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Reconstruction of a Scrotum by Combining Two Skin Flaps in a Ball Shape 结合两个皮瓣成球状重建阴囊
Pub Date : 2022-03-19 DOI: 10.1155/2022/2808821
K. Kashiyama, Motoi Nakano, Akihito Higashi, Shoko Ashizuka, Yuki Moriuchi, Atsuhiko Iwao, Katsumi Tanaka
Background The scrotum functions to maintain spermatogenesis and hormonal production of Leydig cells by preventing the testicles from rising in temperature and protecting them from the outside world. The scrotum, along with the penis, is also an organ that symbolizes masculinity. Therefore, deformity or loss of the scrotum can be a major psychological problem. Various scrotal reconstruction techniques have been reported. In these papers, there is some discussion about the type of skin flap, but little discussion about the method of suturing the skin flap. We devised a way to reconstruct a scrotum to a natural size by suturing two skin flaps together to form a ball shape. Case Presentation. Case 1 was a patient with a missing scrotum due to Fournier's gangrene. Total resection of the scrotum, including the bilateral testes, was performed to save his life. Reconstructive surgery was performed 11 days after the initial surgery. Reconstruction was performed using bilateral gluteal fold flaps. Case 2 was a patient with a congenital defect of the scrotum. The testis on the right side exhibited cryptorchidism, and the scrotum was missing, and the testis on the left side was encased in a hypoplastic scrotum. Reconstruction was performed using an internal pudendal artery perforator flap. Conclusion There are two types of scrotal defects: those with testes present and those with testes missing. This method can be used for both types of scrotal defects, and we were able to create a scrotum that satisfied each patient.
阴囊通过防止睾丸温度升高和保护睾丸不受外界影响来维持精子发生和睾丸间质细胞的激素分泌。阴囊和阴茎一样,也是象征男子气概的器官。因此,阴囊畸形或丢失可能是一个主要的心理问题。各种阴囊重建技术已被报道。在这些文献中,对皮瓣的类型有一些讨论,但对皮瓣的缝合方法讨论甚少。我们设计了一种方法,通过将两个皮瓣缝合在一起形成一个球形来重建阴囊到自然大小。案例演示。病例1是由于富尼耶坏疽导致阴囊缺失的患者。全阴囊切除,包括双侧睾丸,以挽救他的生命。首次手术后11天进行重建手术。采用双侧臀襞皮瓣重建。病例2为阴囊先天性缺损患者。右侧睾丸隐睾,阴囊缺失,左侧睾丸被发育不全的阴囊包裹。使用阴部内动脉穿支皮瓣进行重建。结论阴囊缺损有两种类型:有睾丸者和无睾丸者。这种方法可以用于两种类型的阴囊缺陷,我们能够创造一个满意的阴囊每个病人。
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引用次数: 0
Large Pelvic Hematoma after UroLift® Procedure for Treatment of BPH with Median Lobe UroLift®手术治疗中叶前列腺增生后大盆腔血肿
Pub Date : 2022-03-16 DOI: 10.1155/2022/7065865
Max J. Roehmholdt, D. Bentley
The UroLift® procedure is a minimally invasive technique used to treat benign prostatic hyperplasia (BPH) in the office or hospital setting. As of 2021, over 200,000 of these procedures have been performed, with an excellent safety profile. We present a case report of a patient who underwent the UroLift® procedure and was found to have a 16.5 cm pelvic hematoma within 16 hours. This study was done as a retrospective chart review. In addition, a comprehensive review of the literature was performed, and all relevant government and company websites were reviewed for thorough evaluation. The patient had an uncomplicated inpatient UroLift® procedure for BPH using 5 implants and was discharged from the hospital without incident. The patient presented to the emergency department with abdominal pain 16 hours after the procedure, and a 16.5 cm pelvic hematoma was found on computerized tomography (CT) scan. Since 2015, there have been 27 cases of pelvic hematoma after UroLift® reported to the United States Food and Drug Administration (FDA), and only 2 cases published in the literature. Our patient required hospital admission for 3 days and 3 units of packed red blood cells, but no surgical exploration or intervention. The procedure was technically successful as it improved the patient's voiding and lower urinary tract symptoms (LUTS) as of 2-month follow-up. Potential etiologies include implant firing depth beyond the extent of the prostate, as well as treatment of the median lobe.
