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Metastatic Melanoma to the Urinary Bladder: A Rare Cause of Visible Haematuria 膀胱转移性黑色素瘤:可见血尿的罕见病因
Pub Date : 2024-03-01 DOI: 10.1155/2024/5516547
Olawale O Ogunremi, Dinelle Sirjuesingh, Aniket Deshpande
Bladder metastasis from cutaneous melanoma is a rare pathology. A 79-year-old woman presented to the haematuria clinic on account of painless visible haematuria. Ten years prior to this index presentation, she was diagnosed with melanoma on her right thigh following a total excision of the skin lesion. Cystoscopy showed a pigmented bladder tumour, and the histology report following a transurethral resection was consistent with metastatic melanoma, and further imaging revealed metastasis to the lungs, adrenals, and lymph nodes.
皮肤黑色素瘤转移到膀胱是一种罕见的病理现象。一名 79 岁的妇女因无痛性肉眼血尿来到血尿门诊就诊。十年前,她被诊断为右大腿黑色素瘤,并接受了皮肤病变全切除术。膀胱镜检查显示有色素沉着的膀胱肿瘤,经尿道切除术后的组织学报告与转移性黑色素瘤一致,进一步的影像学检查显示肿瘤已转移至肺部、肾上腺和淋巴结。
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引用次数: 0
Pelvic Abscess Caused by Ureteral Calculus and Abscess Treatment through Aspiration by Transperineal Puncture 输尿管结石引起的盆腔脓肿和经会阴穿刺抽吸法治疗脓肿
Pub Date : 2024-01-25 DOI: 10.1155/2024/1723185
Bo-Ran An, Chao Gao, Di An
Pelvic abscess is mostly caused by gynecological inflammation or digestive system diseases such as appendicitis or Crohn’s disease. This case of pelvic abscess originates from ureteral calculus and is not commonly seen in clinical practice. This is mainly due to the patient’s ureteral stones not being actively treated. After local puncture and pus extraction, as well as the application of effective antibiotics, the patient recovered. Therefore, this case provides clinical doctors with experience that ureteral stones may cause serious complications and should be actively treated after detection.
盆腔脓肿多由妇科炎症或消化系统疾病(如阑尾炎或克罗恩病)引起。本例盆腔脓肿源于输尿管结石,在临床上并不常见。这主要是因为患者的输尿管结石没有得到积极治疗。经过局部穿刺抽脓,并应用有效的抗生素治疗后,患者痊愈。因此,本病例为临床医生提供了经验,即输尿管结石可能引起严重并发症,发现后应积极治疗。
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引用次数: 0
Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy. Pembrolizumab疗法使吉西他滨和顺铂治疗后肺转移灶切除和根治性膀胱切除术后复发的患者获得完全缓解
Pub Date : 2024-01-17 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5586448
Kyohei Ishida, Go Hasegawa, Takehisa Hashimoto, Yohei Ikeda, Noboru Hara, Tsutomu Nishiyama

A 64-year-old man was diagnosed with invasive bladder and right lower ureteral urothelial cancer with right pelvic lymph node and lung metastases. He received four courses of gemcitabine and cisplatin therapy. He underwent lung metastasectomy and radical cystoprostatectomy, with not only primary lesions but also metastatic lesions showing a complete response. New multiple lung metastases were revealed five months after adjuvant chemotherapy. On starting pembrolizumab therapy, the metastatic lesions are notably reduced in size. He is currently receiving pembrolizumab therapy, and no recurrence has been observed for over one year.

