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Prevention of Chemotherapy-related Oral Mucositis by Topical Timolol: A Prospective Randomized, Double-blind, Placebo-controlled Clinical Trial in Cancer Patients.
IF 1.2 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2025-01-24 DOI: 10.2174/0127722708312485250115052258
Fatemeh Saghafi, Fatemeh Shaker-Ardakani, Mohsen Nabi-Meybodi, Hassan-Ali Vahedian-Ardakani, Adeleh Sahebnasagh

Background: Timolol is a beta-adrenergic blocker that has been shown to be effective in the healing of wounds. Oral mucositis (OM), an acute inflammation of the oral mucosa, is a bothersome side effect of some regimens of chemotherapy in which the oral mucosa becomes ulcerated. The current study aimed to evaluate the prophylactic effects of timolol mouthwash in preventing OM in adult patients receiving chemotherapy compared to the placebo.

Method: This randomized, double-blind trial was conducted on 30 adult patients receiving chemotherapy regimen, including doxorubicin or 5-fluorouracil (5-FU). The patients were randomized in a 1:1 ratio to receive either timolol 0.5% (w/v) (n = 15) or placebo (n = 15) mouthwash 5 ml three times per day. The outcomes of the study were the intensity of OM evaluated by the World Health Organization (WHO) mucositis scale and OM-related pain based on the Visual Analog Scale (VAS) weekly during the seven weeks of the study period.

Results: The results of the study showed that the scores of WHO mucositis scale significantly decreased in the timolol group compared to the control group during the study [week 1: mean (SD), 0.02 (0.41) in the timolol group, and 0.67 (0.48) in the control group; week 7: mean (SD), 0.33 (0.61) in the timolol group, and 0.87 (0.74) in the control group; P-value = 0.049]. Moreover, the mean pain scores significantly decreased in the first, second, and third weeks in the timolol group compared to the control group (P-value < 0.05).

Conclusion: The results of this preliminary clinical trial demonstrated that among the patients receiving doxorubicin or 5-FU chemotherapy regimens, the preventive use of timolol mouthwash significantly diminished the severity of OM compared to the control group during the seven weeks of follow-up. The severity of pain was also significantly lower during the first three weeks of the study; however, the effect size was less than the minimal clinically important difference. Further studies are required to assess both the long-term efficacy and safety of timolol mouthwash in preventing OM.

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引用次数: 0
Advanced Drug Delivery Systems: From Microsponges to Nanotechnologies. 先进的药物输送系统:从微海绵到纳米技术。
IF 1.2 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2025-01-01 DOI: 10.2174/277227081901241223145542
Stefano Fiorucci, Ginevra Urbani
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引用次数: 0
The Role of Inflammatory and Hemostatic Markers in the Prediction of Severe Acute Pancreatitis: An Observational Cohort Study. 炎症和止血标志物在预测严重急性胰腺炎中的作用:一项观察性队列研究。
IF 1.2 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-12-17 DOI: 10.2174/0127722708356543241209060544
Liudmila Orbelian, Nikita Trembach, Vladimir Durleshter

Introduction: Acute pancreatitis (AP) is a serious inflammatory disease of the pancreas that can lead to significant morbidity and increased mortality. The special role of inflammation and disruption of the hemostatic system in the development of severe forms of the disease is known, however, the relationship between inflammatory and anti-inflammatory cytokines and thromboelastogram parameters has not been sufficiently studied.

Aim: The aim of this study is to assess the prognostic significance of thromboelastogram parameters, interleukin-6, and interleukin-22 levels in assessing the risk for developing severe forms of acute pancreatitis.

Material and methods: Data from 149 patients with acute pancreatitis were included in the analysis. The classification of AP was performed according to the 2012 Revision of the Atlanta Classification. Data including gender, age, lab tests, radiological information, and prognosis were included. The following scales were used to assess severity: SOFA scale and BISAP scale. IL-6 and IL-22 were analyzed at 24 h and 48 h after the onset of symptoms. The collected TEG parameters included K-time, R-value, and Maximum amplitude value at admission. All patients were divided into three groups: mild, moderate-severe, and severe pancreatitis.

