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Impact of implantation depth and calcium burden on infranodal conduction delay after transcatheter aortic valve replacement 经导管主动脉瓣置换术后植入深度和钙负荷对瓣下传导延迟的影响
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2023.12.003
Andrea Papa MD, Teodor Serban MD, Ivo Strebel PhD, Sven Knecht DSc, PhD, Corinne Isenegger MMed, Thomas Nestelberger MD, Christoph Kaiser MD, Gregor Leibundgut MD, Philipp Haaf MD, Beat Schaer MD, Philipp Krisai MD, Stefan Osswald MD, Christian Sticherling MD, Michael Kühne MD, Patrick Badertscher MD

Background

Infranodal conduction disorders are common after transcatheter aortic valve replacement (TAVR). Risk factors are incompletely understood.

Objective

The purpose of this study was to assess the impact of valve implantation depth and calcium burden of the device landing zone on infranodal conduction intraprocedure pre- and post-TAVR.

Methods

In all patients undergoing TAVR between June 2020 and June 2021, the His-ventricle (HV) interval was measured pre- and post-valve deployment. The difference between the 2 measurements defined delta HV, whereas infranodal conduction delay was defined as HV interval >55 ms. Valve implantation depth was measured as the distance between the aortic annular plane and the ventricular prosthesis end. Calcium burden was quantified as the volume of calcium in 6 regions of interest: the non-, right, and left coronary cusps (NCC, RCC, and LCC, respectively) and the corresponding regions of the left ventricular outflow tract (LVOT) underlying each cusp (LVOTNCC, LVOTRCC, LVOTLCC, respectively).

Results

Of 101 patients (mean age 81 ± 5.7 years; 47% women), 37 demonstrated infranodal conduction delay intraprocedure post-TAVR. Overall, mean implantation depth was 5 ± 3.1 mm, median calcium volume was 2080 mm3 [interquartile range 632–2400]. Delta HV showed no correlation with implantation depth or calcium burden (r = –0.08 and r = 0.12, respectively). However, LVOTNCC calcification was a significant predictor for infranodal conduction delay post-valve deployment in a multivariable logistic regression model (odds ratio 1.62 per 100-mm3 increase (95% confidence interval 1.06–2.69; P = .04).

Conclusion

Assessment of LVOTNCC calcification may identify patients at risk for infranodal conduction delay after TAVR, whereas implantation depth did not predict infranodal conduction delay.

背景经导管主动脉瓣置换术(TAVR)后常见颅内传导障碍。本研究旨在评估瓣膜植入深度和装置着床区的钙负荷对经导管主动脉瓣置换术(TAVR)前后术中下叶传导的影响。方法在 2020 年 6 月至 2021 年 6 月期间接受 TAVR 的所有患者中,测量瓣膜部署前后的 His-ventricle (HV) 间期。两个测量值之间的差值定义为δHV,而下叶传导延迟定义为HV间期>55 ms。瓣膜植入深度以主动脉瓣环平面与心室假体末端之间的距离来衡量。钙负荷量化为 6 个相关区域的钙量:非、右和左冠状动脉尖(分别为 NCC、RCC 和 LCC)以及每个尖下方左室流出道 (LVOT) 的相应区域(分别为 LVOTNCC、LVOTRCC 和 LVOTLCC)。总体而言,平均植入深度为 5 ± 3.1 毫米,中位钙容量为 2080 立方毫米[四分位间范围为 632-2400] 。Delta HV与植入深度或钙负荷无相关性(r = -0.08 和 r = 0.12)。然而,在多变量逻辑回归模型中,LVOTNCC钙化是预测瓣膜置入后瓣下传导延迟的重要因素(每增加100立方毫米的几率为1.62(95%置信区间为1.06-2.69;P = .04))。
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引用次数: 0
Characterizing cardiac contractile motion for noninvasive radioablation of ventricular tachycardia 为室性心动过速的无创射频消融确定心脏收缩运动特征
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2023.12.006
Bryan Wu MD , Todd Atwood PhD, DABR , Arno J. Mundt MD , Jennifer Karunamuni MD , Paul Stark MD , Albert Hsiao MD, PhD , Frederick Han MD , Jonathan C. Hsu MD MAS , Kurt Hoffmayer MD PharmD , Farshad Raissi MD , Ulrika Birgersdotter-Green MD , Gregory Feld MD , David E. Krummen MD , Gordon Ho MD

Background

Respiratory motion management strategies are used to minimize the effects of breathing on the precision of stereotactic ablative radiotherapy for ventricular tachycardia, but the extent of cardiac contractile motion of the human heart has not been systematically explored.