一名 64 岁的男子被诊断出患有浸润性膀胱癌和右输尿管下段尿路上皮癌,并伴有右盆腔淋巴结和肺转移。他接受了四个疗程的吉西他滨和顺铂治疗。他接受了肺转移灶切除术和根治性前列腺膀胱切除术,不仅原发病灶,转移病灶也显示出完全反应。辅助化疗五个月后发现新的多发性肺转移灶。开始接受pembrolizumab治疗后,转移病灶明显缩小。他目前正在接受pembrolizumab治疗,一年多以来未见复发。
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引用次数: 0
Malignant Epithelioid Mesothelioma of the Tunica Vaginalis Testis Presenting as Hydrocele in a Kidney Transplant Recipient 肾移植受者睾丸阴道上皮样恶性间皮瘤表现为鞘膜积液
Pub Date : 2024-01-10 DOI: 10.1155/2024/9227764
Brett M. Behers, C.W. Guske, Benjamin J. Behers, Spencer B. Kortum, Isabella G. Bermingham, Christina L. Warner, Robert I. Carey
Mesotheliomas of the tunica vaginalis testis are rare malignant tumors that can present as a scrotal mass or hydrocele. These tumors are typically aggressive with high rates of recurrence and metastasis. Suspected risk factors for malignant mesothelioma include asbestos exposure, chronic inflammation, trauma, and persistent hydrocele. We report the case of a malignant epithelioid mesothelioma of the tunica vaginalis testis that presented as a finding at hydrocelectomy and was ultimately treated with radical inguinal orchiectomy. This patient was on chronic immunosuppression therapy with tacrolimus and mycophenolate mofetil secondary to a kidney transplant but had none of the common risk factors for mesothelioma formation. To our knowledge, this is the first case describing a possible connection between chronic immunosuppression and mesothelioma of the tunica vaginalis. However, future studies are needed to investigate this association and discern whether this could have played a role in our patient or if his mesothelioma formation was coincidental.
阴道睾丸间皮瘤是一种罕见的恶性肿瘤,可表现为阴囊肿块或鞘膜积液。这些肿瘤通常具有侵袭性,复发率和转移率都很高。恶性间皮瘤的可疑风险因素包括石棉暴露、慢性炎症、外伤和持续性鞘膜积液。我们报告了一例阴道睾丸外膜恶性上皮样间皮瘤病例,该病例是在鞘膜积液切除术中发现的,最终通过腹股沟睾丸根治术进行了治疗。该患者因肾移植而长期使用他克莫司和霉酚酸酯进行免疫抑制治疗,但没有间皮瘤形成的常见风险因素。据我们所知,这是第一例描述慢性免疫抑制与阴道外膜间皮瘤之间可能存在联系的病例。不过,今后还需要对这种关联进行研究,以确定这种关联在我们的病人身上是否起了作用,或者他的间皮瘤的形成是否是偶然的。
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引用次数: 0
A Peculiar Cause of Shock: Analysing Two Clinical Cases 休克的特殊原因:分析两个临床病例
Pub Date : 2023-12-02 DOI: 10.1155/2023/8901383
João Oliveira, Alberto Costa-Silva, L. Vale, D. Costa, Rui Almeida-Pinto, C. Martins-Silva, T. Antunes-Lopes, João Silva
Introduction Pheochromocytoma is a rare neoplasia arising from the adrenal medulla that secretes catecholamines. Those afflicted by this condition can present a wide range of symptoms. One of the most common is paroxysmic hypertension. Interestingly, although rare, some patients present with shock. We describe two cases of pheochromocytoma in which the initial presentation was shock. Case 1. 49 year-old woman, with a history of resistant hypertension, presented to the emergency department with thoracic pain and fever. EKG, echocardiogram (ECC), and myocardial necrosis markers were compatible with Takotsubo syndrome (TS). CT demonstrated a staghorn calculus, hydronephrosis, and signs compatible with xanthogranulomatous pyelonephritis in the right kidney. Additionally, and incidentally, it revealed a 60 mm nodule on the right adrenal gland. Piperacillin/tazobactam was started immediately, and the patient was submitted to urgent upper urinary tract drainage. This procedure was complicated by a cardiorespiratory arrest that was treated with adrenaline administration. The patient was admitted to the ICU due to multifactorial shock and started alpha and, posteriorly, beta blockage. Biochemical adrenal incidentaloma endocrinologic study was negative (under hemodialysis). Multiorgan failure progressively improved. After 2 weeks, the patient was submitted to a laparoscopic transperitoneal right adrenalectomy. No complications were reported. Histological analysis revealed a pheochromocytoma. Case 2. 28-year-old woman presented to the emergency department with headaches and nausea. Vitals were compatible with shock. CT revealed an incidental 72 mm mass on the right adrenal. EKG, ECC, and myocardial necrosis markers were compatible with TS. The patient was started on alpha and, posteriorly, beta blockage. Adrenal incidentaloma endocrinological study demonstrated high urinary catecholamines. Right transperitoneal adrenalectomy was performed. No complications were noted. Histological analysis revealed a pheochromocytoma. Conclusion Pheochromocytoma can present with complex, enigmatic, and rare clinical pictures. Clinicians should be wary of the possibility of this diagnosis when managing adrenal masses.
嗜铬细胞瘤是一种罕见的肿瘤,起源于分泌儿茶酚胺的肾上腺髓质。患有这种疾病的人可能会出现各种各样的症状。其中最常见的是阵发性高血压。有趣的是,虽然罕见,但有些患者会出现休克。我们描述了两例嗜铬细胞瘤,其中最初的表现是休克。案例1。49岁女性,有顽固性高血压病史,因胸痛和发热到急诊科就诊。心电图、超声心动图(ECC)和心肌坏死标志物与Takotsubo综合征(TS)一致。CT显示右肾鹿角状结石、肾积水及黄色肉芽肿性肾盂肾炎征象。另外,顺便一提,在右肾上腺上发现了一个60毫米的结节。立即开始使用哌拉西林/他唑巴坦,患者被提交紧急上尿路引流。这一过程因心肺骤停而变得复杂,并给予肾上腺素治疗。患者因多因素休克而入住ICU,并开始α和后β阻塞。生化肾上腺偶发瘤内分泌学研究阴性(血液透析下)。多器官功能衰竭逐渐改善。2周后,患者接受腹腔镜经腹膜右肾上腺切除术。无并发症报道。组织学分析显示为嗜铬细胞瘤。例2。28岁女性因头痛和恶心到急诊室就诊。生命体征与休克相符。CT显示右肾上腺偶发72毫米肿块。心电图、ECC和心肌坏死标志物与TS一致。患者开始进行α阻滞,随后进行β阻滞。肾上腺偶发瘤内分泌学研究显示尿儿茶酚胺含量高。行右侧经腹膜肾上腺切除术。无并发症。组织学分析显示为嗜铬细胞瘤。结论嗜铬细胞瘤临床表现复杂、难解、罕见。临床医生在处理肾上腺肿块时应警惕这种诊断的可能性。
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引用次数: 0
Prune Belly Syndrome in a Female Newborn following In Vitro Fertilization-Induced Pregnancy: A Case Report and Literature Review. 体外受精诱导妊娠后女性新生儿妊娠脐综合征:病例报告和文献综述。
Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5521590
Ibraheem M Alkhawaldeh, Jaber H Jaradat, Mohammad Al-Jafari, Abdulqadir J Nashwan, Samer Irshaid Alrahamneh

