Pub Date : 2022-12-23DOI: 10.24018/ejpharma.2022.2.3.50
Bi Lane Adrien Goh, Goore Guy Charles Gole Nanti, Stanislas Ouga Zahoui, Semi Anthelme Nene-Bi, F. Traoré
The aim of this study was to evaluate the effects of an aqueous extract of Crotalaria retusa L (Fabaceae) (EACr) on glycemia in Wistar rats, to contribute to the valorization of plants used in traditional medicine for the improvement of people’s health. A phytochemical screening and pharmacological study of the aqueous extract of Crotalaria retusa L (Fabaceae) on glycemia in rats, were carried out. The administration of the substances in animals was made orally. The qualitative phytochemical study carried out with the aqueous extract of the leaves, the flowers, and the pods of Crotalaria retusa L (Fabaceae) made to highlight the presence of polyphenols, flavonoids, catechic, and gallic tannins, quinonic compounds, alkaloids, sterols, and polyterpenes. This extract showed hypoglycemic activity in the normoglycemic animals, treated with the dose of 1000 mg/kg BW with a percentage of reduction of the glycemia of 21.04%. After an overload of glucose, EACr (1000 mg/kg BW) and the glibenclamide (10-2g/kg BW) showed better antihyperglycemic activity in the rats post-treated, with respective percentages of reduction of 41.90 and 50.39%. EACr has hypoglycemic and antihyperglycemic properties which would be probably related to the presence of alkaloids, tannins, and flavonoids. These compounds, generally recognized for their hypoglycemic and antihyperglycemic effects, confer to this extract similar properties to those of certain insulin-secretors. These results support the use of this plant for the treatment of diabetes in traditional medicine and bring a scientific base.
{"title":"Assessment of the effects of an aqueous extract of the leaves, flowers, and seeds of Crotalaria retusa L (Fabaceae) on the glycemia in rats","authors":"Bi Lane Adrien Goh, Goore Guy Charles Gole Nanti, Stanislas Ouga Zahoui, Semi Anthelme Nene-Bi, F. Traoré","doi":"10.24018/ejpharma.2022.2.3.50","DOIUrl":"https://doi.org/10.24018/ejpharma.2022.2.3.50","url":null,"abstract":"\u0000The aim of this study was to evaluate the effects of an aqueous extract of Crotalaria retusa L (Fabaceae) (EACr) on glycemia in Wistar rats, to contribute to the valorization of plants used in traditional medicine for the improvement of people’s health. A phytochemical screening and pharmacological study of the aqueous extract of Crotalaria retusa L (Fabaceae) on glycemia in rats, were carried out. The administration of the substances in animals was made orally. The qualitative phytochemical study carried out with the aqueous extract of the leaves, the flowers, and the pods of Crotalaria retusa L (Fabaceae) made to highlight the presence of polyphenols, flavonoids, catechic, and gallic tannins, quinonic compounds, alkaloids, sterols, and polyterpenes. This extract showed hypoglycemic activity in the normoglycemic animals, treated with the dose of 1000 mg/kg BW with a percentage of reduction of the glycemia of 21.04%. After an overload of glucose, EACr (1000 mg/kg BW) and the glibenclamide (10-2g/kg BW) showed better antihyperglycemic activity in the rats post-treated, with respective percentages of reduction of 41.90 and 50.39%. EACr has hypoglycemic and antihyperglycemic properties which would be probably related to the presence of alkaloids, tannins, and flavonoids. These compounds, generally recognized for their hypoglycemic and antihyperglycemic effects, confer to this extract similar properties to those of certain insulin-secretors. These results support the use of this plant for the treatment of diabetes in traditional medicine and bring a scientific base.\u0000","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126856817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-23DOI: 10.24018/ejpharma.2022.2.3.41
Bhavna B. Gaikwad, B. Rane, Ashish Jain
Oral administration of dosage form is the most recommended mode of administration, because of its self-medication, accurate dose of the drug, and ease of administration. However, trouble swallowing in geriatric patients is one major negative of this route, which can mentally disrupt patients. The goal of this study was to use the direct compression method to make orodispersible tablets of sulindac utilizing various doses of super disintegrant agents such as Sodium starch glycolate Crospovidone and Croscarmellose sodium. Three distinct super disintegrants were used to create nine formulations with varying concentration levels. The preformulation, precompression, and post-compression properties of the powder combinations were assessed. In comparison to the other formulations, tablets from batch F3 containing crospovidone had superior organoleptic qualities, as well as outstanding drug release and in-vitro disintegration time. The super disntegrants addition technique was shown to be a viable method for manufacturing orodispersible tablets using the direct compression method.
