Z. Laučeková, K. Bodova, M. Ňachajová, E. Kudela, R. Fiolka, D. Prídavková, K. Stašková, K. Biringer
Abstract Systemic lupus erythematosus is a chronic inflammatory autoimmune disease with high prevalence in female in reproductive age. In recent years the prognosis of pregnant patients with SLE has improved significantly. Even though the treatment options have improved, the risk of flares, preeclampsia, pregnancy loss, and premature labours remains high compared to healthy women. The aim of this article is to offer a review of current treatment options in pregnant patients with SLE and to present a case report of 32-year-old patient with newly diagnosed acute outbreak of SLE, who experienced a life-threatening multisystem flare at 24 weeks of gestational age. This case represents one of the most extreme manifestations of lupus disease activity associated with pregnancy that has been reported in literature and emphasizes the importance of preconception evaluation and counseling and amultidisciplinary management approach in cases with a complex and evolving clinical course.
{"title":"Systemic Lupus Erythematosus Treatment in Pregnancy: Case Study","authors":"Z. Laučeková, K. Bodova, M. Ňachajová, E. Kudela, R. Fiolka, D. Prídavková, K. Stašková, K. Biringer","doi":"10.2478/acm-2020-0010","DOIUrl":"https://doi.org/10.2478/acm-2020-0010","url":null,"abstract":"Abstract Systemic lupus erythematosus is a chronic inflammatory autoimmune disease with high prevalence in female in reproductive age. In recent years the prognosis of pregnant patients with SLE has improved significantly. Even though the treatment options have improved, the risk of flares, preeclampsia, pregnancy loss, and premature labours remains high compared to healthy women. The aim of this article is to offer a review of current treatment options in pregnant patients with SLE and to present a case report of 32-year-old patient with newly diagnosed acute outbreak of SLE, who experienced a life-threatening multisystem flare at 24 weeks of gestational age. This case represents one of the most extreme manifestations of lupus disease activity associated with pregnancy that has been reported in literature and emphasizes the importance of preconception evaluation and counseling and amultidisciplinary management approach in cases with a complex and evolving clinical course.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"80 - 89"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42317547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Trichoepithelioma (TE) and basal cell carcinoma (BCC) of skin represent distinct tumor entities but they have a close histogenetic and phenotypic relationship. Objective: A unique case of a BCC arising within a TE is described with an emphasis on the analysis of different and for each tumor type typical immunophenotype. Material and Methods: A 71-year-old man presented with a subcutaneous solid tumor in the lumbar region. The resected tumor specimen was studied by immunohistochemistry. Results: Histology revealed a coexistence of classic TE and nodular BCC. Both tumors were strongly positive for BerEP4 and negative for EMA. Neoplastic epithelium of the BCC showed a diffuse staining for Bcl-2, while the TE expressed Bcl-2 almost exclusively in the peripheral cells of tumor islands. In the BCC, neoplastic nodules exhibited a focal staining for CD10, while the peritumorous stroma did not. In contrast, the TE showed a focal immunoreactivity for CD10 in the stromal cells around the neoplastic islands which were completely negative. The TE contained intratumorous CK20-labeled Merkel cells but they were not detected in the BCC. A stromal immunore-activity for CD34 was found in both tumors. Proliferative activity (Ki-67) was slightly higher in the BCC than in the TE. Conclusion: Although a concomitant presence of TE and BCC in the same skin lesion is a unique finding, it may be sometimes encountered in a biopsy practice. Pathologists should provide a careful histologic examination of the whole TE lesion with precise section sampling to unveil such possible association.
