首页 > 最新文献

ARP Rheumatology最新文献

英文 中文
Gastrointestinal bleeding - an atypical presentation of granulomatosis with polyangiitis. 消化道出血--多血管炎肉芽肿病的非典型表现。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/GYJZ4840
Ana Catarina Moniz, Marta Teixeira Almeida, Bruno Pereira, Cristina Ponte, Ana Valido
{"title":"Gastrointestinal bleeding - an atypical presentation of granulomatosis with polyangiitis.","authors":"Ana Catarina Moniz, Marta Teixeira Almeida, Bruno Pereira, Cristina Ponte, Ana Valido","doi":"10.63032/GYJZ4840","DOIUrl":"10.63032/GYJZ4840","url":null,"abstract":"","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"243-245"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota in axial spondyloarthritis : genetics, medications and future treatments. 轴性脊柱关节炎中的肠道微生物群:遗传学、药物和未来疗法。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/WUII1201
Nehal Yemula, Riyad Sheikh

Axial spondyloarthritis, also referred to as ankylosing spondylitis, is a chronic inflammatory condition that predominantly affects the axial spine but may also present with peripheral arthritis. It falls within the umbrella of disorders known as spondyloarthropathies. In addition to axial spondyloarthritis, this group includes psoriatic arthritis, enteropathic arthritis, reactive arthritis, and undifferentiated spondyloarthropathy, with axial spondyloarthritis being one of the most common. The overall mechanisms underlying the development of axial spondyloarthritis are complex and multifactorial. There is a significant and well-recognized association between axial spondyloarthritis and the HLA-B27 gene, but there have also been non-HLA genes identified in the disease process, as well as certain inflammatory cytokines that play a role in the inflammatory process, such as tumor necrosis factor (TNF). More recently, there has been research and new evidence linking changes in the gut microbiota to the disease process of axial spondyloarthritis. Research into the role of the gut microbiota and gut dysbiosis is a large, ever-growing field. It has been associated with a multitude of conditions, including axial spondyloarthritis. This mini-review highlights the symbiotic relationship of the gut microbiota with the pathogenesis, therapeutic agents and future treatments of axial spondyloarthritis.

轴性脊柱关节炎又称强直性脊柱炎,是一种慢性炎症,主要影响轴性脊柱,但也可能伴有外周关节炎。它属于脊柱关节病的范畴。除轴性脊柱关节炎外,这一组疾病还包括银屑病关节炎、肠病性关节炎、反应性关节炎和未分化脊柱关节病,其中轴性脊柱关节炎是最常见的疾病之一。轴性脊柱关节炎的总体发病机制是复杂和多因素的。轴性脊柱关节炎与 HLA-B27 基因之间存在明显的、公认的关联,但在疾病过程中也发现了非 HLA 基因,以及某些在炎症过程中发挥作用的炎性细胞因子,如肿瘤坏死因子(TNF)。最近,有研究和新证据表明,肠道微生物群的变化与轴性脊柱关节炎的发病过程有关。对肠道微生物群的作用和肠道菌群失调的研究是一个庞大且不断发展的领域。它与包括轴性脊柱关节炎在内的多种疾病有关。这篇微型综述重点介绍了肠道微生物群与轴性脊柱关节炎的发病机制、治疗药物和未来治疗方法之间的共生关系。
{"title":"Gut microbiota in axial spondyloarthritis : genetics, medications and future treatments.","authors":"Nehal Yemula, Riyad Sheikh","doi":"10.63032/WUII1201","DOIUrl":"10.63032/WUII1201","url":null,"abstract":"<p><p>Axial spondyloarthritis, also referred to as ankylosing spondylitis, is a chronic inflammatory condition that predominantly affects the axial spine but may also present with peripheral arthritis. It falls within the umbrella of disorders known as spondyloarthropathies. In addition to axial spondyloarthritis, this group includes psoriatic arthritis, enteropathic arthritis, reactive arthritis, and undifferentiated spondyloarthropathy, with axial spondyloarthritis being one of the most common. The overall mechanisms underlying the development of axial spondyloarthritis are complex and multifactorial. There is a significant and well-recognized association between axial spondyloarthritis and the HLA-B27 gene, but there have also been non-HLA genes identified in the disease process, as well as certain inflammatory cytokines that play a role in the inflammatory process, such as tumor necrosis factor (TNF). More recently, there has been research and new evidence linking changes in the gut microbiota to the disease process of axial spondyloarthritis. Research into the role of the gut microbiota and gut dysbiosis is a large, ever-growing field. It has been associated with a multitude of conditions, including axial spondyloarthritis. This mini-review highlights the symbiotic relationship of the gut microbiota with the pathogenesis, therapeutic agents and future treatments of axial spondyloarthritis.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"216-225"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drugs and ANCA - an atypical association. 药物与 ANCA--非典型关联。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/PXUT9006
Tiago Beirão, Beatriz Samões, Catarina Rua, Romana Vieira, Joana Abelha-Aleixo, Patricia Pinto, Flavio Costa, Diogo Fonseca, Margarida Mota, Catarina Amorim Meireles, Taciana Videira

Eosinophilic vasculitis is a rare condition due to vascular damage and infiltration of eosinophils into tissues. Antineutrophil cytoplasmic antibody (ANCA), like perinuclear ANCA (p-ANCA), is common in the context of systemic vasculitis, but its association with illicit drug use is unusual. This case report showcases a distinctive scenario featuring a positive pANCA, prompting a meticulous examination of the interplay between vasculitic manifestations and drug abuse.