{"title":"Formulation and Evaluation of Orodispersible Tablet of Sulindac","authors":"Bhavna B. Gaikwad, B. Rane, Ashish Jain","doi":"10.24018/ejpharma.2022.2.3.41","DOIUrl":"https://doi.org/10.24018/ejpharma.2022.2.3.41","url":null,"abstract":"\u0000Oral administration of dosage form is the most recommended mode of administration, because of its self-medication, accurate dose of the drug, and ease of administration. However, trouble swallowing in geriatric patients is one major negative of this route, which can mentally disrupt patients. The goal of this study was to use the direct compression method to make orodispersible tablets of sulindac utilizing various doses of super disintegrant agents such as Sodium starch glycolate Crospovidone and Croscarmellose sodium. Three distinct super disintegrants were used to create nine formulations with varying concentration levels. The preformulation, precompression, and post-compression properties of the powder combinations were assessed. In comparison to the other formulations, tablets from batch F3 containing crospovidone had superior organoleptic qualities, as well as outstanding drug release and in-vitro disintegration time. The super disntegrants addition technique was shown to be a viable method for manufacturing orodispersible tablets using the direct compression method.\u0000","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116340581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-04DOI: 10.24018/ejpharma.2022.2.3.47
Md. Rokibul Hasan Bhuiyan, Md. Maniruzzaman, Sabina Akter, Sanzia Mehjabin, Md. Rakib Rased Rana, M. Jaman
Diabetics Mellitus is a major problem for city people worldwide. The objective of this study is finding the anti-diabetic and anti-hyper lipidaemic activity by using Carica papaya leaves. This leaves are not generally eaten but this leaves were eaten during dengue fever. The leaves extract is used for the treatment of diabetes and cancer. This leaves were collected from different place of Bangladesh and made methanolic extract then this extract was feed four groups of mice. The results showed that there was a significant (p<0.001 to p<0.05) reduction in blood glucose concentration (mmol/L) by the methanolic extract of C. papaya leaves at dose 100 mg/kg, 200 mg/kg and glibenclamide (used as standard) 5mg/kg body weight. C. papaya leaves extract also regulated the serum lipid profile levels significantly (p<0.001) at same dose in experimental model of diabetes mellitus. The level of serum SGPT, SGOT and CRP were also seen change to the normal level notably (p<0.001) by the oral administration of methanolic extract of C. papaya leaves. In conclusion this research finding indicate that the methanolic extract of Carica papaya leaves contains bioactive substances with hypoglycemic potency.
