Pub Date : 2023-02-20DOI: 10.26452/ijrpp.v13i1.1487
Gandhimathi R, Karthick Raja D, Chandru Ganesh S, Praveen. R. S, Sivi Hirthikha. G. R, Vijey Aanandhi M
Vitex negundo is a plant with medicinal properties that has been employed in traditional medicine to address a wide range of health conditions. This review summarizes the phytochemical and pharmacological activities of Vitex negundo. The plant contains various bioactive compounds such as terpenoids, flavonoids, alkaloids, and essential oils, which exhibit diverse pharmacological activities such as anti-inflammatory, analgesic, antipyretic, antioxidant, antitumor, antimicrobial, antifungal, and antiparasitic effects. Several studies have demonstrated the efficacy of Vitex negundo in the treatment of various diseases. The plant also possesses hepatoprotective, nephroprotective, and neuroprotective effects. However, further studies are needed to fully understand the mechanisms of action of Vitex negundo and to develop new drugs based on its bioactive compounds. In conclusion, Vitex negundo is a promising medicinal plant that deserves further investigation as a potential source of new drugs for the treatment of various diseases.
{"title":"A Review of Phytochemical and Pharmacological Activities of Vitex negundo","authors":"Gandhimathi R, Karthick Raja D, Chandru Ganesh S, Praveen. R. S, Sivi Hirthikha. G. R, Vijey Aanandhi M","doi":"10.26452/ijrpp.v13i1.1487","DOIUrl":"https://doi.org/10.26452/ijrpp.v13i1.1487","url":null,"abstract":"Vitex negundo is a plant with medicinal properties that has been employed in traditional medicine to address a wide range of health conditions. This review summarizes the phytochemical and pharmacological activities of Vitex negundo. The plant contains various bioactive compounds such as terpenoids, flavonoids, alkaloids, and essential oils, which exhibit diverse pharmacological activities such as anti-inflammatory, analgesic, antipyretic, antioxidant, antitumor, antimicrobial, antifungal, and antiparasitic effects. Several studies have demonstrated the efficacy of Vitex negundo in the treatment of various diseases. The plant also possesses hepatoprotective, nephroprotective, and neuroprotective effects. However, further studies are needed to fully understand the mechanisms of action of Vitex negundo and to develop new drugs based on its bioactive compounds. In conclusion, Vitex negundo is a promising medicinal plant that deserves further investigation as a potential source of new drugs for the treatment of various diseases.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132353947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-17DOI: 10.26452/ijrpp.v11i2.1416
Imtiyaz Ansari, Nitesh Gupta, Abhaykumar Yadav
An English solicitor, Jeremy Bentham, disdained the unregulated use of livestock, in the literature of 1780, which cast doubt on the inability to pay morale to animals. Animal experiment was fundamental to scientific science during his life, but it has also been a question of heated popular and intellectual discourse from decades. Since then, general understanding and attitudes have strengthened against the unethical or cruel application of animals for research purposes. Russell & Burch provided in 1959 the principles set out during UFAW of the clinical lab method. The alternative measures, replacements, or non-animal steps shall be used as alternatives for live animal methods, or methods of measurement without live animal use. The term 'alternative' refers to approaches or strategies that substitute the overall use of laboratory animals, minimize the number of animals used, or enhance a current system or technology to reduce animal stress. In recent years, the creation of alternatives to animals has been accelerated by designing projects with the intention of developing and introducing alternatives. This report summarizes the key potential approaches to animal science. An integrated use of these techniques will offer an insight into the minimal use of animals for experimental research.
