M. Amjad, I. Hyder, R. A. Rehman, H. Shafi, M. Seerwan, Ali Shandar Durrani
Objective: To compare efficacy and safety of intracorporeal pneumatic lithotripsy versus extracorporeal shock wave lithotripsy (ESWL) in patients of upper ureteric stones having stone size from 10 to 15 mm. Study Design: Randomized control trial Setting: Study was done at department of Urology, Nishtar Hospital Multan. The duration of the study was from January 2021 to January 2022. Methodology: 140 patients were divided into two groups randomly. In group A ureterorenoscopy (URS) with Pneumatic Lithotripsy was used for proximal ureteric stones management. URS was performed under general anesthesia. In group B, ESWL was done for the management of proximal ureteric stones identified by ultrasound and fluoroscopy. SPSS version 23 was used for data analysis. Results: In this study In Intracorporeal Pneumatic Lithotripsy group the stone cleared in 90% patients and in ESWL group the stone cleared in 78.6% patients (p-value=0.595). In Intracorporeal Pneumatic Lithotripsy group the pain was present in 14.3% patients and in ESWL group the pain was present in 18.6% patients (p-value=0.494). In Intracorporeal Pneumatic Lithotripsy group the bleeding was noted in 25.7% patients and in ESWL group the bleeding was noted in 40.0% patients (p-value=0.072). Conclusion: This study concluded that intracorporeal pneumatic lithotripsy is a good alternate of ESWL for the management of upper ureteric stones (having size from 10 to 15mm). Keywords: Urolithiasis, Intracorporeal Pneumatic Lithotripsy, Extracorporeal Shock Wave Lithotripsy, Ureteric Stone
目的:比较体外冲击波碎石术(ESWL)与体外气压碎石术(ESWL)治疗10 ~ 15mm输尿管上段结石的疗效和安全性。研究设计:随机对照试验设置:研究在木尔坦Nishtar医院泌尿科完成。研究时间为2021年1月至2022年1月。方法:140例患者随机分为两组。A组采用输尿管镜联合气压碎石术治疗输尿管近端结石。全麻下进行尿潴留。B组对经超声和透视检查发现的输尿管近端结石行体外冲击波碎石治疗。使用SPSS version 23进行数据分析。结果:体外气压碎石组结石清除率为90%，体外碎石组结石清除率为78.6% (p值=0.595)。体外气压碎石组疼痛发生率为14.3%，体外碎石组为18.6% (p值=0.494)。体外气压碎石组出血发生率为25.7%，体外冲击波碎石组出血发生率为40.0% (p值=0.072)。结论:体外气压碎石术是治疗输尿管上段结石(直径10 ~ 15mm)的较好方法。关键词:尿石症，体外气压碎石，体外冲击波碎石，输尿管结石
{"title":"Comparison between Intracorporeal Pneumatic Lithotripsy and Extracorporeal Shock Wave Lithotripsy (ESWL) in terms of efficacy and Safety for Management of Proximal Ureteric Stones","authors":"M. Amjad, I. Hyder, R. A. Rehman, H. Shafi, M. Seerwan, Ali Shandar Durrani","doi":"10.53350/pjmhs221610318","DOIUrl":"https://doi.org/10.53350/pjmhs221610318","url":null,"abstract":"Objective: To compare efficacy and safety of intracorporeal pneumatic lithotripsy versus extracorporeal shock wave lithotripsy (ESWL) in patients of upper ureteric stones having stone size from 10 to 15 mm. Study Design: Randomized control trial Setting: Study was done at department of Urology, Nishtar Hospital Multan. The duration of the study was from January 2021 to January 2022. Methodology: 140 patients were divided into two groups randomly. In group A ureterorenoscopy (URS) with Pneumatic Lithotripsy was used for proximal ureteric stones management. URS was performed under general anesthesia. In group B, ESWL was done for the management of proximal ureteric stones identified by ultrasound and fluoroscopy. SPSS version 23 was used for data analysis. Results: In this study In Intracorporeal Pneumatic Lithotripsy group the stone cleared in 90% patients and in ESWL group the stone cleared in 78.6% patients (p-value=0.595). In Intracorporeal Pneumatic Lithotripsy group the pain was present in 14.3% patients and in ESWL group the pain was present in 18.6% patients (p-value=0.494). In Intracorporeal Pneumatic Lithotripsy group the bleeding was noted in 25.7% patients and in ESWL group the bleeding was noted in 40.0% patients (p-value=0.072). Conclusion: This study concluded that intracorporeal pneumatic lithotripsy is a good alternate of ESWL for the management of upper ureteric stones (having size from 10 to 15mm). Keywords: Urolithiasis, Intracorporeal Pneumatic Lithotripsy, Extracorporeal Shock Wave Lithotripsy, Ureteric Stone","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122700383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hina Pirzada, Sehrish Ali, A. Mudassir, Maham Waseem, Humaira Zulfiqar Saifee
