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[Indications regarding early detection screening for genital tract neoplasms]. [生殖道肿瘤早期检测筛查的适应症]。
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1007/s00120-024-02477-2
Pia Paffenholz

Background: Testicular tumors and penile cancer are rare but potentially life-threatening diseases. Testicular tumors primarily affect younger men, while penile cancer is more common in older men. Early detection can significantly improve survival rates.

Objectives: This article investigates the indications for early detection screenings for testicular tumors and penile cancer.

Methods: A comprehensive literature review was conducted to analyze current studies and guidelines.

Results: No general screening programs are recommended for either type of cancer. For testicular tumors, self-examination of the testes is recommended, while for penile carcinomas, education on risk factors such as human papillomavirus (HPV) infections or phimosis is emphasized. In both cases, medical examination is crucial.

Conclusion: Education and awareness, especially among at-risk groups, are essential. Physicians play a key role in conducting and recommending early detection measures.

背景:睾丸肿瘤和阴茎癌是罕见但可能危及生命的疾病。睾丸肿瘤主要影响年轻男性,而阴茎癌则更常见于老年男性。早期发现可大大提高生存率:本文研究了睾丸肿瘤和阴茎癌早期检测筛查的适应症:方法:对目前的研究和指南进行了全面的文献综述分析:结果:对于这两种癌症,均未推荐进行常规筛查。对于睾丸肿瘤,建议对睾丸进行自我检查,而对于阴茎癌,则强调有关风险因素的教育,如人类乳头瘤病毒(HPV)感染或包皮过长。在这两种情况下,医学检查都至关重要:结论:教育和宣传,尤其是对高危人群的教育和宣传至关重要。医生在开展和建议早期检测措施方面发挥着关键作用。
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引用次数: 0
[Objectives of screening and early detection in medicine]. 【医学筛查和早期发现的目的】。
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2025-01-14 DOI: 10.1007/s00120-024-02488-z
Axel Heidenreich, Peter Albers, Maurice Stephan Michel
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引用次数: 0
[Early detection of prostate cancer-individualized, risk-adapted and successful]. [前列腺癌的早期检测个体化,风险适应和成功]。
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1007/s00120-024-02478-1
Anne Hübner, Isabelle Bußhoff, Jale Lakes, Rouvier Al-Monajjed, Jan Philipp Radtke, Peter Albers

Background: Population-based screening for prostate cancer (PC) is still controversially discussed. Furthermore, an organized, risk-adapted screening program is already being called for across Europe. Although large randomized controlled trials have shown that prostate-specific antigen (PSA)-based screening can significantly reduce PC-specific mortality, all known screening strategies still frequently lead to overdiagnosis and consecutively to overtreatment of clinically insignificant PC.

Objective: This review article presents the current evidence regarding PC screening.

Results: The current German early detection program, which is based on the annually recommended digital rectal examination (DRE), lacks specificity and sensitivity. In Germany, an opportunistic PSA screening is currently being carried out, which is no longer recommended due to an unfavorable benefit-risk ratio. Since 2022, the European Commission has been calling for the development of organized, risk-adapted screening strategies that combine the PSA test with magnetic resonance imaging (MRI). The integration of MRI improves the detection of clinically relevant PC and reduces the overdiagnosis of low-risk cancers. In the future, an algorithm for early detection of PC needs to be developed, which, in an organized and personalized screening, combines the PSA test with MRI and possibly genetic markers.

Conclusion: The early detection of prostate cancer should be organized at the population level and integrated into personalized, evidence-based screening strategies.

背景:基于人群的前列腺癌筛查(PC)仍有争议的讨论。此外,一项有组织的、适应风险的筛查计划已经在欧洲各地被呼吁。尽管大型随机对照试验表明,基于前列腺特异性抗原(PSA)的筛查可以显著降低PC特异性死亡率,但所有已知的筛查策略仍然经常导致临床无关紧要的PC的过度诊断和过度治疗。目的:本文综述了目前关于PC筛查的证据。结果:目前德国的早期检测方案是基于每年推荐的直肠指检(DRE),缺乏特异性和敏感性。在德国,目前正在进行机会性PSA筛查,由于不利的获益-风险比,不再推荐。自2022年以来,欧盟委员会一直呼吁制定有组织的、适应风险的筛查策略,将PSA检测与磁共振成像(MRI)相结合。MRI的整合提高了临床相关PC的检测,减少了低危癌症的过度诊断。在未来,需要开发一种早期检测PC的算法,在有组织和个性化的筛查中,将PSA测试与MRI和可能的遗传标记结合起来。结论:前列腺癌的早期发现应在人群层面进行组织,并纳入个性化的循证筛查策略。
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引用次数: 0
[Treatment of BK virus infection in kidney transplant patients]. 肾移植患者BK病毒感染的治疗
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.1007/s00120-024-02491-4
Laila Schneidewind
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引用次数: 0
[Cold plasma in wound healing]. [冷等离子体在伤口愈合中的应用]。
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-07-10 DOI: 10.1007/s00120-024-02376-6
Ursula Elisabeth Maria Werra, Bernhard Dorweiler