Results: Statistically significant differences were found between the groups in the IL-6 level at the first measurement and on day 2 of the study. IL-22 values were also higher in the group with severe pancreatitis, however, on day 2, its level became lower compared to the group of patients with moderate and mild pancreatitis. Statistically significant differences were found in the level of K-time, R-value, Maximum amplitude, fibrinogen concentration, and platelets count, demonstrating a hypercoagulation state in severe pancreatitis at admission. The conducted logistic regression showed that the factors associated with the development of severe forms are the number of points on the BISAP scale, the level of interleukin-6 in the first 24 hours of the disease, delta IL-22, and K-time. (AUC = 0.948).

Conclusion: The study highlights that both IL-6 and IL-22 play crucial roles in the inflammatory cascade of severe acute pancreatitis. Their levels, along with specific hemostasis parameters like K-time and BISAP score, serve as reliable early predictors of disease severity.

简介:急性胰腺炎(AP)是胰腺的一种严重炎症性疾病,可导致显著的发病率和死亡率增加。炎症和止血系统的破坏在严重形式的疾病发展中的特殊作用是已知的,然而,炎症和抗炎细胞因子与血栓弹性图参数之间的关系尚未得到充分的研究。目的:本研究的目的是评估血栓弹性图参数、白细胞介素-6和白细胞介素-22水平在评估发生严重急性胰腺炎风险中的预后意义。材料和方法:149例急性胰腺炎患者的资料被纳入分析。AP的分类依据2012年修订的亚特兰大分类进行。数据包括性别、年龄、实验室检查、放射学信息和预后。采用SOFA量表和BISAP量表评估严重程度。在出现症状后24 h和48 h分析IL-6和IL-22。采集的TEG参数包括K-time、R-value和入场时最大振幅值。所有患者分为轻度、中重度和重度胰腺炎三组。结果:两组间IL-6水平在第一次测量时和研究第2天的差异有统计学意义。IL-22在重症胰腺炎组中也较高,但在第2天,IL-22水平较中轻度胰腺炎组降低。在k时间、r值、最大振幅、纤维蛋白原浓度和血小板计数水平上发现有统计学意义的差异,表明入院时重症胰腺炎存在高凝状态。经logistic回归分析,BISAP分值、发病前24小时白细胞介素-6水平、δ IL-22和k -时间是影响病情发展的因素。(auc = 0.948)。结论:本研究提示IL-6和IL-22在重症急性胰腺炎的炎症级联反应中发挥重要作用。它们的水平,以及特定的止血参数,如k -时间和BISAP评分,可作为疾病严重程度的可靠早期预测指标。
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引用次数: 0
Inflammatory Myopathies and Autoimmune Gluten-related Disorders: A Scoping Review of Pathophysiological Interconnections and Hypothesis. 炎症性肌病和自身免疫性谷蛋白相关疾病:病理生理联系和假设的范围综述。
IF 1.2 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-10-01 DOI: 10.2174/0127722708317244240919113305
Gunhild Alvik Nyborg

Introduction: Anecdotal reports describe patients with concurrent idiopathic inflammatory myopathy (IIM) and celiac disease (CeD) in whom the introduction of a gluten-free diet led to dramatic improvement of myositis. We first systematically reviewed all peer-reviewed publications on concomitant IIM and duodenal biopsy-verified CeD. The collected evidence was suggestive of associations between myositis disease activity and gluten exposure in some patients with IIM-CeD.

Objective/methods: To investigate possible explanations for the observations, an exploratory review of basic pathophysiological relationships between IIM and gluten-related disorders was performed using a combined strategy of systematic and non-systematic literature searches and forward and backward citation tracking.

Results: The investigations revealed close pathophysiological associations between IIM and the autoimmune gluten-related disorders CeD, dermatitis herpetiformis, and gluten ataxia. Common traits include shared genetic predisposition through HLA-DQ2.5/-DQ8, disease activity-associated autoantibodies, histopathological parallels with inflammatory cell infiltrates, and similarly distributed structural homologous transglutaminases (TGs). HLA-DQ2.5-restricted gluten-specific CD4+ T cells of a rare, uniform phenotype are reported in CeD and connective tissue disease. Expanded T-cell clones with identical phenotypes and CDR3β motifs indicate the presence of a continuous, antigen-driven T-cell response.