Objective: To identify the thyroid dysfunction in pregnancy and its outcomes. Study Design: Prospective study Place and Duration of Study: Department of Obstetrics & Gynaecology, Sheikh Khalifa Bin Zayed Al-Nahyan Hospital/CMH Muzaffarabad Azad Kashmir from 1st October 2021 to 31st March 2022. Methodology: Seventeen hundred pregnant women in third trimester were screened. Out of them, 50 were identified to be suffering from thyroid dysfunction. The pregnant women in their third trimester and within the age group of 18-40 years were recruited. By using enzyme linked sorbent assay the serum levels of TSH, Free T3 and Free T4 were determined for each woman as a routine clinical health check-up practice. The women who had raised analytical levels as well as correlated clinical history were identified as suffering from thyroid dysfunction. These women were further followed for the outcomes of their pregnancy. Results: The prevalence of thyroid dysfunction was 2.9%. There were 42% pregnant women suffering from subclinical hypothyroidism while 36% were having overt hypothyroidism and 12% had subclinical hyperthyroidism. Conclusion: The major outcome of thyroid dysfunction in pregnancy in terms of maternal and fetal outcomes was presence of anemia in women and was 4.89%. In women considering fetal outcomes, low birth weight was observed in 32% neonates with a need of neonatal intensive care for 42% of newborns were seen. Keywords: Thyroid dysfunction, Pregnancy, Outcome
目的:探讨妊娠期甲状腺功能障碍及其预后。研究设计:前瞻性研究地点和研究时间:2021年10月1日至2022年3月31日，Sheikh Khalifa Bin Zayed Al-Nahyan医院/CMH Muzaffarabad Azad Kashmir妇产科。方法:对1700名妊娠晚期的孕妇进行了筛查。其中，有50人被诊断患有甲状腺功能障碍。研究人员招募了年龄在18-40岁之间的妊娠晚期的孕妇。采用酶联吸附法测定血清TSH、游离T3、游离T4水平，作为临床常规健康检查。分析水平和相关临床病史均升高的妇女被确定为患有甲状腺功能障碍。对这些妇女的怀孕结果进行了进一步的跟踪调查。结果:甲状腺功能障碍患病率为2.9%。42%的孕妇患有亚临床甲状腺功能减退症，36%的孕妇有明显的甲状腺功能减退症，12%的孕妇有亚临床甲状腺功能亢进症。结论:妊娠期甲状腺功能障碍的主要结局(母胎结局)是妇女出现贫血，占4.89%。在考虑胎儿结局的妇女中，32%的新生儿观察到低出生体重，42%的新生儿需要新生儿重症监护。关键词:甲状腺功能障碍，妊娠，结局
{"title":"Thyroid Dysfunction in Pregnancy and its Outcome","authors":"Hina Pirzada, Sehrish Ali, A. Mudassir, Maham Waseem, Humaira Zulfiqar Saifee","doi":"10.53350/pjmhs221610339","DOIUrl":"https://doi.org/10.53350/pjmhs221610339","url":null,"abstract":"Objective: To identify the thyroid dysfunction in pregnancy and its outcomes. Study Design: Prospective study Place and Duration of Study: Department of Obstetrics & Gynaecology, Sheikh Khalifa Bin Zayed Al-Nahyan Hospital/CMH Muzaffarabad Azad Kashmir from 1st October 2021 to 31st March 2022. Methodology: Seventeen hundred pregnant women in third trimester were screened. Out of them, 50 were identified to be suffering from thyroid dysfunction. The pregnant women in their third trimester and within the age group of 18-40 years were recruited. By using enzyme linked sorbent assay the serum levels of TSH, Free T3 and Free T4 were determined for each woman as a routine clinical health check-up practice. The women who had raised analytical levels as well as correlated clinical history were identified as suffering from thyroid dysfunction. These women were further followed for the outcomes of their pregnancy. Results: The prevalence of thyroid dysfunction was 2.9%. There were 42% pregnant women suffering from subclinical hypothyroidism while 36% were having overt hypothyroidism and 12% had subclinical hyperthyroidism. Conclusion: The major outcome of thyroid dysfunction in pregnancy in terms of maternal and fetal outcomes was presence of anemia in women and was 4.89%. In women considering fetal outcomes, low birth weight was observed in 32% neonates with a need of neonatal intensive care for 42% of newborns were seen. Keywords: Thyroid dysfunction, Pregnancy, Outcome","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125879092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Iqbal, Taimoor Ali, M. Anwarullah, Qazi Ziaullah
Objectives: To note the impact of delayed presentation on the surgical outcome of extradural hematoma in traumatic brain injury. Study Design: A case-series study. Place Duration of the Study: Department of Neurosurgery, Lady Reading Hospital Peshawar from July 2018 to June 2019. Methodology: A total of 119 patients of both genders aged 15-45 years suffering from epidural hematoma with history of head trauma presented after 6 hours having size of hematoma above 30 ml (as per axial images of CT brain) were included. Frequency of favorable and unfavorable outcomes were noted after three months of follow-up. Outcome was termed as favorable if patient had good recover or moderate disability. Results: Out of total 119 patients, 89 (74.8%) were male. Unfavorable outcome was noted in 37.8% (n=45) of total patients with delayed presentation to the hospital, while favorable outcome was noted in 62.2% (n=74) of patients. Good recovery and moderate disability were observed in 27.7% (n=31) and 34.5% (n=41) of total patients respectively. While, severe disability and vegetative state was recorded in 26.1% (n=31) and 7.6% (n=9) of patients respectively. Practical Implications: Efforts should be made to increase awareness about timely presentation and interventions for better surgical outcomes among patients of extradural hematoma. Conclusion: Frequency of unfavorable surgical outcome of extradural hematoma found to be 37.8% in head trauma patients with late presentation. Keywords: Extradural Hematoma, Glasgow Coma scale, surgical outcome