{"title":"Basal Cell Carcinoma Arising within a Trichoepithelioma: An Immunohistochemical Study","authors":"V. Bartoš, Martin Biopsy","doi":"10.2478/acm-2020-0008","DOIUrl":"https://doi.org/10.2478/acm-2020-0008","url":null,"abstract":"Abstract Background: Trichoepithelioma (TE) and basal cell carcinoma (BCC) of skin represent distinct tumor entities but they have a close histogenetic and phenotypic relationship. Objective: A unique case of a BCC arising within a TE is described with an emphasis on the analysis of different and for each tumor type typical immunophenotype. Material and Methods: A 71-year-old man presented with a subcutaneous solid tumor in the lumbar region. The resected tumor specimen was studied by immunohistochemistry. Results: Histology revealed a coexistence of classic TE and nodular BCC. Both tumors were strongly positive for BerEP4 and negative for EMA. Neoplastic epithelium of the BCC showed a diffuse staining for Bcl-2, while the TE expressed Bcl-2 almost exclusively in the peripheral cells of tumor islands. In the BCC, neoplastic nodules exhibited a focal staining for CD10, while the peritumorous stroma did not. In contrast, the TE showed a focal immunoreactivity for CD10 in the stromal cells around the neoplastic islands which were completely negative. The TE contained intratumorous CK20-labeled Merkel cells but they were not detected in the BCC. A stromal immunore-activity for CD34 was found in both tumors. Proliferative activity (Ki-67) was slightly higher in the BCC than in the TE. Conclusion: Although a concomitant presence of TE and BCC in the same skin lesion is a unique finding, it may be sometimes encountered in a biopsy practice. Pathologists should provide a careful histologic examination of the whole TE lesion with precise section sampling to unveil such possible association.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"64 - 71"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45418450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Ultrasound elastography is a relatively new non-invasive diagnostic imaging technology that maps elastic properties and the stiffness of soft tissue. In general, these methods can be classified into strain imaging methods that use internal or external compression stimuli and a shear wave imaging that use ultrasound-generated travelling shear wave stimuli. In this review we describe the basics of ultrasound elastography, discuss differences between various ultrasound elastography techniques, and review advantages, limitations, and the safety of these techniques in clinical practice, especially in neonatology. Furthermore, we review the potential of application of elastography in revealing brain injury and characterizing age dependent differences in preterm and term infants.
{"title":"Ultrasound Elastography: Review of Techniques, Clinical Application, Technical Limitations, and Safety Considerations in Neonatology","authors":"F. Schrenk, P. Uhrík, Z. Uhrikova, Z. Uhrikova","doi":"10.2478/acm-2020-0009","DOIUrl":"https://doi.org/10.2478/acm-2020-0009","url":null,"abstract":"Abstract Ultrasound elastography is a relatively new non-invasive diagnostic imaging technology that maps elastic properties and the stiffness of soft tissue. In general, these methods can be classified into strain imaging methods that use internal or external compression stimuli and a shear wave imaging that use ultrasound-generated travelling shear wave stimuli. In this review we describe the basics of ultrasound elastography, discuss differences between various ultrasound elastography techniques, and review advantages, limitations, and the safety of these techniques in clinical practice, especially in neonatology. Furthermore, we review the potential of application of elastography in revealing brain injury and characterizing age dependent differences in preterm and term infants.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"72 - 79"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43481573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Smolár, I. Dedinská, A. Bobulova, M. Hošala, M. Adámik, M. Grajciar, J. Janik, L. Laca
Abstract Introduction: Fundoplication is the most frequently used action in the surgical treatment of gastroesophageal reflux disease (GERD). There are several types of fundoplication. The objective of our study was to identify complications after surgical treatment of GERD. Material and Methods: We determined several parameters of the monitored and we recorded complications related to surgery: occurrence of surgical, early and late post-surgical complications. Results: 52 patients (24 men and 28 women) with an average age of 53.3 years were included. The most frequently chosen type of fundoplication was Nissen-Rossetti. The most frequently occurring subjective post-surgery difficulties were temporal dysphagia (11.5%), sensation of nausea and vomiting after eating (3.8 %), pain in the surgical wound, and dyspnoea occurring in all patients after thoracotomy. Early post-surgery complication developed in 6 patients (11.5 %) Conclusion: Occurrence of complications in the group monitored by us was up to 11.5 % and perioperative mortality was 0 %. Hiatal hernia is frequently found in patients with GERD and it is considered to be one of the major causes for the development of this disease.