嗜酸性粒细胞性血管炎是一种罕见的疾病,是由于血管损伤和嗜酸性粒细胞浸润组织所致。抗中性粒细胞胞浆抗体(ANCA)与核周 ANCA(p-ANCA)一样,在全身性血管炎中很常见,但与非法药物使用有关的情况并不多见。本病例报告展示了一种以 pANCA 阳性为特征的独特情况,促使人们对血管炎表现与药物滥用之间的相互作用进行细致的研究。
{"title":"Drugs and ANCA - an atypical association.","authors":"Tiago Beirão, Beatriz Samões, Catarina Rua, Romana Vieira, Joana Abelha-Aleixo, Patricia Pinto, Flavio Costa, Diogo Fonseca, Margarida Mota, Catarina Amorim Meireles, Taciana Videira","doi":"10.63032/PXUT9006","DOIUrl":"10.63032/PXUT9006","url":null,"abstract":"<p><p>Eosinophilic vasculitis is a rare condition due to vascular damage and infiltration of eosinophils into tissues. Antineutrophil cytoplasmic antibody (ANCA), like perinuclear ANCA (p-ANCA), is common in the context of systemic vasculitis, but its association with illicit drug use is unusual. This case report showcases a distinctive scenario featuring a positive pANCA, prompting a meticulous examination of the interplay between vasculitic manifestations and drug abuse.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"246-247"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hard as stone: an exuberant form of calcinosis cutis. 坚硬如石:角质钙化症的一种表现形式。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/WGLX8122
Maria João Cadório, João Oliveira, Fernando Albuquerque, Marcelo Neto, Adriana Carones Esteves, Beatriz Mendes, João Teixeira, Maria João Salvador

Dermatomyositis (DM) is an immune-mediated myopathy characterized by proximal skeletal muscle weakness, muscle inflammation, and distinct skin manifestations. Calcinosis cutis, involving the deposition of insoluble calcium salts in the soft tissues, affects approximately 8% of DM patients1 and poses significant treatment challenges. It can complicate with inflammation, ulceration, pain, and local and systemic infections, resulting in considerable morbidity. We present the case of a 69-year-old-woman with dermatomyositis who developed an exuberant form of calcinosis cutis.

皮肌炎(Dermatomyositis,DM)是一种免疫介导的肌病,其特征是近端骨骼肌无力、肌肉炎症和明显的皮肤表现。皮肤钙化症涉及软组织中不溶性钙盐的沉积,约有8%的皮肌炎患者会受到影响1 ,给治疗带来了巨大挑战。它可并发炎症、溃疡、疼痛以及局部和全身感染,导致相当高的发病率。我们为您介绍一例患有皮肌炎的 69 岁女性患者,她患上了大量的皮肤钙化症。
{"title":"Hard as stone: an exuberant form of calcinosis cutis.","authors":"Maria João Cadório, João Oliveira, Fernando Albuquerque, Marcelo Neto, Adriana Carones Esteves, Beatriz Mendes, João Teixeira, Maria João Salvador","doi":"10.63032/WGLX8122","DOIUrl":"10.63032/WGLX8122","url":null,"abstract":"<p><p>Dermatomyositis (DM) is an immune-mediated myopathy characterized by proximal skeletal muscle weakness, muscle inflammation, and distinct skin manifestations. Calcinosis cutis, involving the deposition of insoluble calcium salts in the soft tissues, affects approximately 8% of DM patients1 and poses significant treatment challenges. It can complicate with inflammation, ulceration, pain, and local and systemic infections, resulting in considerable morbidity. We present the case of a 69-year-old-woman with dermatomyositis who developed an exuberant form of calcinosis cutis.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"237-239"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High disease activity influences the presence of vertebral fractures in rheumatoid arthritis. 类风湿关节炎的高疾病活动度会影响脊椎骨折的发生。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/HLRQ1951
Hideo Sakane, Koichi Okamura, Yoichi Iizuka, Akira Honda, Eiji Takasawa, Tokue Mieda, Yukio Yonemoto, Takahito Suto, Tetsuya Kaneko, Hirotaka Chikuda

Introduction: It is important to assess the risk of vertebral fractures (VFs) in patients with rheumatoid arthritis (RA), as RA is associated with a high risk of VFs. However, the epidemiology and risk of VFs in patients with RA remain inconclusive. The present study therefore clarified the prevalence and associated factors of VFs in patients with RA.