UroLift®手术是一种用于治疗办公室或医院环境中的良性前列腺增生(BPH)的微创技术。截至2021年,已经实施了超过20万例此类手术,具有良好的安全性。我们报告了一例患者,他接受了UroLift®手术,并在16小时内发现了16.5厘米的盆腔血肿。本研究采用回顾性图表回顾法。此外,对文献进行了全面的回顾,并对所有相关的政府和公司网站进行了全面的评估。患者接受了简单的UroLift®治疗BPH的住院手术,使用了5个植入物,并顺利出院。手术后16小时,患者以腹痛就诊于急诊科,CT扫描发现16.5 cm盆腔血肿。自2015年以来,向美国食品和药物管理局(FDA)报告的UroLift®术后盆腔血肿27例,文献中仅发表2例。我们的病人需要住院3天和3单位的充血红细胞,但没有手术探查或干预。在2个月的随访中,该手术在技术上是成功的,因为它改善了患者的排尿和下尿路症状(LUTS)。潜在的病因包括植入物发射深度超出前列腺范围,以及正中叶的治疗。
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引用次数: 4
Corrigendum to “Unilateral Giant Hydronephrosis Secondary to Ureteropelvic Junction Obstruction in a Middle-Aged Woman” 《1例中年妇女肾盂输尿管连接处梗阻继发单侧巨大肾积水》的勘误表
Pub Date : 2022-03-02 DOI: 10.1155/2022/9813052
Masresha S Dino, S. Hassen, Tesfaye H. Tufax
[This corrects the article DOI: 10.1155/2021/9900560.].
[这更正了文章DOI: 10.1155/2021/9900560.]。
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引用次数: 0
Laparoscopic Management of an Inflammatory Pseudotumor Mimicking a Locally Advanced Renal Carcinoma: A Diagnostic Pitfall 模拟局部晚期肾癌的炎性假肿瘤的腹腔镜治疗:一个诊断缺陷
Pub Date : 2022-02-23 DOI: 10.1155/2022/4485930
I. Boualaoui, I. Ziani, S. Marrakchi, M. Raiss, F. Zouidia, A. Ibrahimi, H. El Sayegh, Y. Nouini
Inflammatory pseudotumors of the kidney are an infrequent entity. More frequently described in the lung, the genitourinary tract location is rare. Commonly described in the bladder, the kidney damage remains exceptional. Herein, we report the case of 60 years old man with a history of flank pain, initially diagnosed with a locally advanced left renal carcinoma invading the left colon. Then, after performing a laparoscopic radical nephrectomy, the histopathological diagnosis of inflammatory pseudotumor of the left kidney has been made.