Even today, not all wounds can be healed. Treatment, which often takes many years, is a burden for patients and is very cost-intensive. Therefore, additional procedures such as cold plasma are becoming increasingly popular. Active components of cold plasma include electromagnetic radiation and free radicals. The active principle is based on, among other things, damage to bacterial cells and positive interaction with epithelial and endothelial cells. Angiogenesis and cellular oxygen metabolism are stimulated. The evidence base is still limited and heterogeneous, as some results are contradictory and comparability is difficult. However, new, well-designed studies have confirmed previous findings. In order to create a solid database, further studies are needed.

时至今日,并非所有伤口都能愈合。治疗往往需要多年时间,对患者来说是一种负担,而且费用非常昂贵。因此,冷等离子体等附加程序越来越受欢迎。冷等离子体的活性成分包括电磁辐射和自由基。其活性原理主要基于对细菌细胞的破坏以及与上皮细胞和内皮细胞的良性互动。血管生成和细胞氧代谢受到刺激。由于一些结果相互矛盾,很难进行比较,因此证据基础仍然有限且不统一。不过,新的、精心设计的研究证实了之前的发现。为了建立一个可靠的数据库,还需要进一步的研究。
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引用次数: 0
Urologie Kolumne.
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 DOI: 10.1007/s00120-024-02489-y
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引用次数: 0
[Urothelial carcinoma of the upper and lower urinary tract-which risk factors make early detection worthwhile?] [上尿路和下尿路尿路上皮癌--哪些风险因素值得早期发现?]
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1007/s00120-024-02479-0
Niklas Westhoff, Constantin Rieger, Axel Heidenreich, Christian Bolenz, Maurice Stephan Michel

Urothelial carcinoma is one of the most common malignancies both in Germany and worldwide. Due to the frequent occurrence of late-onset or nonspecific symptoms, carcinomas are often diagnosed at advanced stages. Structured early detection programs have the potential to detect urothelial carcinoma in earlier stages and to improve survival rates. Various risk factors are associated with urothelial carcinoma, most notably tobacco abuse and occupational exposure, as well as genetic disorders such as Lynch syndrome in upper urinary tract carcinoma. In clinical practice, diagnostic tools include general examinations and ultrasound imaging of the urinary tract, with microhematuria and urine cytology playing key roles. For screening purposes noninvasive urine markers have demonstrated limited evidence. Despite the lack of optimal diagnostic markers for systematic early detection in high-risk populations, it is essential to ensure that every patient presenting with hematuria undergoes appropriate and risk-adapted diagnostics.

尿路上皮癌是德国乃至全世界最常见的恶性肿瘤之一。由于经常出现起病较晚或无特异性症状的情况,癌症往往在晚期才被诊断出来。有组织的早期检测计划有可能在早期发现尿路癌,并提高存活率。尿路上皮癌与多种风险因素有关,其中最主要的是烟草滥用和职业暴露,以及遗传性疾病,如上尿路癌中的林奇综合征。在临床实践中,诊断工具包括一般检查和泌尿道超声波成像,微量血尿和尿液细胞学起着关键作用。用于筛查的非侵入性尿液标记物证据有限。尽管缺乏对高危人群进行系统性早期检测的最佳诊断标志物,但仍有必要确保每一位出现血尿的患者都能接受适当的风险适应性诊断。
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引用次数: 0
Mitteilungen der DGU. DGU通讯。
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 DOI: 10.1007/s00120-024-02502-4
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引用次数: 0
Termine. Termine。
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 DOI: 10.1007/s00120-024-02500-6
{"title":"Termine.","authors":"","doi":"10.1007/s00120-024-02500-6","DOIUrl":"https://doi.org/10.1007/s00120-024-02500-6","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":"64 1","pages":"102-104"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hepatic hematoma and hemoperitoneum following extracorporeal shock wave lithotripsy (ESWL)]. [体外冲击波碎石术(ESWL)后的肝血肿和腹腔积血]。
IF 0.5 4区 医学 Q4 UROLOGY & NEPHROLOGY Pub Date : 2024-12-18 DOI: 10.1007/s00120-024-02492-3
Georg Prange, Badar Uddin, Steffen Relecker, Gesa Dierke
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引用次数: 0
期刊
Urologie
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