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Knowledge-based mechanical imaging 基于知识的机械成像
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596420
A. Sarvazyan
Mechanical imaging (MI) is a new modality of medical imaging, mimicking palpatory diagnostics. MI provides a 3D reconstruction of the internal structures of body soft tissues using measurements of stress patterns on the surface of the investigated tissue. In contrast to other, existing methods of medical imaging which use sophisticated hardware such as superconductive magnets, expensive X-ray equipment and complex ultrasonic phased arrays, MI hardware consists of inexpensive mechanical sensors and a positioning system connected to a PC. The results of our pilot studies have proven the feasibility of the MI technology. Currently, devices for the MI of the prostate gland and breast are being developed. Recently, the first 3D MI of in-vivo prostate has been obtained. Preliminary data strongly suggest that MI technology is an efficient means of objectively evaluating and imaging the prostate, and of detecting prostate cancer.
机械成像(MI)是一种新的医学成像方式,模仿触诊诊断。MI通过测量所研究组织表面的应力模式,提供身体软组织内部结构的3D重建。其他现有的医学成像方法使用复杂的硬件,如超导磁体、昂贵的x射线设备和复杂的超声波相控阵,而MI硬件由廉价的机械传感器和连接到PC的定位系统组成。我们的试点研究结果证明了MI技术的可行性。目前,前列腺和乳腺的心肌梗死设备正在开发中。最近,首次获得了活体前列腺的三维心肌梗死。初步数据强烈表明,心肌梗死技术是一种客观评价和成像前列腺以及检测前列腺癌的有效手段。
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引用次数: 10
An application of machine learning in the diagnosis of ischaemic heart disease 机器学习在缺血性心脏病诊断中的应用
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596411
M. Kukar, Ciril Groselj, I. Kononenko, J. Fettich
Ischaemic heart disease is one of the world's most important causes of mortality, so improvements and rationalization of diagnostic procedures would be very useful. The four diagnostic levels consist of evaluation of signs and symptoms of the disease and ECG (electrocardiogram) at rest, sequential ECG testing during the controlled exercise, myocardial scintigraphy and finally coronary angiography. The diagnostic process is stepwise and the results are interpreted hierarchically, i.e, the next step is necessary only if the results of the former are inconclusive. Because suggestibility is possible, the results of each step are interpreted individually and only the results of the highest step are valid. On the other hand, machine learning methods may be capable of objective interpretation of all available results for the same patient and in this way increase the diagnostic accuracy, sensitivity and specificity of each step. In the usual setting, the machine learning algorithms are tuned to maximize classification accuracy. In our case, the sensitivity and specificity were much more important, so we generalized the algorithms to take in account the variable misclassification costs. The costs can be tuned in order to bias the algorithms towards higher sensitivity or specificity. We conducted many experiments with four learning algorithms and different variations of our dataset (327 patients with completed diagnostic procedures). Our results show that improvements using machine learning techniques are reasonable and might find good use in practice.
缺血性心脏病是世界上最重要的死亡原因之一,因此改进和合理化诊断程序将非常有用。这四个诊断水平包括:疾病的体征和症状的评估,静息时的心电图,控制运动时的序贯心电图检查,心肌显像,最后是冠状动脉造影。诊断过程是逐步的,结果是分层解释的,也就是说,只有当前者的结果是不确定的,下一步是必要的。因为易受暗示是可能的,所以每个步骤的结果都是单独解释的,只有最高步骤的结果是有效的。另一方面,机器学习方法可能能够客观地解释同一患者的所有可用结果,从而提高每一步的诊断准确性、敏感性和特异性。在通常情况下,机器学习算法被调整为最大限度地提高分类精度。在我们的案例中,敏感性和特异性更为重要,因此我们对算法进行了一般化,以考虑可变的误分类代价。成本可以调整,以使算法偏向于更高的灵敏度或特异性。我们使用四种学习算法和数据集的不同变体(327例完成诊断程序的患者)进行了许多实验。我们的研究结果表明,使用机器学习技术进行改进是合理的,并且可能在实践中得到很好的应用。
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引用次数: 25
Ultrasonic measurement of postural stability and control 超声波测量的姿势稳定性和控制
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596427
S. Badjou, G. Powers, M. Tanas
The study of postural sway is of special interest because of its applications in clinical medicine. Currently, the most accurate device used to study postural sway is the force platform. It is however costly and nonportable. The authors introduce an alternative system that consists of a computer-interfaced ultrasonic device. Ultrasound is emitted by sonar and bounces back from the subject's body. The amplitude of motion of the center of gravity is calculated and displayed graphically in real time. They, and several researchers, have determined that the mean speed of sway is a parameter that could be used to quantify postural sway. They developed software to filter system noise and calculate the mean speed of sway accurately. They tested the sensitivity and reliability by performing measurements of a fixed distance, and of the anterior-posterior and medical-lateral sways of thirty young healthy subjects, 15 males and 15 females. The error on the mean speed of sway was found to be less than 1%. This is no less accurate than the best sway instruments they know of. The results are consistent with force-platform measurements, and demonstrate the reliability of the system, as a means to study accurately postural control.