Methods: We included 107 patients (19 men and 88 women) and retrospectively investigated the number and location of VFs, bone mineral density (BMD), RA disease activity score for 28 joints based on C-reactive protein (DAS28-CRP), and history of medication for RA and osteoporosis. Based on the investigated items, we assessed the prevalence of VFs in patients with RA and the association between the clinical parameters of RA patients and VFs.

Results: The average age, disease duration, and DAS28-CRP were 67.9 years old, 14.9 years, and 2.2, respectively. We found that the prevalence of VFs in patients with RA was 30.8%, and 84.8% of patients with VFs and 62.2% of those without VFs had been treated for osteoporosis. We further found that the prevalence of VFs in patients with RA with a history of anti-osteoporotic agent use was 37.8%. In univariate analyses, patients with RA with VFs had significantly higher DAS28-CRP values, a higher rate of corticosteroid use, and lower BMD (p = 0.018, p = 0.004, and p < 0.001, respectively) than those without VFs. A multivariable logistic regression analysis and ordinal logistic analysis revealed that the DAS28-CRP and BMD were independent factors associated with the presence (p = 0.042 and p = 0.011, respectively) and number (p = 0.036 and p = 0.048, respectively) of VFs.

Conclusions: The prevalence of VFs was relatively high in patients with RA, regardless of the use of anti-osteoporotic agents. A high disease activity score and low BMD are associated with the presence and number of VFs in patients with RA. Based on these findings, to reduce VFs in RA patients, it is important to tightly control the disease activity of RA in addition to osteoporosis treatment.

导言:评估类风湿性关节炎(RA)患者椎体骨折(VFs)的风险非常重要,因为 RA 与椎体骨折的高风险相关。然而,RA 患者椎体骨折的流行病学和风险仍无定论。因此,本研究对 RA 患者中 VFs 的患病率和相关因素进行了澄清:我们纳入了 107 名患者(19 名男性和 88 名女性),并回顾性调查了 VFs 的数量和位置、骨矿密度(BMD)、基于 C 反应蛋白(DAS28-CRP)的 28 个关节的 RA 疾病活动度评分以及 RA 和骨质疏松症的用药史。根据所调查的项目,我们评估了VFs在RA患者中的患病率以及RA患者的临床参数与VFs之间的关联:平均年龄、病程和 DAS28-CRP 分别为 67.9 岁、14.9 年和 2.2。我们发现,RA 患者中 VFs 患病率为 30.8%,84.8% 的 VFs 患者和 62.2% 的非 VFs 患者曾接受过骨质疏松症治疗。我们还发现,在有抗骨质疏松药物使用史的 RA 患者中,VFs 患病率为 37.8%。在单变量分析中,与无VFs的RA患者相比,有VFs的RA患者的DAS28-CRP值明显更高,使用皮质类固醇的比例更高,BMD更低(分别为p = 0.018、p = 0.004和p < 0.001)。多变量逻辑回归分析和顺序逻辑分析显示,DAS28-CRP和BMD是与VFs的存在(分别为p = 0.042和p = 0.011)和数量(分别为p = 0.036和p = 0.048)相关的独立因素:结论:无论是否使用抗骨质疏松药物,RA 患者的 VFs 患病率都相对较高。高疾病活动评分和低 BMD 与 RA 患者 VF 的存在和数量有关。基于这些发现,要减少 RA 患者的 VFs,除了骨质疏松症治疗外,严格控制 RA 的疾病活动也很重要。
{"title":"High disease activity influences the presence of vertebral fractures in rheumatoid arthritis.","authors":"Hideo Sakane, Koichi Okamura, Yoichi Iizuka, Akira Honda, Eiji Takasawa, Tokue Mieda, Yukio Yonemoto, Takahito Suto, Tetsuya Kaneko, Hirotaka Chikuda","doi":"10.63032/HLRQ1951","DOIUrl":"10.63032/HLRQ1951","url":null,"abstract":"<p><strong>Introduction: </strong>It is important to assess the risk of vertebral fractures (VFs) in patients with rheumatoid arthritis (RA), as RA is associated with a high risk of VFs. However, the epidemiology and risk of VFs in patients with RA remain inconclusive. The present study therefore clarified the prevalence and associated factors of VFs in patients with RA.</p><p><strong>Methods: </strong>We included 107 patients (19 men and 88 women) and retrospectively investigated the number and location of VFs, bone mineral density (BMD), RA disease activity score for 28 joints based on C-reactive protein (DAS28-CRP), and history of medication for RA and osteoporosis. Based on the investigated items, we assessed the prevalence of VFs in patients with RA and the association between the clinical parameters of RA patients and VFs.</p><p><strong>Results: </strong>The average age, disease duration, and DAS28-CRP were 67.9 years old, 14.9 years, and 2.2, respectively. We found that the prevalence of VFs in patients with RA was 30.8%, and 84.8% of patients with VFs and 62.2% of those without VFs had been treated for osteoporosis. We further found that the prevalence of VFs in patients with RA with a history of anti-osteoporotic agent use was 37.8%. In univariate analyses, patients with RA with VFs had significantly higher DAS28-CRP values, a higher rate of corticosteroid use, and lower BMD (p = 0.018, p = 0.004, and p < 0.001, respectively) than those without VFs. A multivariable logistic regression analysis and ordinal logistic analysis revealed that the DAS28-CRP and BMD were independent factors associated with the presence (p = 0.042 and p = 0.011, respectively) and number (p = 0.036 and p = 0.048, respectively) of VFs.</p><p><strong>Conclusions: </strong>The prevalence of VFs was relatively high in patients with RA, regardless of the use of anti-osteoporotic agents. A high disease activity score and low BMD are associated with the presence and number of VFs in patients with RA. Based on these findings, to reduce VFs in RA patients, it is important to tightly control the disease activity of RA in addition to osteoporosis treatment.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"189-195"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between anxiety and depression symptoms and clinical and pain characteristics in patients with hip and knee osteoarthritis. 髋关节和膝关节骨关节炎患者的焦虑和抑郁症状与临床和疼痛特征之间的关系。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/SDVB2224
Joana Silveira, Daniela Oliveira, Ana Martins, Lúcia Costa, Fani Neto, Joana Ferreira-Gomes, Carlos Vaz

