Pub Date : 2019-10-28DOI: 10.26452/ijrpp.v9i3.1332
D. Pranitha, Y. Ganeshkumar, D. PhaneendraPavan, M. Ch, Akila Cr
Medicinal plants are of great significance in the evolution of mankind, and the medical systems that are based on the plants and natural resources are gaining importance. Around 50% of the population in the world are using herbal medicine in the present day . This had been practised and used by many healers and others in the usage of the herbs in emphasizing their potency and lack side effects. The plant, Epipremnum pinnatum had been used as a decorative plant in the houses everywhere, and the plant has some potential properties like insecticidal, and anti-hyperlipidemic activities. In the present investigation, the acute, sub-acute and Chronic toxicity of the extract of the aerial parts of the plant were investigated, and the plant safety was suggested based on the results. In this current work, the acute and chronic toxicities of the extracts of the plant were investigated, and the results showed that there was no abnormal weight gain and signs of toxicity. The rats were healthy too. The blood parameters did not show any changes, too indicating that the extract showed no toxicity on the rats.
{"title":"Toxicological Studies of the Extract of Epipremnum pinnatum","authors":"D. Pranitha, Y. Ganeshkumar, D. PhaneendraPavan, M. Ch, Akila Cr","doi":"10.26452/ijrpp.v9i3.1332","DOIUrl":"https://doi.org/10.26452/ijrpp.v9i3.1332","url":null,"abstract":"Medicinal plants are of great significance in the evolution of mankind, and the medical systems that are based on the plants and natural resources are gaining importance. Around 50% of the population in the world are using herbal medicine in the present day . This had been practised and used by many healers and others in the usage of the herbs in emphasizing their potency and lack side effects. The plant, Epipremnum pinnatum had been used as a decorative plant in the houses everywhere, and the plant has some potential properties like insecticidal, and anti-hyperlipidemic activities. In the present investigation, the acute, sub-acute and Chronic toxicity of the extract of the aerial parts of the plant were investigated, and the plant safety was suggested based on the results. In this current work, the acute and chronic toxicities of the extracts of the plant were investigated, and the results showed that there was no abnormal weight gain and signs of toxicity. The rats were healthy too. The blood parameters did not show any changes, too indicating that the extract showed no toxicity on the rats.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127670342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-27DOI: 10.26452/ijrpp.v9i3.1333
Ganesh Kumar Y, Pranitha D, Phaneendra D, Madhava Reddy Ch
Various types of conditions exist in the body that causes fever and pain. Drugs that are used to treat fever are called antipyretics, and those are usually prescribed to treat elevated body temperature. But those drugs result in many other side effects like ulcers, perforations, bleedings and obstructions, which make their use questionable and limiting. Medicinal plants are used in the treatment of diseases from the starting of the human race and the process; they had been subjected to rigorous investigations and tests to establish a scientific proof and validation of the various pharmacological activities and their respective mechanisms of action in treating the herbs. Considering the anti-inflammatory properties of the plant, Xylocarpus mekongesis was investigated for its antipyretic activity in yeast method and 3doses out of which 00mg/kg body weight showed a better activity compared to the standard drug and other extracts too. The mechanism of action was similar to the paracetamol action that is inhibition of prostaglandin synthesis.
{"title":"Antipyretic Activity of the Root Extracts of Xylocarpus","authors":"Ganesh Kumar Y, Pranitha D, Phaneendra D, Madhava Reddy Ch","doi":"10.26452/ijrpp.v9i3.1333","DOIUrl":"https://doi.org/10.26452/ijrpp.v9i3.1333","url":null,"abstract":"Various types of conditions exist in the body that causes fever and pain. Drugs that are used to treat fever are called antipyretics, and those are usually prescribed to treat elevated body temperature. But those drugs result in many other side effects like ulcers, perforations, bleedings and obstructions, which make their use questionable and limiting. Medicinal plants are used in the treatment of diseases from the starting of the human race and the process; they had been subjected to rigorous investigations and tests to establish a scientific proof and validation of the various pharmacological activities and their respective mechanisms of action in treating the herbs. Considering the anti-inflammatory properties of the plant, Xylocarpus mekongesis was investigated for its antipyretic activity in yeast method and 3doses out of which 00mg/kg body weight showed a better activity compared to the standard drug and other extracts too. The mechanism of action was similar to the paracetamol action that is inhibition of prostaglandin synthesis.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121672416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-03DOI: 10.26452/ijrpp.v8i2.1305
Raja Sheker K, Naveen B, Anil kumar A, Abhilash G
Fevers are considered as the most important parameters to evaluate and diagnose most of the disease conditions like inflammations, wounds and other infections. There are effective drugs that treat and control the fevers out of which NSAID's are most important ones. They cause notable side effects like gastric ulcers, gastric mucosal perforations etc. which make the use of those drugs limited. Herbs are used to treat various diseases, starting from the evolution of the human race. During this, herbs had been introduced to many types of tests and scientific investigations to prove the activities that herbs possess. The diseases that the herbs are used for are notable in the medical systems like Ayurveda and other systems. The need for the validation of the activities of the herbs and medicinal plants is utmost important these days. The extracts of the plant leaves of Desmodium gangeticum were extracted with ethanol and then investigated for the antipyretic activity in yeast induced pyretic method. The extract was tested in two doses 200 and 400mg/kg. This was found significant when compared to the standard drug.
