Pub Date : 2024-09-26DOI: 10.23736/S2724-5691.24.10514-X
Wenyu Liu, Jie Li, Wenqian Xue, Xinke Zhao, Shoucai Zhao
{"title":"Clinical study of MATE analysis-based acupuncture method in the treatment of liver-yang hyperactivity type hypertension.","authors":"Wenyu Liu, Jie Li, Wenqian Xue, Xinke Zhao, Shoucai Zhao","doi":"10.23736/S2724-5691.24.10514-X","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10514-X","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.23736/S2724-5691.24.10503-5
Baoheng Liu, Mingyu Liu
{"title":"Preliminary observation of the effect of peanut hemagglutinin on facial skin.","authors":"Baoheng Liu, Mingyu Liu","doi":"10.23736/S2724-5691.24.10503-5","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10503-5","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.23736/S2724-5691.24.10444-3
Gianni Belcaro, Maria R Cesarone, Claudia Scipione, Valeria Scipione, Umberto Cornelli, Roberto Cotellese, Edmondo Ippolito, Mark Dugall, Morio Hosoi, Marcello Corsi, Beatrice Feragalli, Pietro Bavera
Background: The aim of this supplement registry study was to evaluate the efficacy of Pycnogenol® in controlling signs and symptoms of chronic venous insufficiency (CVI), diabetic microangiopathy and microcirculatory parameters - in diabetic patients with CVI and microangiopathy. These CVI patients are eligible for medical procedures as their incompetent superficial veins can be treated with repeated sclerotherapy and or local surgery according to needs.
Methods: During this registry study, only non-interventional managements were used. The effects of the use of elastic compression with standard management (SM) was compared to Pycnogenol® intake (150 mg/day) and SM, without using elastic compression for 8 weeks.
Results: Fifty-eight diabetic patients with CVI completed the study with 28 subjects supplemented with Pycnogenol® and 30 in the control group. The two groups completing 8 weeks were comparable at baseline. After 8 weeks, no side effects were observed; the compliance was optimal with >98.5% of the supplement capsules correctly used. The tolerability to stockings was lower (73% of stockings were not fully used for the whole day). There were no dropouts. Venous pressures were comparable in the two groups at baseline. Microcirculatory and clinical measurements of the patients were comparable at inclusion. After 8 weeks, the differences between Pycnogenol® and elastic compression were statistically significant for skin resting flux (RF), rate of ankle swelling (RAS), transcutaneous PO2 and PCO2 indicating a significant improvement in microcirculatory perfusion with Pycnogenol® in comparison with elastic compression. In parallel, clinical symptoms assessed by the Composite Symptom Score (CSS), the venous Clinical severity Score (VCSS) and the Venous Disability Score (VDS), were significantly lower in the Pycnogenol® group than in the compression group, indicating a significant clinical effect of Pycnogenol® compared to elastic compression (P<0.05). Pycnogenol® showed important antioxidant properties and lowered oxidative stress as seen also in previous studies.
Conclusions: This registry study confirms the clinical and microcirculatory efficacy of Pycnogenol® in CVI in diabetics. The study indicates the significant supplementary, clinical role of Pycnogenol® in the management of this common clinical condition over a short period of time, possibly preventing ulcerations.
{"title":"Pycnogenol® relieves chronic venous insufficiency (CVI) in diabetics: a supplement registry study.","authors":"Gianni Belcaro, Maria R Cesarone, Claudia Scipione, Valeria Scipione, Umberto Cornelli, Roberto Cotellese, Edmondo Ippolito, Mark Dugall, Morio Hosoi, Marcello Corsi, Beatrice Feragalli, Pietro Bavera","doi":"10.23736/S2724-5691.24.10444-3","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10444-3","url":null,"abstract":"<p><strong>Background: </strong>The aim of this supplement registry study was to evaluate the efficacy of Pycnogenol<sup>®</sup> in controlling signs and symptoms of chronic venous insufficiency (CVI), diabetic microangiopathy and microcirculatory parameters - in diabetic patients with CVI and microangiopathy. These CVI patients are eligible for medical procedures as their incompetent superficial veins can be treated with repeated sclerotherapy and or local surgery according to needs.</p><p><strong>Methods: </strong>During this registry study, only non-interventional managements were used. The effects of the use of elastic compression with standard management (SM) was compared to Pycnogenol<sup>®</sup> intake (150 mg/day) and SM, without using elastic compression for 8 weeks.</p><p><strong>Results: </strong>Fifty-eight diabetic patients with CVI completed the study with 28 subjects supplemented with Pycnogenol<sup>®</sup> and 30 in the control group. The two groups completing 8 weeks were comparable at baseline. After 8 weeks, no side effects were observed; the compliance was optimal with >98.5% of the supplement capsules correctly used. The tolerability to stockings was lower (73% of stockings were not fully used for the whole day). There were no dropouts. Venous pressures were comparable in the two groups at baseline. Microcirculatory and clinical measurements of the patients were comparable at inclusion. After 8 weeks, the differences between Pycnogenol<sup>®</sup> and elastic compression were statistically significant for skin resting flux (RF), rate of ankle swelling (RAS), transcutaneous PO<inf>2</inf> and PCO<inf>2</inf> indicating a significant improvement in microcirculatory perfusion with Pycnogenol<sup>®</sup> in comparison with elastic compression. In parallel, clinical symptoms assessed by the Composite Symptom Score (CSS), the venous Clinical severity Score (VCSS) and the Venous Disability Score (VDS), were significantly lower in the Pycnogenol<sup>®</sup> group than in the compression group, indicating a significant clinical effect of Pycnogenol<sup>®</sup> compared to elastic compression (P<0.05). Pycnogenol<sup>®</sup> showed important antioxidant properties and lowered oxidative stress as seen also in previous studies.</p><p><strong>Conclusions: </strong>This registry study confirms the clinical and microcirculatory efficacy of Pycnogenol<sup>®</sup> in CVI in diabetics. The study indicates the significant supplementary, clinical role of Pycnogenol<sup>®</sup> in the management of this common clinical condition over a short period of time, possibly preventing ulcerations.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.23736/S2724-5691.24.10460-1
Meixia Zhang, Shan Guo, Peiyao Hu
{"title":"Application and evaluation of integrated cervicocephalic ultrasound technique in the early diagnosis of ischemic stroke.","authors":"Meixia Zhang, Shan Guo, Peiyao Hu","doi":"10.23736/S2724-5691.24.10460-1","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10460-1","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.23736/S2724-5691.24.10502-3
Qixiao Zhang, Song Yu
{"title":"Role of endoplasmic reticulum stress in osteoarthritis.","authors":"Qixiao Zhang, Song Yu","doi":"10.23736/S2724-5691.24.10502-3","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10502-3","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.23736/S2724-5691.24.10504-7
Wencai Su, Ziming Liu, Guanqiang Zhang, Jin Ma, Chenggang Gu, Yuan Lin
{"title":"Clinical efficacy of unilateral two-channel spinal endoscopy and traditional posterior lumbar interbody fusion in the treatment of degenerative diseases of the lumbar spine.","authors":"Wencai Su, Ziming Liu, Guanqiang Zhang, Jin Ma, Chenggang Gu, Yuan Lin","doi":"10.23736/S2724-5691.24.10504-7","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10504-7","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.23736/S2724-5691.24.10458-3
Qunyan Yao, Jingjing Wang
{"title":"Analysis of the detection rate and influencing factors of pulmonary nodules in a health screening population.","authors":"Qunyan Yao, Jingjing Wang","doi":"10.23736/S2724-5691.24.10458-3","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10458-3","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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