Objectives: This study aimed to estimate the prevalence of anxiety and depression symptoms and explore the association between these symptoms and clinical and pain characteristics in patients with chronic pain (CP) due to hip and knee osteoarthritis (OA).

Methods: In this cross-sectional study, adult patients with CP and knee and/or hip OA were included. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression Scale. Visual analogue scale, Western Ontario and McMaster Universities Arthritis Index (WOMAC) and PainDetect Questionnaire assessed pain characteristics and Health Assessment Questionnaire (HAQ) evaluated functional disability. Correlation coefficients were used to explore the associations between anxiety and depression symptoms and clinical and pain characteristics.

Results: A total of 61 patients (age 66.2±9.4 years, 67.2% female) were included. Most patients (70.5%) had clinically significant anxiety and/or depression symptoms. Patients with anxiety and/or depression symptoms had higher pain severity (p=0.032) and disability (p=0.014). Depression symptoms had a moderate positive correlation with WOMAC physical function subscale (r=0.520), WOMAC total (r=0.511) and HAQ (r=0.405).

Conclusions: Anxiety and depression symptoms are prevalent in knee or hip OA patients with CP and were associated with higher pain severity and functional disability. These findings support the screening of anxiety and depression symptoms in OA patients, in order to develop more effective multidisciplinary treatments.

研究目的本研究旨在估计髋关节和膝关节骨关节炎(OA)引起的慢性疼痛(CP)患者中焦虑和抑郁症状的发生率,并探讨这些症状与临床和疼痛特征之间的关联:在这项横断面研究中,纳入了患有CP和膝关节和/或髋关节OA的成年患者。焦虑和抑郁症状采用医院焦虑抑郁量表(Hospital Anxiety and Depression Scale)进行评估。视觉模拟量表、西安大略和麦克马斯特大学关节炎指数(WOMAC)和疼痛检测问卷评估疼痛特征,健康评估问卷(HAQ)评估功能障碍。相关系数用于探讨焦虑和抑郁症状与临床和疼痛特征之间的关联:共纳入 61 名患者(年龄为 66.2±9.4 岁,67.2% 为女性)。大多数患者(70.5%)有明显的临床焦虑和/或抑郁症状。有焦虑和/或抑郁症状的患者疼痛严重程度(P=0.032)和残疾程度(P=0.014)较高。抑郁症状与 WOMAC 身体功能分量表(r=0.520)、WOMAC 总量表(r=0.511)和 HAQ(r=0.405)呈中度正相关:焦虑和抑郁症状在患有 CP 的膝关节或髋关节 OA 患者中普遍存在,并且与较高的疼痛严重程度和功能障碍相关。这些研究结果支持对 OA 患者的焦虑和抑郁症状进行筛查,以便制定更有效的多学科治疗方案。
{"title":"The association between anxiety and depression symptoms and clinical and pain characteristics in patients with hip and knee osteoarthritis.","authors":"Joana Silveira, Daniela Oliveira, Ana Martins, Lúcia Costa, Fani Neto, Joana Ferreira-Gomes, Carlos Vaz","doi":"10.63032/SDVB2224","DOIUrl":"10.63032/SDVB2224","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to estimate the prevalence of anxiety and depression symptoms and explore the association between these symptoms and clinical and pain characteristics in patients with chronic pain (CP) due to hip and knee osteoarthritis (OA).</p><p><strong>Methods: </strong>In this cross-sectional study, adult patients with CP and knee and/or hip OA were included. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression Scale. Visual analogue scale, Western Ontario and McMaster Universities Arthritis Index (WOMAC) and PainDetect Questionnaire assessed pain characteristics and Health Assessment Questionnaire (HAQ) evaluated functional disability. Correlation coefficients were used to explore the associations between anxiety and depression symptoms and clinical and pain characteristics.</p><p><strong>Results: </strong>A total of 61 patients (age 66.2±9.4 years, 67.2% female) were included. Most patients (70.5%) had clinically significant anxiety and/or depression symptoms. Patients with anxiety and/or depression symptoms had higher pain severity (p=0.032) and disability (p=0.014). Depression symptoms had a moderate positive correlation with WOMAC physical function subscale (r=0.520), WOMAC total (r=0.511) and HAQ (r=0.405).</p><p><strong>Conclusions: </strong>Anxiety and depression symptoms are prevalent in knee or hip OA patients with CP and were associated with higher pain severity and functional disability. These findings support the screening of anxiety and depression symptoms in OA patients, in order to develop more effective multidisciplinary treatments.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"206-215"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transition readiness assessment in Portuguese adolescents and young adults with pediatric-onset rheumatic diseases: a single-center study. 葡萄牙患有小儿风湿病的青少年和年轻人的过渡准备评估:一项单中心研究。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/IYRF3521
Joana Bovião Monteiro, Ana Sofia Figueiredo, Sara Geraldes Paulino, Ana Sofia Teixeira, Sara Ganhão, Mariana Rodrigues, Francisca Aguiar, Iva Brito

