的临界热流密度和传热系数。
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引用次数: 0
Investigation of Passive Radiative Cooling Using Biopolymers 生物聚合物被动辐射制冷研究
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-97143
Zahra Kamali Khanghah, M. M. Tenorio, J. Brown, Guilherme Mainieri Eymael, M. Ghashami
Passive thermal radiative cooling (PTRC) has drawn massive attention in the past few years due to its advantages, including excellent cooling potential, no emission of greenhouse gases, silent operation, low maintenance, and off-grid operation. PTRC has been successfully demonstrated to reduce the electricity consumption required for cooling and ventilation of buildings. Several radiative emitters have been studied in the literature, such as pigmented paints, nanoparticle-based coatings, photonic crystals, metamaterials, and polymers. Among them, polymers have proven to be inherently strong infrared (IR) emitters, scalable, low-cost, flexible, easy to apply, and durable candidates. In addition to these features, biopolymers are eco-friendly and currently abundant in the market. Despite their significant advantages, there have been limited studies on the applications of biopolymers for radiative cooling. In this study, we report promising performances from a commercially available, affordable, and applicable biopolymer, cellulose, as a PTRC emitter. We fabricated several cellulose films with various structural characteristics and thicknesses. The emissivity and reflectivity of these emitter surfaces were measured for the desired wavelengths and direction. The obtained measurements reveal relatively high magnitudes of diffuse emissivity in the atmospheric window and high reflectivity in the solar spectrum range. Using the materials’ reflectivity and emissivity data, we theoretically calculated the net cooling power and the expected temperature drop. Each emitter demonstrated high cooling power and considerable temperature reduction based on the average recorded weather conditions in Lincoln, NE.
被动热辐射制冷(Passive thermal radiation cooling, PTRC)由于其具有制冷潜力好、不排放温室气体、运行静音、维护成本低、离网运行等优点,近年来受到了广泛关注。PTRC已成功地证明可减少建筑物冷却和通风所需的电力消耗。文献中已经研究了几种辐射发射体,如颜料、纳米粒子涂层、光子晶体、超材料和聚合物。其中,聚合物已被证明是固有的强红外(IR)发射器,可扩展,低成本,灵活,易于应用和耐用的候选者。除了这些特点,生物聚合物是生态友好的,目前在市场上很丰富。尽管生物聚合物具有显著的优势,但对其在辐射冷却中的应用研究有限。在这项研究中,我们报告了一种商业上可用的、负担得起的、适用的生物聚合物纤维素作为PTRC发射器的前景良好的性能。我们制备了几种具有不同结构特征和厚度的纤维素薄膜。在所需波长和方向上测量了这些发射体表面的发射率和反射率。所获得的测量结果显示,在大气窗口内具有较高的漫射率,在太阳光谱范围内具有较高的反射率。利用材料的反射率和发射率数据,从理论上计算了净冷却功率和预期温度降。每个发射器显示了高冷却能力和相当大的温度降低基于平均记录的天气条件在林肯,NE。
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引用次数: 0
A Domain Specific Language Applied to Phonon Boltzmann Transport for Heat Conduction 应用于热传导声子玻尔兹曼输运的领域特定语言
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-95034
E. Heisler, Siddharth Saurav, Aadesh Deshmukh, S. Mazumder, P. Sadayappan, H. Sundar
The phonon Boltzmann transport equation is a good model for heat transfer in nanometer scale structures such as semiconductor devices. Computational complexity is one of the main challenges in numerically solving this set of potentially thousands of nonlinearly coupled equations. Writing efficient code will involve careful optimization and choosing an effective parallelization strategy, requiring expertise in high performance computing, mathematical methods, and thermal physics. To address this challenge, we present the domain specific language and code generation software Finch. This language allows a domain scientist to enter the equations in a simple format, provide only basic mathematical functions used in the model, and generate efficient parallel code. Even very complex systems of equations such as phonon Boltzmann transport can be entered in a very simple, intuitive way. A feature of the framework is flexibility in numerical methods, computing environments, parallel strategies, and other aspects of the generated code. We demonstrate Finch on this problem using a variety of parallel strategies and model configurations to demonstrate the flexibility and ease of use.
