In the Diego blood group, the frequency of the Di(a+b+) or Di(a+b-) phenotype among Chinese in Taiwan is estimated to be 3.2%. Here we report a case of severe hemolytic disease caused by anti-Di(superscript a). The baby’s total bilirubin elevated to 23mg/dl at the age of 72 hours. A blood exchange transfusion and phototherapy were performed. We suggest to include Diego positive cell panels in testing antibody specificities that are likely to be encountered in this population.
{"title":"Hemolytic Disease of the Newborn due to Anti-Di(superscript a): Report of One Case","authors":"C. Peng, W. Soong, Hui‐Yu Hu, Benson Huang","doi":"10.7097/APS.199610.0370","DOIUrl":"https://doi.org/10.7097/APS.199610.0370","url":null,"abstract":"In the Diego blood group, the frequency of the Di(a+b+) or Di(a+b-) phenotype among Chinese in Taiwan is estimated to be 3.2%. Here we report a case of severe hemolytic disease caused by anti-Di(superscript a). The baby’s total bilirubin elevated to 23mg/dl at the age of 72 hours. A blood exchange transfusion and phototherapy were performed. We suggest to include Diego positive cell panels in testing antibody specificities that are likely to be encountered in this population.","PeriodicalId":306859,"journal":{"name":"Acta paediatrica sinica","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1996-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124283119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mother-to-infant transmission of hepatitis C virus (HCV) does occur in a lower efficiency way(0-15％,average in 4.7％)in infants of HCV viremic mothers than that of hepatitis B virus. It is very likely due to the lower viral level of mothers. Infants of mothers coinfected by HCV and human immunodeficiency virus (HIV), or with high HCV RNA titer (＞10^6 copies/ml) are at high risk of HCV infection by their mothers. Persistence of HCV infection with transient or persistent abnormal aminotransferase levels occurred in most(81％) HCV infected infants studied longitudimally, although normal liver function profile was also observed. Up to now, no effective way can prevent mother-to-infant transmission of HCV. Further investigation to understand more the natural history of infants perinatally infected by HCV and the indication for antiviral therapies are needed.
{"title":"中華民國小兒科醫學會第145屆學術演講會 教育演講：兒童疾病的新境界—C型肝炎病毒之母子傳染","authors":"張美惠","doi":"10.7097/APS.199604.0013","DOIUrl":"https://doi.org/10.7097/APS.199604.0013","url":null,"abstract":"Mother-to-infant transmission of hepatitis C virus (HCV) does occur in a lower efficiency way(0-15％,average in 4.7％)in infants of HCV viremic mothers than that of hepatitis B virus. It is very likely due to the lower viral level of mothers. Infants of mothers coinfected by HCV and human immunodeficiency virus (HIV), or with high HCV RNA titer (＞10^6 copies/ml) are at high risk of HCV infection by their mothers. Persistence of HCV infection with transient or persistent abnormal aminotransferase levels occurred in most(81％) HCV infected infants studied longitudimally, although normal liver function profile was also observed. Up to now, no effective way can prevent mother-to-infant transmission of HCV. Further investigation to understand more the natural history of infants perinatally infected by HCV and the indication for antiviral therapies are needed.","PeriodicalId":306859,"journal":{"name":"Acta paediatrica sinica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1996-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128202566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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