{"title":"Surgical Therapy of Esophagus Reflux Disease","authors":"M. Smolár, I. Dedinská, A. Bobulova, M. Hošala, M. Adámik, M. Grajciar, J. Janik, L. Laca","doi":"10.2478/acm-2020-0007","DOIUrl":"https://doi.org/10.2478/acm-2020-0007","url":null,"abstract":"Abstract Introduction: Fundoplication is the most frequently used action in the surgical treatment of gastroesophageal reflux disease (GERD). There are several types of fundoplication. The objective of our study was to identify complications after surgical treatment of GERD. Material and Methods: We determined several parameters of the monitored and we recorded complications related to surgery: occurrence of surgical, early and late post-surgical complications. Results: 52 patients (24 men and 28 women) with an average age of 53.3 years were included. The most frequently chosen type of fundoplication was Nissen-Rossetti. The most frequently occurring subjective post-surgery difficulties were temporal dysphagia (11.5%), sensation of nausea and vomiting after eating (3.8 %), pain in the surgical wound, and dyspnoea occurring in all patients after thoracotomy. Early post-surgery complication developed in 6 patients (11.5 %) Conclusion: Occurrence of complications in the group monitored by us was up to 11.5 % and perioperative mortality was 0 %. Hiatal hernia is frequently found in patients with GERD and it is considered to be one of the major causes for the development of this disease.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"56 - 63"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42091740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Slavikova, N. Sekaninova, Olexova L. Bona, Z. Visnovcova, I. Tonhajzerova
Abstract Biofeedback is a therapeutic method of obtaining better awareness of physiological functions based on principles of operant conditioning and learning in general. While patient observes changes in physiological parameters in real-time (e.g. blood pressure, heart rate variability, temperature, electrodermal activity, etc.), he/she learns how to manipulate them at will. By means of this technique, individuals can improve their mental, emotional, and physical health. Clinical biofeedback training becomes popular for treating a variety of medical conditions, manage ment of disease symptoms, and improvement of overall health through training of stress management. There is no center or group to systematically deal with biofeedback methods in Slovakia, except the Slovak Institute of CBT (cognitive-behavioral therapy) that teaches biofeedback as a therapeutic method. However, biofeedback and its opportunities have a relatively long history of exploration and practice, which is the best precondition for positive changes in this area. The review article aims to provide an insight to biofeedback training as a non-pharmacological therapeutic tool in stress management and stress-related diseases and disorders. The article also describes biofeedback modalities and efficacy on various medical conditions.
{"title":"Biofeedback – A Promising Non Pharmacological Tool of Stress – Related Disorders","authors":"M. Slavikova, N. Sekaninova, Olexova L. Bona, Z. Visnovcova, I. Tonhajzerova","doi":"10.2478/acm-2020-0001","DOIUrl":"https://doi.org/10.2478/acm-2020-0001","url":null,"abstract":"Abstract Biofeedback is a therapeutic method of obtaining better awareness of physiological functions based on principles of operant conditioning and learning in general. While patient observes changes in physiological parameters in real-time (e.g. blood pressure, heart rate variability, temperature, electrodermal activity, etc.), he/she learns how to manipulate them at will. By means of this technique, individuals can improve their mental, emotional, and physical health. Clinical biofeedback training becomes popular for treating a variety of medical conditions, manage ment of disease symptoms, and improvement of overall health through training of stress management. There is no center or group to systematically deal with biofeedback methods in Slovakia, except the Slovak Institute of CBT (cognitive-behavioral therapy) that teaches biofeedback as a therapeutic method. However, biofeedback and its opportunities have a relatively long history of exploration and practice, which is the best precondition for positive changes in this area. The review article aims to provide an insight to biofeedback training as a non-pharmacological therapeutic tool in stress management and stress-related diseases and disorders. The article also describes biofeedback modalities and efficacy on various medical conditions.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"1 - 8"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48077921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Clostridium difficile infection (CDI) is the most common infectious cause of diarrhoea in hospitalised patients. It is a severe issue with increasing incidence in healtcare facilities and commmunities. Early and appropriate testing of CDI is very imortant. There are many different approaches that can be used in the CDI laboratory diagnostics. Recently performed studies evaluated diagnostic algorithms to optimize laboratory CDI diagnostics. The aim of the work was to implement an optimal algorithm of testing methods in CDI diagnostics. Materials and methods: The retrospective analysis of patients’ samples suspected on CDI was carried out in 2017. The data was analysed from the Laboratory Klinicka Biochemia in Zilina. The application of ESCMID re -commendation criteria for algorithm of testing, together with procedures in laboratory practice was carried out. Results: The analysis of the data showed that the applied algorithm or testing in CDI and highlighted the importance of preanalytic phase, and the evaluation of testing methods and results, together with clinical findings. Two- and three- step algorithm together with cultivation methods were applied. 87,6% of samples could be eva -luated with positive or negative results according to the 2-step algorhitm. Further samples were assessed and tested by ELISA test or PCR method. Conclusion: CDI represents a significant burden in healthcare facilities. An early diagnostics and interpretation helps to start the early treatment and helps in surveillence of the infection.
