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Book Review: Exchange List and Diet Patterns 书评:交换清单和饮食模式
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1981-02-01 DOI: 10.1177/263501068100700126
J. Kirkpatrick
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引用次数: 0
Bacterially Produced Human Insulin Given Therapeutically 细菌产生的人胰岛素用于治疗
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1981-01-23 DOI: 10.1001/JAMA.1981.03310290004002
W. Check
In mid-December, five Wichita, Kan, patients with newly diagnosed diabetes became the first humans to be treated with a substance produced by recombinant DNA technology. The five began therapy with insulin produced by bacteria into which the human insulin gene had been introduced. The recombinant insulin (also known as biosynthetic insulin), which is being produced by Eli Lilly and Co, had previously been administered to healthy human volunteers in the United States, Great Britain, Greece, and West Germany and found to be free of toxic effects. Phase II testing of the substance is now being carried out under the supervision of Richard Guthrie, MD, professor and chairman of the Department of Pediatrics at the University of Kansas School of Medicine in Wichita; Arthur Krosnick, MD, of the Mercer Medical Center in Trenton, NJ; and Frederick Whitehouse, MD, a former president of the American Diabetes Association who is with the Henry
12月中旬,堪萨斯州威奇托市的五名新诊断为糖尿病的患者成为第一批接受重组DNA技术生产的物质治疗的人。这五名患者开始使用被植入人类胰岛素基因的细菌产生的胰岛素进行治疗。由礼来公司生产的重组胰岛素(也被称为生物合成胰岛素),此前曾在美国、英国、希腊和西德的健康志愿者身上进行过试验,发现没有毒性作用。该物质的第二阶段测试目前正在威奇托堪萨斯大学医学院儿科学系主任、教授Richard Guthrie医学博士的监督下进行;新泽西州特伦顿默瑟医疗中心的亚瑟·克罗斯尼克医学博士;弗雷德里克·怀特豪斯,医学博士,美国糖尿病协会前主席,他是亨利家族的一员
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引用次数: 1
Postprandial Hormonal Responses to Different Types of Complex Carbohydrate in Individuals with Impaired Glucose Tolerance 糖耐量受损患者餐后激素对不同类型复合碳水化合物的反应
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1980-08-01 DOI: 10.1177/263501068100700113
Phillis A. Crapo, Orville G. Kolertman, N. Waldeck, G. Reaven, J. Olefsky
We have studied the effects of dextrose, rice, potato, corn, and bread on postprandial plasma glucose, insulin and glucagon responses in 11 subjects with impaired glucose tolerance. All carbohydrate loads were calculated to contain 50 g of glucose. The data demonstrate that 1) dextrose and potato elicited similar plasma glucose responses whereas rice, and bread elicited lower responses with corn intermediate; 2) dextrose and potato elicited similar plasma insulin responses whereas rice gave lower responses, with bread and corn intermediate; 3) all of the carbohydrate loads suppressed plasma glucagon with dextrose causing the greatest suppression. In conclusion, there is a range of plasma glucose, insulin, and glucagon responses to different complex carbohydrates in subjects with impaired glucose tolerance and the differences in plasma glucose responses may be of therapeutic value in controlling hyperglycemia.
我们研究了葡萄糖、大米、土豆、玉米和面包对11例糖耐量受损患者餐后血糖、胰岛素和胰高血糖素反应的影响。所有碳水化合物负荷均计算为含有50克葡萄糖。数据表明:1)葡萄糖和马铃薯引起了相似的血浆葡萄糖反应,而玉米中间体引起了大米和面包较低的反应;2)葡萄糖和马铃薯引起了类似的血浆胰岛素反应,而大米的反应较低,面包和玉米居中;3)糖负荷对血浆胰高血糖素的抑制作用以葡萄糖抑制作用最大。总之,在糖耐量受损的受试者中,血糖、胰岛素和胰高血糖素对不同复合碳水化合物的反应是不同的,血糖反应的差异可能对控制高血糖具有治疗价值。
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引用次数: 97
Utilizing Orem's Self-Care Nursing Model in Designing an Educational Program for the Diabetic 运用Orem自我护理模式设计糖尿病患者教育方案
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1980-07-01 DOI: 10.1177/263501068100700115
S. Fitzgerald
This review from the Royal Infirmary in Edinburgh , Scotland concerns the safety of the various birth control methods in insulin dependent diabetic women . Combined estrogen/ progestogen pills were associated with an increased risk of thromboembolic disease . Thromboembolic complications included cerebral ischemia, myocardial infarction, and vein thrombosis. In contrast, the progestogen-only pill was found to be successful and associated with only menstrual irregular ities. Intrauterine devices were assoc iated with a high failure rate (11 of 30 became pregnant during the first year) . They concluded that the combined estrogen/progestogen pill and intrauterine devices were potentially dangerous and/or unacceptable forms of contraception and the progestogenonly pill was the preferred method of contraception in insulin-dependent diabetic women . Stephen Hamburger, MD
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引用次数: 6
Depression Masquerading as Diabetic Neuropathy 抑郁症伪装成糖尿病神经病变
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1980-03-21 DOI: 10.1001/JAMA.1980.03300370021019
R. W. Turkington
Fifty-nine patients referred for painful diabetic neuropathy of the lower extremities were evaluated for depression and response to antidepressant drug therapy in a double-blind controlled study. All patients were found to have substantial degrees of depression during psychiatric interview and by Kupfer-Detre test scores (8.1 +/- 0.6, as compared with control values of 4.0 to 4.3 +/- 0.2). Treatment with imipramine hydrochloride or amitriptyline hydrochloride resulted in complete remission of lower extremity pains in all patients in 10 +/- 2 weeks, with concomitant relief of depression and return of depression test scores to 3.8. These results suggest that the syndrome of painful diabetic neuropathy of the lower extremities represents a depressive equivalent in a large proportion of cases and that treatment with imipramine or amitriptyline is a successful mode of therapy for such persons.