Objective: In this study, we aimed to assess the transition readiness levels amongst patients with childhood-onset rheumatic diseases. Additionally, we sought to identify and analyze predictive factors associated with better transition readiness skills in adolescent and young adult (AYAs) patients.

Methods: This is a monocentric cross-sectional study that includes patients between 14 and 26 years of age who attended outpatient pediatric and young adult rheumatology appointments between October and December of 2023 and that were diagnosed with an immune-mediated rheumatic disease before reaching 18 years of age, with at least 1 year of disease duration. Patients were presented with a questionnaire that contained demographic and clinical questions, TRACS (Questionário de Preparação da Transição para a Autonomia nos Cuidados de Saúde) questionnaire - a validated Portuguese version of the Transition Readiness Assessment Questionnaire (TRAQ), and Hospital Anxiety and Depression Scale (HADS) questionnaire. Data was analyzed to assess the significant associations between the different variables and transition readiness outcome measured by the TRACS. Descriptive statistics, statistical comparisons and logistic regression analysis were performed.

Results: A total of 69 patients with a median age of 20 [17.5-22.5] were included in this study. The median TRACS score was 4.41 [4.09-4.74]. Significantly higher TRACS scores were observed in patients who were female, 18 years of age or older, had a higher level of education, were employed, had active disease or that belonged to middle-class (when compared to patients belonging to upper- middle class). The logistic regression analysis demonstrated that being a female or having an educational status equal to 12th grade or superior emerged as predictors of higher transition readiness levels.

Conclusions: Our study identified female sex and higher level of education as predictors of increased transition readiness levels. Therefore, healthcare providers should consider these variables when assessing patients for transition readiness and focus on improving transition process, especially in male and less educated AYAs.

研究目的本研究旨在评估儿童期风湿病患者的过渡准备水平。此外,我们还试图找出并分析与青少年和年轻成人(AYAs)患者更好的过渡准备技能相关的预测因素:这是一项单中心横断面研究,研究对象包括2023年10月至12月期间在儿科和年轻成人风湿病门诊就诊的14至26岁患者,他们在18岁之前被诊断患有免疫介导的风湿病,病程至少1年。患者接受了一份包含人口统计学和临床问题的调查问卷、TRACS(Questionário de Preparação da Transição para a Autonomia nos Cuidados de Saúde)调查问卷--经过验证的葡萄牙语版过渡准备评估调查问卷(TRAQ),以及医院焦虑抑郁量表(HADS)调查问卷。我们对数据进行了分析,以评估不同变量与 TRACS 所测量的过渡准备结果之间的重要关联。研究人员进行了描述性统计、统计比较和逻辑回归分析:本研究共纳入 69 名患者,中位年龄为 20 岁 [17.5-22.5]。TRACS 评分中位数为 4.41 [4.09-4.74]。女性、18 岁或以上、受教育程度较高、有工作、有活动性疾病或属于中产阶级的患者(与属于中上层阶级的患者相比)的 TRACS 分数明显更高。逻辑回归分析表明,女性或受教育程度相当于 12 年级或更高,是较高过渡准备水平的预测因素:我们的研究发现,女性和较高的教育水平是提高过渡准备水平的预测因素。因此,医疗服务提供者在评估患者的过渡准备情况时应考虑这些变量,并重点改善过渡过程,尤其是男性和受教育程度较低的亚裔患者。
{"title":"Transition readiness assessment in Portuguese adolescents and young adults with pediatric-onset rheumatic diseases: a single-center study.","authors":"Joana Bovião Monteiro, Ana Sofia Figueiredo, Sara Geraldes Paulino, Ana Sofia Teixeira, Sara Ganhão, Mariana Rodrigues, Francisca Aguiar, Iva Brito","doi":"10.63032/IYRF3521","DOIUrl":"10.63032/IYRF3521","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to assess the transition readiness levels amongst patients with childhood-onset rheumatic diseases. Additionally, we sought to identify and analyze predictive factors associated with better transition readiness skills in adolescent and young adult (AYAs) patients.</p><p><strong>Methods: </strong>This is a monocentric cross-sectional study that includes patients between 14 and 26 years of age who attended outpatient pediatric and young adult rheumatology appointments between October and December of 2023 and that were diagnosed with an immune-mediated rheumatic disease before reaching 18 years of age, with at least 1 year of disease duration. Patients were presented with a questionnaire that contained demographic and clinical questions, TRACS (Questionário de Preparação da Transição para a Autonomia nos Cuidados de Saúde) questionnaire - a validated Portuguese version of the Transition Readiness Assessment Questionnaire (TRAQ), and Hospital Anxiety and Depression Scale (HADS) questionnaire. Data was analyzed to assess the significant associations between the different variables and transition readiness outcome measured by the TRACS. Descriptive statistics, statistical comparisons and logistic regression analysis were performed.</p><p><strong>Results: </strong>A total of 69 patients with a median age of 20 [17.5-22.5] were included in this study. The median TRACS score was 4.41 [4.09-4.74]. Significantly higher TRACS scores were observed in patients who were female, 18 years of age or older, had a higher level of education, were employed, had active disease or that belonged to middle-class (when compared to patients belonging to upper- middle class). The logistic regression analysis demonstrated that being a female or having an educational status equal to 12th grade or superior emerged as predictors of higher transition readiness levels.</p><p><strong>Conclusions: </strong>Our study identified female sex and higher level of education as predictors of increased transition readiness levels. Therefore, healthcare providers should consider these variables when assessing patients for transition readiness and focus on improving transition process, especially in male and less educated AYAs.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"196-205"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond rheumatoid nodules in rheumatoid arthritis. 类风湿性关节炎的类风湿结节之外。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-07-01 DOI: 10.63032/VLZL5564
Maria João Cadório, João Teixeira, João Oliveira, Tânia Santiago, Margaria Gonçalo, Cátia Duarte