Objective

We aim to assess the magnitude of cardiac contractile motion between different directions and locations in the heart.

Methods

Patients with intracardiac leads or valves who underwent 4-dimensional cardiac computed tomography (CT) prior to a catheter ablation procedure for atrial or ventricular arrhythmias at 2 medical centers were studied retrospectively. The displacement of transvenous right atrial appendage, right ventricular (RV) implantable cardioverter-defibrillator, coronary sinus lead tips, and prosthetic cardiac devices across the cardiac cycle were measured in orthogonal 3-dimensional views on a maximal-intensity projection CT reconstruction.

Results

A total of 31 preablation cardiac 4-dimensional cardiac CT scans were analyzed. The LV lead tip had significantly greater motion compared with the RV lead in the anterior-posterior direction (6.0 ± 2.2 mm vs 3.8 ± 1.7 mm; P = .01) and superior-inferior direction (4.4 ± 2.9 mm vs 3.5 ± 2.0 mm; P = .049). The prosthetic aortic valves had the least movement of all fiducials, specifically compared with the RV lead tip in the left-right direction (3.2 ± 1.2 mm vs 6.1 ± 3.8 mm, P = .04) and the LV lead tip in the anterior-posterior direction (3.8 ± 1.7 mm vs 6.0 ± 2.2 mm, P = .03).

Conclusion

The degree of cardiac contractile motion varies significantly (1 mm to 15.2 mm) across different locations in the heart. The effect of contractile motion on the precision of radiotherapy should be assessed on a patient-specific basis.

背景呼吸运动管理策略用于最大限度地减少呼吸对室性心动过速立体定向消融放疗精确性的影响,但对人体心脏收缩运动的程度尚未进行系统的探讨。方法回顾性研究了在两家医疗中心接受导管消融术治疗房性或室性心律失常的心内导联或瓣膜患者,这些患者在接受导管消融术前都接受了四维心脏计算机断层扫描(CT)。在最大强度投影 CT 重建的正交三维视图中测量了经静脉右房阑尾、右心室 (RV) 植入式心律转复除颤器、冠状窦导联尖端和人工心脏装置在整个心动周期中的位移。在前后方向(6.0 ± 2.2 mm vs 3.8 ± 1.7 mm;P = .01)和上下方向(4.4 ± 2.9 mm vs 3.5 ± 2.0 mm;P = .049),左心室导联尖端的运动明显大于右心室导联。在所有靶标中,人工主动脉瓣的运动最小,特别是与左心室导联尖在左右方向(3.2 ± 1.2 mm vs 6.1 ± 3.8 mm,P = .04)和左心室导联尖在前后方向(3.8 ± 1.7 mm vs 6.0 ± 2.2 mm,P = .03)相比。应根据患者的具体情况评估收缩运动对放疗精确度的影响。
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引用次数: 0
Trends in the 30-year span of Noninfectious Cardiovascular Implantable Electronic Device Complications in Olmsted County 奥姆斯特德县非感染性心血管植入式电子设备并发症 30 年的发展趋势
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2024.02.001
Gurukripa N. Kowlgi, Vaibhav Vaidya, Mingyan Dai, Pragyat Futela, Rahul Mishra, David O. Hodge, Abhishek J. Deshmukh, S. Mulpuru, Paul A. Friedman, Yong- Mei Cha
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引用次数: 0
Ultrasound-guided Explant Technique for Implantable Loop Recorder in Patients with High Body Mass Index: A Practical Approach 高体重指数患者植入式环路记录器的超声引导爆破技术:实用方法
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2024.01.009
Chokanan Thaitirarot, Shirley Sze, Sue Armstrong, Riyaz Somani
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引用次数: 0
Outcomes and Care Quality Metrics for People Living with Rheumatic Heart Disease and Atrial Fibrillation in Uganda 乌干达风湿性心脏病和心房颤动患者的治疗效果和护理质量指标
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2024.02.002
Chinonso C. Opara, Roy H. Lan, J. Rwebembera, E. Okello, David Watkins, Andrew Y Chang, Chris T Longenecker
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引用次数: 0
A pilot study of longitudinal changes in neurocognition, white matter hyperintensities, and cortical thickness in atrial fibrillation patients following catheter ablation vs medical management 导管消融与药物治疗后心房颤动患者神经认知、白质高密度和皮质厚度纵向变化的试点研究
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2024.01.002
Hannah Schwennesen MD , Jeffrey N. Browndyke PhD , Mary Cooter Wright MS , Marat Fudim MD, MHS , James P. Daubert MD, FHRS , Mark F. Newman MD , Joseph P. Mathew MD, MHS, MBA , Jonathan P. Piccini MD, MHS, FHRS