声子玻尔兹曼输运方程是研究半导体器件等纳米尺度结构传热的一个很好的模型。计算复杂性是在数值上解决这组潜在的数千个非线性耦合方程的主要挑战之一。编写高效的代码需要仔细优化和选择有效的并行化策略,这需要高性能计算、数学方法和热物理方面的专业知识。为了应对这一挑战,我们提出了领域特定语言和代码生成软件Finch。该语言允许领域科学家以简单的格式输入方程,只提供模型中使用的基本数学函数,并生成高效的并行代码。即使是非常复杂的方程组,比如声子玻尔兹曼输运,也可以用一种非常简单、直观的方式来描述。该框架的一个特点是在数值方法、计算环境、并行策略和生成代码的其他方面具有灵活性。我们使用各种并行策略和模型配置来演示Finch解决这个问题的灵活性和易用性。
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引用次数: 1
Circulating Tumor Cell Separation in a Zigzag Channel Using Dielectrophoresis Based Inertial Microfluidics 基于介电电泳的惯性微流体在之字形通道中的循环肿瘤细胞分离
Pub Date : 2022-10-30 DOI: 10.1115/imece2022-95384
Md. Sadiqul Islam, M. R. Uddin, Xiaolin Chen
Circulating tumor cells (CTCs) are known to be a primary indicator of vital diagnostic and clinical information for early-stage cancer detection. Effective separation of CTCs from blood is crucial for genetic characterization of CTCs, drug development, and improvement of cell cycle-targeted therapies. Many conventional microfluidic platforms isolate CTCs based on their size difference from other blood cells which renders them impractical for sorting overlapping-sized cells. To address this issue, we propose a method using a zigzag channel for continuous, label-free, and high throughput separation of CTCs coupling Dielectrophoresis (DEP) with inertial microfluidics. This hybrid channel exhibits enhanced similar-sized cell separation resolution and single-step retrieval of viable CTCs by combining inertial lift force, DEP force, and alternating curvature-induced Dean force. Through numerical investigation, separation of MDA-231 CTCs from identical-sized WBCs has been achieved at a relatively high Reynolds number of 125. Furthermore, the working parameters such as Reynolds number, voltage, and electrode configuration have been optimized for enhancing the separation efficiency. The proposed design can provide valuable insight into the development of a versatile, efficient, inexpensive, and novel platform with reduced analysis time for cancer diagnosis and prognosis.
循环肿瘤细胞(CTCs)被认为是早期癌症检测的重要诊断和临床信息的主要指标。从血液中有效分离ctc对于ctc的遗传特征、药物开发和细胞周期靶向治疗的改进至关重要。许多传统的微流控平台基于ctc与其他血细胞的大小差异来分离ctc,这使得它们无法分选大小重叠的细胞。为了解决这一问题,我们提出了一种使用之字形通道的方法,用于连续、无标记、高通量分离ctc耦合Dielectrophoresis (DEP)和惯性微流体。通过结合惯性升力、DEP力和交替曲率诱导的Dean力,这种混合通道具有增强的相似大小的细胞分离分辨率和单步提取活性ctc的能力。通过数值研究,在相对较高的雷诺数125下,实现了MDA-231 ctc与等尺寸wbc的分离。此外,为了提高分离效率,还对雷诺数、电压和电极结构等工作参数进行了优化。提出的设计可以为开发一种多功能、高效、廉价和新颖的平台提供有价值的见解,减少了癌症诊断和预后的分析时间。
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引用次数: 2
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Volume 8: Fluids Engineering; Heat Transfer and Thermal Engineering
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