肾脏炎性假瘤是一种罕见的肿瘤。更常描述在肺,泌尿生殖道的位置是罕见的。通常发生在膀胱,肾脏的损害仍然是例外。在此,我们报告一个60岁的男性,有腹部疼痛史,最初诊断为局部晚期左肾癌侵犯左结肠。然后,在进行腹腔镜根治性肾切除术后,对左肾炎性假瘤进行了组织病理学诊断。
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引用次数: 1
Ureteral Diaphragmatic Hernia Treated with Ureteral Stenting: A Case Report and Review of the Literature 输尿管支架术治疗输尿管膈疝1例报告及文献复习
Pub Date : 2022-02-22 DOI: 10.1155/2022/4866502
Tateki Yoshino, Ayako Itakura, Shinnosuke Fujikawa, Tomoyuki Sugitani, K. Kawakami, Emi Ishibashi, K. Kodama, Shota Oshima
Ureteral diaphragmatic hernia through diaphragmatic defects is an exceptionally rare subset of ureteral hernia with only fourteen such cases reported in English manuscripts. An 85-year-old woman was introduced to our department with right flank pain, fever elevation, and nausea. Urinalysis showed bacteriuria, and Escherichia coli was detected in the urine culture. Blood analysis revealed abnormal findings, including elevated WBC count (10,510/μl) and C-reactive protein (0.28 mg/dl). Computed tomography (CT) of the abdomen demonstrated a defect of the right diaphragmatic crus containing a dilated right ureter with associated hydronephrosis. Retrograde pyelography showed hydronephrosis and dilated ureter loops through the defect of diaphragmatic crus, known as a “curlicue sign,” and the diagnosis was right ureteral diaphragmatic hernia. A ureteral stent was placed on her right side, and the ureter was reducted into the retroperitoneal space. After six months, the ureteral stent was removed, with no subsequent recurrence of the ureteral diaphragmatic hernia at seven months. We reviewed all cases in the literature published in English of ureteral diaphragmatic hernia. While the etiology of ureteral diaphragmatic hernia is unknown, our present case and previous reports suggest that a ureteral diaphragmatic hernia may occur due to hepatic atrophy and/or an elevated position of the right kidney.
经膈缺损的输尿管膈疝是一种非常罕见的输尿管疝亚群,在英文文献中仅报道了14例此类病例。一名85岁妇女因右侧疼痛、发热升高和恶心被介绍到我科。尿液分析显示细菌尿,尿培养检出大肠杆菌。血液分析显示异常,包括白细胞计数(10,510/μl)和c反应蛋白(0.28 mg/dl)升高。腹部计算机断层扫描(CT)显示右侧横膈膜小腿缺损,右侧输尿管扩张伴伴肾积水。逆行肾盂造影显示肾积水及经膈脚缺损的输尿管袢扩张,称为“曲线征”,诊断为右侧输尿管膈疝。在患者右侧放置输尿管支架,并将输尿管缩小至腹膜后间隙。6个月后,输尿管支架被移除,7个月后无输尿管膈疝复发。我们回顾了所有输尿管膈疝的英文文献。虽然输尿管膈疝的病因尚不清楚,但我们目前的病例和以前的报道表明,输尿管膈疝可能是由于肝萎缩和/或右肾位置升高而发生的。
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引用次数: 0
Prune Belly Syndrome Associated with Interstitial 17q12 Microdeletion. 西梅肚综合征与间质17q12微缺失相关。
Pub Date : 2022-02-14 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7364286
Surasak Puvabanditsin, Miry Shim, Jeffrey Suell, Jeffrey Manzano, Kristin Blackledge, Avram Bursky-Tammam, Rajeev Mehta

We report a term male neonate presenting with a "prune belly," bilateral hydronephrosis, hydroureter, posterior urethral obstruction, and bilateral undescended testes. Analysis with the whole genome SNP microarray revealed an interstitial deletion of about 1.49 megabase (MB) at chromosome 17q12. We present a rare association of prune belly syndrome with a chromosomal deletion in this same region.