Conclusion: The investigations revealed that the main components involved in the adaptive immune response in the CeD gut may be present in HLA-DQ2.5+/-DQ8+ IIM muscle. The collected evidence supports the notion that in some genetically predisposed patients with IIM, gluten may act as an exogenous antigen driving myositis. Further Research/Clinical Implications: To test the above hypothesis, clinical trials combined with immunological studies are needed. Meanwhile, the inclusion of HLA-DQ typing may be justified, and subsequent small-intestinal biopsies in HLA-DQ2.5/8+ individuals with IIM.

轶事报道描述了并发特发性炎症性肌病(IIM)和乳糜泻(CeD)的患者,其中引入无麸质饮食导致肌炎的显着改善。我们首先系统地回顾了所有同行评议的关于合并IIM和十二指肠活检证实的CeD的出版物。收集到的证据表明,在一些IIM-CeD患者中,肌炎疾病活动与麸质暴露之间存在关联。目的/方法:采用系统和非系统文献检索以及前后引文跟踪相结合的策略,对IIM与谷蛋白相关疾病之间的基本病理生理关系进行了探索性回顾,以探讨可能的解释。结果:研究揭示了IIM与自身免疫性谷蛋白相关疾病CeD、疱疹样皮炎和谷蛋白共济失调之间的密切病理生理联系。共同特征包括HLA-DQ2.5/-DQ8的共同遗传易感性,疾病活动性相关的自身抗体,与炎症细胞浸润的组织病理学相似,以及相似分布的结构同源谷氨酰胺转酶(tgg)。hla - dq2.5限制性谷蛋白特异性CD4+ T细胞在CeD和结缔组织疾病中罕见,均匀表型。扩增的t细胞克隆具有相同的表型和CDR3β基序,表明存在连续的抗原驱动的t细胞应答。结论:研究表明,参与CeD肠道适应性免疫反应的主要成分可能存在于HLA-DQ2.5+/-DQ8+ IIM肌肉中。收集到的证据支持这样一种观点,即在一些遗传易感的IIM患者中,麸质可能作为外源性抗原驱动肌炎。进一步的研究/临床意义:为了验证上述假设,需要结合免疫学研究进行临床试验。同时,纳入HLA-DQ分型可能是合理的,随后在HLA-DQ2.5/8+ IIM患者中进行小肠活检。
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引用次数: 0
The Potential Anti-psoriatic Effects of Andrographolide: A Comparative Study to Topical Corticosteroids. 穿心莲内酯潜在的抗银屑病作用:与外用皮质类固醇的比较研究
IF 0.4 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-05-06 DOI: 10.2174/0127722708296983240424102212
Indira Dharmasamitha, Luh Made Mas Rusyati, Dyah Kanya Wati, I Made Agus Gelgel Wirasuta

Background: Andrographolide (AP), a bioactive anti-inflammatory compound of Sambiloto, inhibits NF-κB, TNF-α, and interleukin IL-6. Nowadays, molecular docking simulation between AP and dexamethasone against NF-κB receptor presented the energy AP higher than dexamethasone. This becomes a potential treatment for psoriasis.

Objective: This manuscript reported the effectiveness of AP from Sambiloto in treating psoriasis compared to topical steroids.

Methods: This study conducted TLC analysis of AP content and its metabolite impurities, emulgel formulation, molecular docking, in-silico skin toxicity study, and in-vivo anti-psoriatic activity. This was a combination study of an in-silico study and an in-vivo study. This in-silico study was analyzed through multivariate statistical analysis (PCA) to elucidate the data constellation relationship of andrographolide derivatives with several target proteins. The intervention was performed in seven days. The PASI score, molecular parameters (IL-6, IL-17, VEGF, and TNF-a levels), and histopathological findings were assessed.