{"title":"Drug Promising Effect for Diabetic Mice of CARICA PAPAYA Leaves","authors":"Md. Rokibul Hasan Bhuiyan, Md. Maniruzzaman, Sabina Akter, Sanzia Mehjabin, Md. Rakib Rased Rana, M. Jaman","doi":"10.24018/ejpharma.2022.2.3.47","DOIUrl":"https://doi.org/10.24018/ejpharma.2022.2.3.47","url":null,"abstract":"Diabetics Mellitus is a major problem for city people worldwide. The objective of this study is finding the anti-diabetic and anti-hyper lipidaemic activity by using Carica papaya leaves. This leaves are not generally eaten but this leaves were eaten during dengue fever. The leaves extract is used for the treatment of diabetes and cancer. This leaves were collected from different place of Bangladesh and made methanolic extract then this extract was feed four groups of mice. The results showed that there was a significant (p<0.001 to p<0.05) reduction in blood glucose concentration (mmol/L) by the methanolic extract of C. papaya leaves at dose 100 mg/kg, 200 mg/kg and glibenclamide (used as standard) 5mg/kg body weight. C. papaya leaves extract also regulated the serum lipid profile levels significantly (p<0.001) at same dose in experimental model of diabetes mellitus. The level of serum SGPT, SGOT and CRP were also seen change to the normal level notably (p<0.001) by the oral administration of methanolic extract of C. papaya leaves. In conclusion this research finding indicate that the methanolic extract of Carica papaya leaves contains bioactive substances with hypoglycemic potency.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131051429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.24018/ejpharma.2022.2.2.30
Uthman Yusuf, Francine Kafula, Kalande Kaimba, Wandi Kalipenta, Hellen Kabwe, J. A. Mulemena, K. Kamvuma, Sam Beza Phiri, M. Miyoba, B. S. Mesole, Adrian Phiri, B. B. Bwalya, W. Zimba
Herbs have been used as medicinal for several years to cure or rather manage different ailments such as diabetes mellitus. This is very common in rural settings of sub-saharan Africa and is now being adopted in urban areas. Opunta species have widely been seen to contain antihyperglycaemic effects. To evaluate the antihyperglycaemic and histopancreatic effect of aqueous extract of prickly pear cactus (Opuntia species) cladodes in streptozotocin-induced diabetic male Wistar rats in vivo. This was a laboratory based research conducted at Mulungushi University involving 30 wistar rats (Rattus norvegicus) that weighed between 160-200 g which were randomly selected into five groups (6 per cage); normal control, diabetic control, diabetic +metformin, diabetic +cactus and cactus only group. Initial blood glucose levels were obtained from the tail and record then Diabetes mellitus was induced using a single intraperitoneal dose of streptozotocin (70mg/kg BW) and established a persistent state of hyperglycemia after 72hours. The aqueous cactus extract of 100 mg/kg BW and metformin of 100 mg/kg BW was administered orally using intragastric cannula daily for a period of 4 weeks. At the end of the fourth week, Diabetes + cactus and diabetes + metformin groups body weights were statistically significant when compared to the diabetic group (P<0.05). While diabetic group was statistically significant when compared to normal control (P<0.05). The relative weight of the pancreas in diabetic group was statistically significant to other groups (P<0.05). The blood glucose in diabetic + cactus was normoglycaemic at 3rd week, Diabetic + metformin group when compared to diabetic group was statistically significant (P<0.05). The normal control and cactus only groups maintained normoglycaemic till the end of the 4th week. The histological findings of the normal control and cactus only group showed normal pancreatic cytoarchitecture. Diabetes group showed high degree of disorganization in the cytoarchitecture in the islet with reduction in β cell mass and deposition of elastic fibres. The Diabetic+Metformin group showed slight decrease in the cell mass (β cells) and elastic fibres were extensively deposited. Diabetic+Cactus treated group exhibited normal histology of the pancreas with increased number of β cells. Opuntia species are able to lower elevated blood glucose levels and ameliorate the effects of STZ on the pancreatic morphology