在一项双盲对照研究中,对59例下肢疼痛性糖尿病神经病变患者的抑郁和抗抑郁药物治疗反应进行了评估。所有患者在精神病学访谈和Kupfer-Detre测试分数(8.1 +/- 0.6,与对照值4.0至4.3 +/- 0.2相比)中被发现有相当程度的抑郁。用盐酸丙咪嗪或盐酸阿米替林治疗后,所有患者在10 +/- 2周内下肢疼痛完全缓解,抑郁症状得到缓解,抑郁测试得分恢复到3.8分。这些结果表明,下肢疼痛性糖尿病神经病变综合征在很大比例的病例中相当于抑郁症,丙咪嗪或阿米替林治疗是这类患者的成功治疗模式。
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引用次数: 166
Reactive hypoglycemia. 反应性低血糖。
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1980-01-01 DOI: 10.1001/jama.243.11.1151
D. D. Johnson, K. E. Dorr, W. M. Swenson, F. J. Service
The clinical characteristics and scores on the Minnesota Multiphasic Personality Inventory (MMPI) of 192 patients undergoing a five-hour oral glucose tolerance test (OGTT) for evaluation of reactive hypoglycemia were assessed. There were twice as many women as men. One hundred twenty-nine patients had spells of light-headedness, shakiness, diaphoresis, weakness, and fatigue. Hypoglycemic symptoms occurring during the test were not related to level of plasma glucose nadir or to rate of descent of glucose level. Hypoglycemia was not found when glucose levels were measured during occurrence of spontaneous symptoms in 86 patients. MMPI scores were significantly different from those of general medical patients. Both men and women evinced a conversion V profile. The five-hour OGTT seems unreliable for the diagnosis of reactive hypoglycemia, and most patients with symptoms suggestive of hypoglycemia may have emotional disturbances.
对192例接受5小时口服葡萄糖耐量试验(OGTT)评估反应性低血糖的患者的临床特征和明尼苏达多相人格量表(MMPI)评分进行评估。女性的人数是男性的两倍。129名患者出现头晕、颤抖、出汗、虚弱和疲劳的症状。试验期间出现的低血糖症状与血糖最低点水平或血糖水平下降速率无关。在86例患者出现自发性症状时,对血糖水平进行测量,未发现低血糖。MMPI评分与普通内科患者有显著差异。男性和女性都表现出V型转换。5小时OGTT对于诊断反应性低血糖似乎不可靠,而且大多数有低血糖症状的患者可能有情绪障碍。
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引用次数: 1
Counseling the Camp Counselor 咨询夏令营辅导员
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1979-06-01 DOI: 10.1177/263501067900500204
Elizabeth A. Coon, Jamie S. Lawson
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引用次数: 1
Methods of Glycosuria Testing: A Reference for Nursing Personnel 糖尿试验方法:供护理人员参考
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1979-06-01 DOI: 10.1177/263501067900500202
B. Kelly
Although the currently available tests for glycosuria are not difficult to perform, research has shown nurses and auxiliary personnel to be inaccurate in the performance and/ or interpretation of the tests l .3-phenomena which can adversely affect the patient's therapeutic regimen . Derr'' observed that nurses "are often casual about urine testing procedures ." Schumann" reported that "studies suggest that not only do many nurses not understand how to conduct urine tests but that nurses are among the most careless in performing them. "
虽然目前可用的糖尿测试不难进行,但研究表明护士和辅助人员在执行和/或解释测试时不准确,这可能对患者的治疗方案产生不利影响。Derr "观察到护士"对尿检程序常常漫不经心。" Schumann"报告说,"研究表明,许多护士不仅不了解如何进行尿检,而且在进行尿检时也是最粗心的。"
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引用次数: 1
Book Review: You Can't Catch Diabetes from a Friend 书评:你不可能从朋友那里感染糖尿病
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1979-06-01 DOI: 10.1177/263501067900500207
C. Sinicki, C. Wilson
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引用次数: 0
Manuscript Information 手稿的信息
IF 1.9 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 1979-06-01 DOI: 10.1177/263501067900500201
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引用次数: 0
期刊
Science of Diabetes Self-Management and Care
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