我们报告一个男性新生儿表现为“梅子肚”,双侧肾积水,输尿管积水,后尿道梗阻和双侧睾丸隐睾。全基因组SNP芯片分析显示,17q12染色体间质缺失约1.49兆碱基(MB)。我们提出了一个罕见的关联梅干腹综合征与染色体缺失在同一区域。
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引用次数: 0
The "Tri-Glide" Technique: A Case Report on a Novel Intraoperative Approach for Removal of Retained and Encrusted Ureteral Stents. “三滑”技术:术中取出输尿管内保留和结膜支架的新方法一例报告。
Pub Date : 2022-02-03 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5708348
Alejandra Perez, Adam Carl Nolte, Giuseppe Maurici, Alexander Charles Small, Spencer Steve Liem, Jorge Francisco Pereira, Alan Scott Polackwich, Rafael Yanes, Ojas Shah

Background: Retained ureteral stents can result in significant morbidity and can be surgically challenging to urologists. A multimodal approach is often necessary for removal, potentially including retrograde and antegrade procedures performed over multiple anesthetic sessions. We describe the novel "Tri-Glide" technique for treating retained stents, particularly those with stent shaft encrustation prohibiting safe removal. Case Presentation. Two patients with nephrolithiasis and retained, encrusted ureteral stents were managed with the "Tri-Glide" technique. Patient #1 was a 58-year-old man with a severely calcified ureteral stent, retained for 14 years. After undergoing simultaneous cystolitholapaxy and percutaneous nephrolithotomy to treat proximal and distal encrustations, the stent shaft remained trapped in the ureter due to heavy calcifications. Three hydrophilic guidewires were passed alongside the stent, allowing it to easily slide out of the ureter intact. Patient #2 was a 74-year-old man who after only 3-months of stent dwell time developed severe stent shaft encrustation preventing removal. After multiple maneuvers failed, the "Tri-Glide" technique was used to create a smooth track for stent to slide out intact with gentle traction. Both patients did well postoperatively with no complications.

Conclusion: The "Tri-Glide" technique can aid in the management of complex encrusted stent extractions, especially when there is significant shaft encrustation.

背景:留置输尿管支架可导致显著的发病率,对泌尿科医生来说是一个手术挑战。多模式切除通常是必要的,可能包括在多个麻醉过程中进行逆行和顺行手术。我们描述了新颖的“Tri-Glide”技术,用于治疗保留的支架,特别是那些支架轴结皮无法安全移除的支架。案例演示。我们对2例肾结石合并输尿管支架保留、结壳的患者进行了“Tri-Glide”技术的治疗。患者1是一名58岁的男性,输尿管支架严重钙化,保留了14年。同时行膀胱截石术和经皮肾镜取石术治疗近端和远端结痂后,由于钙化严重,支架轴仍滞留在输尿管内。三根亲水导丝被放置在支架旁边,使其可以很容易地完整地滑出输尿管。患者2是一名74岁的男性,在支架放置仅3个月后就出现了严重的支架轴结痂,无法取出。在多次操作失败后,使用“Tri-Glide”技术创建一个平滑的轨道,使支架在温和的牵引下完整地滑出。两例患者术后均表现良好,无并发症。结论:“Tri-Glide”技术可以帮助处理复杂的支架结痂,特别是当有明显的轴部结痂时。
{"title":"The \"Tri-Glide\" Technique: A Case Report on a Novel Intraoperative Approach for Removal of Retained and Encrusted Ureteral Stents.","authors":"Alejandra Perez,&nbsp;Adam Carl Nolte,&nbsp;Giuseppe Maurici,&nbsp;Alexander Charles Small,&nbsp;Spencer Steve Liem,&nbsp;Jorge Francisco Pereira,&nbsp;Alan Scott Polackwich,&nbsp;Rafael Yanes,&nbsp;Ojas Shah","doi":"10.1155/2022/5708348","DOIUrl":"https://doi.org/10.1155/2022/5708348","url":null,"abstract":"<p><strong>Background: </strong>Retained ureteral stents can result in significant morbidity and can be surgically challenging to urologists. A multimodal approach is often necessary for removal, potentially including retrograde and antegrade procedures performed over multiple anesthetic sessions. We describe the novel \"Tri-Glide\" technique for treating retained stents, particularly those with stent shaft encrustation prohibiting safe removal. <i>Case Presentation</i>. Two patients with nephrolithiasis and retained, encrusted ureteral stents were managed with the \"Tri-Glide\" technique. Patient #1 was a 58-year-old man with a severely calcified ureteral stent, retained