{"title":"The Role of an Aqueous Extract of Cactus on Histopancreatic Architecture in Streptozotocin Induced Diabetes Mellitus in Wistar Rats","authors":"Uthman Yusuf, Francine Kafula, Kalande Kaimba, Wandi Kalipenta, Hellen Kabwe, J. A. Mulemena, K. Kamvuma, Sam Beza Phiri, M. Miyoba, B. S. Mesole, Adrian Phiri, B. B. Bwalya, W. Zimba","doi":"10.24018/ejpharma.2022.2.2.30","DOIUrl":"https://doi.org/10.24018/ejpharma.2022.2.2.30","url":null,"abstract":"Herbs have been used as medicinal for several years to cure or rather manage different ailments such as diabetes mellitus. This is very common in rural settings of sub-saharan Africa and is now being adopted in urban areas. Opunta species have widely been seen to contain antihyperglycaemic effects. To evaluate the antihyperglycaemic and histopancreatic effect of aqueous extract of prickly pear cactus (Opuntia species) cladodes in streptozotocin-induced diabetic male Wistar rats in vivo.\u0000This was a laboratory based research conducted at Mulungushi University involving 30 wistar rats (Rattus norvegicus) that weighed between 160-200 g which were randomly selected into five groups (6 per cage); normal control, diabetic control, diabetic +metformin, diabetic +cactus and cactus only group. Initial blood glucose levels were obtained from the tail and record then Diabetes mellitus was induced using a single intraperitoneal dose of streptozotocin (70mg/kg BW) and established a persistent state of hyperglycemia after 72hours. The aqueous cactus extract of 100 mg/kg BW and metformin of 100 mg/kg BW was administered orally using intragastric cannula daily for a period of 4 weeks.\u0000At the end of the fourth week, Diabetes + cactus and diabetes + metformin groups body weights were statistically significant when compared to the diabetic group (P<0.05). While diabetic group was statistically significant when compared to normal control (P<0.05). The relative weight of the pancreas in diabetic group was statistically significant to other groups (P<0.05). The blood glucose in diabetic + cactus was normoglycaemic at 3rd week, Diabetic + metformin group when compared to diabetic group was statistically significant (P<0.05). The normal control and cactus only groups maintained normoglycaemic till the end of the 4th week. The histological findings of the normal control and cactus only group showed normal pancreatic cytoarchitecture. Diabetes group showed high degree of disorganization in the cytoarchitecture in the islet with reduction in β cell mass and deposition of elastic fibres. The Diabetic+Metformin group showed slight decrease in the cell mass (β cells) and elastic fibres were extensively deposited. Diabetic+Cactus treated group exhibited normal histology of the pancreas with increased number of β cells.\u0000Opuntia species are able to lower elevated blood glucose levels and ameliorate the effects of STZ on the pancreatic morphology","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124698246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.24018/ejpharma.2022.2.2.34
M. Sawadogo, M. J. Bangou, Armandine Lema, Mindiempo Hyacinthe Thiombiano, H. Ouoba, Béboila Ouoba
Viral hepatitis is an inflammatory disease of the liver cells caused by cytopathic viruses. It constitutes a major public health problem. The aim of the present study was to identify the recipes used in the treatment of viral hepatitis in four cities of Burkina Faso and to select the most requested recipe for further analysis. Semi-structured interviews in the local language were conducted by the "snowball" technique among traditional medicine practitioners from May to October 2021. A total of 280 traditional healers (80.35% men) were interviewed and 74 species of medicinal plants belonging to 42 botanical families used in composition of 168 anti-viral hepatitis recipes were identified. The most frequently used organs were roots, followed by barks and then leaves with proportions of 34.64%, 26.07% and 20% respectively. Decoction (54,29%) and drinking (77,14%) are respectively the main method of preparation and administration of drugs. The study allowed the selection of one recipe that will be subjected to phytochemical and pharmacological analyses in order to isolate the molecules with hepatoprotective properties.