体位摇摆的研究因其在临床医学中的应用而受到特别关注。目前,用于研究体位摇摆最精确的装置是力台。然而,它是昂贵的和不可携带的。作者介绍了一种由计算机接口超声装置组成的替代系统。超声波是由声纳发射的,并从被测者的身体反射回来。计算了重心的运动幅度,并以图形方式实时显示。他们和几位研究人员已经确定,平均摇摆速度是一个可以用来量化姿势摇摆的参数。他们开发了软件来过滤系统噪声并精确计算平均摇摆速度。他们对30名年轻健康受试者(15名男性和15名女性)进行了固定距离的测量,并测量了前后摆动和医学侧向摆动,从而测试了这种方法的灵敏度和可靠性。平均摇摆速度误差小于1%。这不比他们所知道的最好的摇摆仪器差。结果与力平台测量结果一致,证明了该系统的可靠性,可作为研究精确姿态控制的手段。
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引用次数: 2
Automated recognition of cardiac structures in echocontrast perfusion studies 超声造影灌注研究中心脏结构的自动识别
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596410
P. Merialdo, F. Bilotta, L. Fiorani, G. Gigante
Myocardial perfusion information is crucial in the clinical evaluation of patients with coronary artery disease. A software tool dedicated to the automated analysis of contrast echocardiographic images for the evaluation of myocardial perfusion is presented in this paper. The system recognizes the internal border of the heart during the transit of an ultrasound contrast bolus injection and draws regions of interest. For each region of interest, time intensity curves are derived in order to quantify segmental perfusion.
心肌灌注信息对冠心病患者的临床评价至关重要。本文介绍了一种用于评价心肌灌注的超声造影图像自动分析的软件工具。该系统在超声造影剂注射过程中识别心脏内部边界,并绘制感兴趣的区域。对于每个感兴趣的区域,导出时间强度曲线以量化节段灌注。
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引用次数: 1
The project "Patient en Dossier" “病人档案”项目
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596408
A. Mehuys
The project "Patient en Dossier" is subsidized by the IWT through the Actionprogramme Informationtechnology for Telenet Vlaanderen. The project examines the influence of the "Law for the Protection of the Personal Privacy"/sup 2/ on the electronic medical record (EMR) and the increase of the involvement of the patient in his own health care process. The project started on 1.1.96 and will run for three years.
“病人档案”项目是由国际电讯管理局通过电信网络信息技术行动方案资助的。该项目审查了《保护个人隐私法》对电子医疗记录的影响,以及病人更多地参与自己的保健过程。该项目于1996年1月1日启动,为期三年。
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引用次数: 0
The design and implementation of an automatic computer-controlled infusion pump 计算机自动控制输液泵的设计与实现
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596438
D. Pager
We describe the design and implementation of an automatic computer controlled infusion pump for administering oxytocin to a woman in labor, with emphasis on the hardware and software safety issues. The infusion is applied by means of timed pulses, as opposed to the more usual continuous infusion method. The basic study of the system and its efficiency was described by R.J. Willcourt et al. (1894), while the mathematical algorithms employed were described by D. Pager and R.J. Willcourt (1995), and a patent for the system was granted earlier this year (D. Pager and R.J. Willcourt, 1996). The software safety issues encompass the detection by the system of various kinds of undesirable patient parameters, such as excessively high intrauterine pressure, constant intrauterine pressure, the occurrence of series of contractions closely following each other whose amplitudes are all exceedingly high. The hardware safety issues relate to the reliability of the system, and measures for ensuring that malfunctions are intercepted without the possibility of inappropriate infusion actions.