{"title":"Impact of Delayed Presentation on the Surgical Outcome of Epidural Hematoma in Traumatic Brain Injury Patients","authors":"A. Iqbal, Taimoor Ali, M. Anwarullah, Qazi Ziaullah","doi":"10.53350/pjmhs221610300","DOIUrl":"https://doi.org/10.53350/pjmhs221610300","url":null,"abstract":"Objectives: To note the impact of delayed presentation on the surgical outcome of extradural hematoma in traumatic brain injury. Study Design: A case-series study. Place Duration of the Study: Department of Neurosurgery, Lady Reading Hospital Peshawar from July 2018 to June 2019. Methodology: A total of 119 patients of both genders aged 15-45 years suffering from epidural hematoma with history of head trauma presented after 6 hours having size of hematoma above 30 ml (as per axial images of CT brain) were included. Frequency of favorable and unfavorable outcomes were noted after three months of follow-up. Outcome was termed as favorable if patient had good recover or moderate disability. Results: Out of total 119 patients, 89 (74.8%) were male. Unfavorable outcome was noted in 37.8% (n=45) of total patients with delayed presentation to the hospital, while favorable outcome was noted in 62.2% (n=74) of patients. Good recovery and moderate disability were observed in 27.7% (n=31) and 34.5% (n=41) of total patients respectively. While, severe disability and vegetative state was recorded in 26.1% (n=31) and 7.6% (n=9) of patients respectively. Practical Implications: Efforts should be made to increase awareness about timely presentation and interventions for better surgical outcomes among patients of extradural hematoma. Conclusion: Frequency of unfavorable surgical outcome of extradural hematoma found to be 37.8% in head trauma patients with late presentation. Keywords: Extradural Hematoma, Glasgow Coma scale, surgical outcome","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121994840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Riaz, Afifa Ehsan, Aliya Raza, Umer Abdullah, M. Mehdi, Ejaz Hussain Sahu
Aim:Patients suffering from Diabetes Mellitus havea largerpossibilityofdeveloping oral diseases furthermore; those who have uncontrolled and long-duration of Diabetes Mellitusare also at a greater risk for acquiringperiodontaldisorders. The present study intended to investigate the association of oral fitness knowledge and attitude with different demographic factorsin patients with Type II Diabetes Mellitus visiting a secondary care provincial hospitalin Sargodha, Pakistan. Methods: The present study was a cross-sectional study piloted at a secondary care provincial hospital in District Sargodha which comprised 180 patients suffering from Type II Diabetes Mellitus.Information was collected using a systematized questionnaire which was handed out to study participants visiting the outpatient department of the hospital. Results:Oral health knowledge of the study participants were cross-tabulated with socio-economic and demographic factors and a significant association was seen with gender(P≤0.001), educational status(P≤0.0001), monthly income(P≤0.002), and marital status(P≤0.001). In the present study, 26% of males and 18% of females had adequate knowledge regarding oral health. Advanced levels of learningand income also transpiredto have a strong association with oral health awarenessand attitude(P≤0.01). Conclusions: Results of the present study suggest that oral well-being knowledge and attitude among patients with Type II Diabetes Mellitus were strongly associated in conjunction withgender, higher levels of education, and income. Based on these outcomes, communal-oriented oral well-being campaigns are indispensable to navigating the standard of living of patients with Type II Diabetes Mellitus. Keywords: Dental, Diabetes Mellitus, Knowledge, Oral Health, Oral complications, Type II Diabetes Mellitus.