Prune belly syndrome (PBS) is a rare congenital anomaly characterized by a triad of abdominal flaccidity, varying degrees of urinary system involvement, and cryptorchidism. The exact cause of PBS is unknown. Clinical symptoms can range from stillbirth to significant renal and respiratory abnormalities to almost normal children. Treatment typically involves surgical repair of the abdominal wall defect and urinary tract abnormalities, early orchiopexy, and supportive management of related problems. We report the first case of a female newborn with PBS following in vitro fertilization-induced pregnancy with a comprehensive systematic review of all relevant cases.

槑肚综合征(PBS)是一种罕见的先天性畸形,以腹部松弛、泌尿系统不同程度受累和隐睾三联症为特征。PBS 的确切病因尚不清楚。临床症状从死胎、明显的肾脏和呼吸系统异常到几乎正常的儿童都有。治疗通常包括手术修复腹壁缺损和泌尿道异常、早期睾丸切除术以及相关问题的支持性治疗。我们报告了首例体外受精诱导妊娠后患有 PBS 的女性新生儿病例,并对所有相关病例进行了全面系统的回顾。
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引用次数: 0
Male Genital Mutilation in the Name of Ritual Circumcision: A Case Report and Literature Review. 以仪式包皮环切术为名切割男性生殖器:一例报告及文献复习。
Pub Date : 2023-10-07 eCollection Date: 2023-01-01 DOI: 10.1155/2023/9935247
Latif Dar, Alhareth Baarimah, Saeed Alshehrani, Alhassan Alasiri, Mohammad Alassiri, Saleh Al-Ghamdi

Unlike female genital mutilation, the alteration of male genitals has not received much attention. Circumcision is the most common and oldest surgical procedure being performed. When performed by surgeons or well-trained personal the procedure is safe, but most of the times it is being performed by untrained people with no or little medical background. This has led to many complications. Total skin loss is an uncommon but serious complication. There is an ongoing debate regarding the management of this complication. Here, we present a case of total penile skin loss which had resulted from penile mutilation in the name of ritual circumcision.

与切割女性生殖器不同,男性生殖器的改变没有受到太多关注。包皮环切术是最常见和最古老的外科手术。当由外科医生或训练有素的个人进行手术时,手术是安全的,但大多数时候是由没有或几乎没有医学背景的未经训练的人进行的。这导致了许多复杂情况。皮肤完全脱落是一种罕见但严重的并发症。关于这种复杂情况的管理,目前正在进行辩论。在这里,我们提出了一个完全的阴茎皮肤损失的案例,这是由于以仪式包皮环切的名义切割阴茎造成的。
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引用次数: 0
Unusual Location of Residual Mass in an Uncorrected Undescended Testis with Germ Cell Tumor. 未矫正未发现睾丸生殖细胞肿瘤残留肿块的异常位置。
Pub Date : 2023-10-03 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6626799
Navid Masoumi, Mostafa Farajpour, Atoosa Gharib

Intra-abdominal cancer in an adult with undescended testis (UDT) is rare owing to widespread screening and management during childhood. Here, we present a 33-year-old gentleman with a complaint of abdominal pain and pelvic mass which appeared to be an uncorrected UDT with cancerous degeneration. Additional evaluation revealed a suspicious mass in the retrovesical space which remained after chemotherapy. Histologic evaluation after resection of this mass indicated cancer spread of testicular origin behind the bladder.