{"title":"A review on: Alternatives to animal experimental models","authors":"Imtiyaz Ansari, Nitesh Gupta, Abhaykumar Yadav","doi":"10.26452/ijrpp.v11i2.1416","DOIUrl":"https://doi.org/10.26452/ijrpp.v11i2.1416","url":null,"abstract":"An English solicitor, Jeremy Bentham, disdained the unregulated use of livestock, in the literature of 1780, which cast doubt on the inability to pay morale to animals. Animal experiment was fundamental to scientific science during his life, but it has also been a question of heated popular and intellectual discourse from decades. Since then, general understanding and attitudes have strengthened against the unethical or cruel application of animals for research purposes. Russell & Burch provided in 1959 the principles set out during UFAW of the clinical lab method. The alternative measures, replacements, or non-animal steps shall be used as alternatives for live animal methods, or methods of measurement without live animal use. The term 'alternative' refers to approaches or strategies that substitute the overall use of laboratory animals, minimize the number of animals used, or enhance a current system or technology to reduce animal stress. In recent years, the creation of alternatives to animals has been accelerated by designing projects with the intention of developing and introducing alternatives. This report summarizes the key potential approaches to animal science. An integrated use of these techniques will offer an insight into the minimal use of animals for experimental research.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129545228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-14DOI: 10.26452/ijrpp.v10i4.1384
Dinesh Babu J, Akila CR, Sravan Kumar P, Vinaya B
Peptic ulcer disease, otherwise called as Ulcers, is the most noted disease in the world today. A large population that is affected with the ulcer disease is the age group of people between 20-50 years of age. This disease is not dreadful on its own but is responsible for the causation of many other problems and diseases in the body. This may be due to various factors like the long-term usage of potent drugs like NSAID's, nutrition deficiencies, and unhealthy lifestyle habits like smoking, stress etc. Herbs are being used to treat many diseases, and almost 50% of the population in the world uses herbal-based medicine. Medicinal plants are the primary sources of a cure for those diseases. Numerous plants have been researched and investigated for the anti-ulcer property, and various publications were made too in this respect. Aqueous extract of the plant, Osyris quadripartite was extracted and investigated for the anti-ulcer activity in the ethanol-induced ulcer disease method. The extracts were tested in three doses and compared to the standard drug, Omeprazole. The extract at a higher dose exhibited more significant activity when compared to that at a lower dose and also the standard drug.
{"title":"Anti-ulcer mechanism of the aqueous extract of Osyris quadripartite","authors":"Dinesh Babu J, Akila CR, Sravan Kumar P, Vinaya B","doi":"10.26452/ijrpp.v10i4.1384","DOIUrl":"https://doi.org/10.26452/ijrpp.v10i4.1384","url":null,"abstract":"Peptic ulcer disease, otherwise called as Ulcers, is the most noted disease in the world today. A large population that is affected with the ulcer disease is the age group of people between 20-50 years of age. This disease is not dreadful on its own but is responsible for the causation of many other problems and diseases in the body. This may be due to various factors like the long-term usage of potent drugs like NSAID's, nutrition deficiencies, and unhealthy lifestyle habits like smoking, stress etc. Herbs are being used to treat many diseases, and almost 50% of the population in the world uses herbal-based medicine. Medicinal plants are the primary sources of a cure for those diseases. Numerous plants have been researched and investigated for the anti-ulcer property, and various publications were made too in this respect. Aqueous extract of the plant, Osyris quadripartite was extracted and investigated for the anti-ulcer activity in the ethanol-induced ulcer disease method. The extracts were tested in three doses and compared to the standard drug, Omeprazole. The extract at a higher dose exhibited more significant activity when compared to that at a lower dose and also the standard drug.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131316358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-12DOI: 10.26452/ijrpp.v10i4.1381
Mothilal K, Akila CR, Mahender K, Chaitanya Kumar K, Ravi D
Injuries and wounds are any sorts of damage to the skin or subcutaneous tissue. Usually, any wounds of such sorts are self-healed. Sometimes, there may be a delay in healing, and that delay is caused due to the functional delays in various processes of wound healing. All the Ficus plants show similar activities like the antioxidant, anti-inflammatory and wound healing properties 7including skin conditions like ulcers and rheumatism. The anthelmintic property and immunomodulatory are also seen. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. All the extracts showed a better healing ability, but the extract of FBO-100 showed the highest activity followed by FMO followed by FHO and finally the FRO. Overall, the activity of the extract ointment was comparable and was significant compared to the standard drug ointment. The wound closure of the extract ointment treated groups were better and were completed in 12 days, and the activity was more than 96%. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. The plants of microcarpa, benghalensis, religiosa and hispida are compared for the activity, and the order showed for the activity was FBO>FMO>FHO>FRO.