{"title":"New Approaches to Diagnostics of C.Difficile Infection","authors":"Z. Štofková, E. Nováková, V. Sadloňová","doi":"10.2478/acm-2020-0003","DOIUrl":"https://doi.org/10.2478/acm-2020-0003","url":null,"abstract":"Abstract Introduction: Clostridium difficile infection (CDI) is the most common infectious cause of diarrhoea in hospitalised patients. It is a severe issue with increasing incidence in healtcare facilities and commmunities. Early and appropriate testing of CDI is very imortant. There are many different approaches that can be used in the CDI laboratory diagnostics. Recently performed studies evaluated diagnostic algorithms to optimize laboratory CDI diagnostics. The aim of the work was to implement an optimal algorithm of testing methods in CDI diagnostics. Materials and methods: The retrospective analysis of patients’ samples suspected on CDI was carried out in 2017. The data was analysed from the Laboratory Klinicka Biochemia in Zilina. The application of ESCMID re -commendation criteria for algorithm of testing, together with procedures in laboratory practice was carried out. Results: The analysis of the data showed that the applied algorithm or testing in CDI and highlighted the importance of preanalytic phase, and the evaluation of testing methods and results, together with clinical findings. Two- and three- step algorithm together with cultivation methods were applied. 87,6% of samples could be eva -luated with positive or negative results according to the 2-step algorhitm. Further samples were assessed and tested by ELISA test or PCR method. Conclusion: CDI represents a significant burden in healthcare facilities. An early diagnostics and interpretation helps to start the early treatment and helps in surveillence of the infection.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"18 - 26"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48292725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Malignancies in the ENT (Ear, Nose, and Throat) area are mostly manifested by dysphagia, dysphonia, dyspnea, throat swelling, and other “traditional” head and neck symptoms. Sporadically, a primary tumor or metastasis can reach such a size and it can be localized in such an area in which it can cause the pathology of the brachial plexus. If this appears first, differential diagnosis may be more difficult. In this article the authors review current literature knowledge and present the case of this unusual sign of a head and neck cancer at the Clinic of Otorhinolaryngology and Head and Neck Surgery, Jessenius Faculty of Medicine, Comenius University, and Martin University Hospital, Martin, Slovakia.
{"title":"Brachial Plexopathy as an Unusual First Sign of a Head and Neck Cancer: Case Report","authors":"V. Surova, P. Slávik, V. Calkovsky, A. Hajtman","doi":"10.2478/acm-2020-0005","DOIUrl":"https://doi.org/10.2478/acm-2020-0005","url":null,"abstract":"Abstract Malignancies in the ENT (Ear, Nose, and Throat) area are mostly manifested by dysphagia, dysphonia, dyspnea, throat swelling, and other “traditional” head and neck symptoms. Sporadically, a primary tumor or metastasis can reach such a size and it can be localized in such an area in which it can cause the pathology of the brachial plexus. If this appears first, differential diagnosis may be more difficult. In this article the authors review current literature knowledge and present the case of this unusual sign of a head and neck cancer at the Clinic of Otorhinolaryngology and Head and Neck Surgery, Jessenius Faculty of Medicine, Comenius University, and Martin University Hospital, Martin, Slovakia.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"39 - 44"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47829497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Kalánková, D. Bartoníčková, K. Žiaková, E. Gurková, Radka Kurucová
Abstract Introduction: Safety climate consists of individual dimensions that might be assessed using specific instruments, e.g., the Hospital Survey on Patient Safety Culture (HSOPS). Establishing the safety climate in healthcare facilities leads to improvements in patient safety. Aim: To assess the safety climate at university hospitals in the Slovak Republic from the nurses’ perspective and to determine the relationship between organisational variables and the particular components of the safety climate. Methods: The study has a cross-sectional design. Data were collected using the HSOPS between December 2017 and July 2018. Two university hospitals participated in the study and overall 280 respondents were included. Respondents were recruited through the purposive sampling method. Data were analysed by descriptive and inductive statistics in the statistical programme SPSS 25.0. Results: Results indicate that in the university hospitals there is a low-level of safety climate. The significant relationship was proved between organisational variables such as the experience in the current position, leaving intention, overtime, perception of staff adequacy, unit type, nurse-patient ratio, and the particular components of the safety climate. Conclusion: Our findings may help hospital management to raise the awareness of the safety climate and to gain a sophisticated overview of the particular components of the safety climate. Adding new organisational variables may help to assess the safety climate from multiple perspectives and, thus, identify areas contributing to patient safety.