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease predominantly affecting synovial joints. Extra-articular manifestations, including skin involvement, can also occur. The most frequent cutaneous manifestation in RA patients is rheumatoid nodules, occurring in 20-30% of seropositive individuals. These nodules are typically firm, painless, and located on pressure points such as the hands and elbows. However, in a minority of cases, other skin conditions can complicate RA, notably palisaded neutrophilic granulomatous dermatitis (PNGD). PNGD presents as erythematous papules or plaques, often pruritic and distributed symmetrically over extensor surfaces, making it challenging to differentiate from rheumatoid nodules. Histopathological examination is crucial to establish the diagnosis. High clinical suspicion and appropriate referral to Dermatology are essential for accurate diagnosis and management. Treatment of PNGD is focused on underlying disease control. Other options include topical, intralesional or systemic corticosteroids, dapsone or hydroxychloroquine. Herein, we present the case of a 71-year-old woman with RA who developed PNGD, highlighting the importance of a multidisciplinary approach for achieving a favorable clinical outcome.

类风湿性关节炎(RA)是一种慢性全身性自身免疫疾病,主要影响滑膜关节。也可出现关节外表现,包括皮肤受累。RA 患者最常见的皮肤表现是类风湿结节,20%-30% 的血清反应阳性者会出现类风湿结节。这些结节通常坚实、无痛,位于手部和肘部等受压点。然而,在少数病例中,其他皮肤病也会并发类风湿关节炎,尤其是嗜中性肉芽肿性皮炎(PNGD)。PNGD表现为红斑丘疹或斑块,常伴有瘙痒,对称分布于伸肌表面,因此很难与类风湿结节相鉴别。组织病理学检查是确诊的关键。高度的临床怀疑和适当的皮肤科转诊对于准确诊断和治疗至关重要。治疗 PNGD 的重点是控制潜在疾病。其他选择包括局部、鞘内或全身使用皮质类固醇激素、达泊松或羟氯喹。在此,我们介绍了一名 71 岁女性 RA 患者的病例,她患上了 PNGD,突出了多学科方法对取得良好临床效果的重要性。
{"title":"Beyond rheumatoid nodules in rheumatoid arthritis.","authors":"Maria João Cadório, João Teixeira, João Oliveira, Tânia Santiago, Margaria Gonçalo, Cátia Duarte","doi":"10.63032/VLZL5564","DOIUrl":"10.63032/VLZL5564","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease predominantly affecting synovial joints. Extra-articular manifestations, including skin involvement, can also occur. The most frequent cutaneous manifestation in RA patients is rheumatoid nodules, occurring in 20-30% of seropositive individuals. These nodules are typically firm, painless, and located on pressure points such as the hands and elbows. However, in a minority of cases, other skin conditions can complicate RA, notably palisaded neutrophilic granulomatous dermatitis (PNGD). PNGD presents as erythematous papules or plaques, often pruritic and distributed symmetrically over extensor surfaces, making it challenging to differentiate from rheumatoid nodules. Histopathological examination is crucial to establish the diagnosis. High clinical suspicion and appropriate referral to Dermatology are essential for accurate diagnosis and management. Treatment of PNGD is focused on underlying disease control. Other options include topical, intralesional or systemic corticosteroids, dapsone or hydroxychloroquine. Herein, we present the case of a 71-year-old woman with RA who developed PNGD, highlighting the importance of a multidisciplinary approach for achieving a favorable clinical outcome.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"240-242"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging role of Rituximab in the treatment of large granular lymphocytic leukemia associated with rheumatoid arthritis: a single center experience. 利妥昔单抗在治疗伴有类风湿性关节炎的大颗粒淋巴细胞白血病中的新作用:单中心经验。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-06-22
Mariana Diz Lopes, Carlos Marques Gomes, Inês Santos, Teresa Martins-Rocha, Miguel Bernardes, José Pinto, Lúcia Costa