{"title":"Comparison of the ficus for the wound healing activity in various species","authors":"Mothilal K, Akila CR, Mahender K, Chaitanya Kumar K, Ravi D","doi":"10.26452/ijrpp.v10i4.1381","DOIUrl":"https://doi.org/10.26452/ijrpp.v10i4.1381","url":null,"abstract":"Injuries and wounds are any sorts of damage to the skin or subcutaneous tissue. Usually, any wounds of such sorts are self-healed. Sometimes, there may be a delay in healing, and that delay is caused due to the functional delays in various processes of wound healing. All the Ficus plants show similar activities like the antioxidant, anti-inflammatory and wound healing properties 7including skin conditions like ulcers and rheumatism. The anthelmintic property and immunomodulatory are also seen. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. All the extracts showed a better healing ability, but the extract of FBO-100 showed the highest activity followed by FMO followed by FHO and finally the FRO. Overall, the activity of the extract ointment was comparable and was significant compared to the standard drug ointment. The wound closure of the extract ointment treated groups were better and were completed in 12 days, and the activity was more than 96%. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. The plants of microcarpa, benghalensis, religiosa and hispida are compared for the activity, and the order showed for the activity was FBO>FMO>FHO>FRO.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115645352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-10DOI: 10.26452/ijrpp.v10i3.1360
H. Soujanya, M. Purushothaman, S. Jagadeeshwari, K. Shivakumar
Presently days, a significant objective medication conveyance study is twisted to the improvement of robust medication conveyance frameworks with previously existing dynamic fixings in the event of new medication disclosure. A considerable lot of remedial drug operators are generally viable when made accessible at steady rates close to assimilation locales. Much exertion has been proceeding to create advanced medication conveyance frameworks, for example, osmotic gadgets for oral request. Oral medication conveyance framework is more preferred on famous measured medication conveyance framework in innovative drug work (R and D) business because of increment in attention to clinical and drug network about the significance of sheltered and viable utilization of medication. In the current examination work, pulsatile drug conveyance arrangement of Zileuton tablets was planned by utilizing pressure covering innovation. At first, the centre tablets were set up by 30% groupings of wonderful crumbles; the figured centre tablets were covered with the polymers by utilizing pressure covering innovation. All the centre and press covered tablet details were exposed to different corporeal and concoction assessment tests for centre and press covered tablets. The hardness, thickness and weight variety appeared by all the tablet definitions were originate inside the authorized pharmacopoeias bounds. In-vitro arrival of Zileuton of centre tablet details F1 demonstrated quicker medication discharge after 15 min. Quicker medication delivery can be connected with significant deterioration, and friability saw in this examination. The enteric covered plans C1, C3 indicated the most significant medication discharge following 4 hours. Time subordinate pulsatile drug conveyance framework has been accomplished from the tablet of definition C3, C6 and C9 with 95.5%, 94.76% and 97.48% separately.
