Pub Date : 2023-03-01DOI: 10.23736/s2724-542x.23.02945-0
Naeemeh Rezapour, Mohammad Kamalabadi-Farahani, A. Atashi, V. zarrinpour
{"title":"Paclitaxel resistance and nucleostemin upregulation in metastatic mouse breast cancer cells","authors":"Naeemeh Rezapour, Mohammad Kamalabadi-Farahani, A. Atashi, V. zarrinpour","doi":"10.23736/s2724-542x.23.02945-0","DOIUrl":"https://doi.org/10.23736/s2724-542x.23.02945-0","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"30 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75519638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.23736/s2724-542x.23.02918-8
Xiaoping Cai, Z. Cao, Jiongwei Pan, Hao Zheng
{"title":"Transcription factor NFIC activates STK11 transcription to repress the proliferation, migration, and invasion of lung adenocarcinoma cells","authors":"Xiaoping Cai, Z. Cao, Jiongwei Pan, Hao Zheng","doi":"10.23736/s2724-542x.23.02918-8","DOIUrl":"https://doi.org/10.23736/s2724-542x.23.02918-8","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"44 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76911464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.23736/s2724-542x.22.02913-3
Z. Han, Sujing Huang, Ru Wang, Hongqiong Guan
{"title":"Screening of differential circRNAs in the placenta of patients with preeclampsia and their regulatory mechanism","authors":"Z. Han, Sujing Huang, Ru Wang, Hongqiong Guan","doi":"10.23736/s2724-542x.22.02913-3","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02913-3","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"24 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87302479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.23736/s2724-542x.22.02939-x
F. Patrucco, F. Gavelli, P. Solidoro
{"title":"Transcriptome analysis on bronchoalveolar lavage in COVID-19 patients","authors":"F. Patrucco, F. Gavelli, P. Solidoro","doi":"10.23736/s2724-542x.22.02939-x","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02939-x","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"33 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74839071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.23736/s2724-542x.22.02937-6
M. Wahid, R. Mandal, M. Sikander, A. Hussain, S. Haque
{"title":"A bird eye view on cancer comorbidities in rheumatoid arthritis patients: an underestimated incidences and possible preventive treatments","authors":"M. Wahid, R. Mandal, M. Sikander, A. Hussain, S. Haque","doi":"10.23736/s2724-542x.22.02937-6","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02937-6","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"17 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73704873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.23736/s2724-542x.22.02931-5
G. Chandan, Chetan Kumar, N. Satti, H. Tuli, S. Fagoonee, S. Haque, A. Saini, R. Saini
{"title":"Daturalactones as immunomodulators: activation of immune cells conferring cytotoxicity towards colon and pancreatic cancer cells","authors":"G. Chandan, Chetan Kumar, N. Satti, H. Tuli, S. Fagoonee, S. Haque, A. Saini, R. Saini","doi":"10.23736/s2724-542x.22.02931-5","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02931-5","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"46 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85986147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.23736/s2724-542x.22.02936-4
T. Le, N. Vu, P. Nguyen, P. D. Huynh, Phuc Van Pham
{"title":"Safety and efficacy of injection of exosomes derived from human umbilical cord mesenchymal stem cells in the treatment of limb ischemia: an in-vivo evaluation in mice","authors":"T. Le, N. Vu, P. Nguyen, P. D. Huynh, Phuc Van Pham","doi":"10.23736/s2724-542x.22.02936-4","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02936-4","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"15 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91118948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.23736/s2724-542x.22.02943-1
D. Krenytska, L. Kot, T. Halenova, N. Raksha, T. Vovk, O. Savchuk, R. Pellicano, L. Abenavoli, T. Falalyeyeva, L. Ostapchenko
BACKGROUND: Severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) іnfection induces a pro-inflammatory state of an organism with long-term systemic consequences as a result. Systemic inflammation, characterized by a high circulating level of inflammatory cytokines, is a significant factor influencing articular cartilage metabolism in osteoarthritis (OA). This study aimed to determine the levels of pro-inflammatory and anti-inflammatory cytokines in plasma of patients with OA following SARS-CoV-2 infection and to compare them with those of healthy controls. METHODS: The experiment involved patients of the Orthopedic Specialty Clinic aged 46 to 69 diagnosed with knee OA. Among persons with joint pathology a group of