Results: Molecular docking results revealed andrographolide to exhibit a relatively high binding affinity towards IL-6, NF-kB, and TNF-α which is comparable to the corticosteroids, andrographolide also shares similar residue interaction profile with each of the respective protein's native ligand. In the in-vivo study, we found several parameters statistically significantly different regarding the intervention, including final PASI score (p = 0.017), redness (p = 0.017), scale (p = 0.040), thickness (p = 0.023), total histopathology of psoriasis score (p = 0.037), keratin layer score (p = 0.018).

Conclusion: Emulgel AP 0.1% could lower the anti-inflammatory agent, which is vital to psoriasis progression.

背景:穿心莲内酯(Andrographolide,AP)是一种生物活性抗炎化合物,可抑制 NF-κB、TNF-α 和白细胞介素 IL-6。目前,AP 与地塞米松针对 NF-κB 受体的分子对接模拟显示,AP 的能量高于地塞米松。这成为治疗银屑病的一种潜在方法:本手稿报告了桑比洛托 AP 与外用类固醇相比在治疗银屑病方面的有效性:本研究对 AP 的含量及其代谢物杂质、凝胶配方、分子对接、体内皮肤毒性研究和体内抗银屑病活性进行了 TLC 分析。这是一项综合了室内研究和体内研究的研究。通过多变量统计分析(PCA)对这项体内研究进行了分析,以阐明穿心莲内酯衍生物与几种靶蛋白之间的数据星座关系。干预为期七天。对PASI评分、分子参数(IL-6、IL-17、VEGF和TNF-a水平)以及组织病理学结果进行了评估:分子对接结果显示,穿心莲内酯与IL-6、NF-kB和TNF-α的结合亲和力较高,与皮质类固醇的结合亲和力相当。在体内研究中,我们发现有几个参数在统计学上与干预有显著差异,包括最终的 PASI 评分(p = 0.017)、发红(p = 0.017)、鳞屑(p = 0.040)、厚度(p = 0.023)、银屑病组织病理学总评分(p = 0.037)、角质层评分(p = 0.018):结论:Emulgel AP 0.1%可降低抗炎剂,而抗炎剂对银屑病的发展至关重要。
{"title":"The Potential Anti-psoriatic Effects of Andrographolide: A Comparative Study to Topical Corticosteroids.","authors":"Indira Dharmasamitha, Luh Made Mas Rusyati, Dyah Kanya Wati, I Made Agus Gelgel Wirasuta","doi":"10.2174/0127722708296983240424102212","DOIUrl":"https://doi.org/10.2174/0127722708296983240424102212","url":null,"abstract":"<p><strong>Background: </strong>Andrographolide (AP), a bioactive anti-inflammatory compound of Sambiloto, inhibits NF-κB, TNF-α, and interleukin IL-6. Nowadays, molecular docking simulation between AP and dexamethasone against NF-κB receptor presented the energy AP higher than dexamethasone. This becomes a potential treatment for psoriasis.</p><p><strong>Objective: </strong>This manuscript reported the effectiveness of AP from Sambiloto in treating psoriasis compared to topical steroids.</p><p><strong>Methods: </strong>This study conducted TLC analysis of AP content and its metabolite impurities, emulgel formulation, molecular docking, in-silico skin toxicity study, and in-vivo anti-psoriatic activity. This was a combination study of an in-silico study and an in-vivo study. This in-silico study was analyzed through multivariate statistical analysis (PCA) to elucidate the data constellation relationship of andrographolide derivatives with several target proteins. The intervention was performed in seven days. The PASI score, molecular parameters (IL-6, IL-17, VEGF, and TNF-a levels), and histopathological findings were assessed.</p><p><strong>Results: </strong>Molecular docking results revealed andrographolide to exhibit a relatively high binding affinity towards IL-6, NF-kB, and TNF-α which is comparable to the corticosteroids, andrographolide also shares similar residue interaction profile with each of the respective protein's native ligand. In the in-vivo study, we found several parameters statistically significantly different regarding the intervention, including final PASI score (p = 0.017), redness (p = 0.017), scale (p = 0.040), thickness (p = 0.023), total histopathology of psoriasis score (p = 0.037), keratin layer score (p = 0.018).</p><p><strong>Conclusion: </strong>Emulgel AP 0.1% could lower the anti-inflammatory agent, which is vital to psoriasis progression.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Traditional Medicine to Advanced Therapeutics: The Renaissance of Phyto-nano Interventions in Psoriasis. 从传统医学到高级治疗:植物纳米介入治疗银屑病的复兴。
IF 0.4 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-01-01 DOI: 10.2174/0127722708265612231012080047
Rajneesh Semele, Sonam Grewal, Manish Kumar Jeengar, Thakur Gurjeet Singh, Rajan Swami