我们描述了一种自动计算机控制输注泵的设计和实现,用于给分娩中的妇女注射催产素,重点是硬件和软件的安全问题。输液是通过定时脉冲施加的,而不是更常见的连续输液方法。该系统及其效率的基础研究由R.J. Willcourt等人(1894)描述,而所采用的数学算法由D. Pager和R.J. Willcourt(1995)描述,并于今年早些时候授予该系统专利(D. Pager和R.J. Willcourt, 1996)。软件安全问题包括系统对各种不良患者参数的检测,如宫内压过高、宫内压恒定、出现一系列紧接且幅度都非常大的宫缩。硬件安全问题涉及到系统的可靠性,以及确保故障被拦截而不可能出现不适当的输液动作的措施。
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引用次数: 1
Computer aided ultrasound laboratory 计算机辅助超声实验室
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596403
V. Cerný, R. Zajac
A computer support system works in our sonography laboratory providing essential services like the data-base for medical findings combined with the image data-base. The system is based on the digitization of the video-signal output of the sonograph. We have studied the possibility of easing various picture processing methods to further support the diagnosis-making process. We report here on our experience with three particular methods. So far the most successful method we have developed was the quasi-tomographical processing of images. We take up to 16 scans of the same section plane from different positions of the ultrasonic probe. The final image is obtained as a suitable average of the matched images. The method proved to be very helpful in the diagnostic process and is used on an everyday basis. On a somewhat more academic level we are studying the use of simple neural net classifiers to evaluate textural content in the images. The nets are trained on sets of texture patterns and then used to classify the testing samples. We present here two particular examples: classifying malignant tissue in testes and segmentation (sinus vs parenchyma) in kidney. Our experience with these methods is still limited. However, our conjecture is that the texture information can be used as a supportive tool in clinical praxis.
我们的超声实验室设有计算机辅助系统,提供医学结果数据库和图像数据库等基本服务。该系统是基于超声仪的视频信号输出的数字化。我们研究了简化各种图像处理方法的可能性,以进一步支持诊断过程。我们在这里报告我们使用三种特殊方法的经验。到目前为止,我们开发的最成功的方法是图像的准层析处理。我们从超声探头的不同位置对同一切面进行多达16次扫描。最终图像作为匹配图像的合适平均值得到。该方法在诊断过程中被证明是非常有用的,并在日常基础上使用。在更学术的层面上,我们正在研究使用简单的神经网络分类器来评估图像中的纹理内容。这些网络在纹理模式集上进行训练,然后用于对测试样本进行分类。我们在这里提出两个特别的例子:睾丸恶性组织的分类和肾脏恶性组织的分割(窦性与实质)。我们使用这些方法的经验仍然有限。然而,我们的猜想是纹理信息可以用作临床实践的辅助工具。
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引用次数: 1
Integrating clinical and managerial activities of health care units 整合医疗保健单位的临床和管理活动
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596443
D. Luzi, F. Ricci, L. Serbanati
The first step in understanding information systems in health care units (HCUs) is to develop a conceptual model of HCU able to gather data and knowledge used by the management staff in order to plan, execute, control and evaluate the patient care process. An approach to HCU management modelling is presented in the paper. Our approach is centred on the use of guidelines for all activities which are carried out in HCU environments. Various guidelines may exist. Some of them are clinical, others are managerial. Among the most important managerial guidelines are the communication guidelines. They govern all communication activities inside or between HCUs. A model of guideline-based inter-HCUs communication is presented.