{"title":"Medicinal Plants Used in Composition of Anti-Viral Hepatitis Recipes in Burkina Faso: Ethnobotanical Study","authors":"M. Sawadogo, M. J. Bangou, Armandine Lema, Mindiempo Hyacinthe Thiombiano, H. Ouoba, Béboila Ouoba","doi":"10.24018/ejpharma.2022.2.2.34","DOIUrl":"https://doi.org/10.24018/ejpharma.2022.2.2.34","url":null,"abstract":"Viral hepatitis is an inflammatory disease of the liver cells caused by cytopathic viruses. It constitutes a major public health problem. The aim of the present study was to identify the recipes used in the treatment of viral hepatitis in four cities of Burkina Faso and to select the most requested recipe for further analysis. Semi-structured interviews in the local language were conducted by the \"snowball\" technique among traditional medicine practitioners from May to October 2021. A total of 280 traditional healers (80.35% men) were interviewed and 74 species of medicinal plants belonging to 42 botanical families used in composition of 168 anti-viral hepatitis recipes were identified. The most frequently used organs were roots, followed by barks and then leaves with proportions of 34.64%, 26.07% and 20% respectively. Decoction (54,29%) and drinking (77,14%) are respectively the main method of preparation and administration of drugs. The study allowed the selection of one recipe that will be subjected to phytochemical and pharmacological analyses in order to isolate the molecules with hepatoprotective properties.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125495831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.24018/ejpharma.2022.2.2.20
Joshua John Akwayamai, M. Ahmed, Galaya Tirah, Kadauyina Samuel, W. Usman, Hezekiah Bulus
Dengue virus is an arthropod-borne infectious agent that causes dengue disease. The virus spreads by Aedes aegypti and Aedes albopictus mosquitos. Due to the neglegent care given to the infection, the vectors as well as the virus have expanded globally and millions have already been affected by dengue infection as regards reports by ECDC, CDC and WHO. Dengue virus infection have been alleviated by erratic treatments since there is no precise formulation against it. However, there are plenteous clinical risks alongside using the drugs, this leaves human with no other choices than to reason for other alternative means of treatment to decrease the deleterious effects to minimal level. To introduce newer candidate anti-dengue pharmaceutical agent with minimal/ or no therapeutic lapses, botanical treatments have highly been recognized. Medicinal plants have been observed to be of health benefit in dengue virus infection through promoting immunocompetence, supplying pharmacological aids such as prophylactic effects, decrease viral amplification and lowering morbid condition. The potential anti-dengue activity of medicinal plants have been exemplified in the literature as the principal interest. We tried to find the existing factors behind virucidal activity of plants in the context of anti-dengue virus and the consulted publications indicated that certain flavonoids (Kaempferol-3-Orutinoside, Rutin, Hyperoside, Epicatechin Resveratrol, Quercetin, Emodin, Emodin-8-beta-D-glucoe and Polydatin), Tannins (Galic acid, Tannic acids), Alkaloids (Artesonic Acid, Homoegonol, Myristicin), Fatty acids (Methyldodecanoic acid, Dodecanoic acid, Tridecanoic acid, 12-methyl-methyl-esters, n-hexadecanoic acid), Terpenoids (Beta-asarone, Acoric acid, Andrographolide, Caryophyllene, Cyclododocane) and many others could be the major antiviral factors. This study will assist in giving better insights on anti-dengue activity of medicinal plants divulging dengue virus reliable combaters eventually. However, it is needful to conduct heightened critical clinical studies in this vein for proper verification.
{"title":"A Review of Medicinal Plants with Anti-Dengue Virus Activity","authors":"Joshua John Akwayamai, M. Ahmed, Galaya Tirah, Kadauyina Samuel, W. Usman, Hezekiah Bulus","doi":"10.24018/ejpharma.2022.2.2.20","DOIUrl":"https://doi.org/10.24018/ejpharma.2022.2.2.20","url":null,"abstract":"Dengue virus is an arthropod-borne infectious agent that causes dengue disease. The virus spreads by Aedes aegypti and Aedes albopictus mosquitos. Due to the neglegent care given to the infection, the vectors as well as the virus have expanded globally and millions have already been affected by dengue infection as regards reports by ECDC, CDC and WHO. Dengue virus infection have been alleviated by erratic treatments since there is no precise formulation against it. However, there