Background

Cerebral microembolization and atrophy complicate atrial fibrillation (AF).

Objectives

We aimed to compare changes in neuroimaging findings between AF patients treated with catheter ablation and those treated with medical therapy.

Methods

In this pilot study, we evaluated differences in the change in regional white matter hyperintensity burden (WMHb) and cognitive function from baseline to 6 weeks and 1 year in patients treated with AF ablation (n = 12) and patients treated with medical management alone (n = 11). Change in cortical thickness over time in Alzheimer’s disease (AD) risk, aging-associated, and shared AD risk/aging regions was also compared between groups.

Results

The mean age was 69.7 ± 5.0 years, 78% of patients were male, 39% had persistent AF, and all received oral anticoagulation. There were no significant differences between groups in the change in cognitive function. At 6 weeks, there were no significant differences in periventricular WMHb changes between groups (0.00 vs 0.04, P = .12), but changes in attention/concentration were inversely correlated with periventricular (P = .01) and total (P = .03) WMHb. Medical management patients demonstrated significantly greater cortical thinning in AD risk regions from baseline to 1 year (P = .003).

Conclusions

AF patients who underwent ablation demonstrated less cortical thinning in regions associated with AD risk than patients treated with medical therapy. Larger, prospective studies are needed to better understand the relationship between AF therapies and the development of cognitive decline.

背景脑微栓塞和萎缩是心房颤动(房颤)的并发症。目的我们旨在比较接受导管消融治疗的房颤患者和接受药物治疗的患者的神经影像学结果的变化。方法在这项试验性研究中,我们评估了接受房颤消融治疗的患者(n = 12)和单独接受药物治疗的患者(n = 11)的区域白质高密度负荷(WMHb)和认知功能从基线到6周和1年的变化差异。此外,还比较了不同组间阿尔茨海默病(AD)风险区、衰老相关区和共同AD风险/衰老区皮质厚度随时间的变化情况。结果平均年龄为69.7 ± 5.0岁,78%的患者为男性,39%的患者为持续性房颤,所有患者均接受口服抗凝治疗。各组间认知功能的变化无明显差异。6 周时,各组间脑室周围 WMHb 变化无明显差异(0.00 vs 0.04,P = .12),但注意力/集中力的变化与脑室周围 WMHb(P = .01)和总 WMHb(P = .03)成反比。接受消融治疗的AF患者与接受药物治疗的患者相比,在与AD风险相关的区域表现出更少的皮质变薄。需要进行更大规模的前瞻性研究,以更好地了解房颤疗法与认知能力下降之间的关系。
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引用次数: 0
Adherent skin barrier drape use is associated with a reduced risk of cardiac implantable device infection: Results from a prospective study of 14,225 procedures 使用粘附性皮肤屏障敷料可降低心脏植入器械感染的风险:对 14,225 例手术的前瞻性研究结果。
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2023.12.002
Mehrdad Golian MD , Nicolas M. Berbenetz MD , Roupen Odabashian MD , Mouhannad M. Sadek MD , Vicente Corrales-Medina MD , Alper Aydin MD , Darryl R. Davis MD , Martin S. Green MD , Andres Klein MD , Girish M. Nair MBBS, MSc , Pablo B. Nery MD , F. Daniel Ramirez MD , Calum Redpath MBChB, PhD , Simon P. Hansom MBBS , David H. Birnie MBChB, MD

Background

Cardiac implantable electronic device (CIED) infection is a costly and highly morbid complication. Perioperative interventions, including the use of antibiotic pouches and intensified perioperative antibiotic regimens, have demonstrated marginal efficacy at reducing CIED infection. Additional research is needed to identify additional interventions to reduce infection risk.