{"title":"Impact of Demographic Factors on Oral Health Knowledge and Attitude of patients with Type II Diabetesmellitus Visiting A THQ Hospital in Punjab, Pakistan","authors":"F. Riaz, Afifa Ehsan, Aliya Raza, Umer Abdullah, M. Mehdi, Ejaz Hussain Sahu","doi":"10.53350/pjmhs221610247","DOIUrl":"https://doi.org/10.53350/pjmhs221610247","url":null,"abstract":"Aim:Patients suffering from Diabetes Mellitus havea largerpossibilityofdeveloping oral diseases furthermore; those who have uncontrolled and long-duration of Diabetes Mellitusare also at a greater risk for acquiringperiodontaldisorders. The present study intended to investigate the association of oral fitness knowledge and attitude with different demographic factorsin patients with Type II Diabetes Mellitus visiting a secondary care provincial hospitalin Sargodha, Pakistan. Methods: The present study was a cross-sectional study piloted at a secondary care provincial hospital in District Sargodha which comprised 180 patients suffering from Type II Diabetes Mellitus.Information was collected using a systematized questionnaire which was handed out to study participants visiting the outpatient department of the hospital. Results:Oral health knowledge of the study participants were cross-tabulated with socio-economic and demographic factors and a significant association was seen with gender(P≤0.001), educational status(P≤0.0001), monthly income(P≤0.002), and marital status(P≤0.001). In the present study, 26% of males and 18% of females had adequate knowledge regarding oral health. Advanced levels of learningand income also transpiredto have a strong association with oral health awarenessand attitude(P≤0.01). Conclusions: Results of the present study suggest that oral well-being knowledge and attitude among patients with Type II Diabetes Mellitus were strongly associated in conjunction withgender, higher levels of education, and income. Based on these outcomes, communal-oriented oral well-being campaigns are indispensable to navigating the standard of living of patients with Type II Diabetes Mellitus. Keywords: Dental, Diabetes Mellitus, Knowledge, Oral Health, Oral complications, Type II Diabetes Mellitus.","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128183958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uzma Hasan, M. Fatima, H. Khan, Saeeda Zia, Aatika Khan, M. Habib
Objective: This study was done to evaluate awareness of dental practitioners regarding biocompatibility of dental materials among dental practitioners. Study Design: Cross sectional study Place and duration of study: This study was conducted in Islamic international dental college Islamabad during June 2019 to December 2019. Materials and methods: This was a cross sectional questionnaire based study. Questionnaires were distributed to house officers and post graduate trainees (N=100) of Islamic International Dental Hospital. The recorded data was analyzed using SPSS2015 (version 23) software. Results: 85% of dental practitioners had knowledge about biocompatibility of polymer based materials. 89% were aware of type of adverse reactions associated with latex gloves. 64% of dental practitioners had awareness that eugenol is a cytotoxic substance present in zinc oxide eugenol. 7% of dental practitioners knew about the various methods to diagnose titanium allergy. Practical implication: This study will help the dental practitioners to comprehend what type of allergies are prevalent in their local population and which dental material can give best results without adverse effects. Conclusion: Our participants have sufficient knowledge about the biocompatibility of dental materials but the knowledge about titanium allergy needs to be enhanced. Keywords: awareness, biocompatibility, dental practitioners, dental materials
{"title":"Awareness of Dental Practitioners Regarding Biocompatibilty of Dental Materials","authors":"Uzma Hasan, M. Fatima, H. Khan, Saeeda Zia, Aatika Khan, M. Habib","doi":"10.53350/pjmhs221610420","DOIUrl":"https://doi.org/10.53350/pjmhs221610420","url":null,"abstract":"Objective: This study was done to evaluate awareness of dental practitioners regarding biocompatibility of dental materials among dental practitioners. Study Design: Cross sectional study Place and duration of study: This study was conducted in Islamic international dental college Islamabad during June 2019 to December 2019. Materials and methods: This was a cross sectional questionnaire based study. Questionnaires were distributed to house officers and post graduate trainees (N=100) of Islamic International Dental Hospital. The recorded data was analyzed using SPSS2015 (version 23) software. Results: 85% of dental practitioners had knowledge about biocompatibility of polymer based materials. 89% were aware of type of adverse reactions associated with latex gloves. 64% of dental practitioners had awareness that eugenol is a cytotoxic substance present in zinc oxide eugenol. 