are plenteous clinical risks alongside using the drugs, this leaves human with no other choices than to reason for other alternative means of treatment to decrease the deleterious effects to minimal level. To introduce newer candidate anti-dengue pharmaceutical agent with minimal/ or no therapeutic lapses, botanical treatments have highly been recognized. Medicinal plants have been observed to be of health benefit in dengue virus infection through promoting immunocompetence, supplying pharmacological aids such as prophylactic effects, decrease viral amplification and lowering morbid condition. The potential anti-dengue activity of medicinal plants have been exemplified in the literature as the principal interest. We tried to find the existing factors behind virucidal activity of plants in the context of anti-dengue virus and the consulted publications indicated that certain flavonoids (Kaempferol-3-Orutinoside, Rutin, Hyperoside, Epicatechin Resveratrol, Quercetin, Emodin, Emodin-8-beta-D-glucoe and Polydatin), Tannins (Galic acid, Tannic acids), Alkaloids (Artesonic Acid, Homoegonol, Myristicin), Fatty acids (Methyldodecanoic acid, Dodecanoic acid, Tridecanoic acid, 12-methyl-methyl-esters, n-hexadecanoic acid), Terpenoids (Beta-asarone, Acoric acid, Andrographolide, Caryophyllene, Cyclododocane) and many others could be the major antiviral factors. This study will assist in giving better insights on anti-dengue activity of medicinal plants divulging dengue virus reliable combaters eventually. However, it is needful to conduct heightened critical clinical studies in this vein for proper verification.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131393315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-03DOI: 10.24018/ejpharma.2022.2.1.15
S. Offor, Adedayo A. Tologbonse, S. Akpan, Victor U. Anah, Enobong Anietie Edward
Peptic ulcer disease is a gastrointestinal disorder of high mortality and morbidity. Therapy of this disease condition with conventional drugs presents therapeutic challenge due to incidents of unwanted side effects, and the high cost of these medications. The use of products from natural sources will provide useful alternatives due to their minimal side effects, being inexpensive, and readily available, especially in resource-challenged nations of the continent of Africa and other developing economies. Oils derived from plants are increasingly being used in management of several disease conditions. This study aims at evaluating the antiulcer activity of extra virgin avocado oil in rodents using ethanol-induced, and indomethacin-induced ulcer models. Test group was given extra virgin avocado oil (1ml per 250g weight) for 7 days before induction of ulcer. Positive controls received omeprazole 30 mg/kg, while negative control animals were given distilled water (10ml/kg) for 7 days respectively, before induction of ulcer. The stomachs were excised and their histopathological examinations carried out. Avocado oil significantly reduced the ulcer index in both models when compared to the negative control group, and histopathological findings corroborate that the oil ameliorates ulcerations in both models. The present study has demonstrated that extra virgin avocado oil possesses significant antiulcer activity.
{"title":"Evaluation of the Anti-ulcer Effect of Extra Virgin Avocado (Persea americana) Oil in Rats","authors":"S. Offor, Adedayo A. Tologbonse, S. Akpan, Victor U. Anah, Enobong Anietie Edward","doi":"10.24018/ejpharma.2022.2.1.15","DOIUrl":"https://doi.org/10.24018/ejpharma.2022.2.1.15","url":null,"abstract":"Peptic ulcer disease is a gastrointestinal disorder of high mortality and morbidity. Therapy of this disease condition with conventional drugs presents therapeutic challenge due to incidents of unwanted side effects, and the high cost of these medications. The use of products from natural sources will provide useful alternatives due to their minimal side effects, being inexpensive, and readily available, especially in resource-challenged nations of the continent of Africa and other developing economies. Oils derived from plants are increasingly being used in management of several disease conditions. This study aims at evaluating the antiulcer activity of extra virgin avocado oil in rodents using ethanol-induced, and indomethacin-induced ulcer models. Test group was given extra virgin avocado oil (1ml per 250g weight) for 7 days before induction of ulcer. Positive controls received omeprazole 30 mg/kg, while negative control animals were given distilled water (10ml/kg) for 7 days respectively, before induction of ulcer. The stomachs were excised and their histopathological examinations carried out. Avocado oil significantly reduced the ulcer index in both models when compared to the negative control group, and histopathological findings corroborate that the oil ameliorates ulcerations in both models. The present study has demonstrated that extra virgin avocado oil possesses significant antiulcer activity.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131684319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-27DOI: 10.24018/ejpharma.2021.1.1.4