for 14 years. After undergoing simultaneous cystolitholapaxy and percutaneous nephrolithotomy to treat proximal and distal encrustations, the stent shaft remained trapped in the ureter due to heavy calcifications. Three hydrophilic guidewires were passed alongside the stent, allowing it to easily slide out of the ureter intact. Patient #2 was a 74-year-old man who after only 3-months of stent dwell time developed severe stent shaft encrustation preventing removal. After multiple maneuvers failed, the \"Tri-Glide\" technique was used to create a smooth track for stent to slide out intact with gentle traction. Both patients did well postoperatively with no complications.</p><p><strong>Conclusion: </strong>The \"Tri-Glide\" technique can aid in the management of complex encrusted stent extractions, especially when there is significant shaft encrustation.</p>","PeriodicalId":30323,"journal":{"name":"Case Reports in Urology","volume":" ","pages":"5708348"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39777116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Urethral Prolapse Case Report: Surgical and Social Considerations in Senegal. 尿道脱垂病例报告:塞内加尔的外科和社会考虑。
Pub Date : 2022-01-24 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5541416
Mohamed Jalloh, Jennifer Heibig, Oumar Gaye, William Ghaul, Gabrielle Yankelevich, Medina Ndoye, Mouhamadou Moustapha Mbodji, Ayun Cassell, Lamine Niang, Serigne Magueye Gueye

We present three cases of urethral prolapse in prepubertal females in Senegal who presented with vulvar bleeding. Careful gynecologic and urologic physical exams were performed and revealed urethral origin and prolapse. Conservative versus surgical approaches were taken in different patients, but ultimately, each patient received a urethral meatoplasty. Surgical excision of these masses yielded a full recovery in the patients. A careful review of the literature was then undertaken and showed that surgical excision or ligation of the prolapse is preferable to more conservative treatment. The case series article discusses the rare occurrence of urethral prolapse, as well as the epidemiology and prognostic and therapeutic implications of urethral prolapse in prepubertal females. Introduction. Urethral prolapse is a rare condition occurring mostly in young black females. It can be worrying to the parents as it often causes vulvar bleeding. Case Presentation. We present three cases of urethral prolapse in prepubertal females who presented with vulvar bleeding. Physical exams were performed and revealed urethral origin and prolapse. Each patient underwent a urethral meatoplasty and subsequently experienced a full recovery after respective follow-up of 2 years, 1 year, and 1 year. Conclusion. Urethral prolapse is a rare condition which can be managed successfully by surgery. Plain Language Summary. This case report on pediatric urethral prolapse showcases the different presentations and modalities of treatment, as the literature does not show that a specific treatment is always undertaken. In some countries, there are strong social considerations and they demonstrate difficulty separating sexual abuse from genitourinary pathologies, which are important to address in the treatment of these conditions.

我们提出三例尿道脱垂的青春期前女性在塞内加尔谁提出外阴出血。进行了仔细的妇科和泌尿科体检,发现了尿道起源和脱垂。不同的病人采取了保守和手术的方法,但最终,每个病人都接受了尿道肉成形术。手术切除这些肿块使患者完全康复。对文献进行了仔细的回顾,并表明手术切除或结扎脱垂比保守治疗更可取。本文讨论了尿道脱垂的罕见情况,以及尿道脱垂在青春期前女性中的流行病学和预后及治疗意义。介绍。尿道脱垂是一种罕见的疾病,主要发生在年轻的黑人女性中。它可以担心的父母,因为它经常导致外阴出血。案例演示。我们提出三例尿道脱垂在青春期前女性谁提出外阴出血。进行体格检查,发现尿道起源和脱垂。每位患者都接受了尿道肉成形术,并在分别随访2年、1年和1年后完全恢复。结论。尿道脱垂是一种罕见的疾病,可以通过手术成功治疗。简单的语言总结。小儿尿道脱垂的病例报告展示了不同的表现和治疗方式,因为文献没有显示特定的治疗总是进行。在一些国家,有强烈的社会考虑,他们表现出难以将性虐待与泌尿生殖系统疾病分开,这在治疗这些疾病时很重要。