7% of dental practitioners knew about the various methods to diagnose titanium allergy. Practical implication: This study will help the dental practitioners to comprehend what type of allergies are prevalent in their local population and which dental material can give best results without adverse effects. Conclusion: Our participants have sufficient knowledge about the biocompatibility of dental materials but the knowledge about titanium allergy needs to be enhanced. Keywords: awareness, biocompatibility, dental practitioners, dental materials","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131828110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Nephrotic syndrome (NS) is characterized by excessive proteinuria (> 3.5 g/day), hypoalbuminemia, and edema. Objectives: The main objective of the study is to find the safety and effectiveness of direct Xa inhibitors vs warfarin in patients with nephrotic syndrome. Material and methods: This cross-sectional study was conducted in Akbar Niazi Teaching Hospital, Barakahu, Islamabad from January 2022 till June 2022. The data were collected from 120 patients which diagnosed with nephrotic syndrome. After permission from hospital ethical committee, total 120 patients meeting the inclusion and exclusion criteria was enrolled in the study. Detailed history of kidney disease and physical examination was done to meet the inclusion and exclusion criteria. Informed consent was obtained. Results: The data was collected from 120 patients. Out of 120 participants, 60 were treated with warfarin while 60 were considered as control group. Median age was 26 years in group I and 25.3 years in group II (p=0.705). Female cases counted for 41 (86%) and 19 (14%) in I and II groups, respectively. Risk factors, clinical presentation, affected vessels and AF for both groups are depicted in Table I. Results from both groups were comparable and statistically, no significant differences were observed (p• value more than 0.05). Practical implication: This study will help in treating nephrotic syndrome and kidney complications. Conclusion: It is concluded that awareness about nephrotic syndrome in patients were low and its prevalence continues to remain high and is likely to increase globally. Direct Xa inhibitors were associated with lower hazards of kidney complications and mortality than warfarin in patients with nephrotic syndrome. Keywords: Nephrotic, Syndrome, Complications, Mortality, Warfarin
{"title":"Safety and Effectiveness of Direct Xa Inhibitors vs Warfarin in Patients with Nephrotic Syndrome","authors":"Ayesha Shahjahan, Syed Irfan Ahmed, A. Jamal","doi":"10.53350/pjmhs221610474","DOIUrl":"https://doi.org/10.53350/pjmhs221610474","url":null,"abstract":"Introduction: Nephrotic syndrome (NS) is characterized by excessive proteinuria (> 3.5 g/day), hypoalbuminemia, and edema. Objectives: The main objective of the study is to find the safety and effectiveness of direct Xa inhibitors vs warfarin in patients with nephrotic syndrome. Material and methods: This cross-sectional study was conducted in Akbar Niazi Teaching Hospital, Barakahu, Islamabad from January 2022 till June 2022. The data were collected from 120 patients which diagnosed with nephrotic syndrome. After permission from hospital ethical committee, total 120 patients meeting the inclusion and exclusion criteria was enrolled in the study. Detailed history of kidney disease and physical examination was done to meet the inclusion and exclusion criteria. Informed consent was obtained. Results: The data was collected from 120 patients. Out of 120 participants, 60 were treated with warfarin while 60 were considered as control group. Median age was 26 years in group I and 25.3 years in group II (p=0.705). Female cases counted for 41 (86%) and 19 (14%) in I and II groups, respectively. Risk factors, clinical presentation, affected vessels and AF for both groups are depicted in Table I. Results from both groups were comparable and statistically, no significant differences were observed (p• value more than 0.05). Practical implication: This study will help in treating nephrotic syndrome and kidney complications. Conclusion: It is concluded that awareness about nephrotic syndrome in patients were low and its prevalence continues to remain high and is likely to increase globally. Direct Xa inhibitors were associated with lower hazards of kidney complications and mortality than warfarin in patients with nephrotic syndrome. Keywords: Nephrotic, Syndrome, Complications, Mortality, Warfarin","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"8 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129669965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehwish Iqbal, Athar Razzaq, F. A. Malik, Muhammad Amjad Ali, Muhammad Imran, Maham Shehzadi
Objective: to determine the association of lactate clearance with morbidity and mortality in neonates with sepsis and septic shock at neonatology department of Recep Tayyip Erdogan Hospital Muzaffargarh. Methods: This prospective cohort study was carried out at department of neonatology of Recep Tayyip Erdogan Hospital Muzaffargarh from January 2021 to June 2021. Term neonates, aged less than 28 days and diagnosed as the cases of sepsis, were included. After taking demographic information, a detailed medical history was obtained, and a complete clinical examination was done. Blood samples were taken from all the patients and sent to the Hospital diagnostic laboratory to evaluate the CBC, liver function test, serum creatinine level, coagulation profile, CRP, blood culture, and serum lactate level. All the data were collected by using structured study proforma, and SPSS version 26 was used for the purpose of data analysis. Results: A total of 56 septic neonates were studied, their mean age was 13.14+7.79 days. Females were 51.8% and males were 48.2%. Blood culture was positive in 75.0% of the cases, and CRP was positive in 98.2% of the cases. Overall average of serum lactate at baseline was 2.67+1.73, at 6 hours was 1.91+0.98 and at 24 hours average of serum lactate was 0.21+0.10. 50% of the cases had AKI, 50.0% had AHI, cardiac failure was in 26.8% of the cases, 30.4% of the cases had need of ventilation, and the mortality rate was 35.7%. Septic neonatal morbidity and mortality were statistically insignificant according to serum lactate at baseline and at 24 hours (p >0.05). Despite the fact that serum lactate at 6 hours was significantly associated with mortality and the need for ventilation (p 0.05), Conclusion: As per the study conclusion, neonatal sepsis and septic shock are highly responsible for neonatal morbidity and mortality. Lactate clearance at six hours was found to be significantly related to neonatal mortality and the need for ventilation. Although lactate clearance at 6 hours is observed to be a predictor of neonatal mortality in neonates with sepsis and septic shock, Keywords: Neonatal sepsis, lactate clearance, morbidity, mortality