Large Granular Lymphocytic (LGL) leukemia is a rare lymphoproliferative disorder with a peculiar association with Rheumatoid Arthritis (RA). The most common feature is neutropenia and patients can have splenomegaly, resembling Felty's Syndrome. These diseases have similar clinical and laboratory abnormalities, but the diagnosis of T-cell LGL (T-LGL) leukemia requires evidence of clonality. Even though T-LGL leukemia is indolent in most cases, inadequate treatment when it is indicated can lead to significant morbidity and mortality, mainly associated with recurrent infections. We present two clinical cases that emphasize the emerging role of Rituximab as an effective therapeutic option in patients with T-LGL and RA.

大颗粒淋巴细胞(LGL)白血病是一种罕见的淋巴增生性疾病,与类风湿性关节炎(RA)有特殊的关联。最常见的特征是中性粒细胞减少,患者可有脾肿大,类似费尔蒂综合征。这些疾病具有相似的临床和实验室异常,但 T 细胞 LGL(T-LGL)白血病的诊断需要克隆证据。尽管T-LGL白血病在大多数情况下并不严重,但如果治疗不当,可能会导致严重的发病率和死亡率,主要与反复感染有关。我们介绍了两个临床病例,强调了利妥昔单抗作为一种有效的治疗方案在T-LGL和RA患者中的新作用。
{"title":"The emerging role of Rituximab in the treatment of large granular lymphocytic leukemia associated with rheumatoid arthritis: a single center experience.","authors":"Mariana Diz Lopes, Carlos Marques Gomes, Inês Santos, Teresa Martins-Rocha, Miguel Bernardes, José Pinto, Lúcia Costa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Large Granular Lymphocytic (LGL) leukemia is a rare lymphoproliferative disorder with a peculiar association with Rheumatoid Arthritis (RA). The most common feature is neutropenia and patients can have splenomegaly, resembling Felty's Syndrome. These diseases have similar clinical and laboratory abnormalities, but the diagnosis of T-cell LGL (T-LGL) leukemia requires evidence of clonality. Even though T-LGL leukemia is indolent in most cases, inadequate treatment when it is indicated can lead to significant morbidity and mortality, mainly associated with recurrent infections. We present two clinical cases that emphasize the emerging role of Rituximab as an effective therapeutic option in patients with T-LGL and RA.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":" ","pages":"None"},"PeriodicalIF":1.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary arterial hypertension in systemic sclerosis: a national inpatient analysis. 系统性硬化症肺动脉高压:全国住院病人分析。
IF 1.4 4区 医学 Q3 RHEUMATOLOGY Pub Date : 2024-04-01
Hania Sami, Faria Sami, Almurtada Razok, Mona Dasgupta, Rohan Gajjar

Objectives: We aim to study the prevalence and epidemiology of pulmonary arterial hypertension in SS, and the impact of PAH on SSc hospitalizations in the United States population.

Methods: We utilized the National Inpatient Sample (NIS) from 2016-2019 to obtain adult hospitalizations with the primary/secondary diagnosis of SSc and coexistent PAH (SSc-PAH). Epidemiological variables, mortality rates, and secondary outcomes were studied including pulmonary embolism, atrial flutter, atrial and ventricular fibrillation, pneumonia, sepsis, cardiac arrest and cardiac & renal failure, and ventilator requirement. Healthcare burden was estimated from total hospital charges (THC) and length of stay (LOS). Statistical analysis was performed on STATA 16.1, using linear and logistic regression analyses.

Results: Out of 126,685 adult systemic sclerosis hospitalizations, 16.89% had PAH (SSc-PAH). The SSc-PAH group had significantly more females (85.4 % vs. 83.8%) and higher mean age (64.85±13.29 vs. 62.56±14.51). More African Americans were in this group than in the control group (19.5% vs. 14.6, p-value<0.001) while Whites (61.3% vs. 65.6%, p<0.001) and Asians (18.0 % vs. 2.8%, p<0.001) were less common. Charlson comorbidity index was higher for the SSc-PAH population (3.42 vs. 2.94, p-value<0.001). SSc-PAH group had a higher adjusted odds ratio (aOR) for mortality (aOR: 1.39, p<0.001), increased LOS (6.64 vs. 6.0 days, p<0.001) increased THC ($83,813 vs. $71,016, p <0.001). For the SSc-PAH group, there were also significantly higher odds of cardiac failure (aOR 3.13), ventilator requirement (aOR 2.15), cardiac arrest (aOR 1.39), kidney failure (aOR 1.63), pulmonary embolism (aOR 1.84), atrial flutter (aOR 1.86) atrial fibrillation (aOR1.56) and pneumonia (aOR 1.22). No significant difference in ventricular fibrillation, sepsis, or respiratory failure was noted.