Psoriasis is an autoimmune systemic chronic inflammatory disease that exhibits characteristic detrimental effects on the skin, often leading to infections or comorbid conditions. The multifaceted nature of psoriasis has made it very challenging to treat, especially with current chemotherapy options. Therefore, it is essential to consider phytoconstituents as novel alternatives. However, despite demonstrating higher anti-inflammatory, anti-psoriasis, and immunomodulatory potential, their clinical usage is hindered due to their poor physicochemical properties. To address these drawbacks, nanoparticulate drug delivery systems have been developed, helping to achieve better permeation of phytoconstituents through topical administration. This has breathed new life into traditional systems of medicine, particularly in the context of treating psoriasis. In this current review, we present a detailed, comprehensive, and up-to-date analysis of the literature, which will contribute to affirming the clinical role of phyto-nano interventions against psoriasis.

银屑病是一种自身免疫系统性慢性炎症性疾病,对皮肤表现出特有的有害影响,通常会导致感染或合并症。银屑病的多面性使其治疗极具挑战性,尤其是在目前的化疗方案下。因此,有必要考虑将植物成分作为新的替代品。然而,尽管表现出更高的抗炎、抗银屑病和免疫调节潜力,但由于其较差的物理化学性质,其临床应用受到阻碍。为了解决这些缺点,已经开发了纳米颗粒药物递送系统,有助于通过局部给药实现植物成分的更好渗透。这为传统医学体系注入了新的活力,尤其是在治疗银屑病的背景下。在这篇综述中,我们对文献进行了详细、全面和最新的分析,这将有助于肯定植物纳米干预措施对银屑病的临床作用。
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引用次数: 0
Modulation of the Immune System Mechanisms using Probiotic Bacteria in Allergic Diseases: Focus on Allergic Retinitis and Food Allergies. 过敏性疾病中使用益生菌调节免疫系统机制:关注过敏性视网膜炎和食物过敏。
IF 0.4 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-01-01 DOI: 10.2174/0127722708246899230928080651
Haleh Forouhandeh, Saiedeh Razi Soofiyani, Kamran Hosseini, Sohrab Minaei Beirami, Hossein Ahangari, Yusif Moammer, Sara Ebrahimzadeh, Masoomeh Kashef Nejad, Afsaneh Farjami, Fariba Khodaiefar, Vahideh Tarhriz

Allergic illnesses occur when an organism's immune system is excessively responsive to certain antigens, such as those that are presented in the environment. Some people suffer from a wide range of immune system-related illnesses including allergic rhinitis, asthma, food allergies, hay fever, and even anaphylaxis. Immunotherapy and medications are frequently used to treat allergic disorders. The use of probiotics in bacteriotherapy has lately gained interest. Probiotics are essential to human health by modulating the gut microbiota in some ways. Due to probiotics' immunomodulatory properties present in the gut microbiota of all animals, including humans, these bacterial strains can prevent a wide variety of allergic disorders. Probiotic treatment helps allergy patients by decreasing inflammatory cytokines and enhancing intestinal permeability, which is important in the battle against allergy. By altering the balance of Th1 and Th2 immune responses in the intestinal mucosa, probiotics can heal allergic disorders. Numerous studies have shown a correlation between probiotics and a reduced risk of allergy disorders. A wide range of allergic disorders, including atopic dermatitis, asthma, allergic retinitis and food allergies has been proven to benefit from probiotic bacteria. Therefore, the use of probiotics in the treatment of allergic diseases offers a promising perspective. Considering that probiotic intervention in the treatment of diseases is a relatively new field of study, more studies in this regard seem necessary.