{"title":"Assessment of the Safety Climate at University Hospitals in the Slovak Republic from the Nurses’ Perspective","authors":"D. Kalánková, D. Bartoníčková, K. Žiaková, E. Gurková, Radka Kurucová","doi":"10.2478/acm-2020-0004","DOIUrl":"https://doi.org/10.2478/acm-2020-0004","url":null,"abstract":"Abstract Introduction: Safety climate consists of individual dimensions that might be assessed using specific instruments, e.g., the Hospital Survey on Patient Safety Culture (HSOPS). Establishing the safety climate in healthcare facilities leads to improvements in patient safety. Aim: To assess the safety climate at university hospitals in the Slovak Republic from the nurses’ perspective and to determine the relationship between organisational variables and the particular components of the safety climate. Methods: The study has a cross-sectional design. Data were collected using the HSOPS between December 2017 and July 2018. Two university hospitals participated in the study and overall 280 respondents were included. Respondents were recruited through the purposive sampling method. Data were analysed by descriptive and inductive statistics in the statistical programme SPSS 25.0. Results: Results indicate that in the university hospitals there is a low-level of safety climate. The significant relationship was proved between organisational variables such as the experience in the current position, leaving intention, overtime, perception of staff adequacy, unit type, nurse-patient ratio, and the particular components of the safety climate. Conclusion: Our findings may help hospital management to raise the awareness of the safety climate and to gain a sophisticated overview of the particular components of the safety climate. Adding new organisational variables may help to assess the safety climate from multiple perspectives and, thus, identify areas contributing to patient safety.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"27 - 38"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45480530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Asthma is a heterogenous disease which pathophysiology is still poorly understood. Asthma was traditionally divided into allergic (extrinsic) and non-allergic (intrinsic) types, while patients with allergic type responded better to corticosteroids. Since 2013 the definition of asthma has changed. Recently, better insight into clinical consi -derations and underlying inflammatory phenotypes has been gained. Defining these phenotypes has already led to more specific clinical trials and, therefore, to more personalized and successfully targeted therapy. For future, much more effort is put in identifying new phenotype-specific biomarkers which could be helpful in stratification of heterogeneous patients with asthma.
{"title":"Bronchial Asthma: Current Trends in Treatment","authors":"R. Paľová, J. Adamcakova, D. Mokra, J. Mokrý","doi":"10.2478/acm-2020-0002","DOIUrl":"https://doi.org/10.2478/acm-2020-0002","url":null,"abstract":"Abstract Asthma is a heterogenous disease which pathophysiology is still poorly understood. Asthma was traditionally divided into allergic (extrinsic) and non-allergic (intrinsic) types, while patients with allergic type responded better to corticosteroids. Since 2013 the definition of asthma has changed. Recently, better insight into clinical consi -derations and underlying inflammatory phenotypes has been gained. Defining these phenotypes has already led to more specific clinical trials and, therefore, to more personalized and successfully targeted therapy. For future, much more effort is put in identifying new phenotype-specific biomarkers which could be helpful in stratification of heterogeneous patients with asthma.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"20 1","pages":"9 - 17"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43905681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Adamicová, Ž. Fetisovová, M. Bobrovská, I. Homola
Abstract Desmoplastic malignant melanoma is a rare variant of spindle cell melanoma commonly seen in older adults on sun-exposed areas. It accounts for 1–4 % of all cases of cutaneous melanoma. The common location of the desmoplastic melanoma is the head and neck region, whereasother sites are less common. A 45-year-old male presented with an proliferative growth on nose, after a trauma that was diagnosed as tumor. Histopathological examination with the help of wide panel of immunohistochemical methods and with emphasis on SOX10, was, after a broad diferential diagnosis concluded as a desmoplastic melanoma.
{"title":"The Importance of Using SOX10 for Exact Diagnosis of Desmoplastic Melanoma","authors":"K. Adamicová, Ž. Fetisovová, M. Bobrovská, I. Homola","doi":"10.2478/acm-2019-0015","DOIUrl":"https://doi.org/10.2478/acm-2019-0015","url":null,"abstract":"Abstract Desmoplastic malignant melanoma is a rare variant of spindle cell melanoma commonly seen in older adults on sun-exposed areas. It accounts for 1–4 % of all cases of cutaneous melanoma. The common location of the desmoplastic melanoma is the head and neck region, whereasother sites are less common. A 45-year-old male presented with an proliferative growth on nose, after a trauma that was diagnosed as tumor. Histopathological examination with the help of wide panel of immunohistochemical methods and with emphasis on SOX10, was, after a broad diferential diagnosis concluded as a desmoplastic melanoma.","PeriodicalId":30233,"journal":{"name":"Acta Medica Martiniana","volume":"19 1","pages":"111 - 116"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45215114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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