Arif Hossin, B. Chakma, M. Raju
The current study was conducted to verify the traditional medicinal use and to carry out the in-vitro antioxidant activity of various solvent extracts of Derris trifoliata (aerial part). The percentage yield of ethanol, ethyl acetate and n-hexane extracts were found 2.5% w/w. Freshly prepared extracts were subjected to preliminary phytochemical screening. All extracts revealed the presence of several important phytochemicals which might be responsible for its medicinal properties. In vitro Electron transfer (ET) reaction-based assays of ethanol, ethyl acetate and n-hexane extracts have been investigated using various model systems viz., DPPH, total phenolic, tannin and flavonoid content, ferric ion reducing antioxidant power (FRAP) and reducing power assay. Hydrogen atom transfer (HAT) reaction-based assays have been conducted using Nitric Oxide (NO) scavenging and hydrogen peroxide scavenging activity assay methods. Ethanol extract was found to possess highest DPPH (IC50=16.824 µg/ml), total phenolic content (44.51 GAE/g of dried plant extract), reducing power assay (0.387±0.0006), FRAF assay (IC50=133.51 µg/ml), hydrogen peroxide scavenging (IC50=144.888 µg/ml) and nitric oxide scavenging activities (IC50=152.655 µg/ml). Whereas ethyl acetate extract was found to possess the highest total tannin content (42.56 GAE/g of dried plant extract) and total flavonoid content (78.08 QE/g of dried plant extract). In vitro antioxidant study was also performed in terms of chelation power on ferrous ions. The highest chelation power was found for ethyl acetate extract (IC50=62.489 µg/ml). The above study suggests that Derris trifoliata may be a vital source of nutraceuticals.
{"title":"Assessment of Anti-oxidant Activity of Aerial Parts of Mangrove Plant, Derris trifoliata ( Leguminosae)","authors":"Arif Hossin, B. Chakma, M. Raju","doi":"10.24018/ejpharma.2021.1.1.4","DOIUrl":"https://doi.org/10.24018/ejpharma.2021.1.1.4","url":null,"abstract":"The current study was conducted to verify the traditional medicinal use and to carry out the in-vitro antioxidant activity of various solvent extracts of Derris trifoliata (aerial part). The percentage yield of ethanol, ethyl acetate and n-hexane extracts were found 2.5% w/w. Freshly prepared extracts were subjected to preliminary phytochemical screening. All extracts revealed the presence of several important phytochemicals which might be responsible for its medicinal properties. In vitro Electron transfer (ET) reaction-based assays of ethanol, ethyl acetate and n-hexane extracts have been investigated using various model systems viz., DPPH, total phenolic, tannin and flavonoid content, ferric ion reducing antioxidant power (FRAP) and reducing power assay. Hydrogen atom transfer (HAT) reaction-based assays have been conducted using Nitric Oxide (NO) scavenging and hydrogen peroxide scavenging activity assay methods. Ethanol extract was found to possess highest DPPH (IC50=16.824 µg/ml), total phenolic content (44.51 GAE/g of dried plant extract), reducing power assay (0.387±0.0006), FRAF assay (IC50=133.51 µg/ml), hydrogen peroxide scavenging (IC50=144.888 µg/ml) and nitric oxide scavenging activities (IC50=152.655 µg/ml). Whereas ethyl acetate extract was found to possess the highest total tannin content (42.56 GAE/g of dried plant extract) and total flavonoid content (78.08 QE/g of dried plant extract). In vitro antioxidant study was also performed in terms of chelation power on ferrous ions. The highest chelation power was found for ethyl acetate extract (IC50=62.489 µg/ml). The above study suggests that Derris trifoliata may be a vital source of nutraceuticals.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115122817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-13DOI: 10.34154/2019-EJPR.01(01).PP-01-01/EURAASS
N. Anton
Welcome to the Inaugural Issue of European Journal of Pharmaceutical Research, launched in March 2019!
欢迎来到2019年3月推出的《欧洲药物研究杂志》创刊号!