当生物体的免疫系统对某些抗原(如环境中存在的抗原)反应过度时,就会发生过敏性疾病。有些人患有多种免疫系统相关疾病,包括过敏性鼻炎、哮喘、食物过敏、花粉热,甚至过敏反应。免疫疗法和药物经常用于治疗过敏性疾病。益生菌在细菌治疗中的应用最近引起了人们的兴趣。益生菌通过某些方式调节肠道微生物群,对人类健康至关重要。由于益生菌的免疫调节特性存在于包括人类在内的所有动物的肠道微生物群中,这些菌株可以预防各种过敏性疾病。益生菌治疗通过降低炎症细胞因子和增强肠道通透性来帮助过敏患者,这在对抗过敏的斗争中很重要。通过改变肠粘膜中Th1和Th2免疫反应的平衡,益生菌可以治愈过敏性疾病。大量研究表明,益生菌与降低过敏性疾病风险之间存在相关性。益生菌已被证明对多种过敏性疾病有益,包括特应性皮炎、哮喘、过敏性视网膜炎和食物过敏。因此,益生菌在治疗过敏性疾病中的应用提供了一个很有前景的前景。考虑到益生菌干预治疗疾病是一个相对较新的研究领域,似乎有必要在这方面进行更多的研究。
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引用次数: 0
Biological Potential and Therapeutic Effectiveness of Phytoproduct 'Fargesin' in Medicine: Focus on the Potential of an Active Phytochemical of Magnolia fargesii. 植物产品'Fargesin'在医药方面的生物潜力和治疗效果:关注厚朴活性植物化学物质的潜力。
IF 1.2 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-01-01 DOI: 10.2174/0127722708286664240429093913
Kanika Patel, Dinesh Kumar Patel

Flos Magnoliae is one of the important medicinal plants in different traditional medicine, including Chinese herbal medicine. Lignans and neolignans, including tetrahydrofurofuran, tetrahydrofuran, and aryltetralin, are present in the Flos Magnoliae species. A wide range of pharmacological activity of Flos Magnoliae has been reported in medicine. Fargesin has been isolated from Magnolia fargesii and it is a lignan-class phytochemical. Fargesin has numerous pharmacological activities in medicine, including its effectiveness on lipid and glucose metabolism, oxidative stress, myocardial apoptosis, etc. In the present work, we have summarized the detailed scientific information of fargesin concerning its medicinal properties and pharmacological activities. Numerous biological and chemical aspects of fargesin are discussed here, including the detailed pharmacological activities and analytical aspects of fargesin. In this review, we have also compiled analytical data on fargesin based on available scientific literature. Ethnopharmacological information on fargesin was gathered by a literature survey on PubMed, Science Direct, Google, and Scopus using the terms fargesin, Flos Magnoliae, phytochemical, and herbal medicine. The present review paper compiled the scientific data on fargesin in medicine for its pharmacological activities and analytical aspects in a very concise manner with proper citations. The present work signified the biological importance of fargesin in medicine due to its significant impact on bone disorders, lung injury, colon cancer, atherosclerosis, neurological disorders, ischemia, sars-cov-2, allergy, lipid and glucose metabolism, melanin synthesis, and different classes of enzymes. Furthermore, fargesin also has anti-inflammatory, antihypertensive, antiprotozoal, antimycobacterial, and antifeedant activity. However, analytical methods used for the separation, identification and isolation of fargesin in different biological and non-biological samples were also covered in the present review. The present work revealed the pharmacological activities and analytical aspects of fargesin in medicine and other allied health sectors.