{"title":"Preparation and analysis of human medication tablets in drug delivery system","authors":"H. Soujanya, M. Purushothaman, S. Jagadeeshwari, K. Shivakumar","doi":"10.26452/ijrpp.v10i3.1360","DOIUrl":"https://doi.org/10.26452/ijrpp.v10i3.1360","url":null,"abstract":"Presently days, a significant objective medication conveyance study is twisted to the improvement of robust medication conveyance frameworks with previously existing dynamic fixings in the event of new medication disclosure. A considerable lot of remedial drug operators are generally viable when made accessible at steady rates close to assimilation locales. Much exertion has been proceeding to create advanced medication conveyance frameworks, for example, osmotic gadgets for oral request. Oral medication conveyance framework is more preferred on famous measured medication conveyance framework in innovative drug work (R and D) business because of increment in attention to clinical and drug network about the significance of sheltered and viable utilization of medication. In the current examination work, pulsatile drug conveyance arrangement of Zileuton tablets was planned by utilizing pressure covering innovation. At first, the centre tablets were set up by 30% groupings of wonderful crumbles; the figured centre tablets were covered with the polymers by utilizing pressure covering innovation. All the centre and press covered tablet details were exposed to different corporeal and concoction assessment tests for centre and press covered tablets. The hardness, thickness and weight variety appeared by all the tablet definitions were originate inside the authorized pharmacopoeias bounds. In-vitro arrival of Zileuton of centre tablet details F1 demonstrated quicker medication discharge after 15 min. Quicker medication delivery can be connected with significant deterioration, and friability saw in this examination. The enteric covered plans C1, C3 indicated the most significant medication discharge following 4 hours. Time subordinate pulsatile drug conveyance framework has been accomplished from the tablet of definition C3, C6 and C9 with 95.5%, 94.76% and 97.48% separately.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124805252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-10DOI: 10.26452/ijrpp.v9i2.1247
Vishal N. Kushare, Sagar V. Ghotekar, Manmeet S. Mandloi
Ulcers are one of the dreadful and technically known as Peptic Ulcer Disease (PU Disease). Around 10million people around the world are suffering from the disease, and the majority of the people are about 20-50 years of age. This is not a dangerous disease on its own. Still, the ulcers are responsible for the resulting in other diseases like indigestion stomach pain etc. there are various reasons for the causation of ulcer. They are excessive use of pain killers and anti-inflammatory drugs, malnutrition, and unhealthy food habits, stress and steroids. Almost half of the world population relies on herbs for the treatment, and the major sources of the chemical leads that treat diseases are in the medicinal plants only. Many plants have been investigated and reported for their potential antiulcer benefits and are published too for that. The plant parts of Malvastrum tricuspidatum were extracted using distilled water and were investigated for the antiulcer activity in 3 doses like 100,200 and 400mg. The Extract at a higher dose showed better activity than other lower doses. The activity was compared with the standard drug and showed a significantly better activity that the standard and other doses of Extract too.
{"title":"Ulcer Healing Potential of the Aqueous Extract of Malvastrum tricuspidate Eliminating Toxicity","authors":"Vishal N. Kushare, Sagar V. Ghotekar, Manmeet S. Mandloi","doi":"10.26452/ijrpp.v9i2.1247","DOIUrl":"https://doi.org/10.26452/ijrpp.v9i2.1247","url":null,"abstract":"Ulcers are one of the dreadful and technically known as Peptic Ulcer Disease (PU Disease). Around 10million people around the world are suffering from the disease, and the majority of the people are about 20-50 years of age. This is not a dangerous disease on its own. Still, the ulcers are responsible for the resulting in other diseases like indigestion stomach pain etc. there are various reasons for the causation of ulcer. They are excessive use of pain killers and anti-inflammatory drugs, malnutrition, and unhealthy food habits, stress and steroids. Almost half of the world population relies on herbs for the treatment, and the major sources of the chemical leads that treat diseases are in the medicinal plants only. Many plants have been investigated and reported for their potential antiulcer benefits and are published too for that. The plant parts of Malvastrum tricuspidatum were extracted using distilled water and were investigated for the antiulcer activity in 3 doses like 100,200 and 400mg. The Extract at a higher dose showed better activity than other lower doses. The activity was compared with the standard drug and showed a significantly better activity that the standard and other doses of Extract too.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123175059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-30DOI: 10.26452/ijrpp.v10i1.1190
J. Sujaritha, N. Deepasankar, K. Mathivathani, G. Aravindh, G. Gnanasekaran
Lopinavir, Ritonovir and Interferon (IFN) are anti-viral drugs mainly used in the treatment of HIV infection by protease inhibitors. Chloroquine and Hydroxychloroquine are used in the treatment of malarial causing infection such as Plasmodium falciparum and also auto immune condition such as rheumatoid arthritis. Chloroquine makes toxic for the parasite to digest its host hemoglobin and disrupting the virus ability to enter the cell. The anti-viral and anti-malarial drugs are used in the first line drug therapy for the treatment of COVID-19. The aim of this therapy is to minimize the symptoms and shortens the duration of illness.