convalescent patients from 6-9 months after COVID-19 was identified. The control group involved relatively healthy donors. The plasma levels of pro-inflammatory (IL-1β, IL-6, IL-8, IL-12β, tumor necrosis factor α [TNF-α], interferon-gamma [IFN-γ]) and anti-inflammatory (IL-4 and IL-10) cytokines were determined by enzyme-linked immunosorbent assay. RESULTS: It was established that in patients with OA, as well as after suffering from SARS-CoV-2 infection, an increase in the plasma levels of IL-1β was observed against the background of a decrease in the levels of IL-4, IL-8, IL-10, IL- 12β, TNF-α and IFN-γ, compared to the healthy controls. COVID-19 more significantly influenced the plasma levels of pro-inflammatory cytokines IL-1β and IL-12β. CONCLUSIONS: The results indicate the imbalance of pro- and anti-inflammatory cytokines in the plasma in patients with OA for a long post- COVID. Сhanges in the levels of inflammatory mediators suggest distinct immunoregulatory mechanisms involved in the pathogenesis of both joint pathology and systemic disorders caused by SARS-CoV-2. [ FROM AUTHOR]
{"title":"Cytokine profile in patients with osteoarthritis after SARS-CoV-2 infection","authors":"D. Krenytska, L. Kot, T. Halenova, N. Raksha, T. Vovk, O. Savchuk, R. Pellicano, L. Abenavoli, T. Falalyeyeva, L. Ostapchenko","doi":"10.23736/s2724-542x.22.02943-1","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02943-1","url":null,"abstract":"BACKGROUND: Severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) іnfection induces a pro-inflammatory state of an organism with long-term systemic consequences as a result. Systemic inflammation, characterized by a high circulating level of inflammatory cytokines, is a significant factor influencing articular cartilage metabolism in osteoarthritis (OA). This study aimed to determine the levels of pro-inflammatory and anti-inflammatory cytokines in plasma of patients with OA following SARS-CoV-2 infection and to compare them with those of healthy controls. METHODS: The experiment involved patients of the Orthopedic Specialty Clinic aged 46 to 69 diagnosed with knee OA. Among persons with joint pathology a group of convalescent patients from 6-9 months after COVID-19 was identified. The control group involved relatively healthy donors. The plasma levels of pro-inflammatory (IL-1β, IL-6, IL-8, IL-12β, tumor necrosis factor α [TNF-α], interferon-gamma [IFN-γ]) and anti-inflammatory (IL-4 and IL-10) cytokines were determined by enzyme-linked immunosorbent assay. RESULTS: It was established that in patients with OA, as well as after suffering from SARS-CoV-2 infection, an increase in the plasma levels of IL-1β was observed against the background of a decrease in the levels of IL-4, IL-8, IL-10, IL- 12β, TNF-α and IFN-γ, compared to the healthy controls. COVID-19 more significantly influenced the plasma levels of pro-inflammatory cytokines IL-1β and IL-12β. CONCLUSIONS: The results indicate the imbalance of pro- and anti-inflammatory cytokines in the plasma in patients with OA for a long post- COVID. Сhanges in the levels of inflammatory mediators suggest distinct immunoregulatory mechanisms involved in the pathogenesis of both joint pathology and systemic disorders caused by SARS-CoV-2. [ FROM AUTHOR]","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"50 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75781415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.23736/s2724-542x.22.02946-7
J. Sharifi‐Rad, Z. Almarhoon, C. Adetunji, Olugbenga SAMUEL MICHAEL, Deepak Chandran, R. Radha, N. Sharma, M. Kumar, D. Calina
{"title":"Neuroprotective effect of curcumin and curcumin-integrated nanocarriers in stroke: from mechanisms to therapeutic opportunities","authors":"J. Sharifi‐Rad, Z. Almarhoon, C. Adetunji, Olugbenga SAMUEL MICHAEL, Deepak Chandran, R. Radha, N. Sharma, M. Kumar, D. Calina","doi":"10.23736/s2724-542x.22.02946-7","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02946-7","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"2016 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87826371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.23736/s2724-542x.22.02925-x
Luciano A. Palomino-Kobayashi, M. J. Pons, J. Ruiz
{"title":"Estimation of inherent bacterial DNA contamination in a qPCR master mix: concerns about background DNA of reagents","authors":"Luciano A. Palomino-Kobayashi, M. J. Pons, J. Ruiz","doi":"10.23736/s2724-542x.22.02925-x","DOIUrl":"https://doi.org/10.23736/s2724-542x.22.02925-x","url":null,"abstract":"","PeriodicalId":29824,"journal":{"name":"Minerva Biotechnology and Biomolecular Research","volume":"26 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85489435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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