{"title":"Urethral Prolapse Case Report: Surgical and Social Considerations in Senegal.","authors":"Mohamed Jalloh,&nbsp;Jennifer Heibig,&nbsp;Oumar Gaye,&nbsp;William Ghaul,&nbsp;Gabrielle Yankelevich,&nbsp;Medina Ndoye,&nbsp;Mouhamadou Moustapha Mbodji,&nbsp;Ayun Cassell,&nbsp;Lamine Niang,&nbsp;Serigne Magueye Gueye","doi":"10.1155/2022/5541416","DOIUrl":"https://doi.org/10.1155/2022/5541416","url":null,"abstract":"<p><p>We present three cases of urethral prolapse in prepubertal females in Senegal who presented with vulvar bleeding. Careful gynecologic and urologic physical exams were performed and revealed urethral origin and prolapse. Conservative versus surgical approaches were taken in different patients, but ultimately, each patient received a urethral meatoplasty. Surgical excision of these masses yielded a full recovery in the patients. A careful review of the literature was then undertaken and showed that surgical excision or ligation of the prolapse is preferable to more conservative treatment. The case series article discusses the rare occurrence of urethral prolapse, as well as the epidemiology and prognostic and therapeutic implications of urethral prolapse in prepubertal females. <i>Introduction</i>. Urethral prolapse is a rare condition occurring mostly in young black females. It can be worrying to the parents as it often causes vulvar bleeding. <i>Case Presentation</i>. We present three cases of urethral prolapse in prepubertal females who presented with vulvar bleeding. Physical exams were performed and revealed urethral origin and prolapse. Each patient underwent a urethral meatoplasty and subsequently experienced a full recovery after respective follow-up of 2 years, 1 year, and 1 year. <i>Conclusion</i>. Urethral prolapse is a rare condition which can be managed successfully by surgery. <i>Plain Language Summary</i>. This case report on pediatric urethral prolapse showcases the different presentations and modalities of treatment, as the literature does not show that a specific treatment is always undertaken. In some countries, there are strong social considerations and they demonstrate difficulty separating sexual abuse from genitourinary pathologies, which are important to address in the treatment of these conditions.</p>","PeriodicalId":30323,"journal":{"name":"Case Reports in Urology","volume":" ","pages":"5541416"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39759480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report of COVID-19 in a Living Kidney Transplant Recipient: A Challenging Case with Complete Rehabilitation. 活体肾移植受者感染COVID-19病例报告:一个具有挑战性的完全康复病例
Pub Date : 2022-01-17 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2517674
Mahtab Poor Zamany Nejat Kermaney, Mohammad Hamidi Madani, Milad Bonakdar Hashemi, Alireza Zadmehr, Mehdi Dadpour, Fatemeh Roodneshin

Adjustment of immunosuppressive and COVID-19 treatment in terms of drug interactions is still challenging. Herein, we report a 45-year-old woman with end-stage renal disease due to autosomal dominant polycystic diseases (ADPKD) with COVID-19 and pulmonary involvement following kidney transplantation. The patient was properly treated by discontinuation of immunosuppressive drugs, bronchoscopy, and high volume of blood transfusions. The fact that we quickly used early intubation and a new treatment regimen that suppressed immune systems may help physicians develop optimal treatment strategies for similar severe cases. However, this treatment method requires more detailed evaluations due to the contradictory results in reviewing other studies.