{"title":"An overview of some drugs: Lopinavir, Ritonavir, Chloroquine, Hydroxy chloroquine and Interferon as a effective treatment against COVID-19","authors":"J. Sujaritha, N. Deepasankar, K. Mathivathani, G. Aravindh, G. Gnanasekaran","doi":"10.26452/ijrpp.v10i1.1190","DOIUrl":"https://doi.org/10.26452/ijrpp.v10i1.1190","url":null,"abstract":"Lopinavir, Ritonovir and Interferon (IFN) are anti-viral drugs mainly used in the treatment of HIV infection by protease inhibitors. Chloroquine and Hydroxychloroquine are used in the treatment of malarial causing infection such as Plasmodium falciparum and also auto immune condition such as rheumatoid arthritis. Chloroquine makes toxic for the parasite to digest its host hemoglobin and disrupting the virus ability to enter the cell. The anti-viral and anti-malarial drugs are used in the first line drug therapy for the treatment of COVID-19. The aim of this therapy is to minimize the symptoms and shortens the duration of illness.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130939783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human skin is the highly exposed body organ to pathogens and disease causing micro organism. So it requires a lot of protection and care. Chemical antibiotic gels and anti-acne washes or masks are currently available in the market which are composed of synthetic drugs. Unfortunately these drugs have potential side effects besides curing diseases and fighting pathogens. The need brings us the idea of incorporating the herbs in the formulations to treat acnes. In the current research, herbal face wash is prepared and evaluated for its properties and potency. The Fruit Facewash gel containing grape seed and pulp extract, cucumber juice, orange juice, lemon juice using carbopol 940 was prepared with good consistency. The reduction in the growth of microorganisms is clearly seen in the dishes contained Gel-CRB marked (aft CRB) respectively.
{"title":"Preparation and evaluation of fruit face wash","authors":"Avinash Kumar Reddy G, Samitha Krishna S, Bhavana P, Neelima S, Sanjidha S, Prathyusha S","doi":"10.26452/ijrpp.v9i1.1159","DOIUrl":"https://doi.org/10.26452/ijrpp.v9i1.1159","url":null,"abstract":"Human skin is the highly exposed body organ to pathogens and disease causing micro organism. So it requires a lot of protection and care. Chemical antibiotic gels and anti-acne washes or masks are currently available in the market which are composed of synthetic drugs. Unfortunately these drugs have potential side effects besides curing diseases and fighting pathogens. The need brings us the idea of incorporating the herbs in the formulations to treat acnes. In the current research, herbal face wash is prepared and evaluated for its properties and potency. The Fruit Facewash gel containing grape seed and pulp extract, cucumber juice, orange juice, lemon juice using carbopol 940 was prepared with good consistency. The reduction in the growth of microorganisms is clearly seen in the dishes contained Gel-CRB marked (aft CRB) respectively.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116331966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DM otherwise diabetes is now a days an epidemic with the percentage of patient population rising to almost 10% of the world population. Out of all the DM complications, cataract leads the way contributing to disabilities to about 60% of diabetic population. But the pathogenesis of DM cataract is still a half-understood area of medicine there by posing a problem in the therapy. The data that we have till now gives us enough evidence to advocate the oxidative stress has a major role for the pathogenesis of DM complications like DMnephropathy, DMneuropathy, and cardiac hypertrophy, which suggests the oxidative stress is a central feature of diabetes. In the current research, the pharmacological evaluation of Fisetin for its DM based anti-cataract property was performed. This research concentrates to estimate the possible involvement of Nrf-2 / heme oxygenase (HO)-pathway in the observed therapeutic effect, if any. The data obtained in this study also indicate that the observed beneficial effects mainly due to activation of Nrf2/HO-1 pathway. These effects probably result in increased tissue anti-oxidant status as well as decreased free radical production, which ultimately responsible for the observed beneficial effects of Fisetin against hyperglycemia-induced cataract.