厚朴是包括中药在内的各种传统医学中的重要药用植物之一。木兰科植物中含有木质素和新木质素,包括四氢呋喃、四氢呋喃和芳基四氢萘。据报道,木兰科植物具有广泛的药理活性。远志皂苷(Fargesin)是从远志木兰中分离出来的,是一种木脂素类植物化学物质。Fargesin 具有多种药理活性,包括对脂质和葡萄糖代谢、氧化应激、心肌凋亡等方面的作用。在本研究中,我们总结了法吉辛在药用特性和药理活性方面的详细科学信息。本文讨论了法吉辛的许多生物和化学方面的问题,包括法吉辛的详细药理活性和分析方面的问题。在这篇综述中,我们还根据现有的科学文献,汇编了法吉辛的分析数据。通过在 Pubmed、Science Direct、Google 和 Scopus 上使用 fargesin、Flos Magnoliae、phytochemical 和 herbal medicine 等术语进行文献调查,收集了有关法哥辛的民族药理学信息。本综述论文以非常简洁的方式汇编了法吉辛在药理活性和分析方面的科学数据,并适当引用了相关文献。本研究表明,法吉辛在医学上具有重要的生物学意义,因为它对骨骼疾病、肺损伤、结肠癌、动脉粥样硬化、神经系统疾病、缺血、sars-cov-2、过敏、脂质和葡萄糖代谢、黑色素合成以及不同种类的酶都有显著影响。此外,法吉辛还具有抗炎、抗高血压、抗原虫、抗霉菌和抗飞虫活性。不过,本综述也涵盖了用于在不同生物和非生物样本中分离、鉴定和分离法吉辛的分析方法。本研究揭示了法吉辛在医药和其他相关卫生部门中的药理活性和分析方面。
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引用次数: 0
Immunoinformatic Analysis of Leishmania Major gp46 Protein and Potential Targets for Vaccination against Leishmaniasis. 利什曼病主要 gp46 蛋白的免疫形式分析和利什曼病疫苗的潜在靶标。
IF 1.2 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-01-01 DOI: 10.2174/0127722708283588240124095057
Mohammad Reza Hafezi Ahmadi, Mina Mamizadeh, Davood Siamian, Mehdi Ali Asghari Touyeh, Morteza Shams, Yasaman Rashidi

Background: Cutaneous leishmaniasis (CL) is a parasitic disease with a significant burden in the Old World countries.

Objective: In the current study, some of the primary biochemical properties and IFN-γ inducing epitopes with specific binding capacity to human and mouse MHC alleles were predicted for Leishmania major gp46 antigenic protein.

Methods: Several online servers were used to predict physico-chemical traits, allergenicity, antigenicity, transmembrane domain and signal peptide, subcellular localization, post-translational modifications (PTMs), secondary and tertiary structures, tertiary model refining with validations. Also, IEDB web server was used to predict mouse/human cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte (HTL) epitopes.

Results: The 33.25 kDa protein was stable, hydrophilic, antigenic, while non-allergenic, with enhanced thermotolerance and 45 PTM sites. The secondary structure encompassed a random coil, followed by extended strands and helices. Ramachandran-based analysis of the refined model showed 73.1%, 21.6%, 3.4% and 1.9% of residues in the most favored, additional allowed, generously-allowed and disallowed regions, respectively. Epitope screening demonstrated 4 HTL epitopes against seemingly protective HLA alleles, 5 HTL epitopes against the HLA reference set, 3 human CTL epitopes and a number of mouse MHC-restricted epitopes.

Conclusion: This paper provides insights into the bioinformatics characteristics of the L. major gp46 protein as a promising vaccine candidate.