{"title":"Antipyretic activity of the root extracts of Desmodium Gangeticum","authors":"Raja Sheker K, Naveen B, Anil kumar A, Abhilash G","doi":"10.26452/ijrpp.v8i2.1305","DOIUrl":"https://doi.org/10.26452/ijrpp.v8i2.1305","url":null,"abstract":"Fevers are considered as the most important parameters to evaluate and diagnose most of the disease conditions like inflammations, wounds and other infections. There are effective drugs that treat and control the fevers out of which NSAID's are most important ones. They cause notable side effects like gastric ulcers, gastric mucosal perforations etc. which make the use of those drugs limited. Herbs are used to treat various diseases, starting from the evolution of the human race. During this, herbs had been introduced to many types of tests and scientific investigations to prove the activities that herbs possess. The diseases that the herbs are used for are notable in the medical systems like Ayurveda and other systems. The need for the validation of the activities of the herbs and medicinal plants is utmost important these days. The extracts of the plant leaves of Desmodium gangeticum were extracted with ethanol and then investigated for the antipyretic activity in yeast induced pyretic method. The extract was tested in two doses 200 and 400mg/kg. This was found significant when compared to the standard drug.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114290338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-28DOI: 10.26452/ijrpp.v8i3.1391
Thejaswini Karanth, Someswar Deb, Pranathi R, Kasthuri P
Alcohol consumption results in multiple end-organ damages. Predominantly the nervous system is affected in the form of Wernicke encephalopathy, Korsakoff psychosis, cerebellar ataxia and peripheral neuropathy. Neuropathy due to alcohol consumption depends on the period and extent of total lifetime of alcohol consumption. Cultural and racial factors also play a role in the development of alcohol neuropathy. Alcohol consumption results in multiple end-organ damages. Alcoholic neuropathy is the most common harmful effects of excessive alcohol intake. The incidence of alcoholic neuropathy in the standard population is not accurate as the percentage varies extensively contingent on the description of chronic alcoholism and the criteria used to detect and classify neuropathy. According to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), studies involving clinical and electrodiagnostic tests prove that neuropathy is present in 25-66%. Alcoholic neuropathy depends on the extent and extent of total lifetime of alcohol consumption. Cultural and racial factors also play a role in resulting in alcohol neuropathy. Few studies suggest that the incidence of peripheral neuropathy is higher in alcoholic patients who have a family history of alcohol dependence syndrome. This is study finds the Common peroneal and sural nerves are the most common nerves to be involved in neuropathy. Predominantly axonal degeneration is the main pathology. Units of alcohol and CAGE criteria score has a 100% specificity in detecting patients prone to neuropathy.
{"title":"An efficient approach on alcohol dependence syndrome","authors":"Thejaswini Karanth, Someswar Deb, Pranathi R, Kasthuri P","doi":"10.26452/ijrpp.v8i3.1391","DOIUrl":"https://doi.org/10.26452/ijrpp.v8i3.1391","url":null,"abstract":"Alcohol consumption results in multiple end-organ damages. Predominantly the nervous system is affected in the form of Wernicke encephalopathy, Korsakoff psychosis, cerebellar ataxia and peripheral neuropathy. Neuropathy due to alcohol consumption depends on the period and extent of total lifetime of alcohol consumption. Cultural and racial factors also play a role in the development of alcohol neuropathy. Alcohol consumption results in multiple end-organ damages. Alcoholic neuropathy is the most common harmful effects of excessive alcohol intake. The incidence of alcoholic neuropathy in the standard population is not accurate as the percentage varies extensively contingent on the description of chronic alcoholism and the criteria used to detect and classify neuropathy. According to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), studies involving clinical and electrodiagnostic tests prove that neuropathy is present in 25-66%. Alcoholic neuropathy depends on the extent and extent of total lifetime of alcohol consumption. Cultural and racial factors also play a role in resulting in alcohol neuropathy. Few studies suggest that the incidence of peripheral neuropathy is higher in alcoholic patients who have a family history of alcohol dependence syndrome. This is study finds the Common peroneal and sural nerves are the most common nerves to be involved in neuropathy. Predominantly axonal degeneration is the main pathology. Units of alcohol and CAGE criteria score has a 100% specificity in detecting patients prone to neuropathy.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127378841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-11DOI: 10.26452/ijrpp.v8i2.1303
Naveen B, Raja Sheker K, Anil kumar A, Abhilash G
Seizures are an important and most common disease that affects the human body and are also caused to other neurological manifestations. Most of the people affected in the world currently are middle-aged and are suffering from many brain diseases. 50million people are affected due to epilepsy and convulsions around the world. There are many drugs that helpful and potent against epilepsy. As discussed, they have side effects, and the only solution to avoid those effects is the investigation of herbal sources for their anti-epileptic activity. One of those potent herbs is Nardostachys jatamansi. It was investigated and proved for its anti-epileptic property. The current research was planned to compare the effects of different extracts on the anti-epileptic property. In the process, double distilled water, methanol, ethanol and acetone were used as an extraction medium, and the extracts were tested for its property. Out of all the extracts, aqueous and methanol extracts showed a better activity compared with other extracts and standard drug, Diazepam.