在药物相互作用方面调整免疫抑制和COVID-19治疗仍然具有挑战性。在此,我们报告了一位45岁的女性,由于常染色体显性多囊病(ADPKD)合并COVID-19和肾移植后肺部受累而患有终末期肾脏疾病。停用免疫抑制药物、支气管镜检查和大量输血对患者进行了适当的治疗。事实上,我们迅速使用早期插管和抑制免疫系统的新治疗方案可能有助于医生为类似的严重病例制定最佳治疗策略。然而,由于在回顾其他研究时结果相互矛盾,这种治疗方法需要更详细的评价。
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引用次数: 1
Anti-SARS-CoV-2 Antibody Level among Renal Transplant Recipients: A Case Report from Nepal. 肾移植受者的抗 SARS-CoV-2 抗体水平:来自尼泊尔的病例报告
Pub Date : 2022-01-10 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2889501
Kamal Ranabhat, Bhuvan Saud, Saroj Adhikari, Suraj Bhattarai, Rojan Adhikari, Bhoj Raj Luitel, Mahesh Raj Sigdel

Globally, SARS-CoV-2 has caused significant public health burden, mainly in patients with underlying comorbidities including both communicable and noncommunicable diseases. Solid organ transplant recipients under immunesupressive medication are also amongst the high risk group. There is only sparse data on immunity against SARS-CoV-2 infection among renal transplant recipients. In this case report, we present the level of anti-SARS-CoV-2 antibody of three kidney transplant recipients after vaccination against COVID-19 virus. All three cases had received two doses of Oxford-AstraZeneca COVID-19 vaccine AZD1222 (ChAdOx1). Serological analysis showed protective level of circulating antibodies in the blood of all three cases. Although two out of three patients in the study acquired COVID-19 infection after immunization, they recovered with mild clinical course. Hence, we conclude that despite immune-suppressed status of transplant recipients, COVID-19 vaccination could protect them against severe illness.

在全球范围内,SARS-CoV-2 对公共卫生造成了巨大的负担,主要是对患有传染性和非传染性疾病等潜在合并症的患者。正在接受免疫抑制药物治疗的实体器官移植受者也属于高危人群。关于肾移植受者对 SARS-CoV-2 感染的免疫力,目前只有很少的数据。在本病例报告中,我们介绍了三名肾移植受者在接种 COVID-19 病毒疫苗后的抗 SARS-CoV-2 抗体水平。所有三个病例都接种了两剂牛津-阿斯利康公司生产的 COVID-19 疫苗 AZD1222 (ChAdOx1)。血清学分析显示,所有三个病例的血液中都存在保护性循环抗体。虽然研究中的三名患者中有两名在免疫接种后感染了 COVID-19,但他们都在轻微的临床过程中恢复了健康。因此,我们得出结论:尽管移植受者处于免疫抑制状态,但接种 COVID-19 疫苗可以保护他们免受严重疾病的侵袭。
{"title":"Anti-SARS-CoV-2 Antibody Level among Renal Transplant Recipients: A Case Report from Nepal.","authors":"Kamal Ranabhat, Bhuvan Saud, Saroj Adhikari, Suraj Bhattarai, Rojan Adhikari, Bhoj Raj Luitel, Mahesh Raj Sigdel","doi":"10.1155/2022/2889501","DOIUrl":"10.1155/2022/2889501","url":null,"abstract":"<p><p>Globally, SARS-CoV-2 has caused significant public health burden, mainly in patients with underlying comorbidities including both communicable and noncommunicable diseases. Solid organ transplant recipients under immunesupressive medication are also amongst the high risk group. There is only sparse data on immunity against SARS-CoV-2 infection among renal transplant recipients. In this case report, we present the level of anti-SARS-CoV-2 antibody of three kidney transplant recipients after vaccination against COVID-19 virus. All three cases had received two doses of Oxford-AstraZeneca COVID-19 vaccine AZD1222 (ChAdOx1). Serological analysis showed protective level of circulating antibodies in the blood of all three cases. Although two out of three patients in the study acquired COVID-19 infection after immunization, they recovered with mild clinical course. Hence, we conclude that despite immune-suppressed status of transplant recipients, COVID-19 vaccination could protect them against severe illness.</p>","PeriodicalId":30323,"journal":{"name":"Case Reports in Urology","volume":" ","pages":"2889501"},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39834462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Case Reports in Urology
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