Objective

We sought to evaluate whether adherent skin barrier drape use is associated with a reduction in CIED infection.

Methods

A prospective registry of all CIED implantation procedures was established at our institution in January 2007. The registry was established in collaboration with our hospital infection prevention team with a specific focus on prospectively identifying all potential CIED infections. All potential CIED infections were independently adjudicated by 2 physicians blinded to the use of an adherent skin barrier drape.

Results

Over a 13-year period, 14,225 procedures were completed (mean age 72 ± 14 years; female 4,918 (35%); new implants 10,005 (70%); pulse generator changes 2585 (18%); upgrades 1635 (11%). Of those, 2469 procedures (17.4%) were performed using an adherent skin barrier drape. There were 103 adjudicated device infections (0.73%). The infection rate in patients in the barrier use groups was 8 of 2469 (0.32%) as compared with 95 of 11,756 (0.8%) in the nonuse group (P = .0084). In multivariable analysis, the use of an adherent skin barrier drape was independently associated with a reduction in infection (odds ratio 0.32; 95% confidence interval 0.154–0.665; P = .002).

Conclusion

The use of an adherent skin barrier drape at the time of cardiac device surgery is associated with a lower risk of subsequent infection.

背景心脏植入式电子装置(CIED)感染是一种代价高昂且发病率极高的并发症。围手术期干预措施,包括使用抗生素袋和加强围手术期抗生素治疗,在减少 CIED 感染方面的效果微乎其微。我们试图评估粘附性皮肤屏障帘的使用是否与减少CIED感染有关。方法本院于2007年1月对所有CIED植入手术进行了前瞻性登记。该登记处是与我们的医院感染预防团队合作建立的,重点是前瞻性地识别所有潜在的CIED感染。所有潜在的 CIED 感染均由两名医生独立裁定,他们对使用粘附性皮肤屏障帷幔的情况进行盲测。结果13年间,共完成了 14,225 例手术(平均年龄 72 ± 14 岁;女性 4,918 例(35%);新植入 10,005 例(70%);更换脉冲发生器 2585 例(18%);升级 1635 例(11%))。其中,2469 例手术(17.4%)使用了粘附性皮肤屏障敷料。经裁定的设备感染有 103 例(0.73%)。使用屏障组患者的感染率为 2469 例中的 8 例(0.32%),而未使用屏障组患者的感染率为 11756 例中的 95 例(0.8%)(P = .0084)。在多变量分析中,使用粘附性皮肤屏障敷料与感染率的降低独立相关(几率比 0.32;95% 置信区间 0.154-0.665;P = .002)。
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引用次数: 0
Pericarditis prophylactic therapy after sinus node–sparing hybrid ablation for inappropriate sinus tachycardia/postural orthostatic sinus tachycardia 针对不适当窦性心动过速/体位性正位窦性心动过速的窦房结疏散混合消融术后的心包炎预防疗法
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2024.01.001
Carlo de Asmundis MD, PhD , Lorenzo Marcon MD , Luigi Pannone MD , Domenico Giovanni Della Rocca MD, PhD , Dhanunjaya Lakkireddy MD , Thomas M. Beaver MD , Chad R. Brodt MD , Cinzia Monaco MD , Antonio Sorgente MD, PhD , Charles Audiat MD , Giampaolo Vetta MD , Robbert Ramak MSc , Ingrid Overeinder MD , Rani Kronenberger MD , Gezim Bala MD, PhD , Alexandre Almorad MD , Erwin Ströker MD, PhD , Juan Sieira MD, PhD , Andrea Sarkozy MD, PhD , Pedro Brugada MD, PhD , Mark La Meir MD, PhD

Background

Pericarditis is the most common complication following hybrid sinus node–sparing ablation for inappropriate sinus tachycardia (IST)/postural orthostatic tachycardia syndrome (POTS).

Objective

The study sought to evaluate the association of prophylaxis therapy on the risk of symptomatic pericarditis following hybrid IST/POTS ablation.