目的:探讨穆扎法加尔市雷杰普·塔伊普·埃尔多安医院新生儿科脓毒症和感染性休克新生儿乳酸清除率与发病率和死亡率的关系。方法:本前瞻性队列研究于2021年1月至2021年6月在穆扎法加尔市雷杰普·塔伊普·埃尔多安医院新生儿科进行。年龄小于28天并被诊断为败血症的足月新生儿被纳入研究。在获得人口统计信息后，获得了详细的病史，并进行了完整的临床检查。所有患者均采血，送往医院诊断实验室进行CBC、肝功能、血清肌酐水平、凝血特征、CRP、血培养和血清乳酸水平评估。所有数据的收集采用结构化研究形式，数据分析使用SPSS version 26。结果:本组共56例败血症新生儿，平均年龄13.14+7.79天。女性占51.8%，男性占48.2%。血培养阳性率为75.0%，CRP阳性率为98.2%。基线时血清乳酸总平均值为2.67+1.73,6小时时为1.91+0.98,24小时时为0.21+0.10。AKI占50%，AHI占50.0%，心衰占26.8%，需通气占30.4%，死亡率为35.7%。根据基线和24小时血清乳酸水平比较，脓毒性新生儿发病率和死亡率均无统计学意义(p >0.05)。尽管6小时血清乳酸与新生儿死亡率和通气需求显著相关(p < 0.05)，结论:根据研究结论，新生儿脓毒症和感染性休克是新生儿发病率和死亡率的重要原因。发现6小时乳酸清除率与新生儿死亡率和通气需求显著相关。虽然观察到6小时乳酸清除率是脓毒症和脓毒性休克新生儿死亡率的预测指标，但关键词:新生儿脓毒症，乳酸清除率，发病率，死亡率
{"title":"Association of Lactate Clearance with Morbidity and Mortality in Neonates with Sepsis and Septic Shock at RECEP Tayyip Erdogan Hospital Muzaffargarh","authors":"Mehwish Iqbal, Athar Razzaq, F. A. Malik, Muhammad Amjad Ali, Muhammad Imran, Maham Shehzadi","doi":"10.53350/pjmhs221610471","DOIUrl":"https://doi.org/10.53350/pjmhs221610471","url":null,"abstract":"Objective: to determine the association of lactate clearance with morbidity and mortality in neonates with sepsis and septic shock at neonatology department of Recep Tayyip Erdogan Hospital Muzaffargarh. Methods: This prospective cohort study was carried out at department of neonatology of Recep Tayyip Erdogan Hospital Muzaffargarh from January 2021 to June 2021. Term neonates, aged less than 28 days and diagnosed as the cases of sepsis, were included. After taking demographic information, a detailed medical history was obtained, and a complete clinical examination was done. Blood samples were taken from all the patients and sent to the Hospital diagnostic laboratory to evaluate the CBC, liver function test, serum creatinine level, coagulation profile, CRP, blood culture, and serum lactate level. All the data were collected by using structured study proforma, and SPSS version 26 was used for the purpose of data analysis. Results: A total of 56 septic neonates were studied, their mean age was 13.14+7.79 days. Females were 51.8% and males were 48.2%. Blood culture was positive in 75.0% of the cases, and CRP was positive in 98.2% of the cases. Overall average of serum lactate at baseline was 2.67+1.73, at 6 hours was 1.91+0.98 and at 24 hours average of serum lactate was 0.21+0.10. 50% of the cases had AKI, 50.0% had AHI, cardiac failure was in 26.8% of the cases, 30.4% of the cases had need of ventilation, and the mortality rate was 35.7%. Septic neonatal morbidity and mortality were statistically insignificant according to serum lactate at baseline and at 24 hours (p >0.05). Despite the fact that serum lactate at 6 hours was significantly associated with mortality and the need for ventilation (p 0.05), Conclusion: As per the study conclusion, neonatal sepsis and septic shock are highly responsible for neonatal morbidity and mortality. Lactate clearance at six hours was found to be significantly related to neonatal mortality and the need for ventilation. Although lactate clearance at 6 hours is observed to be a predictor of neonatal mortality in neonates with sepsis and septic shock, Keywords: Neonatal sepsis, lactate clearance, morbidity, mortality","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133153023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saeed Zaman, Masud Khan, Samina Tabussam, S. Nawaz, A. Ayub, S. Shah
Objective: To compare the efficacy of ferrous sulphate versus iron Polymaltose complex (IPC) in the treatment of iron deficiency anemia (IDA) in children. Study Design: Randomized controlled trial. Place and Duration: Department of Pediatrics, Combined Military Hospital, Kharian Pakistan from Jan 2019 to Mar 2020. Methodology: A total of 150 children with IDA were included. At baseline, blood sample was obtained for assessment of hemoglobin level. Then children were randomly divided in two groups. In Group-A (n=75), patients were given ferrous sulphate while in In Group-B (n=75), IPC was given. After 12-weeks of treatment, hemoglobin level was assessed. Efficacy was labeled as “yes” if there was 2 g/dl hemoglobin improvement. Results: In a total of 150 children, the mean age in Group-A was 6.56±2.33 years and 6.05±2.78 years in Group-B. In group A, there were 37 (49.3%) males and 38 (50.7%) females while in Group-B there were 35 (46.7%) males and 40 (53.3%) females. At baseline in group A, the mean hemoglobin level was 6.07±1.12 g/dl while in group B, it was 6.16±1.14 g/dl. After 12-weeks, in Group-A the mean hemoglobin level was 9.44±1.61 g/dl whereas in Group-B, it was 8.83±2.01 g/dl (p=0.0420). There was insignificant difference observed for efficacy in both groups (p-value = 0.051). Practical Implications: Both IPC and ferrous sulphate resulted in significant rise in hemoglobin levels but ferrous sulphate showed better results in comparison to IPC. Conclusion: Although in comparison to IPC, ferrous sulphate resulted in significantly better rise in hemoglobin levels among children with IDA, but overall efficacy between the two studied drugs was relatively similar. Keywords: Ferrous sulphate, iron Polymaltose complex, iron deficiency anemia.