{"title":"Pharmacological study on the possible involvement of a Nrf2 -Heme oxygenase pathways in anti-cataract activity of fisetin","authors":"Krishna Reddy BV, Avinash Kumar Reddy G, Sujitha V, Manasa A","doi":"10.26452/ijrpp.v10i1.1156","DOIUrl":"https://doi.org/10.26452/ijrpp.v10i1.1156","url":null,"abstract":"DM otherwise diabetes is now a days an epidemic with the percentage of patient population rising to almost 10% of the world population. Out of all the DM complications, cataract leads the way contributing to disabilities to about 60% of diabetic population. But the pathogenesis of DM cataract is still a half-understood area of medicine there by posing a problem in the therapy. The data that we have till now gives us enough evidence to advocate the oxidative stress has a major role for the pathogenesis of DM complications like DMnephropathy, DMneuropathy, and cardiac hypertrophy, which suggests the oxidative stress is a central feature of diabetes. In the current research, the pharmacological evaluation of Fisetin for its DM based anti-cataract property was performed. This research concentrates to estimate the possible involvement of Nrf-2 / heme oxygenase (HO)-pathway in the observed therapeutic effect, if any. The data obtained in this study also indicate that the observed beneficial effects mainly due to activation of Nrf2/HO-1 pathway. These effects probably result in increased tissue anti-oxidant status as well as decreased free radical production, which ultimately responsible for the observed beneficial effects of Fisetin against hyperglycemia-induced cataract.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"241 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113996678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-17DOI: 10.26452/ijrpp.v10i1.1147
B. Dwarakesh, Ananda Deepak, M. AsifaNikhat, K. Bhaskarreddy, S. BritoRaj
Among disparate infectious diseases viral infection in particular challenges survival of mankind across the globe. By superseding those events, 2019 novel (CoVID-19) or SARS-CoV-2 has become a new human health crisis threatening the world. Corona viruses (CoV) are large family of viruses that affects birds and mammals. In humans, Corona virus can cause respiratory tract infection ranging from the common cold to more serious infection such as SARS (Severe acute respiratory syndrome), MERS (Middle East Respiratory Syndrome) and CoVID-19 (Corona Virus Disease 2019) which can also become lethal. The Novel corona virus (CoVID-19) originated in 2019, is a novel virus which has not been identified in humans since past. At present, the source of CoVID-19 is not known. Although the infection is presumed to be in origin, person to person transmission is evident. Many supportive and symptomatic therapies where being carried out by the Medical practitioners as per the instructions of World Health Organization (WHO) with a hypothesis and there is no evidence that it works against CoVID-19. best to lower the current crises of infection is prevention and many measures that boosts the immunity are following by the people as directed by the Ministry of AYUSH.
{"title":"Novel corona virus-2019 (SARS CoV-2)","authors":"B. Dwarakesh, Ananda Deepak, M. AsifaNikhat, K. Bhaskarreddy, S. BritoRaj","doi":"10.26452/ijrpp.v10i1.1147","DOIUrl":"https://doi.org/10.26452/ijrpp.v10i1.1147","url":null,"abstract":"Among disparate infectious diseases viral infection in particular challenges survival of mankind across the globe. By superseding those events, 2019 novel (CoVID-19) or SARS-CoV-2 has become a new human health crisis threatening the world. Corona viruses (CoV) are large family of viruses that affects birds and mammals. In humans, Corona virus can cause respiratory tract infection ranging from the common cold to more serious infection such as SARS (Severe acute respiratory syndrome), MERS (Middle East Respiratory Syndrome) and CoVID-19 (Corona Virus Disease 2019) which can also become lethal. The Novel corona virus (CoVID-19) originated in 2019, is a novel virus which has not been identified in humans since past. At present, the source of CoVID-19 is not known. Although the infection is presumed to be in origin, person to person transmission is evident. Many supportive and symptomatic therapies where being carried out by the Medical practitioners as per the instructions of World Health Organization (WHO) with a hypothesis and there is no evidence that it works against CoVID-19. best to lower the current crises of infection is prevention and many measures that boosts the immunity are following by the people as directed by the Ministry of AYUSH.","PeriodicalId":296074,"journal":{"name":"International Journal of Research in Phytochemistry and Pharmacology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115067047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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