{"title":"Inaugural Issue Editorial Note","authors":"N. Anton","doi":"10.34154/2019-EJPR.01(01).PP-01-01/EURAASS","DOIUrl":"https://doi.org/10.34154/2019-EJPR.01(01).PP-01-01/EURAASS","url":null,"abstract":"Welcome to the Inaugural Issue of European Journal of Pharmaceutical Research, launched in March 2019!","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128424258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-13DOI: 10.34154/2019-EJPR.01(01).PP-27-36/EURAASS
A. Rehman, Mayeul Collot, A. Klymchenko, S. Akram, B. Mustafa, T. Vandamme, N. Anton
In general, nano-emulsions are submicron droplets composed of liquid oil phase dispersed in liquid aqueous bulk phase. They are stable and very powerful systems when it regards the encapsulation of lipophilic compounds and their dispersion in aqueous medium. On the other hand, when the properties of the nano-emulsions aim to be modified, e.g. for changing their surface properties, decorating the droplets with targeting ligands, or modifying the surface charge, the dynamic liquid / liquid interfaces make it relatively challenging. In this study, we have explored the development of nano-emulsions which were not anymore stabilized with a classical low-molecular weight surfactant, but instead, with an amphiphilic polymer based on poly(maleic anhydride-alt-1-octadecene) (PMAO) and Jeffamine®, a hydrophilic amino-terminated PPG/PEG copolymer. Using a polymer as stabilizer is a potential solution for the nano-emulsion functionalization, ensuring the droplet stabilization as well as being a platform for the droplet decoration with ligands (for instance after addition of function groups in the terminations of the chains). The main idea of the present work was to understand if the spontaneous emulsification –commonly performed with nonionic surfactants– can be transposed with amphiphilic polymers, and a secondary objective was to identify the main parameters impacting on the process. PMAO was modified with two different Jeffamine®, additionally different oils and different formulation conditions were evaluated. As a control, the parent monomer, octadecyl succinic anhydride (OSA) was also modified and studied in the similar way as that of polymer. The generated nano-emulsions were mainly studied by dynamic light scattering and electron microscopy, that allows discriminating the crucial parameters in the spontaneous process, originally conducted with polymers as only stabilizer.
{"title":"Spontaneous nano-emulsification with tailor-made amphiphilic polymers and related monomers","authors":"A. Rehman, Mayeul Collot, A. Klymchenko, S. Akram, B. Mustafa, T. Vandamme, N. Anton","doi":"10.34154/2019-EJPR.01(01).PP-27-36/EURAASS","DOIUrl":"https://doi.org/10.34154/2019-EJPR.01(01).PP-27-36/EURAASS","url":null,"abstract":"In general, nano-emulsions are submicron droplets composed of liquid oil phase dispersed in liquid aqueous bulk phase. They are stable and very powerful systems when it regards the encapsulation of lipophilic compounds and their dispersion in aqueous medium. On the other hand, when the properties of the nano-emulsions aim to be modified, e.g. for changing their surface properties, decorating the droplets with targeting ligands, or modifying the surface charge, the dynamic liquid / liquid interfaces make it relatively challenging. In this study, we have explored the development of nano-emulsions which were not anymore stabilized with a classical low-molecular weight surfactant, but instead, with an amphiphilic polymer based on poly(maleic anhydride-alt-1-octadecene) (PMAO) and Jeffamine®, a hydrophilic amino-terminated PPG/PEG copolymer. Using a polymer as stabilizer is a potential solution for the nano-emulsion functionalization, ensuring the droplet stabilization as well as being a platform for the droplet decoration with ligands (for instance after addition of function groups in the terminations of the chains). The main idea of the present work was to understand if the spontaneous emulsification –commonly performed with nonionic surfactants– can be transposed with amphiphilic polymers, and a secondary objective was to identify the main parameters impacting on the process. PMAO was modified with two different Jeffamine®, additionally different oils and different formulation conditions were evaluated. As a control, the parent monomer, octadecyl succinic anhydride (OSA) was also modified and studied in the similar way as that of polymer. The generated nano-emulsions were mainly studied by dynamic light scattering and electron microscopy, that allows discriminating the crucial parameters in the spontaneous process, originally conducted with polymers as only stabilizer.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126374364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：