{"title":"Effect of anti-epileptic profile of jatamansi on the brain enzymes","authors":"Naveen B, Raja Sheker K, Anil kumar A, Abhilash G","doi":"10.26452/ijrpp.v8i2.1303","DOIUrl":"https://doi.org/10.26452/ijrpp.v8i2.1303","url":null,"abstract":"Seizures are an important and most common disease that affects the human body and are also caused to other neurological manifestations. Most of the people affected in the world currently are middle-aged and are suffering from many brain diseases. 50million people are affected due to epilepsy and convulsions around the world. There are many drugs that helpful and potent against epilepsy. As discussed, they have side effects, and the only solution to avoid those effects is the investigation of herbal sources for their anti-epileptic activity. One of those potent herbs is Nardostachys jatamansi. It was investigated and proved for its anti-epileptic property. The current research was planned to compare the effects of different extracts on the anti-epileptic property. In the process, double distilled water, methanol, ethanol and acetone were used as an extraction medium, and the extracts were tested for its property. Out of all the extracts, aqueous and methanol extracts showed a better activity compared with other extracts and standard drug, Diazepam.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124071274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Low blood pressure indeed includes a worse prognosis than excessive blood strain. This mechanism, bills for the "reverse causation "seen within the ’ patients, the company of conventional risk elements, such as high blood pressure, , and obesity, appear to be the worst diagnosis. Exogenous products can growth blood strain and requirement of tablets.30 Chronic ECFV overload secondary to activation of axis and disturbances inside the stability of and the contributes to high blood pressure. Improvement in blood pressure can be introduced out with oral sodium restriction, diuretics, and fluid elimination with dialysis. Some patients will continue to be hypertensive notwithstanding of the careful attention to ECFV reputation.LVH is related to reduced endurance of sufferers on /peritoneal dialysis. Lower five-year survival charge in ESRD patients with LVH has a 30%than people missing LVH. This has a look at produces the mean carotid artery thickness turned into higher in sufferers with superior CKD. However, it did now not attain statistical significance, probable due to the smaller sample size. It was also observed that carotid medial thickness did not correlate with . Even though the patients had maintained significantly healthy cholesterol and high HDL levels, there was an increase in CIMT. in CKD patients, CIMT cannot be predicted based on the traditional atherosclerotic risk factors like serum cholesterol and HDL.
{"title":"An Impact of Intima Media Thickness of Carotids in Cardiovascular Profile","authors":"Talluri Jagadeesh, Potlacheruvu Anusha, Reddyboyina Haripriya","doi":"10.26452/ijrpp.v8i1.1244","DOIUrl":"https://doi.org/10.26452/ijrpp.v8i1.1244","url":null,"abstract":"Low blood pressure indeed includes a worse prognosis than excessive blood strain. This mechanism, bills for the \"reverse causation \"seen within the ’ patients, the company of conventional risk elements, such as high blood pressure, , and obesity, appear to be the worst diagnosis. Exogenous products can growth blood strain and requirement of tablets.30 Chronic ECFV overload secondary to activation of axis and disturbances inside the stability of and the contributes to high blood pressure. Improvement in blood pressure can be introduced out with oral sodium restriction, diuretics, and fluid elimination with dialysis. Some patients will continue to be hypertensive notwithstanding of the careful attention to ECFV reputation.LVH is related to reduced endurance of sufferers on /peritoneal dialysis. Lower five-year survival charge in ESRD patients with LVH has a 30%than people missing LVH. This has a look at produces the mean carotid artery thickness turned into higher in sufferers with superior CKD. However, it did now not attain statistical significance, probable due to the smaller sample size. It was also observed that carotid medial thickness did not correlate with . Even though the patients had maintained significantly healthy cholesterol and high HDL levels, there was an increase in CIMT. in CKD patients, CIMT cannot be predicted based on the traditional atherosclerotic risk factors like serum cholesterol and HDL.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125166267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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