Methods

All consecutive patients undergoing to hybrid ablation of symptomatic IST/POTS refractory or intolerant to drugs were retrospectively analyzed. Pharmacological prophylaxis therapy was based on acetylsalicylic acid and colchicine started on the day of the ablation and continued for at least 3 months. The primary endpoint was occurrence of symptomatic pericarditis. The secondary endpoint was occurrence of pericarditis-related complications, including the following: duration of pericarditis >3 months, hospitalization for pericarditis, postpericardiectomy pleuro-pericarditis, and pericardiectomy.

Results

A total of 220 patients undergone to hybrid IST/POTS ablation were included and 44 (20%) underwent prophylaxis therapy. Pericarditis occurred in 101 (45.9%) patients, with 97 (96%) in the first 5 days. At survival analysis, prophylaxis was associated with higher rate of freedom from pericarditis (81.9% vs 47.2%, log-rank P < .001). Pericarditis-related complications were low, occurring in 7 (3.2%) patients. There was no difference in pericarditis-related complications between the patients who underwent prophylaxis therapy and patients who did not. At Cox multivariate analysis, predictors of pericarditis were IST (vs POTS) (hazard ratio 0.61, 95% confidence interval0.39-0.99, P = .04) and prophylaxis therapy (hazard ratio 0.27, 95% confidence interval 0.13-0.55, P < .001).

Conclusion

In a large cohort of patients undergoing hybrid ablation for IST/POTS, a prophylaxis therapy with acetylsalicylic acid and colchicine was associated with a lower rate of symptomatic pericarditis.

背景心包炎是不适当窦性心动过速(IST)/体位性正位性心动过速综合征(POTS)混合窦房结保留消融术后最常见的并发症。方法回顾性分析了所有接受混合消融术的难治性或不能耐受药物的症状性 IST/POTS 患者。药物预防治疗以乙酰水杨酸和秋水仙碱为基础,从消融术当天开始,持续至少 3 个月。主要终点是出现症状性心包炎。次要终点是心包炎相关并发症的发生情况,包括以下内容:心包炎持续时间>3个月、心包炎住院、心包切除术后胸膜炎和心包切除术。结果共纳入220例接受IST/POTS混合消融术的患者,其中44例(20%)接受了预防治疗。101例(45.9%)患者发生了心包炎,其中97例(96%)发生在头5天。在生存分析中,预防性治疗与较高的心包炎治愈率相关(81.9% vs 47.2%,log-rank P <.001)。与心包炎相关的并发症较少,只有 7 例(3.2%)患者出现。接受预防性治疗的患者与未接受预防性治疗的患者在心包炎相关并发症方面没有差异。在 Cox 多变量分析中,心包炎的预测因素为 IST(vs POTS)(危险比 0.61,95% 置信区间 0.39-0.99,P = .04)和预防性治疗(危险比 0.27,95% 置信区间 0.13-0.55,P <.001)。
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引用次数: 0
Safety of Sports for Patients with Subcutaneous Implantable Cardioverter Defibrillator (SPORT S-ICD): Study rationale and protocol 皮下植入式心律转复除颤器(SPORT S-ICD)患者的运动安全性:研究原理和方案
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2024.01.007
E. Chorin, Rachel Lampert, Nick R. Bijsterveld, R. Knops, A. A. Wilde, Hein Heidbuchel, Andrew Krahn, Ilan Goldenberg, Raphael Rosso, D. Viskin, Shir Frydman, Lior Lupu, Sami Viskin
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引用次数: 0
Only the strong survive: The impact of frailty on patients undergoing leadless pacemaker implantation 只有强者才能生存:虚弱对无导线起搏器植入患者的影响
IF 1.9 Pub Date : 2024-02-01 DOI: 10.1016/j.hroo.2024.01.003
Marye J. Gleva MD, Karen Joynt Maddox MD, MPH
{"title":"Only the strong survive: The impact of frailty on patients undergoing leadless pacemaker implantation","authors":"Marye J. Gleva MD,&nbsp;Karen Joynt Maddox MD, MPH","doi":"10.1016/j.hroo.2024.01.003","DOIUrl":"10.1016/j.hroo.2024.01.003","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666501824000047/pdfft?md5=7fcf83db98f7b0afb5272b3d6219639d&pid=1-s2.0-S2666501824000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Heart Rhythm O2
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