背景:皮肤利什曼病(CL皮肤利什曼病(CL)是一种寄生虫病,给旧世界国家带来了沉重负担:本研究预测了利什曼原虫主要抗原蛋白 gp46 的一些主要生化特性以及与人类和小鼠 MHC 等位基因具有特异性结合能力的 IFN-γ 诱导表位:使用多个在线服务器预测理化性状、过敏性、抗原性、跨膜域和信号肽、亚细胞定位、翻译后修饰(PTMs)、二级和三级结构、三级模型提炼和验证。此外,还利用 IEDB 网络服务器预测了小鼠/人类细胞毒性 T 淋巴细胞(CTL)和辅助性 T 淋巴细胞(HTL)表位:33.25 kDa 蛋白稳定、亲水性强、抗原性强、无过敏性、耐热性强,有 45 个 PTM 位点。二级结构包括一个随机线圈,其次是延伸的链和螺旋。基于拉马钱德兰分析法对完善后的模型进行了分析,结果显示,在最有利、额外允许、慷慨允许和不允许区域的残基分别占 73.1%、21.6%、3.4% 和 1.9%。表位筛选结果表明,有 4 个 HTL 表位针对看似具有保护性的 HLA 等位基因,5 个 HTL 表位针对 HLA 参考集,3 个人类 CTL 表位和一些小鼠 MHC 限制表位:本文深入探讨了大肠杆菌 gp46 蛋白作为候选疫苗的生物信息学特征。
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引用次数: 0
Beyond Pharmaceuticals: Harnessing the Potential of Plant-based Compounds for Anti-inflammatory Therapy. 超越药物:利用植物化合物的潜力进行抗炎治疗。
IF 1.2 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2024-01-01 DOI: 10.2174/0127722708292961240508110207
Vishnu Mittal, Anjali Sharma

A complicated biological reaction of vascular tissues to damaging stimuli like infections, harmed cells, or irritants is called inflammation. Symptoms include redness, inflamed joints, stiffness, discomfort in the joints, and loss of joint function. NSAIDs are frequently used to treat inflammation. Sadly, these drugs raise the possibility of blood clots, which can result in heart attacks and strokes. Consequently, there is ongoing research focusing on developing potent anti-inflammatory drugs using natural ingredients. Natural products, due to their diverse chemical composition, offer a rich source for the development of novel medications. The treatment of various inflammation- related disorders heavily relies on a natural substance derived from medicinal plants. The objective of the present study is to assemble information on potential parts of the plants or phytochemicals derived from medicinal plants used on inflammatory models, employing state-ofthe- art scientific methodologies. In this study, state-of-the-art scientific methodologies are utilized to investigate the effects of phytochemicals derived from medicinal plants. Relevant data is collected, focusing on the examination of these phytochemicals in experimental models of inflammation. The study aims to collect thorough data on potential plant parts or promising phytochemicals derived from medicinal plants that have been evaluated using advanced scientific techniques in the realm of inflammation models. This compilation will offer valuable insights into their potential as anti-inflammatory agents. The findings have the potential to contribute to the development of new and improved anti-inflammatory medications with fewer or no adverse effects compared to current treatments. While many of these studies hold academic interest only a few are accepted into clinical trials. Numerous phytoconstituents have been identified for exhibiting diverse pharmacological actions.

血管组织对感染、受损细胞或刺激物等破坏性刺激的复杂生物反应称为炎症。症状包括关节发红、发炎、僵硬、不适以及关节功能丧失。非甾体抗炎药常用于治疗炎症。遗憾的是,这些药物有可能引发血栓,导致心脏病发作和中风。因此,目前的研究重点是利用天然成分开发强效消炎药。天然产品的化学成分多种多样,为开发新型药物提供了丰富的资源。各种炎症相关疾病的治疗在很大程度上依赖于从药用植物中提取的天然物质。本研究的目的是采用最先进的科学方法,收集有关用于炎症模型的植物潜在部分或从药用植物中提取的植物化学物质的信息。本研究采用最先进的科学方法来研究从药用植物中提取的植物化学物质的作用。研究收集了相关数据,重点考察了这些植物化学物质在炎症实验模型中的作用。本研究旨在收集有关药用植物中提取的潜在植物部分或有前景的植物化学物质的详尽数据,这些数据已在炎症模型领域使用先进的科学技术进行了评估。这一汇编将为了解它们作为抗炎剂的潜力提供宝贵的见解。与目前的治疗方法相比,这些研究结果有可能有助于开发新的、更好的抗炎药物,减少或消除不良反应。虽然这些研究中有许多都具有学术意义,但只有少数被纳入临床试验。目前已发现许多植物成分具有不同的药理作用。
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引用次数: 0
期刊
Recent Advances in Inflammation & Allergy Drug Discovery
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