了解卫生保健单位(HCU)信息系统的第一步是开发一个HCU的概念模型,该模型能够收集管理人员使用的数据和知识,以便计划、执行、控制和评估患者护理过程。本文提出了一种HCU管理建模方法。我们的方法集中于在HCU环境中进行的所有活动的指导方针的使用。可能存在各种指导方针。有些是临床的,有些是管理的。其中最重要的管理准则是沟通准则。它们管理着hcu内部或之间的所有通信活动。提出了一种基于准则的hcu间通信模型。
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引用次数: 1
A distributed database on the Internet of 3D models of human pathological organs 人类病理器官的三维模型在互联网上的分布式数据库
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596444
M. Crudele, G. Clapworthy, M. Krokos, G. Salcito, Nickos Vasilonikolidakis
We describe a research project for the development of a system for cataloguing, retrieval and interactive manipulation of 3D models of pathological human organs from a distributed WWW database. The project aims to provide transmission and rendering of three-dimensional models of human pathologies (constructed mainly from MRI and CT slices), enhanced manipulation and fly-through functionality on the models, as well as 3D animation sequences of virtual endoscopy. The system supports standard PC platforms without specialised hardware, thereby allowing accessibility to the widest possible audience. The system will provide the end users with advanced imaging capabilities such as models derived from multi-modal inputs (CT and MRI), stereoscopic display and will incorporate a number of features such as model warping. In addition to interactive utilisation, the service will provide interactive platforms for education, incorporating monitoring and assessment, as well as for information and/or counselling exchange between users.
我们描述了一个研究项目,用于从分布式WWW数据库中编目、检索和交互式操作病理人体器官3D模型的系统的开发。该项目旨在提供人体病理三维模型(主要由MRI和CT切片构建)的传输和渲染,增强模型的操作和飞行功能,以及虚拟内窥镜的三维动画序列。该系统支持标准的PC平台,没有专门的硬件,从而允许访问最广泛的受众。该系统将为最终用户提供先进的成像能力,如从多模态输入(CT和MRI)衍生的模型、立体显示,并将纳入许多特征,如模型翘曲。除了互动使用外,该服务亦会提供互动的教育平台,包括监测和评估,以及使用者之间的资讯和/或咨询交流。
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引用次数: 5
Radial basis function-based image segmentation using a receptive field 基于径向基函数的接受野图像分割
Pub Date : 1997-03-11 DOI: 10.1109/CBMS.1997.596421
D. Kovacevic, S. Lončarić
The paper presents a novel method for CT head image automatic segmentation. The images are obtained from patients having a spontaneous intra-cerebral brain hemorrhage (ICH). The results of the segmentation are images partitioned into five regions of interest corresponding to four tissue classes (skull, brain, calcifications and ICH) and background. Once the images are segmented it is possible to calculate various hemorrhage region parameters such as size, position, etc. The segmentation is performed in three major steps. In the first phase feature extraction and normalization is performed using a receptive field (RF). Experiments were performed to determine the optimal RF structure. Pixels are classified in the second phase using the radial basis function (RBF) artificial neural network. Experiments with different RBF network topologies were performed in order to determine the optimal basis functions, network size and a training algorithm. The segmentation results obtained using the RBF network were compared with results obtained by multi-layer perceptron neural network (MLP). In the third phase the image regions obtained by the RBF network were labeled using an expert system. Experiments have shown that the proposed method successfully performs image segmentation.
提出了一种新的CT头部图像自动分割方法。这些图像来自于自发性脑出血(ICH)患者。分割的结果是图像被划分为五个感兴趣的区域,对应于四种组织类别(头骨,大脑,钙化和ICH)和背景。一旦图像被分割,就可以计算各种出血区域参数,如大小、位置等。分割分为三个主要步骤。在第一阶段,特征提取和归一化是使用接收场(RF)进行的。通过实验确定了最佳的射频结构。第二阶段使用径向基函数(RBF)人工神经网络对像素进行分类。为了确定最优的基函数、网络大小和训练算法,对不同RBF网络拓扑进行了实验。将RBF网络的分割结果与多层感知器神经网络(MLP)的分割结果进行比较。第三阶段,利用专家系统对RBF网络得到的图像区域进行标记。实验表明,该方法能够成功地进行图像分割。
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引用次数: 19
期刊
Proceedings of Computer Based Medical Systems
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