Conclusion: Pulmonary arterial hypertension in SSc is associated with worse outcomes in terms of mortality and morbidity, and higher healthcare burden compared to SSc without PAH. Also, PAH disproportionately affects White, African American & Asian populations. There remains a pressing need to continue efforts for early diagnosis and management of PAH in SSc patients.

目的:我们旨在研究 SS 中肺动脉高压的患病率和流行病学,以及 PAH 对美国 SSc 住院治疗的影响:我们旨在研究 SS 中肺动脉高压的患病率和流行病学,以及 PAH 对美国 SSc 患者住院治疗的影响:我们利用 2016-2019 年的全国住院病人样本(NIS),获得了主要/次要诊断为 SSc 和并存 PAH(SSc-PAH)的成人住院病例。研究了流行病学变量、死亡率和次要结果,包括肺栓塞、心房扑动、心房颤动和心室颤动、肺炎、脓毒症、心脏骤停和心肾功能衰竭以及呼吸机需求。根据住院总费用(THC)和住院时间(LOS)估算医疗负担。统计分析采用 STATA 16.1,使用线性和逻辑回归分析:在 126,685 名住院的系统性硬化症成人患者中,16.89%患有 PAH(SSc-PAH)。SSc-PAH组中女性明显较多(85.4% 对 83.8%),平均年龄较高(64.85±13.29 对 62.56±14.51)。该组非裔美国人比对照组多(19.5% 对 14.6,P 值):与无 PAH 的 SSc 患者相比,SSc 患者的肺动脉高压与死亡率和发病率方面更差的预后以及更高的医疗负担有关。此外,PAH 对白人、非裔美国人和亚裔人群的影响尤为严重。目前仍迫切需要继续努力,对 SSc 患者的 PAH 进行早期诊断和管理。
{"title":"Pulmonary arterial hypertension in systemic sclerosis: a national inpatient analysis.","authors":"Hania Sami, Faria Sami, Almurtada Razok, Mona Dasgupta, Rohan Gajjar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>We aim to study the prevalence and epidemiology of pulmonary arterial hypertension in SS, and the impact of PAH on SSc hospitalizations in the United States population.</p><p><strong>Methods: </strong>We utilized the National Inpatient Sample (NIS) from 2016-2019 to obtain adult hospitalizations with the primary/secondary diagnosis of SSc and coexistent PAH (SSc-PAH). Epidemiological variables, mortality rates, and secondary outcomes were studied including pulmonary embolism, atrial flutter, atrial and ventricular fibrillation, pneumonia, sepsis, cardiac arrest and cardiac & renal failure, and ventilator requirement. Healthcare burden was estimated from total hospital charges (THC) and length of stay (LOS). Statistical analysis was performed on STATA 16.1, using linear and logistic regression analyses.</p><p><strong>Results: </strong>Out of 126,685 adult systemic sclerosis hospitalizations, 16.89% had PAH (SSc-PAH). The SSc-PAH group had significantly more females (85.4 % vs. 83.8%) and higher mean age (64.85±13.29 vs. 62.56±14.51). More African Americans were in this group than in the control group (19.5% vs. 14.6, p-value<0.001) while Whites (61.3% vs. 65.6%, p<0.001) and Asians (18.0 % vs. 2.8%, p<0.001) were less common. Charlson comorbidity index was higher for the SSc-PAH population (3.42 vs. 2.94, p-value<0.001). SSc-PAH group had a higher adjusted odds ratio (aOR) for mortality (aOR: 1.39, p<0.001), increased LOS (6.64 vs. 6.0 days, p<0.001) increased THC ($83,813 vs. $71,016, p <0.001). For the SSc-PAH group, there were also significantly higher odds of cardiac failure (aOR 3.13), ventilator requirement (aOR 2.15), cardiac arrest (aOR 1.39), kidney failure (aOR 1.63), pulmonary embolism (aOR 1.84), atrial flutter (aOR 1.86) atrial fibrillation (aOR1.56) and pneumonia (aOR 1.22). No significant difference in ventricular fibrillation, sepsis, or respiratory failure was noted.</p><p><strong>Conclusion: </strong>Pulmonary arterial hypertension in SSc is associated with worse outcomes in terms of mortality and morbidity, and higher healthcare burden compared to SSc without PAH. Also, PAH disproportionately affects White, African American & Asian populations. There remains a pressing need to continue efforts for early diagnosis and management of PAH in SSc patients.</p>","PeriodicalId":29669,"journal":{"name":"ARP Rheumatology","volume":"3 2","pages":"95-100"},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
ARP Rheumatology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1