{"title":"Comparison of Ferrous Sulphate Versus Iron Polymaltose Complex in the Treatment of Iron Deficiency Anemia in Children","authors":"Saeed Zaman, Masud Khan, Samina Tabussam, S. Nawaz, A. Ayub, S. Shah","doi":"10.53350/pjmhs221610308","DOIUrl":"https://doi.org/10.53350/pjmhs221610308","url":null,"abstract":"Objective: To compare the efficacy of ferrous sulphate versus iron Polymaltose complex (IPC) in the treatment of iron deficiency anemia (IDA) in children. Study Design: Randomized controlled trial. Place and Duration: Department of Pediatrics, Combined Military Hospital, Kharian Pakistan from Jan 2019 to Mar 2020. Methodology: A total of 150 children with IDA were included. At baseline, blood sample was obtained for assessment of hemoglobin level. Then children were randomly divided in two groups. In Group-A (n=75), patients were given ferrous sulphate while in In Group-B (n=75), IPC was given. After 12-weeks of treatment, hemoglobin level was assessed. Efficacy was labeled as “yes” if there was 2 g/dl hemoglobin improvement. Results: In a total of 150 children, the mean age in Group-A was 6.56±2.33 years and 6.05±2.78 years in Group-B. In group A, there were 37 (49.3%) males and 38 (50.7%) females while in Group-B there were 35 (46.7%) males and 40 (53.3%) females. At baseline in group A, the mean hemoglobin level was 6.07±1.12 g/dl while in group B, it was 6.16±1.14 g/dl. After 12-weeks, in Group-A the mean hemoglobin level was 9.44±1.61 g/dl whereas in Group-B, it was 8.83±2.01 g/dl (p=0.0420). There was insignificant difference observed for efficacy in both groups (p-value = 0.051). Practical Implications: Both IPC and ferrous sulphate resulted in significant rise in hemoglobin levels but ferrous sulphate showed better results in comparison to IPC. Conclusion: Although in comparison to IPC, ferrous sulphate resulted in significantly better rise in hemoglobin levels among children with IDA, but overall efficacy between the two studied drugs was relatively similar. Keywords: Ferrous sulphate, iron Polymaltose complex, iron deficiency anemia.","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123671713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naseemullah, Abdul Qayum Khan, F. Khan, Shahzad Rashid Awan, Sarah Riaz Khan
Background: Melasma is a frequently observed dermatological condition. The conventional therapies for melasma improvement established to date are mainly categorized into chemical peeling, topical agents and laser therapy. A new technique to reduce discomfort and post-laser discoloration induced by heat effects is the picosecond laser system. Objective: To find out efficacy of 2% kojic acid containing formulation vs picosecond laser for treatment of melasma Methodology: This was comparative randomized controlled study carried out at the department of dermatology Qazi Hussain Ahmad Medical Complex Nowshera and alshifa clinic and skin aesthetic, Nowshera for duration of one year from July 2020 to July 2021. Totally, 300 patients were included in the study. Each picosecond laser and kojic acid group comprise of 150 patients. All the information was recorded at the baseline and each following visit. Severity Index (MASI) score was calculated and color photographs were taken of all patients. Results: At baseline, the mean MASI scores for picosecond laser and kojic acid group was 10.5±3.5 and 11.2±4.1 respectively (p=0.31). In both the group significant improvement occur in the MASI scores at weeks 12 and week 20. In picosecond laser group, the most remarkable improvement rate (62%) was noted while in kojic acid containing formulation group the rate of improvement was 41.96%. Conclusion: Our study concludes that picosecond Laser device is an efficient and well-tolerated therapeutic option for melasma as compared to kojic acid containing formulation. Keywords: Efficacy; Kojic acid; Picosecond laser; Melasma
{"title":"Efficacy of 2% Kojic Acid Containing Formulation vs Picosecond Laser for Treatment of Melasma","authors":"Naseemullah, Abdul Qayum Khan, F. Khan, Shahzad Rashid Awan, Sarah Riaz Khan","doi":"10.53350/pjmhs221610368","DOIUrl":"https://doi.org/10.53350/pjmhs221610368","url":null,"abstract":"Background: Melasma is a frequently observed dermatological condition. The conventional therapies for melasma improvement established to date are mainly categorized into chemical peeling, topical agents and laser therapy. A new technique to reduce discomfort and post-laser discoloration induced by heat effects is the picosecond laser system. Objective: To find out efficacy of 2% kojic acid containing formulation vs picosecond laser for treatment of melasma Methodology: This was comparative randomized controlled study carried out at the department of dermatology Qazi Hussain Ahmad Medical Complex Nowshera and alshifa clinic and skin aesthetic, Nowshera for duration of one year from