由于儿童时期广泛的筛查和治疗,患有睾丸下发(UDT)的成年人的术中癌症是罕见的。在这里,我们介绍一位33岁的先生,他主诉腹痛和骨盆肿块,这似乎是一个未经矫正的UDT,伴有癌变。进一步评估显示,化疗后膀胱后间隙有可疑肿块。切除该肿块后的组织学评估表明,癌症起源于睾丸,在膀胱后扩散。
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引用次数: 0
First Two Cases of Conservative Treatment for Extreme Proximal Penile Fracture of the Corpora Cavernosa. 阴茎海绵体近端极端骨折保守治疗的头两个病例。
Pub Date : 2023-06-10 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5706109
Alicia Blondeau, Aurélie Grandmougin, Clément Larose, Charles Mazeaud

Penile fracture is a urological emergency, and surgery is usually recommended to prevent complications. However, proximal locations are scarce and not well investigated. We present two rare penile fractures involving the proximal corpora cavernosa with an original conservative strategy to manage this clinical presentation. Twenty-five- and thirty-eight-year-old men with no previous medical history were admitted to the emergency room for penile trauma during sexual intercourse a few months apart. Both presented with "butterfly pattern" ecchymosis with a palpable hematoma on the perineum. They had no hematuria or voiding dysfunction. Ultrasound found a hematoma and a tear of the proximal corpus cavernosum for the younger one. Then, an MRI confirmed a longitudinal fracture of the right corpus cavernosum for the first patient and left for the second, without urethral injury. In agreement with the patients facing this atypical presentation, we proposed a conservative treatment with analgesics, monitoring, and advice to stop sexual activity for three weeks. After six weeks and four weeks, respectively, we performed a clinical evaluation and a second MRI that found no residual tear or hematoma. The IIEF-5 questionnaire was 24/25 and 25/25. The patients were clinically symptom-free at 8 and 11 months of follow-up. Extreme proximal fracture of the corpus cavernosum can be managed conservatively in selected situations. MRI is useful for decision-making by confirming the diagnosis and location to avoid surgery.

阴茎骨折是泌尿科急症,通常建议采用手术治疗以预防并发症。然而,近端位置的骨折很少见,而且研究也不深入。我们介绍了两例罕见的阴茎骨折,均涉及阴茎海绵体近端,并采用独创的保守策略来处理这一临床表现。25岁和38岁的男性无病史,因性交时阴茎外伤被送入急诊室,时间相隔数月。两人都出现了 "蝴蝶状 "瘀斑,会阴部可触及血肿。他们没有血尿或排尿功能障碍。超声波检查发现血肿,年轻患者的海绵体近端撕裂。然后,核磁共振检查证实,第一名患者的右侧海绵体纵向骨折,第二名患者的左侧海绵体纵向骨折,但没有尿道损伤。针对患者的这种非典型表现,我们建议采取保守治疗,使用镇痛剂,进行监测,并建议患者在三周内停止性生活。六周和四周后,我们分别进行了临床评估和第二次核磁共振成像检查,均未发现残余撕裂或血肿。IIEF-5调查问卷分别为24/25和25/25。随访8个月和11个月时,患者均无临床症状。在某些情况下,海绵体近端极端骨折可以采取保守治疗。核磁共振成像有助于通过确诊和确定位置做出决策,从而避免手术。
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引用次数: 0
Robot-Assisted Removal of a Partially Intravesical Intrauterine Device (IUD) and Large Bladder Stone. 机器人辅助移除部分膀胱内节育器(IUD)和大膀胱结石。
Pub Date : 2023-01-27 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8074689
Cassandra Heaney, Paul Lee, Andrew Winer

An intrauterine device (IUD) is a highly effective and widely utilized option for long-acting reversible contraception. IUDs are generally well-tolerated with a low rate of serious complications. Perforation of an IUD through the uterine wall and into the urinary bladder is a rare event that may be asymptomatic. The approach for surgical removal primarily depends on the location of the device. We present a case report of a 41-year-old woman who was found to have a partially intravesical IUD and associated 2.4 cm bladder calculus. Removal of the intravesical IUD and stone was achieved with cystoscopy, cystolitholapaxy, and robot-assisted laparoscopic cystotomy.

宫内节育器(IUD)是一种高效且广泛使用的长效可逆避孕方法。宫内节育器通常耐受性良好,严重并发症发生率较低。宫内节育器穿过子宫壁进入膀胱是一种罕见的无症状事件。手术切除的方法主要取决于器械的位置。我们报告了一名41岁女性的病例报告,她被发现有部分膀胱内宫内节育器和相关的2.4 cm膀胱结石。通过膀胱镜检查、膀胱取石术和机器人辅助腹腔镜膀胱切开术去除膀胱内宫内节育器和结石。
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引用次数: 0
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Case Reports in Urology
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