July 2020 to July 2021. Totally, 300 patients were included in the study. Each picosecond laser and kojic acid group comprise of 150 patients. All the information was recorded at the baseline and each following visit. Severity Index (MASI) score was calculated and color photographs were taken of all patients. Results: At baseline, the mean MASI scores for picosecond laser and kojic acid group was 10.5±3.5 and 11.2±4.1 respectively (p=0.31). In both the group significant improvement occur in the MASI scores at weeks 12 and week 20. In picosecond laser group, the most remarkable improvement rate (62%) was noted while in kojic acid containing formulation group the rate of improvement was 41.96%. Conclusion: Our study concludes that picosecond Laser device is an efficient and well-tolerated therapeutic option for melasma as compared to kojic acid containing formulation. Keywords: Efficacy; Kojic acid; Picosecond laser; Melasma","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115824806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aqeel Moazzam, Agha Momin, K. Saeed, N. Mughal, Muhammad Akhtar
Objective: To compare the closed reduction and percutaneous K wire fixation method outcomes in the treatment of supracondylar displaced fracture of elbow in children. Study Design: Prospective study Place and Duration of Study: Department of Orthopaedics, Arif Memorial Teaching Hospital, Lahore from 2nd April 2021 to 31st September 2021. Methodology: One hundred and seventy children were included. Those children having supracondylar displaced fractures of elbow with a grade 3 were included in the study as participant. K wires of 1.5-2cm were used after closed reductions were satisfactorily achieved. Padded-Back slabs at posterior position of elbow were applied. At 2 weeks’ suture removal and pin configuration was also observed. Callus production was observed through radiological x ray images. Results: Majority of the children belonged to the age group of 6-10 years. There were 59.4% males while 40.58% were females. Within the total number of cases 55% were administered two lateral parallel K wires while 45% were administered cross K wire. Pin tract infection was formed in 2.5% of lateral K wire cases while it was observed in only 1.2 % of Cross wire cases. Most of the children got the fracture while playing a sport. The recovery phase was of 3.5 months while fracture joined in a mean value of 1 month. Conclusion: Lateral percutaneous pin technique for the management of supracondylar fracture of humerus bone is a more suitable method and offers same results without involvement of iatrogenic ulnar nerve injury. Keywords: Humerus, Ulnar nerve, Pin method, K-wire, Deformation
{"title":"Supracondylar Displaced Fracture of Elbow in Children Treated with Closed Reduction and Percutaneous K Wire Fixation","authors":"Aqeel Moazzam, Agha Momin, K. Saeed, N. Mughal, Muhammad Akhtar","doi":"10.53350/pjmhs221610328","DOIUrl":"https://doi.org/10.53350/pjmhs221610328","url":null,"abstract":"Objective: To compare the closed reduction and percutaneous K wire fixation method outcomes in the treatment of supracondylar displaced fracture of elbow in children. Study Design: Prospective study Place and Duration of Study: Department of Orthopaedics, Arif Memorial Teaching Hospital, Lahore from 2nd April 2021 to 31st September 2021. Methodology: One hundred and seventy children were included. Those children having supracondylar displaced fractures of elbow with a grade 3 were included in the study as participant. K wires of 1.5-2cm were used after closed reductions were satisfactorily achieved. Padded-Back slabs at posterior position of elbow were applied. At 2 weeks’ suture removal and pin configuration was also observed. Callus production was observed through radiological x ray images. Results: Majority of the children belonged to the age group of 6-10 years. There were 59.4% males while 40.58% were females. Within the total number of cases 55% were administered two lateral parallel K wires while 45% were administered cross K wire. Pin tract infection was formed in 2.5% of lateral K wire cases while it was observed in only 1.2 % of Cross wire cases. Most of the children got the fracture while playing a sport. The recovery phase was of 3.5 months while fracture joined in a mean value of 1 month. Conclusion: Lateral percutaneous pin technique for the management of supracondylar fracture of humerus bone is a more suitable method and offers same results without involvement of iatrogenic ulnar nerve injury. Keywords: Humerus, Ulnar nerve, Pin method, K-wire, Deformation","PeriodicalId":296492,"journal":{"name":"Pakistan Journal of Medical & Health Sciences","volume":"717 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130073787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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